Browsing by Author "Nikolic, D. (26023650800)"

Objectives: This randomized study aimed to evaluate the correlation between bone mineral densities (BMD) measured at different sites and the frequency of vertebral fractures in a group of Serbian postmenopausal women. Method: BMD was measured in 130 naïve postmenopausal women by dual X-ray absorptiometry (DXA) at the ultra-distal part of the forearms, at the hip and at the lumbar spine. At each of the measurement sites, the patients were categorized as osteoporotic, or osteopenic, or in the reference range. Vertebral fractures were examined using thoracic and lumbar spine radiography. Results: A T-score at different skeletal sites showed discordance in the site-specific region. Vertebral fractures were found in 58.82% of patients with hip osteopenia, in 45% with forearm osteopenia and in 54.54% with lumbar spine osteoporosis. Conclusions: The study confirmed that the reduction of BMD depends on age and choice of measurement site. The best correlation was obtained in the women with osteopenia at all measurement sites. The discovery of vertebral fractures by lateral thoracic and lumbar spine radiography improves prompt treatment. Reference values of BMD do not exclude vertebral fractures. Of vertebral fractures, 72.5% were asymptomatic and thus spine radiographies are obligatory. Currently discussed is the position of DXA for measuring BMD as a method of detection for patients at risk of fracture. © 2016 International Menopause Society.

Background: The Aim of our study was to present and analyze the distribution of cerebrovascular insult types and their localization in patients with normal body temperature by means of computerized tomography, and in those with elevated body temperature by means of neuroradiographic findings. Methods: In our study we evaluated 103 patients that suffered a cerebrovascular insult and were treated at Special Hospital for Cerebrovascular disorders "Saint Sava" in Belgrade. All patients were divided into two groups due to the presence of elevated body temperature. Results: Fever as a complication in period after acute cerebrovascular insult is presented in almost every fifth patient. In the group of patients with fever, the most common presentation was acute ischemic cerebrovascular insult, namely in 45.63 %, while in the group of patients with normal body temperature, the most common presentation was lacunar infarction, namely in 46.60 % of participants. The most frequent localization of cerebrovascular insult is in cortex and subcortex regions. Conclusions: It should be stated that some patients with specific types of cerebrovascular insult as well as their localization are at higher risk for development of complications. This study suggests that appropriate diagnostics as well as prevention and management of in-hospital complications could improve the short-term and long-term prognoses after stroke (Tab. 3, Ref. 14). Full Text (Free, PDF) www.bmj.sk.

Aim. The aim of this study was to evaluate correlation and influence of recreational physical activity during 10 years of follow-up on four types of lipid fractions in school children of the YUSAD study. Methods. School children from Serbia were evaluated on three different occasions when they were 10, 15 and 19/20 years of age, respectively. Four types of lipid fractions, total cholesterol, triglycerides, HDL and LDL, were separately evaluated in physically active boys and girls. Results. We evaluated 1172 children when they were 10 years of age, 870 children when they were 15 and 1230 children when they were 19/20. All children were from the same population. Our results pointed out that there is no linear correlation between the two evaluated variables: physical activity and lipid fractions. However there is a very weak positive or negative correlation of coherence regarding recreational physical activity and the four types of evaluated lipid fractions. Conclusion. Since this period of growth is very specific for metabolic processes that can influence variations of evaluated parameters, such investigation can give us additional knowledge and further directions that could lead to better understanding the correlation of different risk factors on the atherosclerosis development.

Aim. The aim of this study was to evaluate correlation and influence of recreational physical activity during 10 years of follow-up on four types of lipid fractions in school children of the YUSAD study. Methods. School children from Serbia were evaluated on three different occasions when they were 10, 15 and 19/20 years of age, respectively. Four types of lipid fractions, total cholesterol, triglycerides, HDL and LDL, were separately evaluated in physically active boys and girls. Results. We evaluated 1172 children when they were 10 years of age, 870 children when they were 15 and 1230 children when they were 19/20. All children were from the same population. Our results pointed out that there is no linear correlation between the two evaluated variables: physical activity and lipid fractions. However there is a very weak positive or negative correlation of coherence regarding recreational physical activity and the four types of evaluated lipid fractions. Conclusion. Since this period of growth is very specific for metabolic processes that can influence variations of evaluated parameters, such investigation can give us additional knowledge and further directions that could lead to better understanding the correlation of different risk factors on the atherosclerosis development.

Background: Aim of our study was to evaluate degree of genetic homozygosity in male and female gender of spina bifida (SB) occulta and SB aperta patients. Patients and Methods: We evaluated 95 patients with SB occulta and 51 with SB aperta. Degree of genetic homozygosity was evaluated by direct observation of 15 homozygously recessive characteristics (HRC) by HRC-test separately for SB occulta and SB aperta participants. Additionally 370 individuals without SB from Serbia were randomly selected and evaluated as control group. Male and female gender was separately evaluated for assessing degree of genetic homozygosity. Results: There was no significant difference in mean values of HRC between male and female gender in control group (male gender -3.9±1.2, female gender -4.0±1.4, z=0.39; p>0.05), SB occulta (male gender -4.1±1.5, female gender -4.7±1.4, z=1.87, p>0.05) and SB aperta patients (male gender -4.3±1.6, female gender -4.5±1.4, z=0.66, p>0.05), while there was significantly increased recessive homozygosity in female SB occulta group versus control female group (Females: SB occulta -4.7±1.4, Control group -4.0±1.4, z=3.16, p<0.01) and female SB aperta group versus control female group (Females: SB aperta -4.5±1.4, Control group -4.0±1.4, z=2.05, p<0.05). Conclusion: There is increased recessive homozygosity in tested female SB occulta and female SB aperta individuals versus SB male participants and significantly increased recessive homozygosity in female groups of SB patients versus control female group. These findings could lead to the possible assumption that different genes in different degree might be expressed in SB occulta and SB aperta patients.