Browsing by Author "Orlic, Natasa Karadzov (41561546900)"

Background/Objectives: Cesarean section (CS) is an essential intervention in obstetric care, significantly contributing to reducing the rate of maternal and neonatal mortality and morbidity. It has been recommended that the acceptable CS rate should not go beyond 10–15% across all deliveries. Nonetheless, the CS rate has escalated over the past decades. To understand the factors contributing to the rise in CS rates, the Robson classification that relies on pre-labor, intrapartum, and postpartum parameters has been proposed. As no journal-reported data are currently available on the implementation of the Robson classification in Serbia, we aimed to identify trends in CS rates, as well as the Robson groups with the highest risk for CS at our tertiary care clinic. Methods: We conducted a retrospective, cross-sectional analysis of 6574 women who gave birth to live fetuses weighing a minimum of 500 g and with a gestational age of at least 22 weeks. Results: The overall CS rate was 30.5%, with a statistically significant difference in CS rates between different Robson groups (X2 = 2703.9, p < 0.001). Robson groups 1 (31.9%), 3 (30.4%), and 5 (10.3%) were the largest, and groups 9 (0.9%) and 7 (1.3%) were the smallest. The CS rate in group 5 was the highest (30.3%), followed by groups 1 (20.3%) and 2 (13.2%). Group 5 was the largest contributor to the absolute CS rate (9.25%), followed by groups 1 (6.21%) and 2 (4.03%). Conclusions: We effectively implemented Robson classification for monitoring CS rates and distinguishing specific groups that individually contribute to these rates. © 2025 by the authors.

Recurrent pregnancy loss (RPL) is a heterogeneous condition affecting up to 5% of women of reproductive age. Inherited thrombophilia have been postulated as one of the causes of RPL. Here we examined the prevalence of nine thrombophilic gene polymorphisms among women with history of recurrent miscarriages and fertile controls. The study included 70 women with history of at least three early pregnancy losses and 31 fertile controls with no miscarriages. We investigated mutations in genes responsible for clotting and fibrinolysis, including factor V (FV) Leiden, FV H1299R, factor II (FII) G20210A, methylene tetrahydrofolate reductase (MTHFR) C677T and A1298C, factor XIII (FXIII) V34L, plasminogen activator inhibitor-1 (PAI-1) 4G/5G and endothelial protein C receptor (EPCR) H1 and H3 haplotypes using reverse polymerase chain reaction ViennaLab cardiovascular disease StrippAssays. Our results showed no significant increase in prevalence of tested polymorphisms in women with RPL. However, relative risk for PRL among women heterozygous for FXIII V34L was 2.81 times increased (OR 2.81, 95% CI 1.15-6.87, P=0.023). Haplotype analysis showed that combined presence of high-risk genotypes for FXIII and PAI-1 significantly increases risk for RPL (OR 13.98, CI 95% 1.11-17.46, P=0.044). This is the first study in Serbian population that investigated prevalence of FVR2, A1298C, FXIII V34L and EPCR gene variants. Compound heterozygosity for FXIII V34L and PAI-1 4G is significant risk factor for recurrent miscarriage. Our results should be viewed in context of small case-control study, so further large prospective studies are need for confirmation of our findings. © 2019 Society of Medical Biochemists of Serbia and Montenegro.

Recurrent pregnancy loss (RPL) is a heterogeneous condition affecting up to 5% of women of reproductive age. Inherited thrombophilia have been postulated as one of the causes of RPL. Here we examined the prevalence of nine thrombophilic gene polymorphisms among women with history of recurrent miscarriages and fertile controls. The study included 70 women with history of at least three early pregnancy losses and 31 fertile controls with no miscarriages. We investigated mutations in genes responsible for clotting and fibrinolysis, including factor V (FV) Leiden, FV H1299R, factor II (FII) G20210A, methylene tetrahydrofolate reductase (MTHFR) C677T and A1298C, factor XIII (FXIII) V34L, plasminogen activator inhibitor-1 (PAI-1) 4G/5G and endothelial protein C receptor (EPCR) H1 and H3 haplotypes using reverse polymerase chain reaction ViennaLab cardiovascular disease StrippAssays. Our results showed no significant increase in prevalence of tested polymorphisms in women with RPL. However, relative risk for PRL among women heterozygous for FXIII V34L was 2.81 times increased (OR 2.81, 95% CI 1.15-6.87, P=0.023). Haplotype analysis showed that combined presence of high-risk genotypes for FXIII and PAI-1 significantly increases risk for RPL (OR 13.98, CI 95% 1.11-17.46, P=0.044). This is the first study in Serbian population that investigated prevalence of FVR2, A1298C, FXIII V34L and EPCR gene variants. Compound heterozygosity for FXIII V34L and PAI-1 4G is significant risk factor for recurrent miscarriage. Our results should be viewed in context of small case-control study, so further large prospective studies are need for confirmation of our findings. © 2019 Society of Medical Biochemists of Serbia and Montenegro.

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