Browsing by Author "Popadić, Aleksandra Perić (6603789117)"

Aim. To test the discriminative metric properties and specificity of the Serbian version of the Asthma Quality of Life Questionnaire (AQLQ) for assessment of the quality of life in asthma patients. Method. We studied 100 atopic and 60 nonatopic adult asthma patients with different disease severity, who were consecutively recruited from the outpatient and inpatient departments of the Institute of Allergology and Immunology, University Center of Serbia, between March 2000 and June 2002. After linguistic validation, AQLQ was administered, as well as Paykel's scale of stressful life events. Tests of statistical significance and General Linear Model were used to explore the correlation between characteristics of patients, disease, and environment, and AQLQ scores. Reliability of the questionnaire was evaluated by determining its internal consistency with Cronbach's alpha coefficient. Results. A more severe form of the disease (F = 16.05; p < 0.001), life in rural disease areas (t = -2.67; p = 0.008) and changes in weather conditions (t= 3.05; p= 0.003) were significantly associated with worse overall quality of life of the tested asthma patients. Older patients had poorer quality of life in domains of activity limitation (B = -0.024; 95% confidence interval [CI], -0.036 to -0. 011; p < 0.001) and exposure to environmental stimuli (B = -0.022; 95% CI, -0.039 to -0.006; p = 0.008). Higher values of forced expiratory volume in one second (FEV 1 , % predicted) were correlated with better quality of life in overall (B = 0.017; 95% CI, 0.009-0.025; p < 0.001) and other questionnaire domains, except in domain of environmental stimuli. Poorer overall quality of life was recorded in atopic patients sensitive to house dust mites (t = 2,60; p = 0.011). Form (atopic and nonatopic) and duration of disease, as well as stressful life events were not significantly related to asthmatic patients' quality of life. The Cronbach's alpha ranged from 0.72 to 0.93. Conclusion. Disease severity, place of residence, weather conditions, age, and FEV 1 (% predicted) were significantly related to quality of life in our patients. The Serbian version of AQLQ was highly reliable.

Background and objectives: The relationship between air pollen quantity and the sensitization of allergic patients is crucial for both the diagnosis and treatment of allergic diseases. Weather conditions influence the distribution of allergenic pollen and increases in pollen concentration may negatively affect the health of allergic patients. The aim of this study was to analyze the implementation of allergen immunotherapy with regard to air pollen concentration. Material and Methods: Here we examined the relationship between Betula air pollen concentration and the usage of Betula verrucosa allergen immunotherapy in Serbia. Examination covered the period from 2015 to 2018. Measurement of airborne pollen concentration was performed with Lanzoni volumetric pollen traps. The evidence of the usage of sublingual allergen immunotherapy (SLIT) was gathered from patients with documented sensitization to specific pollen. Results: During this period tree pollens were represented with 58% ± 21% of all measured air pollen species, while Betula pollen represented 15% ± 8% of all tree pollens. Betula pollination peaked in April. Allergen immunotherapy to Betula verrucosa in Serbia is entirely conducted as sublingual immunotherapy and represents 47.1% ± 1.4% of issued tree pollen SLIT. The use of pollen SLIT increased by 68% from 2015 to 2018, with an even greater increase in usage recorded for Betula SLIT—80%. Conclusions: This analysis shows a clear causative relationship between pollination and the type/prevalence of applied allergen immunotherapy. Information about the flowering seasons of allergenic plants is very important for people who suffer from allergy, for clinical allergologists, as well as for governing authorities. The presented data is of practical importance to the proper timing of immunotherapy initiation and of importance for urban landscaping. The obtained data can be the starting point for the instatement of a thorough epidemiological study and the inclusion of Serbia on the pollen map of Europe. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.