Browsing by Author "Ninkov, V. (6701635031)"

Haemoregeneration after the irradiation with 600 R was studied using two different fractions given before and after the transplantation of bone-marrow cells. The dose of 600 R was divided in two uneven fractions: 500 + 100 R, 400 + 200 R and 300 + 300 R. During the free interval between the two doses (5 min) transplantation of bone-marrow cells was performed. Recolonization of bone-marrow and spleen was analysed on the 10th day after treatment. For analysis, samples of blood, bone-marrow and spleen were used. Maximal effect was found in the experimental group of animals irradiated with 500 R before and with 100 R after marrow-cell transplantation. Minimal haematopoietic response was in the group irradiated with 300 R before and after transplantation. This points at the importance of the primary dose for acceptance of the transplants and their activation.

Haemoregeneration after the irradiation with 600 R was studied using two different fractions given before and after the transplantation of bone-marrow cells. The dose of 600 R was divided in two uneven fractions: 500 + 100 R, 400 + 200 R and 300 + 300 R. During the free interval between the two doses (5 min) transplantation of bone-marrow cells was performed. Recolonization of bone-marrow and spleen was analysed on the 10th day after treatment. For analysis, samples of blood, bone-marrow and spleen were used. Maximal effect was found in the experimental group of animals irradiated with 500 R before and with 100 R after marrow-cell transplantation. Minimal haematopoietic response was in the group irradiated with 300 R before and after transplantation. This points at the importance of the primary dose for acceptance of the transplants and their activation.

Fractional doses of cyclophosphamide (Cy; 5 × 60 mg per kg) given to rats caused more severe initial destruction of thymic cortex and medulla, with a corresponding decrease of thymic mass, than did a single dose of the same amount (300 mg per kg). After the fractional dose, regeneration was retarded and repopulation was suppressed, so that on day 15 the thymus was almost totally alymphoid, in contrast to the initial regeneration seen after the single dose. On day 20 after the fractional dose of Cy an initial degree of regeneration corresponding to that seen on day 15 after the single dose, was found. The delayed restriction of regenerative capacity was more marked after the divided dose than after the single dose of Cy. © 1984.

Fractional doses of cyclophosphamide (Cy; 5 × 60 mg per kg) given to rats caused more severe initial destruction of thymic cortex and medulla, with a corresponding decrease of thymic mass, than did a single dose of the same amount (300 mg per kg). After the fractional dose, regeneration was retarded and repopulation was suppressed, so that on day 15 the thymus was almost totally alymphoid, in contrast to the initial regeneration seen after the single dose. On day 20 after the fractional dose of Cy an initial degree of regeneration corresponding to that seen on day 15 after the single dose, was found. The delayed restriction of regenerative capacity was more marked after the divided dose than after the single dose of Cy. © 1984.

Restriction of thymic regenerative capacity, in contrast to the data in the literature, was found 30 days after a single (300 mg per kg) or fractionated doses (5 × 60 mg per kg) of Cyclophosphamide. Detailed cellular analysis revealed myelometaplastic changes in the thymic parenchyma, especially in the outer cortex and cortico-medullary zone. Plasmoid elements also appeared in the outer cortex. The capsular and septal connective tissue was markedly thickened. The thymic mass was decreased. The changes were more marked after the fractionated than after the single dose of Cyclophosphamide. © 1984.

Restriction of thymic regenerative capacity, in contrast to the data in the literature, was found 30 days after a single (300 mg per kg) or fractionated doses (5 × 60 mg per kg) of Cyclophosphamide. Detailed cellular analysis revealed myelometaplastic changes in the thymic parenchyma, especially in the outer cortex and cortico-medullary zone. Plasmoid elements also appeared in the outer cortex. The capsular and septal connective tissue was markedly thickened. The thymic mass was decreased. The changes were more marked after the fractionated than after the single dose of Cyclophosphamide. © 1984.