Browsing by Author "Popović, Mirjana B. (55300928500)"

The goal of this study was to investigate repetitive finger tapping patterns in patients with Parkinson's disease (PD), progressive supranuclear palsy-Richardson syndrome (PSP-R), or multiple system atrophy of parkinsonian type (MSA-P). The finger tapping performance was objectively assessed in PD (n = 13), PSP-R (n = 15), and MSA-P (n = 14) patients and matched healthy controls (HC; n = 14), using miniature inertial sensors positioned on the thumb and index finger, providing spatio-temporal kinematic parameters. The main finding was the lack or only minimal progressive reduction in amplitude during the finger tapping in PSP-R patients, similar to HC, but significantly different from the sequence effect (progressive decrement) in both PD and MSA-P patients. The mean negative amplitude slope of -0.12°/cycle revealed less progression of amplitude decrement even in comparison to HC (-0.21°/cycle, p = 0.032), and particularly from PD (-0.56°/cycle, p = 0.001), and MSA-P patients (-1.48°/cycle, p = 0.003). No significant differences were found in the average finger separation amplitudes between PD, PSP-R and MSA-P patients (pmsa-pd = 0.726, pmsa-psp = 0.363, ppsp-pd = 0.726). The lack of clinically significant sequence effect during finger tapping differentiated PSP-R from both PD and MSA-P patients, and might be specific for PSP-R. The finger tapping kinematic parameter of amplitude slope may be a neurophysiological marker able to differentiate particular forms of parkinsonism. © 2016 Elsevier Ltd. All rights reserved.

The goal of this study was to investigate repetitive finger tapping patterns in patients with Parkinson's disease (PD), progressive supranuclear palsy-Richardson syndrome (PSP-R), or multiple system atrophy of parkinsonian type (MSA-P). The finger tapping performance was objectively assessed in PD (n = 13), PSP-R (n = 15), and MSA-P (n = 14) patients and matched healthy controls (HC; n = 14), using miniature inertial sensors positioned on the thumb and index finger, providing spatio-temporal kinematic parameters. The main finding was the lack or only minimal progressive reduction in amplitude during the finger tapping in PSP-R patients, similar to HC, but significantly different from the sequence effect (progressive decrement) in both PD and MSA-P patients. The mean negative amplitude slope of -0.12°/cycle revealed less progression of amplitude decrement even in comparison to HC (-0.21°/cycle, p = 0.032), and particularly from PD (-0.56°/cycle, p = 0.001), and MSA-P patients (-1.48°/cycle, p = 0.003). No significant differences were found in the average finger separation amplitudes between PD, PSP-R and MSA-P patients (pmsa-pd = 0.726, pmsa-psp = 0.363, ppsp-pd = 0.726). The lack of clinically significant sequence effect during finger tapping differentiated PSP-R from both PD and MSA-P patients, and might be specific for PSP-R. The finger tapping kinematic parameter of amplitude slope may be a neurophysiological marker able to differentiate particular forms of parkinsonism. © 2016 Elsevier Ltd. All rights reserved.

Introduction/Objective The aim of this study was to compare kinematic features and graphic rules of writing between children with attention deficit/hyperactivity disorder (ADHD) (with and without medical treatment) and typically developed children (TDC). Methods In total, 55 children (26 with ADHD/ten subjects were on methylphenidate treatment and 29 TDC) completed a writing task on a digitizing board (in three repetitions; using non-inking stylus) which included a semicircle tracing, triangle, and letter copying. Kinematic features of movements in all tasks and graphic rules during a semicircle tracing were analyzed. Graphic rules were observed as expected movements (selecting the starting point and direction of tracing). Results The values of kinematic parameter jerk were significantly larger in TDC group compared to all ADHD subjects (regardless of treatment) and increased constantly with semicircle task progression and repetition in both groups. Children with ADHD without methylphenidate treatment used overall slower movements compared to TDC. The tracing of children with ADHD taking methylphenidate was more automated (with less change in movement velocity and acceleration) compared to TDC. In ADHD group only, those with treatment traced faster and more automated compared to those without treatment. The majority of subjects used expected movements in semicircle tracing and this percentage increased with the task repetition (without difference between ADHD and TDC). Conclusion Both children with ADHD and TDC used similar approach in the tracing task and were compliant with graphic rules. Methylphenidate treatment may positively influence writing kinematics in children with ADHD. Task repetition also influences writing. © 2020, Serbia Medical Society. All rights reserved.