Browsing by Author "Petrovic, Jovan (57315862300)"

Peripheral arterial disease (PAD) and coronary artery disease (CAD) are manifestations of atherosclerosis, affecting a substantial proportion of the population. Despite their interrelation, the prevalence of CAD in severe PAD varies, prompting the need to understand their complex relationship. This study retrospectively analyzes prospectively collected data from a high-volume vascular center to assess CAD prevalence, risk factors, and implications for patients undergoing vascular surgery. Among 667 arterial disease patients, 19.5% underwent coronary angiography, with CAD detected in 61.5% of cases. CAD varied across vascular beds. Decision-making around preoperative coronary angiography and revascularization remains complex, with benefits for high-risk patients still being debated. In accordance with current guidelines, the routine practice of coronary revascularization preceding vascular surgery is generally discouraged. This study underscores the need for risk stratification to identify patients who might benefit from coronary revascularization prior to vascular surgery while adhering to cost-effectiveness and avoiding unnecessary and time-consuming diagnostics in the majority of patients. Patient demographics, risk factors, and clinical presentation were analyzed alongside hospital stay, mortality, and complications. The study highlights the challenges in managing patients with concurrent CAD and PAD and calls for improved protocols for treating this high-risk group. © The Author(s) 2023.

Background: The management of mitral regurgitation during aortic valve replacement remains a complex question. Secondary mitral regurgitation often improves post-aortic valve replacement without mitral valve surgery, but residual mitral regurgitation can significantly affect long-term outcomes. This study investigates the natural history of mitral regurgitation following isolated aortic valve replacement and identifies prognostic factors for persistent mitral regurgitation. Methods: A retrospective study was conducted on 108 patients who underwent isolated aortic valve replacement. Patients were categorized based on mitral regurgitation improvement. Additionally, patients were divided into patient-prosthesis mismatch and non-patient-prosthesis mismatch groups based on the aortic prosthesis. Preoperative and postoperative echocardiographic data were analyzed. Results: In total, 63% of patients showed mitral regurgitation improvement. The improved functional MR group showed significant reductions in peak and mean transvalvular pressure gradients. In contrast, the patient-prosthesis mismatch group had persistent mitral regurgitation improvement in 59.2% of patients. The non-patient-prosthesis mismatch group exhibited significant structural improvements and a reduction in mitral regurgitation severity in 68.6% of patients. Conclusions: The study shows that aortic valve replacement could significantly improve MR when patient-prosthesis mismatch is avoided. This approach maximizes hemodynamic outcomes, mitigates the risk of residual or worsening mitral regurgitation, and potentially reduces the need for additional mitral valve interventions. © 2024 by the authors.

Background: This report contributes to VASCUNET data on treating peripheral artery disease (PAD) in Serbia, addressing sex differences, revascularization types, procedure characteristics, and morbidity and mortality. Methods: SerbVasc, part of the VASCUNET collaboration, includes vascular procedures from 27 Serbian hospitals. Data from 1681 PAD patients were analyzed, focusing on sex disparities, diabetes prevalence, previous procedures, infection and tissue loss, and morbidity and mortality rates. Results: Males formed the majority, comprising 1169 (69.5%) of the patients. Men were significantly more often treated open surgically compared to women (77.6% vs 68.0%; p=0.000). Diabetes stood at 40.2% prevalence. Smoking history was noted in 61.9% of patients, predominantly males. Complication rates stood at 7.5%, with diabetic patients more prone to reinterventions and graft restenosis. The in-hospital mortality rate was 1.6%, with significant predictors of mortality including urgent procedures and recent myocardial infarction. The severity of the infection was correlated with diabetes (r=0.250, p=0.000) and previous amputations (r=0.186, p=0.000). Patients undergoing revascularization followed by minor amputations had a significantly lower incidence of major amputation (0.1% vs 2.9%, p=0.000). Conclusions: SerbVasc data provides a comprehensive overview of PAD management, highlighting the significant impact of diabetes and smoking on disease progression and outcomes. Clinical Impact: This study highlights critical aspects of PAD management in developing countries, emphasizing sex differences, risk factors, and outcomes. Males predominated and are more likely to undergo open surgery. Diabetes and smoking significantly influenc disease progression, with diabetic patients experiencing higher rates of graft restenosis and reinterventions. Urgent procedures and recent myocardial infarctions are key predictors of in-hospital mortality. Combining revascularization with minor amputations reduced major amputation rates. These findings provide valuable data for tailoring treatment strategies, optimizing resource allocation, and improving outcomes for PAD patients, with implications extending beyond Serbia to similar healthcare systems. © The Author(s) 2024.

The primary aim of the presented study is to analyze and compare the rate of carotid restenosis in patients after eversion carotid endarterectomy (eCEA), primary carotid angioplasty and stenting (CASp), and stenting for carotid artery restenosis after previous eCEA (CASr). The secondary aim is to compare clinical outcomes in patients with carotid restenosis. The total number of patients with evident carotid restenosis was 223 (24.8%). In patients with eCEA, significant carotid restenosis rate was 12.7%, in the CASp group 18.7%, and CASr 6.7%. Patients with carotid restenosis were asymptomatic in 95.1% of cases. Patients in the CASp group experienced transient ischemic attack more than patients with eCEA (P =.007), while no difference was observed regarding cerebrovascular insult (CVI). The incidence of carotid restenosis was higher in CASp patients, and increased during the follow-up. The majority of patients are asymptomatic post-procedural and the degree of carotid restenosis does not correlate with the occurrence of postoperative symptoms. High low-density lipoprotein cholesterol (LDL-C) levels, low high-density lipoprotein cholesterol (HDL-C) levels, smoking, and a history of vascular surgery correlate with higher degrees of carotid restenosis. The most important factor in the prevention of carotid restenosis is risk factor control as well as adequate pharmacological therapy. © The Author(s) 2022.

Colic artery aneurysms (CAA) are among the rarest visceral artery aneurysms that carry a significant risk of rupture with a high mortality rate. Concomitant occlusive disease of the mesenteric arteries can significantly alter the type of treatment undertaken (open or endovascular). We present the case of a 68-year-old woman with a visceral artery aneurysm that was discovered coincidently during a routine ultrasound examination. The patient reported no abdominal or back pain or any symptoms associated with mesenteric ischemia. Computed tomography angiography showed a near total occlusion of the celiac trunk, segmental complete occlusion of the superior mesenteric artery, and a middle colic artery (MCA) aneurysm measuring 22 mm in diameter. Complete resection of the MCA aneurysm was performed, with subsequent reconstruction by end-to-end anastomosis. There is no clear evidence to support indications for intervention according to aneurysm size in asymptomatic patients with CAA. Endovascular occlusion of the proximal and distal arterial segments is often considered a first-line approach, which was inappropriate in our case. Open surgical reconstruction was mandatory to preserve collateral circulation and avoid bowel ischemia in circumstances of occlusive mesenteric artery disease. We decided not to treat the stenotic lesions of the mesenteric arteries, given the absence of mesenteric ischemia symptoms. © Indian Association of Cardiovascular-Thoracic Surgeons 2025.

[No abstract available]

Subclavian artery aneurysm (SAA) is a rare and potentially life and limb-threatening disease. Fibromuscular dysplasia (FMD) is an idiopathic, segmental, non-atherosclerotic and non-inflammatory disease of the musculature of arterial walls, leading to stenosis of small- and medium-sized arteries. We are presenting a case of surgical treatment of SAA due to FMD with compression symptoms. A 63-year-old woman was admitted due to an 18-mm right SAA. She complained of constant pain in the right shoulder. Due to the significant compression symptoms, risk of rupture, embolization and thrombosis, surgical treatment was indicated. The aneurysm was isolated through the supraclavicular incision and resected with subsequent subclavian artery (SA) reconstruction. Histopathological findings showed FMD, with thickened intima and fibroplasia of the subintimal layer of the arterial wall and luminal nodular formation as a striking feature, with tunica media being atrophic and replaced by fibrous tissue. The postoperative course was uneventful, and after 6 months, the patient was doing well with SA flow well preserved and no more pain in the right shoulder. SAA due to FMD is rare. Surgical treatment in such cases is the preferable treatment option over endovascular, due to the relief of aneurysmal sac compression symptoms on surrounding nerves and structures. In the case of isolated subclavian artery pseudoaneurysm, one should suspect that the cause could be FMD. © Indian Association of Cardiovascular-Thoracic Surgeons 2024.

This is a case report of a 63-year-old man who presented with a pseudoaneurysm of the left common carotid artery following a previous neck injury. The pseudoaneurysm was discovered incidentally during a routine Doppler ultrasound of the neck after the patient suffered a stroke with right-sided hemiparesis and dysphasia. A multi-detector computed tomography angiography scan showed a 25-mm pseudoaneurysm with a partial thrombus in the lumen, originating from the left common carotid artery. The patient underwent open surgery with reconstruction done by the interposition of a prosthetic graft between the common and internal carotid arteries. The postoperative course was uneventful, and the patient was discharged on the third postoperative day. The rarity of extracranial carotid artery pseudoaneurysms and their potential to cause serious complications such as stroke and rupture underscores the need for prompt diagnosis and management. The question of the best treatment remains controversial, and there are no studies that directly compare the success of open surgery and endovascular treatment of extracranial carotid artery pseudoaneurysm. Regular ultrasound monitoring should be performed in patients with confirmed neck trauma and/or operations to detect any delayed onset of carotid pseudoaneurysms. © Association of Surgeons of India 2023.

Todd’s paralysis is a neurological deficit that is observed in <10% of patients following epileptic seizures. Cerebral hyperperfusion syndrome (CHS) is a rare complication following carotid endarterectomy (CEA), seen in 0-3% of the patients, characterized by focal neurological deficit, headache, disorientation, and sometimes seizures. In this case report, we present a case of CHS after CEA followed by seizures and Todd’s paralysis that mimicked postoperative stroke. A 75-year-old female patient was admitted for CEA of the right internal carotid artery, following a transient ischemic attack two months prior. Four hours after CEA with graft interposition, the patient suffered a temporary weakness of the left arm and leg followed by generalized spasms within a few seconds. CT angiography showed regular patency of the carotid arteries and the graft, and brain CT showed no sign of oedema, ischemia or hemorrhage. However, left-sided hemiplegia occurred following the seizure, and the patient suffered four more seizures over the next 48 hours, with persisting hemiplegia. On the second postoperative day, the motor skills of the left side fully recovered, and the patient was communicative, and of orderly mental status. Brain CT performed on the third postoperative day showed entire right hemisphere oedema. A moderate hemiparesis with seizures as a consequence of CHS after CEA has been described, however in all cases with seizures and hemiplegia, the underlying cause was always a verified stroke or intracerebral hemorrhage. This case highlights the importance of considering Todd’s paralysis in patients with seizures after CEA due to CHS and prolonged periods of hemiplegia after the seizures. © 2023 EDIZIONI MINERVA MEDICA.