Browsing by Author "Murray, Christopher J.L. (55481130700)"
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Publication Burden of obesity in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study(2018) ;Mokdad, Ali H (7004813962) ;El Bcheraoui, Charbel (25027689700) ;Afshin, Ashkan (57217465455) ;Charara, Raghid (56514085300) ;Khalil, Ibrahim (58255049500) ;Moradi-Lakeh, Maziar (35617421300) ;Kassebaum, Nicholas J (57202562224) ;Collison, Michael (57202309052) ;Daoud, Farah (57201079837) ;Krohn, Kristopher J (57194138806) ;Chew, Adrienne (57209171085) ;Biryukov, Stan H (57195296731) ;Cornaby, Leslie (57191837051) ;Foreman, Kyle J (57209064414) ;Kutz, Michael (57195617315) ;Liu, Patrick (56170368200) ;Reitsma, Marissa (57208766315) ;Sur, Patrick (57218360398) ;Wang, Haidong (16507828100) ;Zipkin, Ben (57200737130) ;Ärnlöv, Johan (6602512227) ;Abbafati, Cristiana (54917122400) ;Abdulle, Abdishakur M (6603592018) ;Abu-Rmeileh, Niveen M.E. (57216675148) ;Ahmed, Muktar Beshir (57207802317) ;Al-Aly, Ziyad (9738161500) ;Alam, Khurshid (57203681299) ;Alizadeh-Navaei, Reza (36024974700) ;Alkerwi, Ala'a (57197724313) ;Altirkawi, Khalid A (57202762923) ;Alvis-Guzman, Nelson (57210741239) ;Baune, Bernhard T (6603807336) ;Bedi, Neeraj (57988442200) ;Bennett, Derrick A (57650836400) ;Beyene, Addisu S (57209036705) ;Bhutta, Zulfiqar A (24342648300) ;Birhanu, Mulugeta M (57195446157) ;Danawi, Hadi (57201079895) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fischer, Florian (55508208800) ;Gebrehiwot, Tsegaye Tewelde (57216482917) ;Gill, Paramjit Singh (7202766660) ;Gona, Philimon N (57219703762) ;Gupta, Vipin (57199940653) ;Habtewold, Tesfa Dejenie (57079013900) ;Hamadeh, Randah Ribhi (57202769526) ;Hamidi, Samer (24366336000) ;Hareri, Habtamu Abera (57195292447) ;Horino, Masako (57195769276) ;Hsairi, Mohamed (57209033943) ;Javanbakht, Mehdi (57204619886) ;John, Denny (57194230095) ;Jonas, Jost B (7202492953) ;Joshua, Vasna (57196474987) ;Kasaeian, Amir (57195540738) ;Ketema, Ezra B (56866354200) ;Khader, Yousef Saleh (55654192600) ;Khan, Ejaz Ahmad (57218791274) ;Khubchandani, Jagdish (57211720011) ;Kim, Daniel (57223019104) ;Kim, Yun Jin (57211086375) ;Kinfu, Yohannes (12770281900) ;Kokubo, Yoshihiro (56155004000) ;Larson, Heidi J (57202559142) ;Lee, Paul H (57200302692) ;Lunevicius, Raimundas (57216165063) ;Abd El Razek, Hassan Magdy (57195948985) ;Abd El Razek, Mohammed Magdy (57192379650) ;Malekzadeh, Reza (7005197760) ;Mate, Kedar K (57209031379) ;Memish, Ziad A (7005059350) ;Mengistie, Mubarek Abera (56045752700) ;Mensah, George A (57196028147) ;Ogbo, Felix Akpojene (57200737136) ;Pourmalek, Farshad (8309390500) ;Rafay, Anwar (57212263323) ;Qorbani, Mostafa (24831040300) ;Rahimi-Movaghar, Vafa (6507646446) ;Rana, Saleem M (57204884092) ;Rawaf, Salman (6602475959) ;Renzaho, Andre M.N. (6505786588) ;Rezaei, Satar (55791003000) ;Rezai, Mohammad Sadegh (55273796300) ;Safdarian, Mahdi (57203849024) ;Sahraian, Mohammad Ali (55886074600) ;Salamati, Payman (14045860600) ;Samy, Abdallah M (36973661300) ;Sanabria, Juan Ramon (7006262917) ;Santric Milicevic, Milena M. (57211144346) ;Sartorius, Benn (12788526800) ;Sepanlou, Sadaf G (36248136000) ;Shaikh, Masood Ali (57203122601) ;Shiri, Rahman (57200737050) ;Silva, Diego Augusto Santos (36985158000) ;Singh, Jasvinder A (7404421736) ;Terkawi, Abdullah Sulieman (57211144258) ;Tiruye, Tenaw Yimer (57194055872) ;Ukwaja, Kingsley Nnanna (57202824584) ;Vasankari, Tommi (57200592416) ;Vlassov, Vasiliy Victorovich (57211633239) ;Wakayo, Tolassa (57205609717) ;Werdecker, Andrea (57210505244) ;Yonemoto, Naohiro (57204947657) ;Younis, Mustafa Z (8549393000) ;Zein, Bassel (57195293856) ;Jumaan, Aisha O (6603612494) ;Vos, Theo (57223885848) ;Hay, Simon I (7101875313) ;Naghavi, Mohsen (57207906323)Murray, Christopher J.L. (55481130700)Objectives: We used the Global Burden of Disease (GBD) 2015 study results to explore the burden of high body mass index (BMI) in the Eastern Mediterranean Region (EMR). Methods: We estimated the prevalence of overweight and obesity among children (2–19 years) and adults (≥20 years) in 1980 and 2015. The burden of disease related to high BMI was calculated using the GBD comparative risk assessment approach. Results: The prevalence of obesity increased for adults from 15.1% (95% UI 13.4–16.9) in 1980 to 20.7% (95% UI 18.8–22.8) in 2015. It increased from 4.1% (95% UI 2.9–5.5) to 4.9% (95% UI 3.6–6.4) for the same period among children. In 2015, there were 417,115 deaths and 14,448,548 disability-adjusted life years (DALYs) attributable to high BMI in EMR, which constitute about 10 and 6.3% of total deaths and DALYs, respectively, for all ages. Conclusions: This is the first study to estimate trends in obesity burden for the EMR from 1980 to 2015. We call for EMR countries to invest more resources in prevention and health promotion efforts to reduce this burden. © 2017, The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Department of Error: Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017 (The Lancet (2020) 395(10239) (1779–1801), (S0140673620301148), (10.1016/S0140-6736(20)30114-8))(2020) ;Reiner, Robert C. (57203229088) ;Wiens, Kirsten E. (55515807800) ;Deshpande, Aniruddha (57208579336) ;Baumann, Mathew M. (57211550981) ;Lindstedt, Paulina A. (57211558396) ;Blacker, Brigette F. (57202420381) ;Troeger, Christopher E. (57195223624) ;Earl, Lucas (57190371340) ;Munro, Sandra B. (7004622934) ;Abate, Degu (57204237665) ;Abbastabar, Hedayat (57212441848) ;Abd-Allah, Foad (36503428900) ;Abdelalim, Ahmed (7801307783) ;Abdollahpour, Ibrahim (36997151900) ;Abdulkader, Rizwan Suliankatchi (57195295816) ;Abebe, Getaneh (57202422848) ;Abegaz, Kedir Hussein (57200726326) ;Abreu, Lucas Guimarães (55937631400) ;Abrigo, Michael R.M. 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(57204849530) ;Yip, Paul (7102503720) ;Yirsaw, Biruck Desalegn (49664327400) ;Yisma, Engida (55556060700) ;Yonemoto, Naohiro (57204947657) ;Younis, Mustafa Z. (8549393000) ;Yousof, Hebat-Allah Salah A. (56183368000) ;Yu, Chuanhua (57208140344) ;Yusefzadeh, Hasan (55887807200) ;Zamani, Mohammad (57096222300) ;Zambrana-Torrelio, Carlos (57193255530) ;Zandian, Hamed (57205175627) ;Zeleke, Ayalew Jejaw (57193096860) ;Zepro, Nejimu Biza (57193095335) ;Zewale, Taye Abuhay (57209219258) ;Zhang, Dongyu (57216327764) ;Zhang, Yunquan (56568510200) ;Zhao, Xiu-Ju (8360350900) ;Ziapour, Arash (57202571078) ;Zodpey, Sanjay (7003415080)Hay, Simon I. (7101875313)Reiner RC Jr, Hay SI. Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017. Lancet 2020; 395: 1779–801—In this Article, the author byline has been amended to Local Burden of Disease Diarrhoea Collaborators. This correction has been made to the online version as of June 4, 2020, and the printed version is correct. © 2020 Elsevier Ltd - Some of the metrics are blocked by yourconsent settings
Publication Evolution and patterns of global health financing 1995-2014: Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries(2017) ;Dieleman, Joseph (54891678100) ;Campbell, Madeline (57192869720) ;Chapin, Abigail (57159731300) ;Eldrenkamp, Erika (57194530102) ;Fan, Victoria Y. (9737474800) ;Haakenstad, Annie (56079498000) ;Kates, Jennifer (7006961170) ;Liu, Yingying (57194531196) ;Matyasz, Taylor (57194529771) ;Micah, Angela (57193064978) ;Reynolds, Alex (57216683497) ;Sadat, Nafis (57219687343) ;Schneider, Matthew T. (35332956100) ;Sorensen, Reed (57196918748) ;Evans, Tim (7401454148) ;Evans, David (57193990382) ;Kurowski, Christoph (6602392515) ;Tandon, Ajay (7103281804) ;Abbas, Kaja M. (57190285707) ;Abera, Semaw Ferede (57205180598) ;Ahmad Kiadaliri, Aliasghar (57199100665) ;Ahmed, Kedir Yimam (57190386244) ;Ahmed, Muktar Beshir (57207802317) ;Alam, Khurshid (57203681299) ;Alizadeh-Navaei, Reza (36024974700) ;Alkerwi, Ala'a (57197724313) ;Amini, Erfan (35073393800) ;Ammar, Walid (57208159281) ;Amrock, Stephen Marc (57211220414) ;Antonio, Carl Abelardo T. (55247644500) ;Atey, Tesfay Mehari (57209784978) ;Avila-Burgos, Leticia (8530790100) ;Awasthi, Ashish (57200155811) ;Barac, Aleksandra (55550748700) ;Bernal, Oscar Alberto (44060935600) ;Beyene, Addisu Shunu (57209036705) ;Beyene, Tariku Jibat (57201181881) ;Birungi, Charles (57195448297) ;Bizuayehu, Habtamu Mellie (56507519700) ;Breitborde, Nicholas J.K. (6603260895) ;Cahuana-Hurtado, Lucero (57207890731) ;Castro, Ruben Estanislao (55798606600) ;Catalá-López, Ferran (57202553733) ;Dalal, Koustuv (23469128200) ;Dandona, Lalit (7007017243) ;Dandona, Rakhi (57203043697) ;De Jager, Pieter (55445666600) ;Dharmaratne, Samath D. (57216324802) ;Dubey, Manisha (57219898654) ;Farinha, Carla Sofia E. Sa (57190279273) ;Faro, Andre (36770969600) ;Feigl, Andrea B. (57202461042) ;Fischer, Florian (55508208800) ;Fitchett, Joseph Robert Anderson (57219697690) ;Foigt, Nataliya (57216998893) ;Giref, Ababi Zergaw (57219994468) ;Gupta, Rahul (57204120071) ;Hamidi, Samer (24366336000) ;Harb, Hilda L. (57221443122) ;Hay, Simon I. (7101875313) ;Hendrie, Delia (6602071966) ;Horino, Masako (57195769276) ;Jürisson, Mikk (55547524800) ;Jakovljevic, Mihajlo B. (14318929700) ;Javanbakht, Mehdi (57204619886) ;John, Denny (57194230095) ;Jonas, Jost B. (7202492953) ;Karimi, Seyed M. (57220096578) ;Khang, Young-Ho (57198904674) ;Khubchandani, Jagdish (57211720011) ;Kim, Yun Jin (57211086375) ;Kinge, Jonas M. (56133084600) ;Krohn, Kristopher J. (57194138806) ;Kumar, G. Anil (57139550500) ;Magdy Abd El Razek, Hassan (57195948985) ;Magdy Abd El Razek, Mohammed (57201191366) ;Majeed, Azeem (7102027801) ;Malekzadeh, Reza (7005197760) ;Masiye, Felix (57216327983) ;Meier, Toni (36678887300) ;Meretoja, Atte (12775885500) ;Miller, Ted R. (7403948600) ;Mirrakhimov, Erkin M. (57216202888) ;Mohammed, Shafiu (57838689000) ;Nangia, Vinay (57201490837) ;Olgiati, Stefano (56372296100) ;Osman, Abdalla Sidahmed (57194529575) ;Owolabi, Mayowa O. (57222581892) ;Patel, Tejas (57207871841) ;Paternina Caicedo, Angel J. (35769665400) ;Pereira, David M. (57200690024) ;Perelman, Julian (22938580800) ;Polinder, Suzanne (12766122200) ;Rafay, Anwar (57212263323) ;Rahimi-Movaghar, Vafa (6507646446) ;Rai, Rajesh Kumar (51864423900) ;Ram, Usha (26653819000) ;Ranabhat, Chhabi Lal (56719695500) ;Roba, Hirbo Shore (57200684844) ;Salama, Joseph (57202975625) ;Savic, Miloje (57204524150) ;Sepanlou, Sadaf G. (36248136000) ;Shrime, Mark G. (57204703404) ;Talongwa, Roberto Tchio (57195568335) ;Te Ao, Braden J. (55480837300) ;Tediosi, Fabrizio (6603388399) ;Tesema, Azeb Gebresilassie (57194530110) ;Thomson, Alan J. (57969994200) ;Tobe-Gai, Ruoyan (57209276611) ;Topor-Madry, Roman (57211182892) ;Undurraga, Eduardo A. (57204092789) ;Vasankari, Tommi (57189653936) ;Violante, Francesco S. (7003555890) ;Werdecker, Andrea (57208964895) ;Wijeratne, Tissa (14051317700) ;Xu, Gelin (57203583113) ;Yonemoto, Naohiro (57204947657) ;Younis, Mustafa Z. (8549393000) ;Yu, Chuanhua (57201889726) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922)Murray, Christopher J.L. (55481130700)Background: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, types of services purchased, and development assistance for health disbursed change with economic development. We also identify countries that deviate from the trends. Methods: We estimated national health spending by type of care and by source, including development assistance for health, based on a diverse set of data including programme reports, budget data, national estimates, and 964 National Health Accounts. These data represent health spending for 184 countries from 1995 through 2014. We converted these data into a common inflation-adjusted and purchasing power-adjusted currency, and used non-linear regression methods to model the relationship between health financing, time, and economic development. Findings: Between 1995 and 2014, economic development was positively associated with total health spending and a shift away from a reliance on development assistance and out-of-pocket (OOP) towards government spending. The largest absolute increase in spending was in high-income countries, which increased to purchasing power-adjusted $5221 per capita based on an annual growth rate of 3.0%. The largest health spending growth rates were in upper-middle-income (5.9) and lower-middle-income groups (5.0), which both increased spending at more than 5% per year, and spent $914 and $267 per capita in 2014, respectively. Spending in low-income countries grew nearly as fast, at 4.6%, and health spending increased from $51 to $120 per capita. In 2014, 59.2% of all health spending was financed by the government, although in low-income and lower-middle-income countries, 29.1% and 58.0% of spending was OOP spending and 35.7% and 3.0% of spending was development assistance. Recent growth in development assistance for health has been tepid; between 2010 and 2016, it grew annually at 1.8%, and reached US$37.6 billion in 2016. Nonetheless, there is a great deal of variation revolving around these averages. 29 countries spend at least 50% more than expected per capita, based on their level of economic development alone, whereas 11 countries spend less than 50% their expected amount. Interpretation: Health spending remains disparate, with low-income and lower-middle-income countries increasing spending in absolute terms the least, and relying heavily on OOP spending and development assistance. Moreover, tremendous variation shows that neither time nor economic development guarantee adequate prepaid health resources, which are vital for the pursuit of universal health coverage. © The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Future and potential spending on health 2015-40: Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries(2017) ;Dieleman, Joseph L. (54891678100) ;Campbell, Madeline (57192869720) ;Chapin, Abigail (57159731300) ;Eldrenkamp, Erika (57194530102) ;Fan, Victoria Y. (9737474800) ;Haakenstad, Annie (56079498000) ;Kates, Jennifer (7006961170) ;Li, Zhiyin (57194530861) ;Matyasz, Taylor (57194529771) ;Micah, Angela (57193064978) ;Reynolds, Alex (57216683497) ;Sadat, Nafis (57219687343) ;Schneider, Matthew T. (35332956100) ;Sorensen, Reed (57196918748) ;Abbas, Kaja M. (57190285707) ;Abera, Semaw Ferede (57205180598) ;Ahmad Kiadaliri, Aliasghar (57199100665) ;Ahmed, Muktar Beshir (57207802317) ;Alam, Khurshid (57203681299) ;Alizadeh-Navaei, Reza (36024974700) ;Alkerwi, Ala'a (57197724313) ;Amini, Erfan (35073393800) ;Ammar, Walid (57208159281) ;Antonio, Carl Abelardo T. (55247644500) ;Atey, Tesfay Mehari (57209784978) ;Avila-Burgos, Leticia (8530790100) ;Awasthi, Ashish (57200155811) ;Barac, Aleksandra (55550748700) ;Berheto, Tezera Moshago (56382955400) ;Beyene, Addisu Shunu (57209036705) ;Beyene, Tariku Jibat (57201181881) ;Birungi, Charles (57195448297) ;Bizuayehu, Habtamu Mellie (56507519700) ;Breitborde, Nicholas J.K. (6603260895) ;Cahuana-Hurtado, Lucero (57207890731) ;Castro, Ruben Estanislao (55798606600) ;Catalá-López, Ferran (57202553733) ;Dalal, Koustuv (23469128200) ;Dandona, Lalit (7007017243) ;Dharmaratne, Rakhi Dandona Samath D. (57197827278) ;Dubey, Manisha (57219898654) ;Faro, Andé (36770969600) ;Feigl, Andrea B. (57202461042) ;Fischer, Florian (55508208800) ;Fitchett, Joseph R. Anderson (57219697690) ;Foigt, Nataliya (57216998893) ;Giref, Ababi Zergaw (57219994468) ;Gupta, Rahul (57204120071) ;Hamidi, Samer (24366336000) ;Harb, Hilda L. (57221443122) ;Hay, Simon I. (7101875313) ;Hendrie, Delia (6602071966) ;Horino, Masako (57195769276) ;Jürisson, Mikk (55547524800) ;Jakovljevic, Mihajlo B. (14318929700) ;Javanbakht, Mehdi (57204619886) ;John, Denny (57194230095) ;Jonas, Jost B. (7202492953) ;Karimi, Seyed M. (57220096578) ;Khang, Young-Ho (57198904674) ;Khubchandani, Jagdish (57211720011) ;Kim, Yun Jin (57211086375) ;Kinge, Jonas M. (56133084600) ;Krohn, Kristopher J. (57194138806) ;Kumar, G. Anil (57139550500) ;Leung, Ricky (56276497100) ;Magdy Abd El Razek, Hassan (57195948985) ;Magdy Abd El Razek, Mohammed (57201191366) ;Majeed, Azeem (7102027801) ;Malekzadeh, Reza (7005197760) ;Malta, Deborah Carvalho (15835283500) ;Meretoja, Atte (12775885500) ;Miller, Ted R. (7403948600) ;Mirrakhimov, Erkin M. (57216202888) ;Mohammed, Shafiu (57838689000) ;Molla, Gedefaw (57197832200) ;Nangia, Vinay (57201490837) ;Olgiati, Stefano (56372296100) ;Owolabi, Mayowa O. (57222581892) ;Patel, Tejas (57207871841) ;Paternina Caicedo, Angel J. (35769665400) ;Pereira, David M. (57200690024) ;Perelman, Julian (22938580800) ;Polinder, Suzanne (12766122200) ;Rafay, Anwar (57212263323) ;Rahimi-Movaghar, Vafa (6507646446) ;Rai, Rajesh Kumar (51864423900) ;Ram, Usha (26653819000) ;Ranabhat, Chhabi Lal (56719695500) ;Roba, Hirbo Shore (57200684844) ;Savic, Miloje (57204524150) ;Sepanlou, Sadaf G. (36248136000) ;Te Ao, Braden J. (55480837300) ;Tesema, Azeb Gebresilassie (57194530110) ;Thomson, Alan J. (57969994200) ;Tobe-Gai, Ruoyan (57209276611) ;Topor-Madry, Roman (57211182892) ;Undurraga, Eduardo A. (57204092789) ;Vargas, Veronica (14018617400) ;Vasankari, Tommi (57200592416) ;Violante, Francesco S. (7003555890) ;Wijeratne, Tissa (14051317700) ;Xu, Gelin (57203583113) ;Yonemoto, Naohiro (57204947657) ;Younis, Mustafa Z. (8549393000) ;Yu, Chuanhua (57201889726) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922)Murray, Christopher J.L. (55481130700)Background: The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study, we estimate future gross domestic product (GDP), all-sector government spending, and health spending disaggregated by source, and we compare expected future spending to potential future spending. Methods: We extracted GDP, government spending in 184 countries from 1980-2015, and health spend data from 1995-2014. We used a series of ensemble models to estimate future GDP, all-sector government spending, development assistance for health, and government, out-of-pocket, and prepaid private health spending through 2040. We used frontier analyses to identify patterns exhibited by the countries that dedicate the most funding to health, and used these frontiers to estimate potential health spending for each low-income or middle-income country. All estimates are inflation and purchasing power adjusted. Findings: We estimated that global spending on health will increase from US$9.21 trillion in 2014 to $24.24 trillion (uncertainty interval [UI] 20.47-29.72) in 2040. We expect per capita health spending to increase fastest in upper-middle-income countries, at 5.3% (UI 4.1-6.8) per year. This growth is driven by continued growth in GDP, government spending, and government health spending. Lower-middle income countries are expected to grow at 4.2% (3.8-4.9). High-income countries are expected to grow at 2.1% (UI 1.8-2.4) and low-income countries are expected to grow at 1.8% (1.0-2.8). Despite this growth, health spending per capita in low-income countries is expected to remain low, at $154 (UI 133-181) per capita in 2030 and $195 (157-258) per capita in 2040. Increases in national health spending to reach the level of the countries who spend the most on health, relative to their level of economic development, would mean $321 (157-258) per capita was available for health in 2040 in low-income countries. Interpretation: Health spending is associated with economic development but past trends and relationships suggest that spending will remain variable, and low in some low-resource settings. Policy change could lead to increased health spending, although for the poorest countries external support might remain essential. © The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013(2015) ;Naghavi, Mohsen (57207906323) ;Wang, Haidong (16507828100) ;Lozano, Rafael (7102198442) ;Davis, Adrian (7404296836) ;Liang, Xiaofeng (26662590300) ;Zhou, Maigeng (57054557200) ;Vollset, Stein Emil (57196315778) ;Abbasoglu Ozgoren, Ayse (56133944200) ;Abdalla, Safa (7005715928) ;Abd-Allah, Foad (36503428900) ;Abdel Aziz, Muna I. (56013017300) ;Abera, Semaw Ferede (57205180598) ;Aboyans, Victor (56214736500) ;Abraham, Biju (57202568691) ;Abraham, Jerry P. (57203894879) ;Abuabara, Katrina E. (6507310339) ;Abubakar, Ibrahim (57220174401) ;Abu-Raddad, Laith J. (14032724700) ;Abu-Rmeileh, Niveen M.E. (57216675148) ;Achoki, Tom (57202561099) ;Adelekan, Ademola (57216109261) ;Ademi, Zanfina (32867460300) ;Adofo, Koranteng (57216996837) ;Adou, Arséne Kouablan (56531895000) ;Adsuar, José C. (21738958900) ;Ärnlov, Johan (6602512227) ;Agardh, Emilie Elisabet (57202373873) ;Akena, Dickens (36141858100) ;Al Khabouri, Mazin J. (57199096118) ;Alasfoor, Deena (57211114684) ;Albittar, Mohammed (56276571900) ;Alegretti, Miguel Angel (56276408300) ;Aleman, Alicia V. (57204772329) ;Alemu, Zewdie Aderaw (57202557784) ;Alfonso-Cristancho, Rafael (26326133000) ;Alhabib, Samia (57194933167) ;Ali, Mohammed K. (7404486641) ;Ali, Raghib (57196506541) ;Alla, Francois (6701580827) ;Al Lami, Faris (57200737005) ;Allebeck, Peter (7005187575) ;AlMazroa, Mohammad A. (35572530900) ;Al-Shahi Salman, Rustam (15842833200) ;Alsharif, Ubai (57211633255) ;Alvarez, Elena (57216675106) ;Alviz-Guzman, Nelson (56541894600) ;Amankwaa, Adansi A. (57202564178) ;Amare, Azmeraw T. (57202220009) ;Ameli, Omid (57193900801) ;Amini, Hassan (57202568400) ;Ammar, Walid (57208159281) ;Anderson, H. Ross (7402166391) ;Anderson, Benjamin O. (22937050900) ;Antonio, Carl Abelardo T. (55247644500) ;Anwari, Palwasha (57217465526) ;Apfel, Henry (56843487800) ;Argeseanu Cunningham, Solveig (55663597400) ;Arsic Arsenijevic, Valentina S. (6507940363) ;Artaman, Al (57217223811) ;Asad, Majed Masoud (56004010200) ;Asghar, Rana J. (57209013760) ;Assadi, Reza (57201282579) ;Atkins, Lydia S. (56132848600) ;Atkinson, Charles (57200782428) ;Badawi, Alaa (57216776029) ;Bahit, Maria C. (57216775889) ;Bakfalouni, Talal (56003760100) ;Balakrishnan, Kalpana (7103222725) ;Balalla, Shivanthi (55808205900) ;Banerjee, Amitava (57208560645) ;Barber, Ryan M. (57202560423) ;Barker-Collo, Suzanne L. (57193065514) ;Barquera, Simon (6601928375) ;Barregard, Lars (55953218700) ;Barrero, Lope H. (57208560675) ;Barrientos-Gutierrez, Tonatiuh (16548801900) ;Basu, Arindam (16315264400) ;Basu, Sanjay (9335409500) ;Basulaiman, Mohammed Omar (57218332983) ;Beardsley, Justin (57207800229) ;Bedi, Neeraj (57988442200) ;Beghi, Ettore (7004809655) ;Bekele, Tolesa (57195086149) ;Bell, Michelle L. (7401466450) ;Benjet, Corina (57211220427) ;Bennett, Derrick A. (57650836400) ;Bensenor, Isabela M. (7004830338) ;Benzian, Habib (57195256480) ;Bertozzi-Villa, Amelia (57192900191) ;Beyene, Tariku Jibat (57201181881) ;Bhala, Neeraj (15759186000) ;Bhalla, Ashish (57202555305) ;Bhutta, Zulfiqar A. (24342648300) ;Bikbov, Boris (57219957158) ;Bin Abdulhak, Aref (57201757922) ;Biryukov, Stan (57195296731) ;Blore, Jed D. (57202562230) ;Blyth, Fiona M. (6603553964) ;Bohensky, Megan A. (12808517400) ;Borges, Guilherme (35373585600) ;Bose, Dipan (57205255835) ;Boufous, Soufiane (6507794444) ;Bourne, Rupert R. (7103377631) ;Boyers, Lindsay N. (56166392600) ;Brainin, Michael (7006405278) ;Brauer, Michael (57218330976) ;Brayne, Carol E.G. (57210386759) ;Brazinova, Alexandra (57216996405) ;Breitborde, Nicholas (6603260895) ;Brenner, Hermann (7201832825) ;Briggs, Adam D.M. (57193915655) ;Brown, Jonathan C. (57212760159) ;Brugha, Traolach S. (35370057100) ;Buckle, Geoffrey C. (57202771556) ;Bui, Linh Ngoc (58379318200) ;Bukhman, Gene (57189462853) ;Burch, Michael (7005588453) ;Campos Nonato, Ismael Ricardo (57203424784) ;Carabin, Hélène (57208461675) ;Cárdenas, Rosario (57216482927) ;Carapetis, Jonathan (7003343936) ;Carpenter, David O. (7201795413) ;Caso, Valeria (55401514700) ;Castañeda-Orjuela, Carlos A. (35769124700) ;Castro, Ruben Estanislao (55798606600) ;Catalá-López, Ferrán (57202553733) ;Cavalleri, Fiorella (57203080582) ;Chang, Jung-Chen (57202568248) ;Charlson, Fiona C. (57191632086) ;Che, Xuan (56133389400) ;Chen, Honglei (35331605500) ;Chen, Yingyao (7601437030) ;Chen, Jian Sheng (56541894700) ;Chen, Zhengming (55577325200) ;Chiang, Peggy Pei-Chia (59846886500) ;Chimed-Ochir, Odgerel (57217262222) ;Chowdhury, Rajiv (57216138475) ;Christensen, Hanne (57202099623) ;Christophi, Costas A. (57202522550) ;Chuang, Ting-Wu (6603108974) ;Chugh, Sumeet S. (35253639000) ;Cirillo, Massimo (35247478400) ;Coates, Matthew M. (57211076754) ;Coffeng, Luc Edgar (15847631700) ;Coggeshall, Megan S. (56132969600) ;Cohen, Aaron (7404780942) ;Colistro, Valentina (57214065358) ;Colquhoun, Samantha M. (57205178937) ;Colomar, Mercedes (57218434254) ;Cooper, Leslie Trumbull (15754277900) ;Cooper, Cyrus (36041345700) ;Coppola, Luis M. (56541888400) ;Cortinovis, Monica (57207893885) ;Courville, Karen (56133151600) ;Cowie, Benjamin C. (57202566182) ;Criqui, Michael H. (7005209601) ;Crump, John A. (57202595111) ;Cuevas-Nasu, Lucia (57216429130) ;Da Costa Leite, Iuri (13405114500) ;Dabhadkar, Kaustubh C. (37041226700) ;Dandona, Lalit (7007017243) ;Dandona, Rakhi (57203043697) ;Dansereau, Emily (57203833128) ;Dargan, Paul I. (57212154356) ;Dayama, Anand (57202564137) ;De La Cruz-Góngora, Vanessa (55326484300) ;De La Vega, Shelley F. (56541890300) ;De Leo, Diego (7006128644) ;Degenhardt, Louisa (7004040033) ;Del Pozo-Cruz, Borja (42061354100) ;Dellavalle, Robert P. (7003806771) ;Deribe, Kebede (57193912587) ;Des Jarlais, Don C. (56990451200) ;Dessalegn, Muluken (57192148714) ;De Veber, Gabrielle A. (57204345472) ;Dharmaratne, Samath D. (57216324802) ;Dherani, Mukesh (57216939981) ;Diaz-Ortega, Jose-Luis (6601970463) ;Diaz-Torne, Cesar (12779759300) ;Dicker, Daniel (57196026676) ;Ding, Eric L. (54413849800) ;Dokova, Klara (57201523771) ;Dorsey, E. Ray (23102496300) ;Driscoll, Tim R. (7005928308) ;Duan, Leilei (56150781400) ;Duber, Herbert C. (55522646900) ;Durrani, Adnan M. (57202572082) ;Ebel, Beth E. (7003709059) ;Edmond, Karen M. (57202571133) ;Ellenbogen, Richard G. (7007098380) ;Elshrek, Yousef (57207895368) ;Ermakov, Sergey Petrovich (7006796196) ;Erskine, Holly E. (57202798676) ;Eshrati, Babak (16030619200) ;Esteghamati, Alireza (11240321100) ;Estep, Kara (57216550964) ;Fürst, Thomas (57208431345) ;Fahimi, Saman (57216775706) ;Fahrion, Anna S. (23389248900) ;Faraon, Emerito Jose A. (57195414019) ;Farzadfar, Farshad (57195049611) ;Fay, Derek F.J. (57216717128) ;Feigl, Andrea B. (57202461042) ;Feigin, Valery L. (57203677957) ;Felicio, Manuela Mendonca (56132957300) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fernandes, Jefferson G. (57220736619) ;Ferrari, Alize J. (57195348907) ;Fleming, Thomas D. (57222727747) ;Foigt, Nataliya (57216998893) ;Foreman, Kyle (57209064414) ;Forouzanfar, Mohammad H. (55882758900) ;Fowkes, F. Gerry R. (55395407300) ;Fra Paleo, Urbano (15053114000) ;Franklin, Richard C. (7201428429) ;Futran, Neal D. (35554564000) ;Gaffikin, Lynne (6701866671) ;Gambashidze, Ketevan (13610194000) ;Gankpé, Fortuné Gbètoho (57201341525) ;García-Guerra, Francisco Armando (56641898300) ;Garcia, Ana Cristina (12753360300) ;Geleijnse, Johanna M. (35195702500) ;Gessner, Bradford D. (7005779769) ;Gibney, Katherine B. (57202564104) ;Gillum, Richard F. (7103181331) ;Gilmour, Stuart (8561716600) ;Ginawi, Ibrahim Abdelmageem Mohamed (57192378390) ;Giroud, Maurice (7203027541) ;Glaser, Elizabeth L. (56133254300) ;Goenka, Shifalika (57217111080) ;Gomez Dantes, Hector (57202555692) ;Gona, Philimon (57219703762) ;Gonzalez-Medina, Diego (57202595524) ;Guinovart, Caterina (23024511900) ;Gupta, Rahul (56453686300) ;Gupta, Rajeev (55705295300) ;Gosselin, Richard A. (57193194468) ;Gotay, Carolyn C. (35480913900) ;Goto, Atsushi (36339255500) ;Gouda, Hebe N. (57202432343) ;Graetz, Nicholas (56276346000) ;Greenwell, K. Fern (57607180600) ;Gugnani, Harish Chander (7005567008) ;Gunnell, David (7006194937) ;Gutiérrez, Reyna A. (57200298415) ;Haagsma, Juanita (57202571125) ;Hafezi-Nejad, Nima (57216814261) ;Hagan, Holly (7003999040) ;Hagstromer, Maria (57204338713) ;Halasa, Yara A. (57202569911) ;Hamadeh, Randah Ribhi (57202769526) ;Hamavid, Hannah (57194279323) ;Hammami, Mouhanad (57216961083) ;Hancock, Jamie (57202975481) ;Hankey, Graeme J. (7102816661) ;Hansen, Gillian M. (57202959410) ;Harb, Hilda L. (57221443122) ;Harewood, Heather (56346933400) ;Haro, Josep Maria (57215877903) ;Havmoeller, Rasmus (57212075728) ;Hay, Roderick J. (56785229200) ;Hay, Simon I. (7101875313) ;Hedayati, Mohammad T. (23979915700) ;Heredia Pi, Ileana B. (36941085200) ;Heuton, Kyle R. (57202568555) ;Heydarpour, Pouria (57189359029) ;Higashi, Hideki (57190802917) ;Hijar, Martha (57216555124) ;Hoek, Hans W. (57202570421) ;Hoffman, Howard J. (7201677665) ;Hornberger, John C. (56825487700) ;Hosgood, H. Dean (56353204400) ;Hossain, Mazeda (57203734792) ;Hotez, Peter J. (7004958298) ;Hoy, Damian G. (8553772600) ;Hsairi, Mohamed (57209033943) ;Hu, Guoqing (57218106596) ;Huang, John J. (56135699200) ;Huffman, Mark D. (26967803300) ;Hughes, Andrew J. (57210505161) ;Husseini, Abdullatif (6603689690) ;Huynh, Chantal (57202556112) ;Iannarone, Marissa (57218422772) ;Iburg, Kim M. (57216814160) ;Idrisov, Bulat T. (57208773503) ;Ikeda, Nayu (57203693946) ;Innos, Kaire (57217314902) ;Inoue, Manami (8889234100) ;Islami, Farhad (56926442900) ;Ismayilova, Samaya (57202561097) ;Jacobsen, Kathryn H. (26029163100) ;Jassal, Simerjot (57190118903) ;Jayaraman, Sudha P. (57204716526) ;Jensen, Paul N. (57224209864) ;Jha, Vivekanand (7005119423) ;Jiang, Guohong (56984997300) ;Jiang, Ying (57216138470) ;Jonas, Jost B. (7202492953) ;Joseph, Jonathan (56541885500) ;Juel, Knud (7005077250) ;Kabagambe, Edmond Kato (6602704484) ;Kan, Haidong (7101602991) ;Karch, André (55917217700) ;Karimkhani, Chante (57210249332) ;Karthikeyan, Ganesan (57188672173) ;Kassebaum, Nicholas (55522621100) ;Kaul, Anil (16156995700) ;Kawakami, Norito (35377339000) ;Kazanjan, Konstantin (57193091626) ;Kazi, Dhruv S. (57216814161) ;Kemp, Andrew H. (57218313462) ;Kengne, Andre Pascal (7801322838) ;Keren, Andre (7005620132) ;Kereselidze, Maia (55659152900) ;Khader, Yousef Saleh (55654192600) ;Khalifa, Shams Eldin Ali Hassan (59831217100) ;Khan, Ejaz Ahmed (57218791274) ;Khan, Gulfaraz (6701635515) ;Khang, Young-Ho (57198904674) ;Kieling, Christian (57218820714) ;Kinfu, Yohannes (12770281900) ;Kinge, Jonas M. (56133084600) ;Kim, Daniel (57223019104) ;Kim, Sungroul (57218664381) ;Kivipelto, Miia (6701347410) ;Knibbs, Luke (16313525200) ;Knudsen, Ann Kristin (57192966362) ;Kokubo, Yoshihiro (56155004000) ;Kosen, Sowarta (57211346192) ;Kotagal, Meera (6507911408) ;Kravchenko, Michael A. (57202569007) ;Krishnaswami, Sanjay (7101616028) ;Krueger, Hans (7102340018) ;Kuate Defo, Barthelemy (6602271655) ;Kuipers, Ernst J. (55171198600) ;Kucuk Bicer, Burcu (57204528360) ;Kulkarni, Chanda (59869378300) ;Kulkarni, Veena S. (57200084922) ;Kumar, Kaushalendra (59070501700) ;Kumar, Ravi B. (59600303400) ;Kwan, Gene F. 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(56541894900)Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specific causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65·3 years (UI 65·0-65·6) in 1990, to 71·5 years (UI 71·0-71·9) in 2013, while the number of deaths increased from 47·5 million (UI 46·8-48·2) to 54·9 million (UI 53·6-56·3) over the same interval. Global progress masked variation by age and sex: for children, average absolute differences between countries decreased but relative differences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative differences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10·7%, from 4·3 million deaths in 1990 to 4·8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specific mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade. Funding Bill & Melinda Gates Foundation. © 2015 Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016(2017) ;Naghavi, Mohsen (57207906323) ;Abajobir, Amanuel Alemu (57203613441) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. 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(7005209601) ;Dandona, Lalit (7007017243) ;Dandona, Rakhi (57203043697) ;Dargan, Paul I. (57212154356) ;Das Neves, José (57208073193) ;Davitoiu, Dragos V. (57202555163) ;Davletov, Kairat (6602803024) ;De Courten, Barbora (57208309416) ;Degenhardt, Louisa (7004040033) ;Deiparine, Selina (57205252200) ;Deribe, Kebede (57193912587) ;Deribew, Amare (25625914400) ;Dey, Subhojit (25958052600) ;Dicker, Daniel (57196026676) ;Ding, Eric L. (54413849800) ;Djalalinia, Shirin (37113718000) ;Do, Huyen Phuc (57200737094) ;Doku, David Teye (36015210300) ;Douwes-Schultz, Dirk (57196081398) ;Driscoll, Tim R. (7005928308) ;Dubey, Manisha (57219898654) ;Duncan, Bruce Bartholow (35476478500) ;Echko, Michelle (57196076782) ;El-Khatib, Ziad Ziad (54908919000) ;Ellingsen, Christian Lycke (7801360950) ;Enayati, Ahmadali (6507139052) ;Erskine, Holly E. (57202798676) ;Eskandarieh, Sharareh (57211720158) ;Esteghamati, Alireza (11240321100) ;Ermakov, Sergey P. (7006796196) ;Estep, Kara (57216550964) ;Sa Farinha, Carla Sofae (57190279273) ;Faro, André (36770969600) ;Farzadfar, Farshad (57195049611) ;Feigin, Valery L. (57203677957) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fernandes, João C (35274726800) ;Ferrari, Alize J. (57195348907) ;Feyissa, Tesfaye Regassa (57222562476) ;Filip, Irina (55570061400) ;Finegold, Samuel (57195558156) ;Fischer, Florian (55508208800) ;Fitzmaurice, Christina (57212628757) ;Flaxman, Abraham D. (6602883567) ;Foigt, Nataliya (57216998893) ;Frank, Tahvi (57195993514) ;Fraser, Maya (57202561859) ;Fullman, Nancy (57211064970) ;Fürst, Thomas (57208431345) ;Furtado, Joao M. (36801755000) ;Gakidou, Emmanuela (57202567277) ;Garcia-Basteiro, Alberto L (57200187168) ;Gebre, Teshome (57202565005) ;Gebregergs, Gebremedhin Berhe (57078990000) ;Gebrehiwot, Tsegaye Tewelde (57216482917) ;Gebremichael, Delelegn Yilma (57015331400) ;Geleijnse, Johanna M. (35195702500) ;Genova-Maleras, Ricard (15070563900) ;Gesesew, Hailay Abrha (56412148300) ;Gething, Peter W. (57193559189) ;Gillum, Richard F. (7103181331) ;Ginawi, Ibrahim Abdelmageem Mohamed (57192378390) ;Giref, Ababi Zergaw (57219994468) ;Giroud, Maurice (7203027541) ;Giussani, Giorgia (57200843076) ;Godwin, William W. (57191841675) ;Gold, Audra L. (57194129483) ;Goldberg, Ellen M. (57191842703) ;Gona, Philimon N. (57219703762) ;Gopalani, Sameer Vali (57190277891) ;Gouda, Hebe N. (57202432343) ;Goulart, Alessandra Carvalho (57201181348) ;Griswold, Max (57191836595) ;Gupta, Prakash C. (58767181900) ;Gupta, Rajeev (55705295300) ;Gupta, Tanush (57219956402) ;Gupta, Vipin (57199940653) ;Haagsma, Juanita A. (57202571125) ;Hafezi-Nejad, Nima (57216814261) ;Hailu, Alemayehu Desalegne (57225733572) ;Hailu, Gessessew Bugssa (57219637263) ;Hamadeh, Randah Ribhi (57202769526) ;Hambisa, Mitiku Teshome (57203666810) ;Hamidi, Samer (24366336000) ;Hammami, Mouhanad (57216961083) ;Hancock, Jamie (57202975481) ;Handal, Alexis J. (57208977398) ;Hankey, Graeme J. (7102816661) ;Hao, Yuantao (57202554333) ;Harb, Hilda L. (57221443122) ;Hareri, Habtamu Abera (57195292447) ;Hassanvand, Mohammad Sadegh (35085056400) ;Havmoeller, Rasmus (57212075728) ;Hay, Simon I. (7101875313) ;He, Fei (59031207400) ;Hedayati, Mohammad T. (23979915700) ;Henry, Nathaniel J. (57196076616) ;Heredia-Pi, Ileana Beatriz (36941085200) ;Herteliu, Claudiu (26035943100) ;Hoek, Hans W. (57202570421) ;Horino, Masako (57195769276) ;Horita, Nobuyuki (57217110823) ;Hosgood, H. Dean (56353204400) ;Hostiuc, Sorin (24829099800) ;Hotez, Peter J. (7004958298) ;Hoy, Damian G. 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(57202562224) ;Katikireddi, Srinivasa Vittal (6508254091) ;Kawakami, Norito (35377339000) ;Keiyoro, Peter Njenga (57203177260) ;Kemmer, Laura (57205017265) ;Kesavachandran, Chandrasekharan Nair (57218000521) ;Khader, Yousef Saleh (55654192600) ;Khan, Ejaz Ahmad (57218791274) ;Khang, Young-Ho (57198904674) ;Khoja, Abdullah Tawfh Abdullah (57194229795) ;Khosravi, Ardeshir (57201190837) ;Khosravi, Mohammad Hossein (56524167000) ;Khubchandani, Jagdish (57211720011) ;Kieling, Christian (57218820714) ;Kievlan, Daniel (55940685500) ;Kim, Daniel (57223019104) ;Kim, Yun Jin (57211086375) ;Kimokoti, Ruth W. (8647554600) ;Kinfu, Yohannes (12770281900) ;Kissoon, Niranjan (7006364038) ;Kivimaki, Mika (7004391239) ;Knudsen, Ann Kristin (57192966362) ;Kopec, Jacek A. (7006284395) ;Kosen, Soewarta (57211346192) ;Koul, Parvaiz A. (14022262900) ;Koyanagi, Ai (57197741912) ;Defo, Barthelemy Kuate (6602271655) ;Kulikof, Xie Rachel (57202024253) ;Kumar, G. Anil (57139550500) ;Kumar, Pushpendra (57208849920) ;Kutz, Michael (57195617315) ;Kyu, Hmwe H. (57217040073) ;Lal, Dharmesh Kumar (57222488984) ;Lalloo, Ratilal (57189334553) ;Lambert, Tea Lallukka Nkurunziza (57208159086) ;Lan, Qing (56682598900) ;Lansingh, Van C. (57194598546) ;Larsson, Anders (56381985300) ;Lee, Paul H. (57200302692) ;Leigh, James (7202089604) ;Leung, Janni (57214397752) ;Levi, Miriam (54893035000) ;Li, Yongmei (56147667800) ;Kappe, Darya Li (57202014108) ;Liang, Xiaofeng (26662590300) ;Liben, Misgan Legesse (57188568119) ;Lim, Stephen S. (57201800433) ;Liu, Angela (57196080772) ;Liu, Patrick Y. (56170368200) ;Liu, Yang (57202561981) ;Lodha, Rakesh (7007019609) ;Logroscino, Giancarlo (7004888005) ;Lorkowski, Stefan (57203677656) ;Lotufo, Paulo A. (7003331101) ;Lozano, Rafael (7102198442) ;Lucas, Timothy C.D. (57216683591) ;Ma, Stefan (7403723389) ;Macarayan, Erlyn Rachelle King (56330601800) ;Maddison, Emilie R. (57196084094) ;Abd El Razek, Mohammed Magdy (57192379650) ;Majdan, Marek (36147855100) ;Majdzadeh, Reza (9246620000) ;Majeed, Azeem (7102027801) ;Malekzadeh, Reza (7005197760) ;Malhotra, Rajesh (7202423297) ;Malta, Deborah Carvalho (15835283500) ;Manguerra, Helena (57208121153) ;Manyazewal, Tsegahun (55414403100) ;Mapoma, Chabila C. (57208956832) ;Marczak, Laurie B. (57200295553) ;Markos, Desalegn (57210741352) ;Martinez-Raga, Jose (57202861191) ;Martins-Melo, Francisco Rogerlândio (57204796807) ;Martopullo, Ira (57193550189) ;McAlinden, Colm (35325278500) ;McGaughey, Madeline (57206867033) ;McGrath, John J. (57202560550) ;Mehata, Suresh (57211773159) ;Meier, Toni (36678887300) ;Meles, Kidanu Gebremariam (57951018400) ;Memiah, Peter (57217207827) ;Memish, Ziad A. (7005059350) ;Mengesha, Melkamu Merid (57192953602) ;Mengistu, Desalegn Tadese (57194776802) ;Menota, Bereket Gebremichael (57195329507) ;Mensah, George A. (57196028147) ;Meretoja, Atte (12775885500) ;Meretoja, Tuomo J. (57202554188) ;Millear, Anoushka (57204879537) ;Miller, Ted R. (7403948600) ;Minnig, Shawn (57193238817) ;Mirarefn, Mojde (57202024712) ;Mirrakhimov, Erkin M. (57216202888) ;Misganaw, Awoke (57202808713) ;Mishra, Shiva Raj (57208010960) ;Mohammad, Karzan Abdulmuhsin (57205300378) ;Mohammadi, Alireza (56720095000) ;Mohammed, Shafu (57838689000) ;Mokdad, Ali H. (7004813962) ;Mola, Glen Liddell D. (57221824056) ;Mollenkopf, Sarah K. (57203646247) ;Molokhia, Mariam (7004121920) ;Monasta, Lorenzo (7801520497) ;Hernandez, Julio C. Montañez (57199371040) ;Montico, Marcella (57202563609) ;Mooney, Meghan D. (57216598823) ;Moradi-Lakeh, Maziar (35617421300) ;Moraga, Paula (46761426800) ;Morawska, Lidia (7004773965) ;Morrison, Shane D. (45661573100) ;Morozof, Chloe (57202020530) ;Mountjoy-Venning, Clif (57210505240) ;Mruts, Kalayu Birhane (57221822877) ;Muller, Kate (57196075658) ;Murthy, Gudlavalleti Venkata Satyanarayana (7101778322) ;Musa, Kamarul Imran (57194536466) ;Nachega, Jean B. (6701544088) ;Naheed, Aliya (57202560989) ;Naldi, Luigi (7004954781) ;Nangia, Vinay (57201490837) ;Nascimento, Bruno Ramos (14424406800) ;Nasher, Jamal T. (56003685800) ;Natarajan, Gopalakrishnan (55804491100) ;Negoi, Ionut (57200640014) ;Ngunjiri, Josephine Wanjiku (57195296110) ;Nguyen, Cuong Tat (56531347200) ;Nguyen, Grant (57191591002) ;Nguyen, Minh (58203329200) ;Nguyen, Quyen Le (57223642100) ;Nguyen, Trang Huyen (59142352200) ;Nichols, Emma (57205756163) ;Ningrum, Dina Nur Anggraini (57195329470) ;Nong, Vuong Minh (55507077200) ;Noubiap, Jean Jacques N. (55490374000) ;Ogbo, Felix Akpojene (57200737136) ;Oh, In-Hwan (57204090669) ;Okoro, Anselm (54682112200) ;Olagunju, Andrew Toyin (26029995700) ;Olsen, Helen E. (57203080494) ;Olusanya, Bolajoko Olubukunola (57218504682) ;Olusanya, Jacob Olusegun (57222488860) ;Ong, Kanyin (57224697159) ;Opio, John Nelson (57200124403) ;Oren, Eyal (36815569400) ;Ortiz, Alberto (7201911399) ;Osman, Majdi (59804857900) ;Ota, Erika (57202554474) ;Mahesh, P.A. (57202421244) ;Pacella, Rosana E. (57194839077) ;Pakhale, Smita (57220937499) ;Pana, Adrian (57191837583) ;Panda, Basant Kumar (57196077672) ;Jonas, Songhomitra (57198344150) ;Papachristou, Christina (7005498635) ;Park, Eun-Kee (57216814178) ;Patten, Scott B. (57201492915) ;Patton, George C. (7102184358) ;Paudel, Deepak (57207871851) ;Paulson, Katherine (57203437789) ;Pereira, David M. (57200690024) ;Perez-Ruiz, Fernando (57190090281) ;Perico, Norberto (56481931200) ;Pervaiz, Aslam (57202521714) ;Petzold, Max (7003628893) ;Phillips, Michael Robert (57202563610) ;Pigott, David M. (55320335600) ;Pinho, Christine (57212482983) ;Plass, Dietrich (57217142114) ;Pletcher, Martin A. (57196075669) ;Polinder, Suzanne (12766122200) ;Postma, Maarten J. (7006296502) ;Pourmalek, Farshad (8309390500) ;Purcell, Caroline (56203575500) ;Qorbani, Mostafa (24831040300) ;Radfar, Amir (57194428768) ;Rafay, Anwar (57212263323) ;Rahimi-Movaghar, Vafa (6507646446) ;Rahman, Mahfuzar (35571661300) ;Ur Rahman, Mohammad Hifz (57202017378) ;Rai, Rajesh Kumar (51864423900) ;Ranabhat, Chhabi Lal (56719695500) ;Rankin, Zane (57200251742) ;Rao, Puja C. (57191835613) ;Rath, Goura Kishor (35444818200) ;Rawaf, Salman (6602475959) ;Ray, Sarah E. (57196078769) ;Rehm, Jürgen (7102718648) ;Reiner, Robert C. (57203229088) ;Reitsma, Marissa B. (57208766315) ;Remuzzi, Giuseppe (56466188600) ;Rezaei, Satar (55273796300) ;Rezai, Mohammad Sadegh (57226200664) ;Rokni, Mohammad Bagher (36119103200) ;Ronfani, Luca (6602565620) ;Roshandel, Gholamreza (14034446800) ;Roth, Gregory A. (55074747400) ;Rothenbacher, Dietrich (7004765162) ;Ruhago, George Mugambage (50761517500) ;Rizwan, S.A. (57195295816) ;Saadat, Soheil (16310355800) ;Sachdev, Perminder S. (7102284091) ;Sadat, Nafs (57219687343) ;Safdarian, Mahdi (57203849024) ;Saf, Sare (57202019735) ;Safiri, Saeid (56009654100) ;Sagar, Rajesh (26643103100) ;Sahathevan, Ramesh (35332739200) ;Salama, Joseph (57202975625) ;Salamati, Payman (14045860600) ;Salomon, Joshua A. (56745638600) ;Samy, Abdallah M. (36973661300) ;Sanabria, Juan Ramon (7006262917) ;Sanchez-Niño, Maria Dolores (57202569015) ;Santomauro, Damian (56912450700) ;Santos, Itamar S. (57198312911) ;Milicevic, Milena M. Santric (57211144346) ;Sartorius, Benn (12788526800) ;Satpathy, Maheswar (57202563691) ;Shahraz, Saeid (57215142060) ;Schmidt, Maria Inês (7404398885) ;Schneider, Ione J.C. (57201292772) ;Schulhofer-Wohl, Sam (14322452700) ;Schutte, Aletta E. (57216814352) ;Schwebel, David C. (6603681532) ;Schwendicke, Falk (55639536600) ;Sepanlou, Sadaf G. (36248136000) ;Servan-Mori, Edson E. (57202594826) ;Shackelford, Katya Anne (57202959163) ;Shaikh, Masood Ali (57203122601) ;Shamsipour, Mansour (57197846052) ;Shamsizadeh, Morteza (57195940127) ;Islam, Sheikh Mohammed Shariful (56400111100) ;Sharma, Jayendra (57195329457) ;Sharma, Rajesh (58228412600) ;She, Jun (57209122131) ;Sheikhbahaei, Sara (57219637352) ;Shey, Muki (10138820000) ;Shi, Peilin (57203064901) ;Shields, Chloe (57196083232) ;Shigematsu, Mika (23968093000) ;Shiri, Rahman (57200737050) ;Shirude, Shreya (57216599051) ;Shiue, Ivy (35811219800) ;Shoman, Haitham (57208324664) ;Shrime, Mark G. (57204703404) ;Sigfusdottir, Inga Dora (57195363778) ;Silpakit, Naris (57202401404) ;Silva, João Pedro (7403023631) ;Singh, Abhishek (59639211800) ;Singh, Jasvinder A. (7404421736) ;Skiadaresi, Eirini (37100428500) ;Sligar, Amber (57190284582) ;Smith, Alison (57191843859) ;Smith, David L. (55574206203) ;Smith, Mari (57195484737) ;Sobaih, Badr H.A. (57202564080) ;Soneji, Samir (57204096389) ;Sorensen, Reed J.D. (57196918748) ;Soriano, Joan B. (7101973935) ;Sreeramareddy, Chandrashekhar T. (57212263335) ;Srinivasan, Vinay (57196077031) ;Stanaway, Jefrey D. (57201210928) ;Stathopoulou, Vasiliki (57209726581) ;Steel, Nicholas (6603791873) ;Stein, Dan J. (55769747595) ;Steiner, Caitlyn (57205358084) ;Steinke, Sabine (57203777687) ;Stokes, Mark Andrew (7102859000) ;Strong, Mark (12783473200) ;Strub, Bryan (57211781720) ;Subart, Michelle (57194140438) ;Sufyan, Muawiyyah Babale (57203947220) ;Sunguya, Bruno F. (57209060557) ;Sur, Patrick J. (57218360398) ;Swaminathan, Soumya (7102380757) ;Sykes, Bryan L. (57211183396) ;Tabarés-Seisdedos, Rafael (6602981102) ;Tadakamadla, Santosh Kumar (57207799926) ;Takahashi, Ken (55741242600) ;Takala, Jukka S. (35425471300) ;Talongwa, Roberto Tchio (57195568335) ;Tarawneh, Mohammed Rasoul (56742235200) ;Tavakkoli, Mohammad (57202524239) ;Taveira, Nuno (6602731390) ;Tegegne, Teketo Kassaw (57216998561) ;Tehrani-Banihashemi, Arash (57204006020) ;Temsah, Mohamad-Hani (56115852000) ;Terkawi, Abdullah Sulieman (57211144258) ;Thakur, J.S. (57204002123) ;Thamsuwan, Ornwipa (55484605700) ;Thankappan, Kavumpurathu Raman (57202955435) ;Thomas, Katie E. (56239717800) ;Thompson, Alex H. (57196083297) ;Thomson, Alan J. (57969994200) ;Thrift, Amanda G. (7004824524) ;Tobe-Gai, Ruoyan (57209276611) ;Topor-Madry, Roman (57211182892) ;Torre, Anna (57196074351) ;Tortajada, Miguel (16242320900) ;Towbin, Jefrey Allen (7102520568) ;Tran, Bach Xuan (57209107515) ;Troeger, Christopher (57195223624) ;Truelsen, Thomas (57202824565) ;Tsoi, Derrick (57196074984) ;Tuzcu, Emin Murat (7005951350) ;Tyrovolas, Stefanos (57207793475) ;Ukwaja, Kingsley N. (57202824584) ;Undurraga, Eduardo A. (57204092789) ;Updike, Rachel (57204698680) ;Uthman, Olalekan A. (23026328100) ;Uzochukwu, Benjamin S. Chudi (57211633289) ;Van Boven, Job F.M. (53464198500) ;Vasankari, Tommi (57200592416) ;Venketasubramanian, Narayanaswamy (56804702100) ;Violante, Francesco S. (7003555890) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Vos, Theo (57223885848) ;Wakayo, Tolassa (57205609717) ;Wallin, Mitchell T. (57201573668) ;Wang, Yuan-Pang (8576812100) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Weiss, Daniel J. (8609275600) ;Werdecker, Andrea (57208964895) ;Westerman, Ronny (57218361023) ;Whetter, Brian (57201998502) ;Whiteford, Harvey A. (55906494000) ;Wijeratne, Tissa (14051317700) ;Wiysonge, Charles Shey (6507441509) ;Woldeyes, Belete Getahun (57195329524) ;Wolfe, Charles D.A. (57202754705) ;Woodbrook, Rachel (57200298006) ;Workicho, Abdulhalik (56720337100) ;Xavier, Denis (55403963100) ;Xiao, Qingyang (59797114300) ;Xu, Gelin (57203583113) ;Yaghoubi, Mohsen (57212400558) ;Yakob, Bereket (57203811497) ;Yano, Yuichiro (57196965200) ;Yaseri, Mehdi (23029507000) ;Yimam, Hassen Hamid (57196325590) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922) ;Zegeye, Elias Asfaw (57209171278) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zerfu, Taddese Alemu (55358278900) ;Zhang, Anthony Lin (56391112900) ;Zhang, Xueying (56283378700) ;Zipkin, Ben (57200737130) ;Zodpey, Sanjay (7003415080) ;Lopez, Alan D. (7401455668)Murray, Christopher J.L. (55481130700)Background: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specifc mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. Methods: We estimated cause-specifc deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specifc causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specifc deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016. Findings: The quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72·3% (95% uncertainty interval [UI] 71·2-73·2) of deaths in 2016 with 19·3% (18·5-20·4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8·43% (8·00-8·67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006-16 - age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1·80 million deaths (95% UI 1·59 million to 1·89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176-181) increase in deaths in ages 90-94 years and a 210% (208-212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL signifcantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2·89%); the median annualised rate of change for all other causes was lower (a decrease of 1·59%) during the same interval. Globally, the fve leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a fner level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations. Other leading causes of YLLs for which YLLs were notably lower than expected included neonatal preterm birth complications in many locations in both south Asia and southeast Asia, and cerebrovascular disease in western Europe. Interpretation: The past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages suggests success in reducing many causes of early death. YLLs have increased globally for causes such as diabetes mellitus or some neoplasms, and in some locations for causes such as drug use disorders, and confict and terrorism. Increasing levels of YLLs might refect outcomes from conditions that required high levels of care but for which efective treatments remain elusive, potentially increasing costs to health systems. Copyright © 2017 The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national burden of tuberculosis, 1990-2016: Results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study(2018) ;Kyu, Hmwe Hmwe (57217040073) ;Maddison, Emilie R. (57196084094) ;Henry, Nathaniel J. (57196076616) ;Ledesma, Jorge R. (57204449040) ;Wiens, Kirsten E. (55515807800) ;Reiner, Robert (57203229088) ;Biehl, Molly H. (57196041812) ;Shields, Chloe (57196083232) ;Osgood-Zimmerman, Aaron (57195835977) ;Ross, Jennifer M. (56895463600) ;Carter, Austin (57201756395) ;Frank, Tahvi D. (57203197110) ;Wang, Haidong (16507828100) ;Srinivasan, Vinay (57196077031) ;Abebe, Zegeye (57193002719) ;Agarwal, Sanjay Kumar (57206276269) ;Alahdab, Fares (55135922900) ;Alene, Kefyalew Addis (57202583764) ;Ali, Beriwan Abdulqadir (57208356112) ;Alvis-Guzman, Nelson (57210741239) ;Andrews, Jason R. (15058787200) ;Antonio, Carl Abelardo T. (55247644500) ;Atique, Suleman (56505419100) ;Atre, Sachin R. (22933845900) ;Awasthi, Ashish (58420926700) ;Ayele, Henok Tadesse (55573710400) ;Badali, Hamid (15123728900) ;Badawi, Alaa (57216776029) ;Barac, Aleksandra (55550748700) ;Bedi, Neeraj (57988442200) ;Behzadifar, Masoud (57204671696) ;Behzadifar, Meysam (59429991000) ;Bekele, Bayu Begashaw (57196083941) ;Belay, Saba Abraham (57203298880) ;Bensenor, Isabela M. (7004830338) ;Butt, Zahid A. (57202522739) ;Carvalho, Félix (7103070417) ;Cercy, Kelly (57208777587) ;Christopher, Devasahayam J. (57209863533) ;Daba, Alemneh Kabeta (57203300408) ;Dandona, Lalit (7007017243) ;Dandona, Rakhi (57203043697) ;Daryani, Ahmad (16021522200) ;Demeke, Feleke Mekonnen (57204717669) ;Deribe, Kebede (57193912587) ;Dharmaratne, Samath Dhamminda (57216324802) ;Doku, David Teye (36015210300) ;Dubey, Manisha (57219898654) ;Edessa, Dumessa (56922334200) ;El-Khatib, Ziad (54908919000) ;Enany, Shymaa (23972375400) ;Fernandes, Eduarda (34770207500) ;Fischer, Florian (55508208800) ;Garcia-Basteiro, Alberto L. (57200187168) ;Gebre, Abadi Kahsu (59426751000) ;Gebregergs, Gebremedhin Berhe (57078990000) ;Gebremichael, Teklu Gebrehiwo (57204566728) ;Gelano, Tilayie Feto (57200628899) ;Geremew, Demeke (57196299505) ;Gona, Philimon N. (57219703762) ;Goodridge, Amador (55801980200) ;Gupta, Rahul (57204120071) ;Bidgoli, Hassan Haghparast (57201491554) ;Hailu, Gessessew Bugssa (57219637263) ;Hassen, Hamid Yimam (57188660707) ;Hedayati, Mohammad T. Tadesse (23979915700) ;Henok, Andualem (57196451824) ;Hostiuc, Sorin (24829099800) ;Hussen, Mamusha Aman (57221268448) ;Ilesanmi, Olayinka Stephen (54782692800) ;Irvani, Seyed Sina Naghibi (57202975543) ;Jacobsen, Kathryn H. (26029163100) ;Johnson, Sarah C. (57207904886) ;Jonas, Jost B. (7202492953) ;Kahsay, Amaha (57216608121) ;Kant, Surya (59567335600) ;Kasaeian, Amir (57195540738) ;Kassa, Tesfaye Dessale (58686045600) ;Khader, Yousef Saleh (55654192600) ;Khafaie, Morteza Abdullatif (55608324700) ;Khalil, Ibrahim (58255049500) ;Khan, Ejaz Ahmad (57218791274) ;Khang, Young-Ho (57198904674) ;Kim, Yun Jin (57211086375) ;Kochhar, Sonali (57214107714) ;Koyanagi, Ai (57197741912) ;Krohn, Kristopher J. (57194138806) ;Kumar, G. Anil (57139550500) ;Lakew, Ayenew Molla (57200821341) ;Leshargie, Cheru Tesema (57195295462) ;Lodha, Rakesh (7007019609) ;MacArayan, Erlyn Rachelle King (56330601800) ;Majdzadeh, Reza (9246620000) ;Martins-Melo, Francisco Rogerlândio (57204796807) ;Melese, Addisu (56901393600) ;Memish, Ziad A. (7005059350) ;Mendoza, Walter (57216905642) ;Mengistu, Desalegn Tadese (57194776802) ;Mengistu, Getnet (57193539632) ;Mestrovic, Tomislav (6507240107) ;Moazen, Babak (57204324006) ;Mohammad, Karzan Abdulmuhsin (57205300378) ;Mohammed, Shafiu (57838689000) ;Mokdad, Ali H. (7004813962) ;Moosazadeh, Mahmood (35771326500) ;Mousavi, Seyyed Meysam (56165159700) ;Mustafa, Ghulam (57190395960) ;Nachega, Jean B. (6701544088) ;Nguyen, Long Hoang (56567321800) ;Nguyen, Son Hoang (59662830400) ;Nguyen, Trang Huyen (59142352200) ;Ningrum, Dina Nur Anggraini (57195329470) ;Nirayo, Yirga Legesse (57201651103) ;Nong, Vuong Minh (55507077200) ;Ofori-Asenso, Richard (57209300265) ;Ogbo, Felix Akpojene (57217186813) ;Oh, In-Hwan (57204090669) ;Oladimeji, Olanrewaju (57216495380) ;Olagunju, Andrew T. (26029995700) ;Oren, Eyal (36815569400) ;Pereira, David M. (57200690024) ;Prakash, Swayam (57212263375) ;Qorbani, Mostafa (24831040300) ;Rafay, Anwar (57212263323) ;Rai, Rajesh Kumar (51864423900) ;Ram, Usha (26653819000) ;Rubino, Salvatore (55240504800) ;Safiri, Saeid (56009654100) ;Salomon, Joshua A. (56745638600) ;Samy, Abdallah M. (36973661300) ;Sartorius, Benn (12788526800) ;Satpathy, Maheswar (57202563691) ;Seyedmousavi, Seyedmojtaba (57204698893) ;Sharif, Mehdi (16022734200) ;Silva, João Pedro (57204703526) ;Silveira, Dayane Gabriele Alves (57190284103) ;Singh, Jasvinder A. (7404421736) ;Sreeramareddy, Chandrashekhar T. (57212263335) ;Tran, Bach Xuan (57209107515) ;Tsadik, Afewerki Gebremeskel (57204562442) ;Ukwaja, Kingsley Nnanna (57202824584) ;Ullah, Irfan (56992676600) ;Uthman, Olalekan A. (23026328100) ;Vlassov, Vasily (57211633239) ;Vollset, Stein Emil (57196315778) ;Vu, Giang (57202424871) ;Weldegebreal, Fitsum (56112812300) ;Werdecker, Andrea (57208964895) ;Yimer, Ebrahim M. (57202256312) ;Yonemoto, Naohiro (57204947657) ;Yotebieng, Marcel (26325950800) ;Naghavi, Mohsen (57207906323) ;Vos, Theo (57223885848) ;Hay, Simon I. (7101875313)Murray, Christopher J.L. (55481130700)Background Although a preventable and treatable disease, tuberculosis causes more than a million deaths each year. As countries work towards achieving the Sustainable Development Goal (SDG) target to end the tuberculosis epidemic by 2030, robust assessments of the levels and trends of the burden of tuberculosis are crucial to inform policy and programme decision making. We assessed the levels and trends in the fatal and non-fatal burden of tuberculosis by drug resistance and HIV status for 195 countries and territories from 1990 to 2016. Methods We analysed 15 943 site-years of vital registration data, 1710 site-years of verbal autopsy data, 764 site-years of sample-based vital registration data, and 361 site-years of mortality surveillance data to estimate mortality due to tuberculosis using the Cause of Death Ensemble model. We analysed all available data sources, including annual case notifications, prevalence surveys, population-based tuberculin surveys, and estimated tuberculosis cause-specific mortality to generate internally consistent estimates of incidence, prevalence, and mortality using DisMod-MR 2.1, a Bayesian meta-regression tool. We assessed how the burden of tuberculosis differed from the burden predicted by the Socio-demographic Index (SDI), a composite indicator of income per capita, average years of schooling, and total fertility rate. Findings Globally in 2016, among HIV-negative individuals, the number of incident cases of tuberculosis was 9·02 million (95% uncertainty interval [UI] 8·05-10·16) and the number of tuberculosis deaths was 1·21 million (1·16-1·27). Among HIV-positive individuals, the number of incident cases was 1·40 million (1·01-1·89) and the number of tuberculosis deaths was 0·24 million (0·16-0·31). Globally, among HIV-negative individuals the agestandardised incidence of tuberculosis decreased annually at a slower rate (-1·3% [-1·5 to -1·2]) than mortality did (-4·5% [-5·0 to -4·1]) from 2006 to 2016. Among HIV-positive individuals during the same period, the rate of change in annualised age-standardised incidence was -4·0% (-4·5 to -3·7) and mortality was -8·9% (-9·5 to -8·4). Several regions had higher rates of age-standardised incidence and mortality than expected on the basis of their SDI levels in 2016. For drug-susceptible tuberculosis, the highest observed-to-expected ratios were in southern sub-Saharan Africa (13·7 for incidence and 14·9 for mortality), and the lowest ratios were in high-income North America (0·4 for incidence) and Oceania (0·3 for mortality). For multidrug-resistant tuberculosis, eastern Europe had the highest observed-to-expected ratios (67·3 for incidence and 73·0 for mortality), and high-income North America had the lowest ratios (0·4 for incidence and 0·5 for mortality). Interpretation If current trends in tuberculosis incidence continue, few countries are likely to meet the SDG target to end the tuberculosis epidemic by 2030. Progress needs to be accelerated by improving the quality of and access to tuberculosis diagnosis and care, by developing new tools, scaling up interventions to prevent risk factors for tuberculosis, and integrating control programmes for tuberculosis and HIV. Funding Bill & Melinda Gates Foundation. © 2018 The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016(2017) ;Gakidou, Emmanuela (57202567277) ;Afshin, Ashkan (57217465455) ;Abajobir, Amanuel Alemu (57203613441) ;Abate, Kalkidan Hassen (57207943858) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abd-Allah, Foad (36503428900) ;Abdulle, Abdishakur M. (6603592018) ;Abera, Semaw Ferede (57205180598) ;Aboyans, Victor (56214736500) ;Abu-Raddad, Laith J. (14032724700) ;Abu-Rmeileh, Niveen M.E. (57216675148) ;Abyu, Gebre Yitayih (57190277969) ;Adedeji, Isaac Akinkunmi (57208456508) ;Adetokunboh, Olatunji (56598104300) ;Afarideh, Mohsen (56227034300) ;Agrawal, Anurag (35214460700) ;Agrawal, Sutapa (57202841733) ;Ahmad Kiadaliri, Aliasghar (57199100665) ;Ahmadieh, Hamid (57203677679) ;Ahmed, Muktar Beshir (57207802317) ;Aichour, Amani Nidhal (57195486768) ;Aichour, Ibtihel (57195485980) ;Aichour, Miloud Taki Eddine (57195488258) ;Akinyemi, Rufus Olusola (25633566800) ;Akseer, Nadia (57207801968) ;Alahdab, Fares (55135922900) ;Al-Aly, Ziyad (9738161500) ;Alam, Khurshid (57203681299) ;Alam, Noore (57202437697) ;Alam, Tahiya (57205589820) ;Alasfoor, Deena (57211114684) ;Alene, Kefyalew Addis (57202583764) ;Ali, Komal (57201650740) ;Alizadeh-Navaei, Reza (36024974700) ;Alkerwi, Ala'a (57197724313) ;Alla, François (6701580827) ;Allebeck, Peter (7005187575) ;Al-Raddadi, Rajaa (57219673720) ;Alsharif, Ubai (57211633255) ;Altirkawi, Khalid A. (57202762923) ;Alvis-Guzman, Nelson (57210741239) ;Amare, Azmeraw T. (57202220009) ;Amini, Erfan (35073393800) ;Ammar, Walid (57208159281) ;Amoako, Yaw Ampem (44960986700) ;Ansari, Hossein (56919376000) ;Antó, Josep M. (56196020900) ;Antonio, Carl Abelardo T. (55247644500) ;Anwari, Palwasha (57217465526) ;Arian, Nicholas (57199421908) ;Ärnlöv, Johan (6602512227) ;Artaman, Al (57217223811) ;Aryal, Krishna Kumar (57203859052) ;Asayesh, Hamid (55334322800) ;Asgedom, Solomon Weldegebreal (57203681037) ;Atey, Tesfay Mehari (57209784978) ;Avila-Burgos, Leticia (8530790100) ;Avokpaho, Euripide Frinel G. Arthur (57209842037) ;Awasthi, Ashish (57200155811) ;Azzopardi, Peter (56861081000) ;Bacha, Umar (57200173721) ;Badawi, Alaa (57216776029) ;Balakrishnan, Kalpana (7103222725) ;Ballew, Shoshana H. (34067516900) ;Barac, Aleksandra (55550748700) ;Barber, Ryan M. (57202560423) ;Barker-Collo, Suzanne L. (57193065514) ;Bärnighausen, Till (23011726900) ;Barquera, Simon (6601928375) ;Barregard, Lars (55953218700) ;Barrero, Lope H. (57208560675) ;Batis, Carolina (57194576758) ;Battle, Katherine E. (55221714400) ;Baune, Bernhard T. (6603807336) ;Beardsley, Justin (57207800229) ;Bedi, Neeraj (57988442200) ;Beghi, Ettore (7004809655) ;Bell, Michelle L. (7401466450) ;Bennett, Derrick A. (57650836400) ;Bennett, James R. (59110116800) ;Bensenor, Isabela M. (7004830338) ;Berhane, Adugnaw (57200410735) ;Berhe, Derbew Fikadu (57204007429) ;Bernabé, Eduardo (57194696150) ;Betsu, Balem Demtsu (57196316128) ;Beuran, Mircea (25229806700) ;Beyene, Addisu Shunu (57209036705) ;Bhansali, Anil (7005642796) ;Bhutta, Zulfqar A. (24342648300) ;Bikbov, Boris (57219957158) ;Birungi, Charles (57195448297) ;Biryukov, Stan (57195296731) ;Blosser, Christopher D. (57194239081) ;Boneya, Dube Jara (57194067231) ;Bou-Orm, Ibrahim R. (57193524147) ;Brauer, Michael (57218330976) ;Breitborde, Nicholas J.K. (6603260895) ;Brenner, Hermann (7201832825) ;Brugha, Traolach S. (35370057100) ;Bulto, Lemma Negesa Bulto (57196074547) ;Baumgarner, Blair R. (57208560663) ;Butt, Zahid A. (57202522739) ;Cahuana-Hurtado, Lucero (57207890731) ;Cárdenas, Rosario (57216482927) ;Carrero, Juan Jesus (16834646800) ;Castañeda-Orjuela, Carlos A. (35769124700) ;Catalá-López, Ferrán (57202553733) ;Cercy, Kelly (57208777587) ;Chang, Hsing-Yi (7407523087) ;Charlson, Fiona J. (57191632086) ;Chimed-Ochir, Odgerel (57217262222) ;Chisumpa, Vesper Hichilombwe (56761895800) ;Chitheer, Abdulaal A. (57209314488) ;Christensen, Hanne (57202099623) ;Christopher, Devasahayam Jesudas (57209863533) ;Cirillo, Massimo (35247478400) ;Cohen, Aaron J. (7404780942) ;Comfort, Haley (57218875721) ;Cooper, Cyrus (36041345700) ;Coresh, Josef (7005367498) ;Cornaby, Leslie (57191837051) ;Cortesi, Paolo Angelo (57200306512) ;Criqui, Michael H. (7005209601) ;Crump, John A. (57202595111) ;Dandona, Lalit (7007017243) ;Dandona, Rakhi (57203043697) ;Das Neves, José (57208073193) ;Davey, Gail (7102000901) ;Davitoiu, Dragos V. (57202555163) ;Davletov, Kairat (6602803024) ;De Courten, Barbora (57208309416) ;Degenhardt, Louisa (7004040033) ;Deiparine, Selina (57205252200) ;Dellavalle, Robert P. (7003806771) ;Deribe, Kebede (57193912587) ;Deshpande, Aniruddha (57202673979) ;Dharmaratne, Samath D. (57216324802) ;Ding, Eric L. (54413849800) ;Djalalinia, Shirin (37113718000) ;Do, Huyen Phuc (57200737094) ;Dokova, Klara (57201523771) ;Doku, David Teye (36015210300) ;Dorsey, E. Ray (23102496300) ;Driscoll, Tim R. (7005928308) ;Dubey, Manisha (57219898654) ;Duncan, Bruce Bartholow (35476478500) ;Duncan, Sarah (57199417426) ;Ebert, Natalie (20333943200) ;Ebrahimi, Hedyeh (57195329214) ;El-Khatib, Ziad Ziad (54908919000) ;Enayati, Ahmadali (6507139052) ;Endries, Aman Yesuf (57216324852) ;Ermakov, Sergey Petrovich (7006796196) ;Erskine, Holly E. (57202798676) ;Eshrati, Babak (16030619200) ;Eskandarieh, Sharareh (57211720158) ;Esteghamati, Alireza (11240321100) ;Estep, Kara (57216550964) ;Faraon, Emerito Jose Aquino (57195414019) ;Farinha, Carla Sofia E. Sa (57190279273) ;Faro, André (36770969600) ;Farzadfar, Farshad (57195049611) ;Fay, Kairsten (57217858217) ;Feigin, Valery L. (57203677957) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fernandes, João C. (35274726800) ;Ferrari, Alize J. (57195348907) ;Feyissa, Tesfaye Regassa (57222562476) ;Filip, Irina (55570061400) ;Fischer, Florian (55508208800) ;Fitzmaurice, Christina (57212628757) ;Flaxman, Abraham D. (6602883567) ;Foigt, Nataliya (57216998893) ;Foreman, Kyle J. (57209064414) ;Frostad, Joseph J. (57222306717) ;Fullman, Nancy (57211064970) ;Fürst, Thomas (57208431345) ;Furtado, Joao M. (36801755000) ;Ganji, Morsaleh (57211874807) ;Garcia-Basteiro, Alberto L. (57200187168) ;Gebrehiwot, Tsegaye Tewelde (57216482917) ;Geleijnse, Johanna M. 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(56135699200) ;Iburg, Kim Moesgaard (57216814160) ;Ikeda, Chad (57202720108) ;Inoue, Manami (57202880842) ;Irvine, Caleb Mackay Salpeter (57203666733) ;Jackson, Maria Delores (55456026100) ;Jacobsen, Kathryn H. (26029163100) ;Jahanmehr, Nader (57203122718) ;Jakovljevic, Mihajlo B. (14318929700) ;Jauregui, Alejandra (57204716988) ;Javanbakht, Mehdi (57204619886) ;Jeemon, Panniyammakal (57216324831) ;Johansson, Lars R.K. (7401510247) ;Johnson, Catherine O. (57212301236) ;Jonas, Jost B. (7202492953) ;Jürisson, Mikk (55547524800) ;Kabir, Zubair (57207901718) ;Kadel, Rajendra (57196080325) ;Kahsay, Amaha (57216608121) ;Kamal, Ritul (57203177242) ;Karch, André (57223444197) ;Karema, Corine Kakizi (57202557522) ;Kasaeian, Amir (57195540738) ;Kassebaum, Nicholas J. 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(7004813962) ;Monasta, Lorenzo (7801520497) ;Montañez Hernandez, Julio Cesar (57203977041) ;Montico, Marcella (57202563609) ;Moradi-Lakeh, Maziar (35617421300) ;Moraga, Paula (46761426800) ;Morawska, Lidia (7004773965) ;Morrison, Shane D. (45661573100) ;Mountjoy-Venning, Cliff (57196081878) ;Mueller, Ulrich O. (8512347500) ;Mullany, Erin C. (57208989650) ;Muller, Kate (57196075658) ;Murthy, Gudlavalleti Venkata Satyanarayana (7101778322) ;Musa, Kamarul Imran (57194536466) ;Naghavi, Mohsen (57207906323) ;Naheed, Aliya (57202560989) ;Nangia, Vinay (57201490837) ;Natarajan, Gopalakrishnan (55804491100) ;Negoi, Ionut (57200640014) ;Negoi, Ruxandra Irina (55566106200) ;Nguyen, Cuong Tat (56531347200) ;Nguyen, Grant (57191591002) ;Nguyen, Minh (58203329200) ;Nguyen, Quyen Le (57223642100) ;Nguyen, Trang Huyen (59142352200) ;Nichols, Emma (57205756163) ;Ningrum, Dina Nur Anggraini (57195329470) ;Nomura, Marika (57191838057) ;Nong, Vuong Minh (55507077200) ;Norheim, Ole F. (7004082597) ;Norrving, Bo (12792377500) ;Noubiap, Jean Jacques N. (55490374000) ;Obermeyer, Carla Makhlouf (57209300189) ;Ogbo, Felix Akpojene (57200737136) ;Oh, In-Hwan (57204090669) ;Oladimeji, Olanrewaju (57216495380) ;Olagunju, Andrew Toyin (26029995700) ;Olagunju, Tinuke Oluwasefunmi (57203076824) ;Olivares, Pedro R. (7003510190) ;Olsen, Helen E. (57203080494) ;Olusanya, Bolajoko Olubukunola (57218504682) ;Olusanya, Jacob Olusegun (57222488860) ;Opio, John Nelson (57200124403) ;Oren, Eyal (36815569400) ;Ortiz, Alberto (7201911399) ;Ota, Erika (57202554474) ;Owolabi, Mayowa O. (57222581892) ;Pa, Mahesh (57212735186) ;Pacella, Rosana E. (57194839077) ;Pana, Adrian (57191837583) ;Panda, Basant Kumar (57196077672) ;Panda-Jonas, Songhomitra (6603112353) ;Pandian, Jeyaraj D. (6701618847) ;Papachristou, Christina (7005498635) ;Park, Eun-Kee (57216814178) ;Parry, Charles D. (7102561312) ;Patten, Scott B. (57201492915) ;Patton, George C. (7102184358) ;Pereira, David M. 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(57208766315) ;Reynales-Shigematsu, Luz Myriam (12142340100) ;Remuzzi, Giuseppe (56466188600) ;Renzaho, Andre M.N. (6505786588) ;Resnikoff, Serge (7006012071) ;Rezaei, Satar (55791003000) ;Ribeiro, Antonio L. (7201676223) ;Rivera, Juan A. (7202308740) ;Roba, Kedir Teji (57203667432) ;Rojas-Rueda, David (57203642966) ;Roman, Yesenia (57191841842) ;Room, Robin (57202570958) ;Roshandel, Gholamreza (14034446800) ;Roth, Gregory A. (55074747400) ;Rothenbacher, Dietrich (7004765162) ;Rubagotti, Enrico (57208389589) ;Rushton, Lesley (57202561819) ;Sadat, Nafis (57219687343) ;Safdarian, Mahdi (57203849024) ;Safi, Sare (57219477293) ;Safiri, Saeid (56009654100) ;Sahathevan, Ramesh (35332739200) ;Salama, Joseph (57202975625) ;Salomon, Joshua A. (56745638600) ;Samy, Abdallah M. (36973661300) ;Sanabria, Juan Ramon (7006262917) ;Sanchez-Niño, Maria Dolores (57202569015) ;Sánchez-Pimienta, Tania G. (57042673800) ;Santomauro, Damian (56912450700) ;Santos, Itamar S. (57198312911) ;Santric Milicevic, Milena M. (57211144346) ;Sartorius, Benn (12788526800) ;Satpathy, Maheswar (57202563691) ;Sawhney, Monika (57217153893) ;Saxena, Sonia (57203151746) ;Schaeffner, Elke (6507021741) ;Schmidt, Maria Inês (7404398885) ;Schneider, Ione J.C. (57201292772) ;Schutte, Aletta E. (57216814352) ;Schwebel, David C. (6603681532) ;Schwendicke, Falk (55639536600) ;Seedat, Soraya (7003445887) ;Sepanlou, Sadaf G. (36248136000) ;Serdar, Berrin (57216717159) ;Servan-Mori, Edson E. (57202594826) ;Shaddick, Gavin (57216802010) ;Shaheen, Amira (57202560956) ;Shahraz, Saeid (57215142060) ;Shaikh, Masood Ali (57203122601) ;Shamah Levy, Teresa (55989758300) ;Shamsipour, Mansour (57197846052) ;Shamsizadeh, Morteza (57195940127) ;Shariful Islam, Sheikh Mohammed (56400111100) ;Sharma, Jayendra (57195329457) ;Sharma, Rajesh (58228412600) ;She, Jun (57209122131) ;Shen, Jiabin (57199271940) ;Shi, Peilin (57203064901) ;Shibuya, Kenji (8948057900) ;Shields, Chloe (57196083232) ;Shiferaw, Mekonnen Sisay (57205232012) ;Shigematsu, Mika (23968093000) ;Shin, Min-Jeong (7401536640) ;Shiri, Rahman (57200737050) ;Shirkoohi, Reza (12776374400) ;Shishani, Kawkab (14025005500) ;Shoman, Haitham (57208324664) ;Shrime, Mark G. (57204703404) ;Sigfusdottir, Inga Dora (57195363778) ;Silva, Diego Augusto Santos (36985158000) ;Silva, João Pedro (7403023631) ;Silveira, Dayane Gabriele Alves (57190284103) ;Singh, Jasvinder A. (7404421736) ;Singh, Virendra (57191848598) ;Sinha, Dhirendra Narain (7201637609) ;Skiadaresi, Eirini (37100428500) ;Slepak, Erica Leigh (57205356367) ;Smith, David L. (55574206203) ;Smith, Mari (57195484737) ;Sobaih, Badr H.A. (57202564080) ;Sobngwi, Eugene (6701427993) ;Soneji, Samir (57204096389) ;Sorensen, Reed J.D. (57196918748) ;Sposato, Luciano A. (25640261000) ;Sreeramareddy, Chandrashekhar T. (57212263335) ;Srinivasan, Vinay (57196077031) ;Steel, Nicholas (6603791873) ;Stein, Dan J. (55769747595) ;Steiner, Caitlyn (57205358084) ;Steinke, Sabine (57203777687) ;Stokes, Mark Andrew (7102859000) ;Strub, Bryan (57211781720) ;Subart, Michelle (57194140438) ;Sufiyan, Muawiyyah Babale (58294633600) ;Suliankatchi, Rizwan Abdulkader (57195295816) ;Sur, Patrick J. (57218360398) ;Swaminathan, Soumya (7102380757) ;Sykes, Bryan L. (57211183396) ;Szoeke, Cassandra E.I. (6505920990) ;Tabarés-Seisdedos, Rafael (6602981102) ;Tadakamadla, Santosh Kumar (57207799926) ;Takahashi, Ken (55741242600) ;Takala, Jukka S. (35425471300) ;Tandon, Nikhil (7101833756) ;Tanner, Marcel (7202127772) ;Tarekegn, Yihunie L. (57202809688) ;Tavakkoli, Mohammad (57202524239) ;Tegegne, Teketo Kassaw (57216998561) ;Tehrani-Banihashemi, Arash (57204006020) ;Terkawi, Abdullah Sulieman (57211144258) ;Tesssema, Belay (57195294962) ;Thakur, J.S. (57204002123) ;Thamsuwan, Ornwipa (55484605700) ;Thankappan, Kavumpurathu Raman (57202955435) ;Theis, Andrew M. (57196076787) ;Thomas, Matthew Lloyd (57191835351) ;Thomson, Alan J. (57969994200) ;Thrift, Amanda G. (7004824524) ;Tillmann, Taavi (57190211142) ;Tobe-Gai, Ruoyan (57209276611) ;Tobollik, Myriam (56549045300) ;Tollanes, Mette C. (16833860000) ;Tonelli, Marcello (7103102534) ;Topor-Madry, Roman (57211182892) ;Torre, Anna (57196074351) ;Tortajada, Miguel (16242320900) ;Touvier, Mathilde (8877033300) ;Tran, Bach Xuan (57209107515) ;Truelsen, Thomas (57202824565) ;Tuem, Kald Beshir (57216106503) ;Tuzcu, Emin Murat (7005951350) ;Tyrovolas, Stefanos (57207793475) ;Ukwaja, Kingsley Nnanna (57202824584) ;Uneke, Chigozie Jesse (57202824589) ;Updike, Rachel (57204698680) ;Uthman, Olalekan A. (23026328100) ;Van Boven, Job F.M. (53464198500) ;Van Donkelaar, Aaron (15926418500) ;Varughese, Santosh (22942817500) ;Vasankari, Tommi (57200592416) ;Veerman, Lennert J. (8222114200) ;Venkateswaran, Vidhya (59829999400) ;Venketasubramanian, Narayanaswamy (56804702100) ;Violante, Francesco S. (7003555890) ;Vladimirov, Sergey K. (57195959162) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Vos, Theo (57223885848) ;Wadilo, Fiseha (57194049305) ;Wakayo, Tolassa (57205609717) ;Wallin, Mitchell T. (57201573668) ;Wang, Yuan-Pang (8576812100) ;Weichenthal, Scott (57202555239) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Weiss, Daniel J. (8609275600) ;Werdecker, Andrea (57208964895) ;Westerman, Ronny (57218361023) ;Whiteford, Harvey A. (55906494000) ;Wiysonge, Charles Shey (6507441509) ;Woldeyes, Belete Getahun (57195329524) ;Wolfe, Charles D.A. (57202754705) ;Woodbrook, Rachel (57200298006) ;Workicho, Abdulhalik (56720337100) ;Wulf Hanson, Sarah (57212263269) ;Xavier, Denis (55403963100) ;Xu, Gelin (57203583113) ;Yadgir, Simon (57192837280) ;Yakob, Bereket (57203811497) ;Yan, Lijing L. (57198311895) ;Yaseri, Mehdi (23029507000) ;Yimam, Hassen Hamid (57196325590) ;Yip, Paul (7102503720) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922) ;Zavala-Arciniega, Luis (57196083471) ;Zhang, Xueying (56283378700) ;Zimsen, Stephanie Raman M. (57196078433) ;Zipkin, Ben (57200737130) ;Zodpey, Sanjay (7003415080) ;Lim, Stephen S. (57201800433)Murray, Christopher J.L. (55481130700)Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. Methods: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2016. This study included 481 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk (RR) and exposure estimates from 22 717 randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources, according to the GBD 2016 source counting methods. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. Finally, we explored four drivers of trends in attributable burden: population growth, population ageing, trends in risk exposure, and all other factors combined. Findings: Since 1990, exposure increased significantly for 30 risks, did not change significantly for four risks, and decreased significantly for 31 risks. Among risks that are leading causes of burden of disease, child growth failure and household air pollution showed the most significant declines, while metabolic risks, such as body-mass index and high fasting plasma glucose, showed significant increases. In 2016, at Level 3 of the hierarchy, the three leading risk factors in terms of attributable DALYs at the global level for men were smoking (124.1 million DALYs [95% UI 111.2 million to 137.0 million]), high systolic blood pressure (122.2 million DALYs [110.3 million to 133.3 million], and low birthweight and short gestation (83.0 million DALYs [78.3 million to 87.7 million]), and for women, were high systolic blood pressure (89.9 million DALYs [80.9 million to 98.2 million]), high body-mass index (64.8 million DALYs [44.4 million to 87.6 million]), and high fasting plasma glucose (63.8 million DALYs [53.2 million to 76.3 million]). In 2016 in 113 countries, the leading risk factor in terms of attributable DALYs was a metabolic risk factor. Smoking remained among the leading five risk factors for DALYs for 109 countries, while low birthweight and short gestation was the leading risk factor for DALYs in 38 countries, particularly in sub-Saharan Africa and South Asia. In terms of important drivers of change in trends of burden attributable to risk factors, between 2006 and 2016 exposure to risks explains an 9.3% (6.9-11.6) decline in deaths and a 10.8% (8.3-13.1) decrease in DALYs at the global level, while population ageing accounts for 14.9% (12.7-17.5) of deaths and 6.2% (3.9-8.7) of DALYs, and population growth for 12.4% (10.1-14.9) of deaths and 12.4% (10.1-14.9) of DALYs. The largest contribution of trends in risk exposure to disease burden is seen between ages 1 year and 4 years, where a decline of 27.3% (24.9-29.7) of the change in DALYs between 2006 and 2016 can be attributed to declines in exposure to risks. Interpretation: Increasingly detailed understanding of the trends in risk exposure and the RRs for each risk-outcome pair provide insights into both the magnitude of health loss attributable to risks and how modification of risk exposure has contributed to health trends. Metabolic risks warrant particular policy attention, due to their large contribution to global disease burden, increasing trends, and variable patterns across countries at the same level of development. GBD 2016 findings show that, while it has huge potential to improve health, risk modification has played a relatively small part in the past decade. © The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017(2018) ;Kyu, Hmwe Hmwe (57217040073) ;Abate, Degu (57204237665) ;Abate, Kalkidan Hassen (57207943858) ;Abay, Solomon M. (35306466900) ;Abbafati, Cristiana (54917122400) ;Abbasi, Nooshin (57212442022) ;Abbastabar, Hedayat (57212441848) ;Abd-Allah, Foad (36503428900) ;Abdela, Jemal (57200613000) ;Abdelalim, Ahmed (7801307783) ;Abdollahpour, Ibrahim (36997151900) ;Abdulkader, Rizwan Suliankatchi (57195295816) ;Abebe, Molla (57211131124) ;Abebe, Zegeye (57193002719) ;Abil, Olifan Zewdie (57204558002) ;Aboyans, Victor (56214736500) ;Abrham, Aklilu Roba (57202704637) ;Abu-Raddad, Laith Jamal (14032724700) ;Abu-Rmeileh, Niveen M.E. (57216675148) ;Accrombessi, Manfred Mario Kokou (55353650500) ;Acharya, Dilaram (56770895600) ;Acharya, Pawan (56435749900) ;Ackerman, Ilana N. (8925517400) ;Adamu, Abdu A. (57202024381) ;Adebayo, Oladimeji M. (57194329853) ;Adekanmbi, Victor (53463192900) ;Ademi, Zanfina (32867460300) ;Adetokunboh, Olatunji O. (56598104300) ;Adib, Mina G. (57204560513) ;Adsuar, Jose C. (21738958900) ;Afanvi, Kossivi Agbelenko (57189844785) ;Afarideh, Mohsen (56227034300) ;Afshin, Ashkan (57217465455) ;Agarwal, Gina (57220151944) ;Agesa, Kareha M. 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(57198311895) ;Yano, Yuichiro (57196965200) ;Yaseri, Mehdi (23029507000) ;Yasin, Yasin Jemal (57204565144) ;Yeshaneh, Alex (57204564144) ;Yimer, Ebrahim M. (57202256312) ;Yip, Paul (7102503720) ;Yisma, Engida (55556060700) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Yousefifard, Mahmoud (57204566585) ;Yu, Chuanhua (57208140344) ;Zadnik, Vesna (57202975428) ;Zaidi, Zoubida (57197376721) ;Zaman, Sojib Bin (57193070058) ;Zamani, Mohammad (57096222300) ;Zandian, Hamed (57205175627) ;Zar, Heather J. (7006236599) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zipkin, Ben (57200737130) ;Zhou, Maigeng (57054557200) ;Zodpey, Sanjay (7003415080) ;Zucker, Inbar (47461733200) ;Zuhlke, Liesl Joanna (57209027746)Murray, Christopher J.L. (55481130700)Background: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted lifeyears (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severityof ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-speci?c mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Sociodemographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7·4 years (95% uncertainty interval 7·1-7·8), from 65·6 years (65·3-65·8) in 1990 to 73·0 years (72·7-73·3) in 2017. The increase in years of life varied from 5·1 years (5·0-5·3) in high SDI countries to 12·0 years (11·3-12·8) in low SDI countries. Of the additional years of life expected at birth, 26·3% (20·1-33·1) were expected to be spent in poor health in high SDI countries compared with 11·7% (8·8-15·1) in low-middle SDI countries. HALE at birth increased by 6·3 years (5·9-6·7), from 57·0 years (54·6-59·1) in 1990 to 63·3 years (60·5-65·7) in 2017. The increase varied from 3·8 years (3·4-4·1) in high SDI countries to 10·5 years (9·8-11·2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1·0 year (0·4-1·7) in Saint Vincent and the Grenadines (62·4 years [59·9-64·7] in 1990 to 63·5 years [60·9-65·8] in 2017) to 23·7 years (21·9-25·6) in Eritrea (30·7 years [28·9-32·2] in 1990 to 54·4 years [51·5-57·1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1·4 years (0·6-2·3) in Algeria to 11·9 years (10·9-12·9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75·8 years [72·4-78·7]) and males (72·6 years [69·8-75·0]) and the lowest estimates were in Central African Republic (47·0 years [43·7-50·2] for females and 42·8 years [40·1-45·6] for males). Globally, in 2017, the ?ve leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41·3% (38·8-43·5) for communicable diseases and by 49·8% (47·9-51·6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40·1% (36·8-43·0), although age-standardised DALY rates decreased by 18·1% (16·0-20·2). Interpretation With increasing life expectancy in most countries, the question of whether the additional years of life gained are spent in good health or poor health has been increasingly relevant because of the potential policy implications, such as health-care provisions and extending retirement ages. In some locations, a large proportion of those additional years are spent in poor health. Large inequalities in HALE and disease burden exist across countries in different SDI quintiles and between sexes. The burden of disabling conditions has serious implications for health system planning and health-related expenditures. Despite the progress made in reducing the burden of communicable diseases and neonatal disorders in low SDI countries, the speed of this progress could be increased by scaling up proven interventions. The global trends among non-communicable diseases indicate that more effort is needed to maximise HALE, such as risk prevention and attention to upstream determinants of health. Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013(2014) ;Murray, Christopher J.L. (55481130700) ;Ortblad, Katrina F. (57190076688) ;Guinovart, Caterina (23024511900) ;Lim, Stephen S. (7404081544) ;Wolock, Timothy M. (57210784314) ;Roberts, D. Allen (57188657365) ;Dansereau, Emily A. (57203833128) ;Graetz, Nicholas (56276346000) ;Barber, Ryan M. (57202560423) ;Brown, Jonathan C. (57212760159) ;Wang, Haidong (16507828100) ;Duber, Herbert C. (55522646900) ;Naghavi, Mohsen (57207906323) ;Dicker, Daniel (57196026676) ;Dandona, Lalit (7007017243) ;Salomon, Joshua A. (56745638600) ;Heuton, Kyle R. (57202568555) ;Foreman, Kyle (57209064414) ;Phillips, David E. (57202564185) ;Fleming, Thomas D. (57222727747) ;Flaxman, Abraham D. (6602883567) ;Phillips, Bryan K. (56132903100) ;Johnson, Elizabeth K. (56276328900) ;Coggeshall, Megan S. (56132969600) ;Abd-Allah, Foad (36503428900) ;Abera, Semaw Ferede (57205180598) ;Abraham, Jerry P. (57203894879) ;Abubakar, Ibrahim (57220174401) ;Abu-Raddad, Laith J. (14032724700) ;Abu-Rmeileh, Niveen Me (57216675148) ;Achoki, Tom (57202561099) ;Adeyemo, Austine Olufemi (56276318500) ;Adou, Arsène Kouablan (56531895000) ;Adsuar, José C. (21738958900) ;Agardh, Emilie Elisabet (57202373873) ;Akena, Dickens (36141858100) ;Al Kahbouri, Mazin J. (56132885900) ;Alasfoor, Deena (57211114684) ;Albittar, Mohammed I. (56276571900) ;Alcalá-Cerra, Gabriel (35769097100) ;Alegretti, Miguel Angel (56276408300) ;Alemu, Zewdie Aderaw (57202557784) ;Alfonso-Cristancho, Rafael (26326133000) ;Alhabib, Samia (57194933167) ;Ali, Raghib (57196506541) ;Alla, Francois (6701580827) ;Allen, Peter J. (58444261300) ;Alsharif, Ubai (57211633255) ;Alvarez, Elena (57216675106) ;Alvis-Guzman, Nelson (57210741239) ;Amankwaa, Adansi A. (57202564178) ;Amare, Azmeraw T. 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(56804702100) ;Violante, Francesco S. (7003555890) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Waller, Stephen (57201445180) ;Wallin, Mitchell T. (7005704608) ;Wang, Linhong (57303731300) ;Wang, Xiao Rong (59881699400) ;Wang, Yanping (57215440165) ;Weichenthal, Scott (57202555239) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Westerman, Ronny (57218361023) ;White, Richard A. (57212709680) ;Wilkinson, James D. (57207903571) ;Williams, Thomas Neil (35430527200) ;Woldeyohannes, Solomon Meseret (57195461619) ;Wong, John Q. (56491997300) ;Xu, Gelin (14049536200) ;Yang, Yang C. (39763666500) ;Yano, Yuichiro (57196965200) ;Yentur, Gokalp Kadri (57211728019) ;Yip, Paul (7102503720) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Younis, Mustafa (8549393000) ;Yu, Chuanhua (57201889726) ;Jin, Kim Yun (57211086375) ;El Sayed Zaki, Maysaa (57203666922) ;Zhao, Yong (59798995400) ;Zheng, Yingfeng (58918045300) ;Zhou, Maigeng (57054557200) ;Zhu, Jun (56215097100) ;Zou, Xiao Nong (57216284159) ;Lopez, Alan D. (7401455668)Vos, Theo (57223885848)Background The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration. Methods To estimate incidence and mortality for HIV, we used the UNAIDS Spectrum model appropriately modifi ed based on a systematic review of available studies of mortality with and without antiretroviral therapy (ART). For concentrated epidemics, we calibrated Spectrum models to fi t vital registration data corrected for misclassifi cation of HIV deaths. In generalised epidemics, we minimised a loss function to select epidemic curves most consistent with prevalence data and demographic data for all-cause mortality. We analysed counterfactual scenarios for HIV to assess years of life saved through prevention of mother-to-child transmission (PMTCT) and ART. For tuberculosis, we analysed vital registration and verbal autopsy data to estimate mortality using cause of death ensemble modelling. We analysed data for corrected case-notifi cations, expert opinions on the case-detection rate, prevalence surveys, and estimated cause-specifi c mortality using Bayesian meta-regression to generate consistent trends in all parameters. We analysed malaria mortality and incidence using an updated cause of death database, a systematic analysis of verbal autopsy validation studies for malaria, and recent studies (2010-13) of incidence, drug resistance, and coverage of insecticide-treated bednets. Findings Globally in 2013, there were 1·8 million new HIV infections (95% uncertainty interval 1·7 million to 2·1 million), 29·2 million prevalent HIV cases (28·1 to 31·7), and 1·3 million HIV deaths (1·3 to 1·5). At the peak of the epidemic in 2005, HIV caused 1·7 million deaths (1·6 million to 1·9 million). Concentrated epidemics in Latin America and eastern Europe are substantially smaller than previously estimated. Through interventions including PMTCT and ART, 19·1 million life-years (16·6 million to 21·5 million) have been saved, 70·3% (65·4 to 76·1) in developing countries. From 2000 to 2011, the ratio of development assistance for health for HIV to years of life saved through intervention was US$4498 in developing countries. Including in HIV-positive individuals, all-form tuberculosis incidence was 7·5 million (7·4 million to 7·7 million), prevalence was 11·9 million (11·6 million to 12·2 million), and number of deaths was 1·4 million (1·3 million to 1·5 million) in 2013. In the same year and in only individuals who were HIV-negative, all-form tuberculosis incidence was 7·1 million (6·9 million to 7·3 million), prevalence was 11·2 million (10·8 million to 11·6 million), and number of deaths was 1·3 million (1·2 million to 1·4 million). Annualised rates of change (ARC) for incidence, prevalence, and death became negative after 2000. Tuberculosis in HIV-negative individuals disproportionately occurs in men and boys (versus women and girls); 64·0% of cases (63·6 to 64·3) and 64·7% of deaths (60·8 to 70·3). Globally, malaria cases and deaths grew rapidly from 1990 reaching a peak of 232 million cases (143 million to 387 million) in 2003 and 1·2 million deaths (1·1 million to 1·4 million) in 2004. Since 2004, child deaths from malaria in sub-Saharan Africa have decreased by 31·5% (15·7 to 44·1). Outside of Africa, malaria mortality has been steadily decreasing since 1990. Interpretation Our estimates of the number of people living with HIV are 18·7% smaller than UNAIDS's estimates in 2012. The number of people living with malaria is larger than estimated by WHO. Incidence rates for HIV, tuberculosis, and malaria have all decreased since 2000. At the global level, upward trends for malaria and HIV deaths have been reversed and declines in tuberculosis deaths have accelerated. 101 countries (74 of which are developing) still have increasing HIV incidence. Substantial progress since the Millennium Declaration is an encouraging sign of the effect of global action. Funding Bill & Melinda Gates Foundation. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2017, and forecasts to 2030, for 195 countries and territories: A systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017(2019) ;Frank, Tahvi D. (57203197110) ;Carter, Austin (57201756395) ;Jahagirdar, Deepa (57213764835) ;Biehl, Molly H. (57196041812) ;Douwes-Schultz, Dirk (57196081398) ;Larson, Samantha Leigh (57204569813) ;Arora, Megha (57196080797) ;Dwyer-Lindgren, Laura (50461317900) ;Steuben, Krista M. (57208867341) ;Abbastabar, Hedayat (57212441848) ;Abu-Raddad, Laith Jamal (14032724700) ;Abyu, Direslgne Misker (56507277900) ;Adabi, Maryam (57190491886) ;Adebayo, Oladimeji M. (57194329853) ;Adekanmbi, Victor (53463192900) ;Adetokunboh, Olatunji O. 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(55481130700)Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980-2017 and forecast these estimates to 2030 for 195 countries and territories. Methods We determined a modelling strategy for each country on the basis of the availability and quality of data. For countries and territories with data from population-based seroprevalence surveys or antenatal care clinics, we estimated prevalence and incidence using an open-source version of the Estimation and Projection Package - a natural history model originally developed by the UNAIDS Reference Group on Estimates, Modelling, and Projections. For countries with cause-specific vital registration data, we corrected data for garbage coding (ie, deaths coded to an intermediate, immediate, or poorly defined cause) and HIV misclassification. We developed a process of cohort incidence bias adjustment to use information on survival and deaths recorded in vital registration to back-calculate HIV incidence. For countries without any representative data on HIV, we produced incidence estimates by pulling information from observed bias in the geographical region. We used a re-coded version of the Spectrum model (a cohort component model that uses rates of disease progression and HIV mortality on and off ART) to produce agesex- specific incidence, prevalence, and mortality, and treatment coverage results for all countries, and forecast these measures to 2030 using Spectrum with inputs that were extended on the basis of past trends in treatment scale-up and new infections. Findings Global HIV mortality peaked in 2006 with 1·95 million deaths (95% uncertainty interval 1·87-2·04) and has since decreased to 0·95 million deaths (0·91-1·01) in 2017. New cases of HIV globally peaked in 1999 (3·16 million, 2·79-3·67) and since then have gradually decreased to 1·94 million (1·63-2·29) in 2017. These trends, along with ART scale-up, have globally resulted in increased prevalence, with 36·8 million (34·8-39·2) people living with HIV in 2017. Prevalence of HIV was highest in southern sub-Saharan Africa in 2017, and countries in the region had ART coverage ranging from 65·7% in Lesotho to 85·7% in eSwatini. Our forecasts showed that 54 countries will meet the UNAIDS target of 81% ART coverage by 2020 and 12 countries are on track to meet 90% ART coverage by 2030. Forecasted results estimate that few countries will meet the UNAIDS 2020 and 2030 mortality and incidence targets. Interpretation Despite progress in reducing HIV-related mortality over the past decade, slow decreases in incidence, combined with the current context of stagnated funding for related interventions, mean that many countries are not on track to reach the 2020 and 2030 global targets for reduction in incidence and mortality. With a growing population of people living with HIV, it will continue to be a major threat to public health for years to come. The pace of progress needs to be hastened by continuing to expand access to ART and increasing investments in proven HIV prevention initiatives that can be scaled up to have population-level impact. © 2019 The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2017, and forecasts to 2030, for 195 countries and territories: A systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017(2019) ;Frank, Tahvi D. (57203197110) ;Carter, Austin (57201756395) ;Jahagirdar, Deepa (57213764835) ;Biehl, Molly H. (57196041812) ;Douwes-Schultz, Dirk (57196081398) ;Larson, Samantha Leigh (57204569813) ;Arora, Megha (57196080797) ;Dwyer-Lindgren, Laura (50461317900) ;Steuben, Krista M. (57208867341) ;Abbastabar, Hedayat (57212441848) ;Abu-Raddad, Laith Jamal (14032724700) ;Abyu, Direslgne Misker (56507277900) ;Adabi, Maryam (57190491886) ;Adebayo, Oladimeji M. (57194329853) ;Adekanmbi, Victor (53463192900) ;Adetokunboh, Olatunji O. (56598104300) ;Ahmadi, Alireza (56336080700) ;Ahmadi, Keivan (59396073300) ;Ahmadian, Elham (57210821126) ;Ahmadpour, Ehsan (55067754700) ;Ahmed, Muktar Beshir (57207802317) ;Akal, Chalachew Genet (57205385708) ;Alahdab, Fares (55135922900) ;Alam, Noore (57202437697) ;Albertson, Samuel B. (57204573505) ;Alemnew, Birhan Tamene T. (57211138846) ;Alene, Kefyalew Addis (57202583764) ;Alipour, Vahid (56436629300) ;Alvis-Guzman, Nelson (57210741239) ;Amini, Saeed (57210811281) ;Anbari, Zohreh (56127678500) ;Anber, Nahla Hamed (57202351369) ;Anjomshoa, Mina (57204563282) ;Antonio, Carl Abelardo T. (55247644500) ;Arabloo, Jalal (57208760927) ;Aremu, Olatunde (57214958833) ;Areri, Habtamu Abera (57204564768) ;Asfaw, Ephrem Tsegay (57203306449) ;Ashagre, Alebachew Fasil (57211139593) ;Asmelash, Daniel (57203871244) ;Asrat, Anemaw A. (56946683800) ;Avokpaho, Euripide F.G.A. 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(55481130700)Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980-2017 and forecast these estimates to 2030 for 195 countries and territories. Methods We determined a modelling strategy for each country on the basis of the availability and quality of data. For countries and territories with data from population-based seroprevalence surveys or antenatal care clinics, we estimated prevalence and incidence using an open-source version of the Estimation and Projection Package - a natural history model originally developed by the UNAIDS Reference Group on Estimates, Modelling, and Projections. For countries with cause-specific vital registration data, we corrected data for garbage coding (ie, deaths coded to an intermediate, immediate, or poorly defined cause) and HIV misclassification. We developed a process of cohort incidence bias adjustment to use information on survival and deaths recorded in vital registration to back-calculate HIV incidence. For countries without any representative data on HIV, we produced incidence estimates by pulling information from observed bias in the geographical region. We used a re-coded version of the Spectrum model (a cohort component model that uses rates of disease progression and HIV mortality on and off ART) to produce agesex- specific incidence, prevalence, and mortality, and treatment coverage results for all countries, and forecast these measures to 2030 using Spectrum with inputs that were extended on the basis of past trends in treatment scale-up and new infections. Findings Global HIV mortality peaked in 2006 with 1·95 million deaths (95% uncertainty interval 1·87-2·04) and has since decreased to 0·95 million deaths (0·91-1·01) in 2017. New cases of HIV globally peaked in 1999 (3·16 million, 2·79-3·67) and since then have gradually decreased to 1·94 million (1·63-2·29) in 2017. These trends, along with ART scale-up, have globally resulted in increased prevalence, with 36·8 million (34·8-39·2) people living with HIV in 2017. Prevalence of HIV was highest in southern sub-Saharan Africa in 2017, and countries in the region had ART coverage ranging from 65·7% in Lesotho to 85·7% in eSwatini. Our forecasts showed that 54 countries will meet the UNAIDS target of 81% ART coverage by 2020 and 12 countries are on track to meet 90% ART coverage by 2030. Forecasted results estimate that few countries will meet the UNAIDS 2020 and 2030 mortality and incidence targets. Interpretation Despite progress in reducing HIV-related mortality over the past decade, slow decreases in incidence, combined with the current context of stagnated funding for related interventions, mean that many countries are not on track to reach the 2020 and 2030 global targets for reduction in incidence and mortality. With a growing population of people living with HIV, it will continue to be a major threat to public health for years to come. The pace of progress needs to be hastened by continuing to expand access to ART and increasing investments in proven HIV prevention initiatives that can be scaled up to have population-level impact. © 2019 The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013(2015) ;Vos, Theo (57223885848) ;Barber, Ryan M. (57202560423) ;Bell, Brad (57191846370) ;Bertozzi-Villa, Amelia (57192900191) ;Biryukov, Stan (57195296731) ;Bolliger, Ian (57202568683) ;Charlson, Fiona (57191632086) ;Davis, Adrian (7404296836) ;Degenhardt, Louisa (7004040033) ;Dicker, Daniel (57196026676) ;Duan, Leilei (56150781400) ;Erskine, Holly (57202798676) ;Feigin, Valery L. (57203677957) ;Ferrari, Alize J. (57195348907) ;Fitzmaurice, Christina (57212628757) ;Fleming, Thomas (57222727747) ;Graetz, Nicholas (56276346000) ;Guinovart, Caterina (23024511900) ;Haagsma, Juanita (57202571125) ;Hansen, Gillian M. (57202959410) ;Hanson, Sarah Wulf (57212263269) ;Heuton, Kyle R. 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(57202594826) ;Shackelford, Katya (57202959163) ;Shaheen, Amira (57202560956) ;Shahraz, Saeid (57215142060) ;Levy, Teresa Shamah (55989758300) ;Shangguan, Siyi (55983936400) ;She, Jun (57209122131) ;Sheikhbahaei, Sara (57219637352) ;Shepard, Donald S. (56425525300) ;Shi, Peilin (57203064901) ;Shibuya, Kenji (8948057900) ;Shinohara, Yukito (57203303862) ;Shiri, Rahman (57200737050) ;Shishani, Kawkab (14025005500) ;Shiue, Ivy (35811219800) ;Shrime, Mark G. (57204703404) ;Sigfusdottir, Inga D. (57195363778) ;Silberberg, Donald H. (57223420256) ;Simard, Edgar P. (57211913376) ;Sindi, Shireen (57209045912) ;Singh, Jasvinder A. (7404421736) ;Singh, Lavanya (55823444300) ;Skirbekk, Vegard (57202564482) ;Sliwa, Karen (57207223988) ;Soljak, Michael (57202841728) ;Soneji, Samir (57204096389) ;Soshnikov, Sergey S. (57195195606) ;Speyer, Peter (56809541200) ;Sposato, Luciano A. (25640261000) ;Sreeramareddy, Chandrashekhar T. 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(8222114200) ;Velasquez-Melendez, Gustavo (6701742027) ;Venketasubramanian, Narayanaswamy (56804702100) ;Vijayakumar, Lakshmi (57202973343) ;Villalpando, Salvador (7005159171) ;Violante, Francesco S. (7003555890) ;Vlassov, Vasiliy V. (57211633239) ;Waller, Stephen (57201445180) ;Wallin, Mitchell T. (57201573668) ;Wan, Xia (57197110584) ;Wang, Linhong (59088832100) ;Wang, Jianli (9250575900) ;Wang, Yanping (57215440165) ;Warouw, Tati S. (57202569029) ;Weichenthal, Scott (57202555239) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Werdecker, Andrea (57208964895) ;Wessells, K. Ryan (22936372700) ;Westerman, Ronny (57218361023) ;Wilkinson, James D. (57207903571) ;Williams, Hywel C. (23500447000) ;Williams, Thomas N. (35430527200) ;Woldeyohannes, Solomon M. (57195461619) ;Wolfe, Charles D.A. (57202754705) ;Wong, John Q. (56491997300) ;Wong, Haidong (56809533300) ;Woolf, Anthony D. (7102882171) ;Wright, Jonathan L. (55483255900) ;Wurtz, Brittany (57202555477) ;Xu, Gelin (14049536200) ;Yang, Gonghuan (57203587368) ;Yano, Yuichiro (57196965200) ;Yenesew, Muluken A. (39361108000) ;Yentur, Gokalp K. (57211728019) ;Yip, Paul (7102503720) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Younis, Mustafa (8549393000) ;Yu, Chuanhua (57201889726) ;Kim, Kim Yun (56809537500) ;Zaki, Maysaa El Sayed (57203666922) ;Zhang, Yong (59821743000) ;Zhao, Zheng (57221109851) ;Zhao, Yong (59798995400) ;Zhu, Jun (56215097100) ;Zonies, David (6507066392) ;Zunt, Joseph R. (6602746216) ;Salomon, Joshua A. (56745638600)Murray, Christopher J.L. (55481130700)Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. © 2015 Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016(2017) ;Vos, Theo (57223885848) ;Abajobir, Amanuel Alemu (57203613441) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abate, Kalkidan Hassen (57207943858) ;Abd-Allah, Foad (36503428900) ;Abdulle, Abdishakur M. (6603592018) ;Abebo, Teshome Abuka (57195738441) ;Abera, Semaw Ferede (57205180598) ;Aboyans, Victor (56214736500) ;Abu-Raddad, Laith J. (14032724700) ;Ackerman, Ilana N. (8925517400) ;Adamu, Abdu Abdullahi (57202024381) ;Adetokunboh, Olatunji (56598104300) ;Afarideh, Mohsen (56227034300) ;Afshin, Ashkan (57217465455) ;Agarwal, Sanjay Kumar (7403190321) ;Aggarwal, Rakesh (7203024985) ;Agrawal, Anurag (35214460700) ;Agrawal, Sutapa (57202841733) ;Ahmad Kiadaliri, Aliasghar (57199100665) ;Ahmadieh, Hamid (57203677679) ;Ahmed, Muktar Beshir (57207802317) ;Aichour, Amani Nidhal (57195486768) ;Aichour, Ibtihel (57195485980) ;Aichour, Miloud Taki Eddine (57195488258) ;Aiyar, Sneha (57216813717) ;Akinyemi, Rufus Olusola (25633566800) ;Akseer, Nadia (57207801968) ;Al Lami, Faris Hasan (57200737005) ;Alahdab, Fares (55135922900) ;Al-Aly, Ziyad (9738161500) ;Alam, Khurshid (57203681299) ;Alam, Noore (57202437697) ;Alam, Tahiya (57205589820) ;Alasfoor, Deena (57192936248) ;Alene, Kefyalew Addis (57202583764) ;Ali, Raghib (57196506541) ;Alizadeh-Navaei, Reza (36024974700) ;Alkerwi, Ala'a (57197724313) ;Alla, François (6701580827) ;Allebeck, Peter (7005187575) ;Allen, Christine (57200170678) ;Al-Maskari, Fatma (25824744400) ;Al-Raddadi, Rajaa (57219673720) ;Alsharif, Ubai (57211633255) ;Alsowaidi, Shirina (26867516400) ;Altirkawi, Khalid A. 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Sa (57190279273) ;Faro, André (36770969600) ;Farzadfar, Farshad (57195049611) ;Fazeli, Mir Sohail (56579103600) ;Feigin, Valery L. (57203677957) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fernandes, João C. (35274726800) ;Ferrari, Alize J. (57195348907) ;Feyissa, Tesfaye Regassa (57222562476) ;Filip, Irina (55570061400) ;Fischer, Florian (55508208800) ;Fitzmaurice, Christina (57212628757) ;Flaxman, Abraham D. (6602883567) ;Flor, Luisa Sorio (54414102000) ;Foigt, Nataliya (57216998893) ;Foreman, Kyle J. (57209064414) ;Franklin, Richard C. (7201428429) ;Fullman, Nancy (57211064970) ;Fürst, Thomas (57208431345) ;Furtado, Joao M. (36801755000) ;Futran, Neal D. (35554564000) ;Gakidou, Emmanuela (57202567277) ;Ganji, Morsaleh (57211874807) ;Garcia-Basteiro, Alberto L. (57200187168) ;Gebre, Teshome (57202565005) ;Gebrehiwot, Tsegaye Tewelde (57216482917) ;Geleto, Ayele (57204564615) ;Gemechu, Bikila Lencha (57201195568) ;Gesesew, Hailay Abrha (56412148300) ;Gething, Peter W. 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(7102816661) ;Hao, Yuantao (57202554333) ;Harb, Hilda L. (57221443122) ;Hareri, Habtamu Abera (57195292447) ;Haro, Josep Maria (57215877903) ;Harvey, James (57196074369) ;Hassanvand, Mohammad Sadegh (35085056400) ;Havmoeller, Rasmus (57212075728) ;Hawley, Caitlin (57196078801) ;Hay, Roderick J. (56785229200) ;Hay, Simon I. (7101875313) ;Henry, Nathaniel J. (57196076616) ;Heredia-Pi, Ileana Beatriz (36941085200) ;Heydarpour, Pouria (57189359029) ;Hoek, Hans W. (57202570421) ;Hoffman, Howard J. (7201677665) ;Horita, Nobuyuki (57217110823) ;Hosgood, H. Dean (56353204400) ;Hostiuc, Sorin (24829099800) ;Hotez, Peter J. (7004958298) ;Hoy, Damian G. (57216593652) ;Htet, Aung Soe (57202555179) ;Hu, Guoqing (57218106596) ;Huang, Hsiang (57202278530) ;Huynh, Chantal (57202556112) ;Iburg, Kim Moesgaard (57216814160) ;Igumbor, Ehimario Uche (26537691100) ;Ikeda, Chad (57202720108) ;Irvine, Caleb Mackay Salpeter (57203666733) ;Jacobsen, Kathryn H. (26029163100) ;Jahanmehr, Nader (57203122718) ;Jakovljevic, Mihajlo B. (14318929700) ;Jassal, Simerjot K. (57190118903) ;Javanbakht, Mehdi (57204619886) ;Jayaraman, Sudha P. (57204716526) ;Jeemon, Panniyammakal (57216324831) ;Jensen, Paul N. (57224209864) ;Jha, Vivekanand (7005119423) ;Jiang, Guohong (56984997300) ;John, Denny (57194230095) ;Johnson, Catherine O. (57212301236) ;Johnson, Sarah Charlotte (57207904886) ;Jonas, Jost B. (7202492953) ;Jürisson, Mikk (55547524800) ;Kabir, Zubair (57207901718) ;Kadel, Rajendra (57196080325) ;Kahsay, Amaha (57216608121) ;Kamal, Ritul (57203177242) ;Kan, Haidong (7101602991) ;Karam, Nadim E. (57221993192) ;Karch, André (57223444197) ;Karema, Corine Kakizi (57202557522) ;Kasaeian, Amir (57195540738) ;Kassa, Getachew Mullu (56229895500) ;Kassaw, Nigussie Assefa (57196473578) ;Kassebaum, Nicholas J. 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(55074747400) ;Roy, Ambuj (7402704658) ;Rubagotti, Enrico (57208389589) ;Ruhago, George Mugambage (50761517500) ;Saadat, Soheil (16310355800) ;Sadat, Nafis (57219687343) ;Safdarian, Mahdi (57203849024) ;Safi, Sare (57219477293) ;Safiri, Saeid (56009654100) ;Sagar, Rajesh (26643103100) ;Sahathevan, Ramesh (35332739200) ;Salama, Joseph (57202975625) ;Salomon, Joshua A. (56745638600) ;Salvi, Sundeep Santosh (7005258777) ;Samy, Abdallah M. (36973661300) ;Sanabria, Juan R. (7006262917) ;Santomauro, Damian (56912450700) ;Santos, Itamar S. (57198312911) ;Santos, João Vasco (57226214352) ;Santric Milicevic, Milena M. (57211144346) ;Sartorius, Benn (12788526800) ;Satpathy, Maheswar (57202563691) ;Sawhney, Monika (57217153893) ;Saxena, Sonia (57203151746) ;Schmidt, Maria Inês (7404398885) ;Schneider, Ione J.C. (57201292772) ;Schöttker, Ben (37665918200) ;Schwebel, David C. (6603681532) ;Schwendicke, Falk (55639536600) ;Seedat, Soraya (7003445887) ;Sepanlou, Sadaf G. (36248136000) ;Servan-Mori, Edson E. (57202594826) ;Setegn, Tesfaye (37075667700) ;Shackelford, Katya Anne (57202959163) ;Shaheen, Amira (57202560956) ;Shaikh, Masood Ali (57203122601) ;Shamsipour, Mansour (57197846052) ;Shariful Islam, Sheikh Mohammed (56400111100) ;Sharma, Jayendra (57195329457) ;Sharma, Rajesh (58228412600) ;She, Jun (57209122131) ;Shi, Peilin (57203064901) ;Shields, Chloe (57196083232) ;Shigematsu, Mika (23968093000) ;Shinohara, Yukito (57203303862) ;Shiri, Rahman (57200737050) ;Shirkoohi, Reza (12776374400) ;Shirude, Shreya (57216599051) ;Shishani, Kawkab (14025005500) ;Shrime, Mark G. (57204703404) ;Sibai, Abla Mehio (7005466998) ;Sigfusdottir, Inga Dora (57195363778) ;Silva, Diego Augusto Santos (36985158000) ;Silva, João Pedro (7403023631) ;Silveira, Dayane Gabriele Alves (57190284103) ;Singh, Jasvinder A. (7404421736) ;Singh, Narinder Pal (57211864736) ;Sinha, Dhirendra Narain (7201637609) ;Skiadaresi, Eirini (37100428500) ;Skirbekk, Vegard (57202564482) ;Slepak, Erica Leigh (57205356367) ;Sligar, Amber (57190284582) ;Smith, David L. (55574206203) ;Smith, Mari (57195484737) ;Sobaih, Badr H.A. (57202564080) ;Sobngwi, Eugene (6701427993) ;Sorensen, Reed J.D. (57196918748) ;Sousa, Tatiane Cristina Moraes (57195329460) ;Sposato, Luciano A. (25640261000) ;Sreeramareddy, Chandrashekhar T. (57212263335) ;Srinivasan, Vinay (57196077031) ;Stanaway, Jeffrey D. (57201210928) ;Stathopoulou, Vasiliki (57195644148) ;Steel, Nicholas (6603791873) ;Stein, Dan J. (55769747595) ;Stein, Murray B. (7402996817) ;Steiner, Caitlyn (57205358084) ;Steiner, Timothy J. 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(57195959162) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Wadilo, Fiseha (57194049305) ;Wakayo, Tolassa (57205609717) ;Wang, Yuan-Pang (8576812100) ;Weaver, Marcia (7201548872) ;Weichenthal, Scott (57202555239) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Werdecker, Andrea (57208964895) ;Westerman, Ronny (57218361023) ;Whiteford, Harvey A. (55906494000) ;Wijeratne, Tissa (14051317700) ;Wiysonge, Charles Shey (6507441509) ;Wolfe, Charles D.A. (57202754705) ;Woodbrook, Rachel (57200298006) ;Woolf, Anthony D. (7102882171) ;Workicho, Abdulhalik (56720337100) ;Wulf Hanson, Sarah (57212263269) ;Xavier, Denis (55403963100) ;Xu, Gelin (57203583113) ;Yadgir, Simon (57192837280) ;Yaghoubi, Mohsen (56402926900) ;Yakob, Bereket (57203811497) ;Yan, Lijing L. (35933756700) ;Yano, Yuichiro (57196965200) ;Ye, Pengpeng (57202839295) ;Yimam, Hassen Hamid (57196325590) ;Yip, Paul (7102503720) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Zaidi, Zoubida (57197376721) ;Zaki, Maysaa El Sayed (57203666922) ;Zegeye, Elias Asfaw (57209171278) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zhang, Xueying (56283378700) ;Zhou, Maigeng (57054557200) ;Zipkin, Ben (57200737130) ;Zodpey, Sanjay (7003415080) ;Zuhlke, Liesl Joanna (57209027746)Murray, Christopher J.L. (55481130700)Background As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. Methods We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8-75·9 million [7·2%, 6·0-8·3]), 45·1 million (29·0-62·8 million [5·6%, 4·0-7·2]), 36·3 million (25·3-50·9 million [4·5%, 3·8-5·3]), 34·7 million (23·0-49·6 million [4·3%, 3·5-5·2]), and 34·1 million (23·5-46·0 million [4·2%, 3·2-5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3-3·1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10·4% (95% UI 9·0-11·8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout were the main conditions contributing to higher YLD rates in women. Men had higher age-standardised rates of substance use disorders, diabetes, cardiovascular diseases, cancers, and all injuries apart from sexual violence. Globally, we noted much less geographical variation in disability than has been documented for premature mortality. In 2016, there was a less than two times difference in age-standardised YLD rates for all causes between the location with the lowest rate (China, 9201 YLDs per 100 000, 95% UI 6862-11943) and highest rate (Yemen, 14 774 YLDs per 100 000, 11 018-19 228). Interpretation The decrease in death rates since 1990 for most causes has not been matched by a similar decline in age-standardised YLD rates. For many large causes, YLD rates have either been stagnant or have increased for some causes, such as diabetes. As populations are ageing, and the prevalence of disabling disease generally increases steeply with age, health systems will face increasing demand for services that are generally costlier than the interventions that have led to declines in mortality in childhood or for the major causes of mortality in adults. Up-todate information about the trends of disease and how this varies between countries is essential to plan for an adequate health-system response. © The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national levels and causes of maternal mortality during 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013(2014) ;Kassebaum, Nicholas J. (55522621100) ;Bertozzi-Villa, Amelia (57192900191) ;Coggeshall, Megan S. (56132969600) ;Shackelford, Katya A. (57202959163) ;Steiner, Caitlyn (57205358084) ;Heuton, Kyle R. (57202568555) ;Gonzalez-Medina, Diego (57202595524) ;Barber, Ryan (57202560423) ;Huynh, Chantal (57202556112) ;Dicker, Daniel (57196026676) ;Templin, Tara (56133572500) ;Wolock, Timothy M. (57210784314) ;Ozgoren, Ayse Abbasoglu (59158236200) ;Abd-Allah, Foad (36503428900) ;Abera, Semaw Ferede (57205180598) ;Abubakar, Ibrahim (57220174401) ;Achoki, Tom (57202561099) ;Adelekan, Ademola (57216109261) ;Ademi, Zanfina (32867460300) ;Adou, Arsène Kouablan (56531895000) ;Adsuar, José C. (21738958900) ;Agardh, Emilie E. 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(7404081544) ;Lin, Hsien-Ho (39061859200) ;Lipshultz, Steven E. (7006950713) ;Liu, Shiwei (57209574351) ;Liu, Yang (57202561981) ;Lloyd, Belinda K. (55313086800) ;London, Stephanie J. (56988756100) ;Lotufo, Paulo A. (7003331101) ;Ma, Jixiang (57219562158) ;Ma, Stefan (7403723389) ;Machado, Vasco Manuel Pedro (56133788500) ;Mainoo, Nana Kwaku (56133064200) ;Majdan, Marek (36147855100) ;Mapoma, Christopher Chabila (57208956832) ;Marcenes, Wagner (7005668102) ;Marzan, Melvin Barrientos (57200737144) ;Mason-Jones, Amanda J. (7201563263) ;Mehndiratta, Man Mohan (57202557864) ;Mejia-Rodriguez, Fabiola (56013641600) ;Memish, Ziad A. (7005059350) ;Mendoza, Walter (57216905642) ;Miller, Ted R. (7403948600) ;Mills, Edward J. (7102584704) ;Mokdad, Ali H. (7004813962) ;Mola, Glen Liddell (57221824056) ;Monasta, Lorenzo (7801520497) ;De La Cruz Monis, Jonathan (56132934000) ;Hernandez, Julio Cesar Montañez (57199371040) ;Moore, Ami R. 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(57201292772) ;Schumacher, Austin (57209276410) ;Schwebel, David C. (6603681532) ;Seedat, Soraya (7003445887) ;Sepanlou, Sadaf G. (36248136000) ;Servan-Mori, Edson E. (57202594826) ;Shakh-Nazarova, Marina (56133525500) ;Sheikhbahaei, Sara (57219637352) ;Shibuya, Kenji (8948057900) ;Shin, Hwashin Hyun (56132914500) ;Shiue, Ivy (35811219800) ;Sigfusdottir, Inga Dora (57195363778) ;Silberberg, Donald H. (57223420256) ;Silva, Andrea P. (59594831400) ;Singh, Jasvinder A. (7404421736) ;Skirbekk, Vegard (57202564482) ;Sliwa, Karen (57207223988) ;Soshnikov, Sergey S. (57195195606) ;Sposato, Luciano A. (25640261000) ;Sreeramareddy, Chandrashekhar T. (57212263335) ;Stroumpoulis, Konstantinos (57211777127) ;Sturua, Lela (37662283900) ;Sykes, Bryan L. (57211183396) ;Tabb, Karen M. (51162023700) ;Talongwa, Roberto Tchio (57195568335) ;Tan, Feng (56429971500) ;Teixeira, Carolina Maria (56133286100) ;Tenkorang, Eric Yeboah (57216997115) ;Terkawi, Abdullah Sulieman (57211144258) ;Thorne-Lyman, Andrew L. (57194437700) ;Tirschwell, David L. (7003788101) ;Towbin, Jeffrey A. (7102520568) ;Tran, Bach X. (57209107515) ;Tsilimbaris, Miltiadis (6701721894) ;Uchendu, Uche S. (56328470200) ;Ukwaja, Kingsley N. (57202824584) ;Undurraga, Eduardo A. (57204092789) ;Uzun, Selen Begüm (57200327315) ;Vallely, Andrew J. (21744114400) ;Van Gool, Coen H. (57217153933) ;Vasankari, Tommi J. (57189653936) ;Vavilala, Monica S. (7004076648) ;Venketasubramanian, N. (56804702100) ;Villalpando, Salvador (7005159171) ;Violante, Francesco S. (7003555890) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vos, Theo (57223885848) ;Waller, Stephen (57201445180) ;Wang, Haidong (16507828100) ;Wang, Linhong (59088832100) ;Wang, Xiao Rong (59881699400) ;Wang, Yanping (57215440165) ;Weichenthal, Scott (57202555239) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Westerman, Ronny (57218361023) ;Wilkinson, James D. (57207903571) ;Woldeyohannes, Solomon Meseret (57195461619) ;Wong, John Q. (56491997300) ;Wordofa, Muluemebet Abera (57211398351) ;Xu, Gelin (14049536200) ;Yang, Yang C. (39763666500) ;Yano, Yuichiro (57196965200) ;Yentur, Gokalp Kadri (57211728019) ;Yip, Paul (7102503720) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Younis, Mustafa Z. (8549393000) ;Yu, Chuanhua (57201889726) ;Jin, Kim Yun (57211086375) ;El Sayed Zaki, Maysaa (57203666922) ;Zhao, Yong (59798995400) ;Zheng, Yingfeng (58918045300) ;Zhou, Maigeng (57054557200) ;Zhu, Jun (56215097100) ;Zou, Xiao Nong (57216284159) ;Lopez, Alan D. (7401455668) ;Naghavi, Mohsen (57207906323) ;Murray, Christopher J.L. (55481130700)Lozano, Rafael (7102198442)Background The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100 000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery. Methods We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basis of a systematic review of the relative risk of dying during pregnancy for HIV-positive women compared with HIV-negative women. We also estimated the fraction of these deaths aggravated by pregnancy on the basis of a systematic review. To estimate the numbers of maternal deaths due to nine diff erent causes, we identified 61 sources from a systematic review and 943 site-years of vital registration data. We also did a systematic review of reports about the timing of maternal death, identifying 142 sources to use in our analysis. We developed estimates for each country for 1990-2013 using Bayesian meta-regression. We estimated 95% uncertainty intervals (UIs) for all values. Findings 292 982 (95% UI 261 017-327 792) maternal deaths occurred in 2013, compared with 376 034 (343 483-407 574) in 1990. The global annual rate of change in the MMR was -0.3% (-1.1 to 0.6) from 1990 to 2003, and -2.7% (-3.9 to -1.5) from 2003 to 2013, with evidence of continued acceleration. MMRs reduced consistently in south, east, and southeast Asia between 1990 and 2013, but maternal deaths increased in much of sub-Saharan Africa during the 1990s. 2070 (1290-2866) maternal deaths were related to HIV in 2013, 0.4% (0.2-0.6) of the global total. MMR was highest in the oldest age groups in both 1990 and 2013. In 2013, most deaths occurred intrapartum or postpartum. Causes varied by region and between 1990 and 2013. We recorded substantial variation in the MMR by country in 2013, from 956.8 (685.1-1262.8) in South Sudan to 2.4 (1.6-3.6) in Iceland. Interpretation Global rates of change suggest that only 16 countries will achieve the MDG 5 target by 2015. Accelerated reductions since the Millennium Declaration in 2000 coincide with increased development assistance for maternal, newborn, and child health. Setting of targets and associated interventions for after 2015 will need careful consideration of regions that are making slow progress, such as west and central Africa. Funding Bill & Melinda Gates Foundation. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: A systematic analysis for the Global Burden of Disease Study 2016(2017) ;Wang, Haidong (16507828100) ;Abajobir, Amanuel Alemu (57203613441) ;Abate, Kalkidan Hassen (57207943858) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abd-Allah, Foad (36503428900) ;Abera, Semaw Ferede (57205180598) ;Abraha, Haftom Niguse (57195289877) ;Abu-Raddad, Laith J. (14032724700) ;Abu-Rmeileh, Niveen M.E. (57216675148) ;Adedeji, Isaac Akinkunmi (57208456508) ;Adedoyin, Rufus Adesoji (55947572800) ;Adetifa, Ifedayo Morayo O. 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(57195959162) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Vos, Theo (57223885848) ;Waid, Jillian L. (57191965831) ;Wakayo, Tolassa (57205609717) ;Wang, Yuan-Pang (8576812100) ;Weichenthal, Scott (57202555239) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Werdecker, Andrea (57208964895) ;Wesana, Joshua (56688521300) ;Wijeratne, Tissa (14051317700) ;Wilkinson, James D. (57207903571) ;Wiysonge, Charles Shey (6507441509) ;Woldeyes, Belete Getahun (57195329524) ;Wolfe, Charles D.A. (57202754705) ;Workicho, Abdulhalik (56720337100) ;Workie, Shimelash Bitew (57191837199) ;Xavier, Denis (55403963100) ;Xu, Gelin (57203583113) ;Yaghoubi, Mohsen (56402926900) ;Yakob, Bereket (57203811497) ;Yalew, Ayalnesh Zemene (57190286375) ;Yan, Lijing L. (57198311895) ;Yano, Yuichiro (57196965200) ;Yaseri, Mehdi (23029507000) ;Ye, Pengpeng (57202839295) ;Yimam, Hassen Hamid (57196325590) ;Yip, Paul (7102503720) ;Yirsaw, Biruck Desalegn (49664327400) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922) ;Zeeb, Hajo (57203073012) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zerfu, Taddese Alemu (55358278900) ;Zhang, Anthony Lin (56391112900) ;Zhang, Xueying (56283378700) ;Zodpey, Sanjay (7003415080) ;Zuhlke, Liesl Joanna (57209027746) ;Lopez, Alan D. (7401455668)Murray, Christopher J.L. (55481130700)Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods: We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0.5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Socio-demographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. Findings: Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates - a measure of relative inequality - increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86.9 years (95% UI 86.7-87.2), and for men in Singapore, at 81.3 years (78.8-83.7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, and the gap between male and female life expectancy increased with progression to higher levels of SDI. Some countries with exceptional health performance in 1990 in terms of the difference in observed to expected life expectancy at birth had slower progress on the same measure in 2016. Interpretation Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both level and rate of changes in age-specific mortality; increases in mortality for certain age groups occurred in some locations. We found evidence that the absolute gap between countries in age-specific death rates has declined, although the relative gap for some age-sex groups increased. Countries that now lead in terms of having higher observed life expectancy than that expected on the basis of development alone, or locations that have either increased this advantage or rapidly decreased the deficit from expected levels, could provide insight into the means to accelerate progress in nations where progress has stalled. Copyright © The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: A novel analysis from the global burden of disease study 2015(2017) ;Barber, Ryan M. (57202560423) ;Fullman, Nancy (57211064970) ;Sorensen, Reed J.D. (57196918748) ;Bollyky, Thomas (36677045500) ;McKee, Martin (7202304775) ;Nolte, Ellen (7005556106) ;Abajobir, Amanuel Alemu (57203613441) ;Abate, Kalkidan Hassen (57207943858) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abd-Allah, Foad (36503428900) ;Abdulle, Abdishakur M. (6603592018) ;Abdurahman, Ahmed Abdulahi (56677630600) ;Abera, Semaw Ferede (57205180598) ;Abraham, Biju (57202568691) ;Abreha, Girmatsion Fisseha (6504124710) ;Adane, Kelemework (57202841698) ;Adelekan, Ademola Lukman (57216109261) ;Adetifa, Ifedayo Morayo O. 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(57226213785) ;Farinha, Carla Sofia E. Sa (57190279273) ;Faro, Andre (36770969600) ;Farvid, Maryam S. (57216534761) ;Farzadfar, Farshad (57195049611) ;Feigin, Valery L. (57203677957) ;Feigl, Andrea B. (57202461042) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fernandes, Jefferson G. (57220736619) ;Fernandes, João C. (35274726800) ;Feyissa, Tesfaye Regassa (57222562476) ;Fischer, Florian (55508208800) ;Fitzmaurice, Christina (57212628757) ;Fleming, Thomas D. (57222727747) ;Foigt, Nataliya (57216998893) ;Foreman, Kyle J. (57209064414) ;Forouzanfar, Mohammad H. (57202562738) ;Franklin, Richard C. (7201428429) ;Frostad, Joseph (57222306717) ;Ghiwot, Tsegaye Tewelde (57195446566) ;Gakidou, Emmanuela (57202567277) ;Gambashidze, Ketevan (13610194000) ;Gamkrelidze, Amiran (6506029209) ;Gao, Wayne (57194140360) ;Garcia-Basteiro, Alberto L. 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Dean (56353204400) ;Htet, Aung Soe (57202555179) ;Hu, Guoqing (57218106596) ;Huang, Hsiang (57202278530) ;Huang, John J. (56135699200) ;Huntley, Bethany M. (57195329465) ;Huynh, Chantal (57202556112) ;Iburg, Kim Moesgaard (57216814160) ;Ileanu, Bogdan Vasile (57202148423) ;Innos, Kaire (57217314902) ;Irenso, Asnake Ararsa (57195329443) ;Jahanmehr, Nader (57203122718) ;Jakovljevic, Mihajlo B. (14318929700) ;James, Peter (7402640931) ;James, Spencer Lewis (57202557998) ;Javanbakht, Mehdi (57204619886) ;Jayaraman, Sudha P. (57204716526) ;Jayatilleke, Achala Upendra (23389151200) ;Jeemon, Panniyammakal (57216324831) ;Jha, Vivekanand (7005119423) ;John, Denny (57194230095) ;Johnson, Catherine (57212301236) ;Johnson, Sarah C. (57207904886) ;Jonas, Jost B. (7202492953) ;Juel, Knud (7005077250) ;Kabir, Zubair (57207901718) ;Kalkonde, Yogeshwar (57200250807) ;Kamal, Ritul (57203177242) ;Kan, Haidong (7101602991) ;Karch, Andre (57223444197) ;Karema, Corine Kakizi (57202557522) ;Karimi, Seyed M. 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(55481130700)Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015. Methods We mapped the most widely used list of causes amenable to personal health care developed by Nolte and McKee to 32 GBD causes. We accounted for variations in cause of death certification and misclassifications through the extensive data standardisation processes and redistribution algorithms developed for GBD. To isolate the effects of personal health-care access and quality, we risk-standardised cause-specific mortality rates for each geography-year by removing the joint effects of local environmental and behavioural risks, and adding back the global levels of risk exposure as estimated for GBD 2015. We employed principal component analysis to create a single, interpretable summary measure-the Healthcare Quality and Access (HAQ) Index-on a scale of 0 to 100. The HAQ Index showed strong convergence validity as compared with other health-system indicators, including health expenditure per capita (r=0·88), an index of 11 universal health coverage interventions (r=0·83), and human resources for health per 1000 (r=0·77). We used free disposal hull analysis with bootstrapping to produce a frontier based on the relationship between the HAQ Index and the Socio-demographic Index (SDI), a measure of overall development consisting of income per capita, average years of education, and total fertility rates. This frontier allowed us to better quantify the maximum levels of personal health-care access and quality achieved across the development spectrum, and pinpoint geographies where gaps between observed and potential levels have narrowed or widened over time. Findings Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. Of 195 geographies, 167 had statistically significant increases in HAQ Index levels since 1990, with South Korea, Turkey, Peru, China, and the Maldives recording among the largest gains by 2015. Performance on the HAQ Index and individual causes showed distinct patterns by region and level of development, yet substantial heterogeneities emerged for several causes, including cancers in highest-SDI countries; chronic kidney disease, diabetes, diarrhoeal diseases, and lower respiratory infections among middle-SDI countries; and measles and tetanus among lowest-SDI countries. While the global HAQ Index average rose from 40·7 (95% uncertainty interval, 39·0-42·8) in 1990 to 53·7 (52·2-55·4) in 2015, far less progress occurred in narrowing the gap between observed HAQ Index values and maximum levels achieved; at the global level, the difference between the observed and frontier HAQ Index only decreased from 21·2 in 1990 to 20·1 in 2015. If every country and territory had achieved the highest observed HAQ Index by their corresponding level of SDI, the global average would have been 73·8 in 2015. Several countries, particularly in eastern and western sub-Saharan Africa, reached HAQ Index values similar to or beyond their development levels, whereas others, namely in southern sub-Saharan Africa, the Middle East, and south Asia, lagged behind what geographies of similar development attained between 1990 and 2015. Interpretation This novel extension of the GBD Study shows the untapped potential for personal health-care access and quality improvement across the development spectrum. Amid substantive advances in personal health care at the national level, heterogeneous patterns for individual causes in given countries or territories suggest that few places have consistently achieved optimal health-care access and quality across health-system functions and therapeutic areas. This is especially evident in middle-SDI countries, many of which have recently undergone or are currently experiencing epidemiological transitions. The HAQ Index, if paired with other measures of health-system characteristics such as intervention coverage, could provide a robust avenue for tracking progress on universal health coverage and identifying local priorities for strengthening personal health-care quality and access throughout the world. Copyright © The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Intentional injuries in the Eastern Mediterranean Region, 1990–2015: findings from the Global Burden of Disease 2015 study(2018) ;Mokdad, Ali H (7004813962) ;Moradi-Lakeh, Maziar (35617421300) ;Charara, Raghid (56514085300) ;El Bcheraoui, Charbel (25027689700) ;Khalil, Ibrahim (58255049500) ;Afshin, Ashkan (57217465455) ;Kassebaum, Nicholas J (57202562224) ;Collison, Michael (57202309052) ;Chew, Adrienne (57209171085) ;Krohn, Kristopher J (57194138806) ;Daoud, Farah (57201079837) ;Colombara, Danny (37025591000) ;Graetz, Nicholas (56276346000) ;Kutz, Michael (57195617315) ;Wang, Haidong (16507828100) ;Abd-Allah, Foad (36503428900) ;Abu-Raddad, Laith J. (14032724700) ;Ahmad Kiadaliri, Aliasghar (57199100665) ;Beshir Ahmed, Muktar (57207802317) ;Alam, Khurshid (57203681299) ;Alghnam, Suliman (57200675199) ;Alizadeh-Navaei, Reza (36024974700) ;Al-Raddadi, Rajaa (57219673720) ;Altirkawi, Khalid A (57202762923) ;Anber, Nahla (57202351369) ;Anwari, Palwasha (57217465526) ;Avila-Burgos, Leticia (8530790100) ;Awasthi, Ashish (57200155811) ;Barac, Aleksandra (55550748700) ;Barker-Collo, Suzanne L. (57193065514) ;Bedi, Neeraj (57988442200) ;Bhutta, Zulfiqar A (24342648300) ;Borschmann, Rohan (35091024300) ;Boufous, Soufiane (6507794444) ;Butt, Zahid A (57202522739) ;Castañeda-Orjuela, Carlos A. (35769124700) ;Dalal, Koustuv (23469128200) ;Danawi, Hadi (57201079895) ;De Leo, Diego (7006128644) ;Dharmaratne, Samath D (57216324802) ;Djalalinia, Shirin (37113718000) ;Doyle, Kerrie E (55693710800) ;Esteghamati, Alireza (11240321100) ;Faro, André (36770969600) ;Farvid, Maryam S (57216534761) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fischer, Florian (55508208800) ;Tewelde Gebrehiwot, Tsegaye (57202401977) ;Gutiérrez, Reyna A. (57200298415) ;Hafezi-Nejad, Nima (57216814261) ;Ribhi Hamadeh, Randah (57202769526) ;Hamidi, Samer (24366336000) ;Maria Haro, Josep (57221369192) ;Hendrie, Delia (6602071966) ;Hu, Guoqing (57218106596) ;Jonas, Jost B (7202492953) ;Kasaeian, Amir (57195540738) ;Njenga Keiyoro, Peter (57202495897) ;Saleh Khader, Yousef (55654192600) ;Ahmad Khan, Ejaz (55583420000) ;Khubchandani, Jagdish (57211720011) ;Kopec, Jacek A (7006284395) ;Larson, Heidi J (57202559142) ;Abdul Latif, Asma (57192380848) ;Tesema Leshargie, Cheru (57202505340) ;Lunevicius, Raimundas (57216165063) ;Magdy Abd El Razek, Mohammed (57201191366) ;Majeed, Azeem (7102027801) ;Malekzadeh, Reza (7005197760) ;Memish, Ziad A (7005059350) ;Meretoja, Tuomo J (57202554188) ;Miller, Ted R (7403948600) ;Mohammed, Shafiu (57838689000) ;Makhlouf Obermeyer, Carla (57209300189) ;Akpojene Ogbo, Felix (57200737136) ;Robert Phillips, Michael (57223805257) ;Pourmalek, Farshad (8309390500) ;Qorbani, Mostafa (24831040300) ;Radfar, Amir (57194428768) ;Rafay, Anwar (57212263323) ;Rahimi-Movaghar, Afarin (8696686900) ;Rahimi-Movaghar, Vafa (6507646446) ;Kumar Rai, Rajesh (55621126400) ;Laith Rawaf, David (57202399089) ;Rawaf, Salman (6602475959) ;Rezaei, Satar (55791003000) ;Sadegh Rezai, Mohammad (55273796300) ;Roshandel, Gholamreza (14034446800) ;Safdarian, Mahdi (57203849024) ;Safiri, Saeid (56009654100) ;Salamati, Payman (14045860600) ;Samy, Abdallah M (36973661300) ;Sartorius, Benn (12788526800) ;Seedat, Soraya (7003445887) ;Sepanlou, Sadaf G (36248136000) ;Ali Shaikh, Masood (57203122601) ;Sobaih, Badr H.A. (57202564080) ;Tabb, Karen M (51162023700) ;Tehrani-Banihashemi, Arash (57204006020) ;Temsah, Mohamad-Hani (56115852000) ;Sulieman Terkawi, Abdullah (57211144258) ;Topor-Madry, Roman (57211182892) ;Nnanna Ukwaja, Kingsley (57202824584) ;Uthman, Olalekan A (23026328100) ;Yaseri, Mehdi (23029507000) ;Yonemoto, Naohiro (57204947657) ;Younis, Mustafa Z (8549393000) ;Jumaan, Aisha O (6603612494) ;Vos, Theo (57223885848) ;Hay, Simon I (7101875313) ;Naghavi, Mohsen (57207906323)Murray, Christopher J.L. (55481130700)Objectives: We used GBD 2015 findings to measure the burden of intentional injuries in the Eastern Mediterranean Region (EMR) between 1990 and 2015. Methods: The Global Burden of Disease (GBD) study defines intentional injuries as a combination of self-harm (including suicide), interpersonal violence, collective violence (war), and legal intervention. We estimated number of deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) for each type of intentional injuries. Results: In 2015, 28,695 individuals (95% UI: 25,474–37,832) died from self-harm, 35,626 (95% UI: 20,947–41,857) from interpersonal violence, and 143,858 (95% UI: 63,554–223,092) from collective violence and legal interventions. In 2015, collective violence and legal intervention was the fifth-leading cause of DALYs in the EMR and the leading cause in Syria, Yemen, Iraq, Afghanistan, and Libya; they account for 49.7% of total DALYs in Syria. Conclusions: Our findings call for increased efforts to stabilize the region and assist in rebuilding the health systems, as well as increasing transparency and employing preventive strategies to reduce self-harm and interpersonal injuries. © 2017, The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: Analysis for the Global Burden of Disease Study 2017(2020) ;Reiner, Robert C. (57203229088) ;Wiens, Kirsten E. (55515807800) ;Deshpande, Aniruddha (57208579336) ;Baumann, Mathew M. (57211550981) ;Lindstedt, Paulina A. (57211558396) ;Blacker, Brigette F. (57202420381) ;Troeger, Christopher E. (57195223624) ;Earl, Lucas (57190371340) ;Munro, Sandra B. (7004622934) ;Abate, Degu (57204237665) ;Abbastabar, Hedayat (57212441848) ;Abd-Allah, Foad (36503428900) ;Abdelalim, Ahmed (7801307783) ;Abdollahpour, Ibrahim (36997151900) ;Abdulkader, Rizwan Suliankatchi (57195295816) ;Abebe, Getaneh (57202422848) ;Abegaz, Kedir Hussein (57200726326) ;Abreu, Lucas Guimarães (55937631400) ;Abrigo, Michael R.M. (56018773400) ;Accrombessi, Manfred Mario Kokou (55353650500) ;Acharya, Dilaram (56770895600) ;Adabi, Maryam (57190491886) ;Adebayo, Oladimeji M. (57194329853) ;Adedoyin, Rufus Adesoji (55947572800) ;Adekanmbi, Victor (53463192900) ;Adetokunboh, Olatunji O. (56598104300) ;Adham, Davoud (55346682700) ;Adhena, Beyene Meressa (57209325570) ;Afarideh, Mohsen (56227034300) ;Ahmadi, Keivan (59396073300) ;Ahmadi, Mehdi (16644923000) ;Ahmed, Anwar E. (58205901100) ;Ahmed, Muktar Beshir (57207802317) ;Ahmed, Rushdia (57195530549) ;Ajumobi, Olufemi (14033771400) ;Akal, Chalachew Genet (57205385708) ;Akalu, Temesgen Yihunie (57203189637) ;Akanda, Ali S. (35290419100) ;Alamene, Genet Melak (57211135938) ;Alanzi, Turki M. (55978240000) ;Albright, James R. (57210320079) ;Alcalde Rabanal, Jacqueline Elizabeth (35749450200) ;Alemnew, Birhan Tamene (57211138846) ;Alemu, Zewdie Aderaw (57202557784) ;Ali, Beriwan Abdulqadir (57208356112) ;Ali, Muhammad (57221004192) ;Alijanzadeh, Mehran (56236864700) ;Alipour, Vahid (56436629300) ;Aljunid, Syed Mohamed (6504304159) ;Almasi, Ali (19433600700) ;Almasi-Hashiani, Amir (42360952700) ;Al-Mekhlafi, Hesham M. (8625547100) ;Altirkawi, Khalid (57202762923) ;Alvis-Guzman, Nelson (57210741239) ;Alvis-Zakzuk, Nelson J. (57193279948) ;Amare, Azmeraw T. (57202220009) ;Amini, Saeed (57210811281) ;Amit, Arianna Maever Loreche (57211322011) ;Andrei, Catalina Liliana (36543507200) ;Anegago, Masresha Tessema (57216865286) ;Anjomshoa, Mina (57204563282) ;Ansari, Fereshteh (56478531800) ;Antonio, Carl Abelardo T. 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(57218716651) ;Bragazzi, Nicola Luigi (57212030091) ;Briko, Andrey Nikolaevich (57202792237) ;Briko, Nikolay Ivanovich (7004344976) ;Burugina Nagaraja, Sharath (46961272800) ;Butt, Zahid A. (57202522739) ;Campos-Nonato, Ismael R. (57203424784) ;Campuzano Rincon, Julio Cesar (6505846919) ;Cárdenas, Rosario (57216482927) ;Carvalho, Felix (7103070417) ;Castro, Franz (57204567353) ;Chansa, Collins (24400981500) ;Chatterjee, Pranab (57202798650) ;Chattu, Vijay Kumar (55743746500) ;Chauhan, Bal Govind (57195315447) ;Chin, Ken Lee (57216745370) ;Christopher, Devasahayam J. (57209863533) ;Chu, Dinh-Toi (56239816300) ;Claro, Rafael M. (16834671700) ;Cormier, Natalie M. (57216638260) ;Costa, Vera M. (17134373000) ;Damiani, Giovanni (57218701806) ;Daoud, Farah (57201079837) ;Dandona, Lalit (7007017243) ;Dandona, Rakhi (57203043697) ;Darwish, Amira Hamed (57194473558) ;Daryani, Ahmad (16021522200) ;Das, Jai K. 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(57225394332) ;Durães, Andre R. (30867558600) ;Duraisamy, Senbagam (58956978800) ;Effiong, Andem (57213158150) ;Eftekhari, Aziz (56829076800) ;El Sayed, Iman (7004479194) ;El Sayed Zaki, Maysaa (57203666922) ;El Tantawi, Maha (57214851491) ;Elemineh, Demelash Abewa (57214777126) ;El-Jaafary, Shaimaa I. (34869528300) ;Elkout, Hajer (36102315300) ;Elsharkawy, Aisha (55683285000) ;Enany, Shymaa (23972375400) ;Endalamaw, Aklilu (57202040629) ;Endalew, Daniel Adane (57211158603) ;Eskandarieh, Sharareh (57211720158) ;Esteghamati, Alireza (11240321100) ;Etemadi, Arash (7004686554) ;Farag, Tamer H. (16230217600) ;Faraon, Emerito Jose A. (57195414019) ;Fareed, Mohammad (24491815600) ;Faridnia, Roghiyeh (55945212000) ;Farioli, Andrea (57207608705) ;Faro, Andre (36770969600) ;Farzam, Hossein (57202061001) ;Fazaeli, Ali Akbar (57204568731) ;Fazlzadeh, Mehdi (55199878200) ;Fentahun, Netsanet (56394665400) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fernandes, Eduarda (34770207500) ;Filip, Irina (55570061400) ;Fischer, Florian (55508208800) ;Foroutan, Masoud (58948371300) ;Francis, Joel Msafiri (35198028700) ;Franklin, Richard Charles (7201428429) ;Frostad, Joseph Jon (57222306717) ;Fukumoto, Takeshi (26531100300) ;Gayesa, Reta Tsegaye (57225049499) ;Gebremariam, Kidane Tadesse (57191226393) ;Gebremedhin, Ketema Bizuwork (57200529247) ;Gebremeskel, Gebreamlak Gebremedhn (57748459200) ;Gedefaw, Getnet Azeze (57204453564) ;Geramo, Yilma Chisha Dea (57204563310) ;Geta, Birhanu (57208190927) ;Gezae, Kebede Embaye (57204561611) ;Ghashghaee, Ahmad (57194174020) ;Ghassemi, Fariba (35271776100) ;Gill, Paramjit Singh (7202766660) ;Ginawi, Ibrahim Abdelmageed (57192378390) ;Goli, Srinivas (39761832500) ;Gomes, Nelson G.M. (55326199700) ;Gopalani, Sameer Vali (57190277891) ;Goulart, Barbara Niegia Garcia (55958854600) ;Grada, Ayman (55797741000) ;Gugnani, Harish Chander (7005567008) ;Guido, Davide (56314778600) ;Guimarães, Rafael Alves (56534712800) ;Guo, Yuming (55712472800) ;Gupta, Rahul (57204120071) ;Gupta, Rajeev (55705295300) ;Hafezi-Nejad, Nima (57216814261) ;Haile, Michael Tamene (57204564050) ;Hailu, Gessessew Bugssa (57219637263) ;Haj-Mirzaian, Arvin (57210768364) ;Haj-Mirzaian, Arya (57226201352) ;Hall, Brian James (57218302519) ;Handiso, Demelash Woldeyohannes (57201501075) ;Haririan, Hamidreza (36157009700) ;Hariyani, Ninuk (57190349243) ;Hasaballah, Ahmed I. (56002305300) ;Hasan, Md. Mehedi (57213529757) ;Hasanzadeh, Amir (57193162243) ;Hassankhani, Hadi (26436359700) ;Hassen, Hamid Yimam (57188660707) ;Hayelom, Desta Haftu (57216638000) ;Heidari, Behnam (6603217356) ;Henry, Nathaniel J. (57196076616) ;Herteliu, Claudiu (26035943100) ;Heydarpour, Fatemeh (57192381690) ;de Hidru, Hagos D. (57216634249) ;Hoang, Chi Linh (57205123375) ;Hoogar, Praveen (57204240256) ;Hoseini-Ghahfarokhi, Mojtaba (57003517600) ;Hossain, Naznin (57195380270) ;Hosseini, Mostafa (57204569481) ;Hosseinzadeh, Mehdi (57201880569) ;Househ, Mowafa (8667908000) ;Hu, Guoqing (57218106596) ;Humayun, Ayesha (25226911300) ;Hussain, Syed Ather (56910575300) ;Ibitoye, Segun Emmanuel (57212027408) ;Ilesanmi, Olayinka Stephen (54782692800) ;Ilic, Milena D. (7102981394) ;Inbaraj, Leeberk Raja (55988289600) ;Irvani, Seyed Sina Naghibi (57202975543) ;Islam, Sheikh Mohammed Shariful (56400111100) ;Iwu, Chinwe Juliana (56904084900) ;Jaca, Anelisa (57191066193) ;Jafari Balalami, Nader (57211139609) ;Jahanmehr, Nader (57203122718) ;Jakovljevic, Mihajlo (14318929700) ;Jalali, Amir (23469738000) ;Jayatilleke, Achala Upendra (57204797176) ;Jenabi, Ensiyeh (15755615100) ;Jha, Ravi Prakash (58586863400) ;Jha, Vivekanand (7005119423) ;Ji, John S. (58562329500) ;Jia, Peng (55092981100) ;Johnson, Kimberly B. 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(57204849530) ;Yip, Paul (7102503720) ;Yirsaw, Biruck Desalegn (49664327400) ;Yisma, Engida (55556060700) ;Yonemoto, Naohiro (57204947657) ;Younis, Mustafa Z. (8549393000) ;Yousof, Hebat-Allah Salah A. (56183368000) ;Yu, Chuanhua (57208140344) ;Yusefzadeh, Hasan (55887807200) ;Zamani, Mohammad (57096222300) ;Zambrana-Torrelio, Carlos (57193255530) ;Zandian, Hamed (57205175627) ;Zeleke, Ayalew Jejaw (57193096860) ;Zepro, Nejimu Biza (57193095335) ;Zewale, Taye Abuhay (57209219258) ;Zhang, Dongyu (57216327764) ;Zhang, Yunquan (56568510200) ;Zhao, Xiu-Ju (8360350900) ;Ziapour, Arash (57202571078) ;Zodpey, Sanjay (7003415080)Hay, Simon I. (7101875313)Background Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood diarrhoea. Methods We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000 to 2017. From these data, we estimated the burden of diarrhoea at varying subnational levels (termed units) by spatially aggregating draws, and we investigated the drivers of subnational patterns by creating aggregated risk factor estimates. Findings The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1-65·8), 17·4% (7·7-28·4), and 59·5% (34·2-86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. Although children in much of Africa remain at high risk of death due to diarrhoea, regions with the most deaths were outside Africa, with the highest mortality units located in Pakistan. Indonesia showed the greatest within-country geographical inequality; some regions had mortality rates nearly four times the average country rate. Reductions in mortality were correlated to improvements in water, sanitation, and hygiene (WASH) or reductions in child growth failure (CGF). Similarly, most high-risk areas had poor WASH, high CGF, or low oral rehydration therapy coverage. Interpretation By co-analysing geospatial trends in diarrhoeal burden and its key risk factors, we could assess candidate drivers of subnational death reduction. Further, by doing a counterfactual analysis of the remaining disease burden using key risk factors, we identified potential intervention strategies for vulnerable populations. In view of the demands for limited resources in LMICs, accurately quantifying the burden of diarrhoea and its drivers is important for precision public health. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. - Some of the metrics are blocked by yourconsent settings
Publication Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: A systematic analysis from the Global Burden of Disease Study 2016(2018) ;Fullman, Nancy (57211064970) ;Yearwood, Jamal (57202282849) ;Abay, Solomon M. (35306466900) ;Abbafati, Cristiana (54917122400) ;Abd-Allah, Foad (36503428900) ;Abdela, Jemal (57200613000) ;Abdelalim, Ahmed (7801307783) ;Abebe, Zegeye (57193002719) ;Abebo, Teshome Abuka (57195738441) ;Aboyans, Victor (56214736500) ;Abraha, Haftom Niguse (57195289877) ;Abreu, Daisy M.X. (9747083200) ;Abu-Raddad, Laith J. 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(57198311895) ;Yano, Yuichiro (57196965200) ;Yaseri, Mehdi (23029507000) ;Yimer, Nigus Bililign (57216264444) ;Yin, Peng (7103219312) ;Yip, Paul (7102503720) ;Yirsaw, Biruck Desalegn (49664327400) ;Yonemoto, Naohiro (57204947657) ;Yonga, Gerald (57203907041) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Yu, Chuanhua (57201889726) ;Zadnik, Vesna (57202975428) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922) ;Zaman, Sojib Bin (57193070058) ;Zamani, Mohammad (57096222300) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zhou, Maigeng (57054557200) ;Zhu, Jun (56215097100) ;Zimsen, Stephanie R.M. (57196078433) ;Zipkin, Ben (57200737130) ;Zodpey, Sanjay (7003415080) ;Zuhlke, Liesl Joanna (57209027746) ;Murray, Christopher J.L. (55481130700)Lozano, Rafael (7102198442)Background A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) to assess personal health-care access and quality with the Healthcare Access and Quality (HAQ) Index for 195 countries and territories, as well as subnational locations in seven countries, from 1990 to 2016. Methods Drawing from established methods and updated estimates from GBD 2016, we used 32 causes from which death should not occur in the presence of effective care to approximate personal health-care access and quality by location and over time. To better isolate potential effects of personal health-care access and quality from underlying risk factor patterns, we risk-standardised cause-specific deaths due to non-cancers by location-year, replacing the local joint exposure of environmental and behavioural risks with the global level of exposure. Supported by the expansion of cancer registry data in GBD 2016, we used mortality-to-incidence ratios for cancers instead of risk-standardised death rates to provide a stronger signal of the effects of personal health care and access on cancer survival. We transformed each cause to a scale of 0-100, with 0 as the first percentile (worst) observed between 1990 and 2016, and 100 as the 99th percentile (best); we set these thresholds at the country level, and then applied them to subnational locations. We applied a principal components analysis to construct the HAQ Index using all scaled cause values, providing an overall score of 0-100 of personal health-care access and quality by location over time. We then compared HAQ Index levels and trends by quintiles on the Socio-demographic Index (SDI), a summary measure of overall development. As derived from the broader GBD study and other data sources, we examined relationships between national HAQ Index scores and potential correlates of performance, such as total health spending per capita. Findings In 2016, HAQ Index performance spanned from a high of 97·1 (95% UI 95·8-98·1) in Iceland, followed by 96·6 (94·9-97·9) in Norway and 96·1 (94·5-97·3) in the Netherlands, to values as low as 18·6 (13·1-24·4) in the Central African Republic, 19·0 (14·3-23·7) in Somalia, and 23·4 (20·2-26·8) in Guinea-Bissau. The pace of progress achieved between 1990 and 2016 varied, with markedly faster improvements occurring between 2000 and 2016 for many countries in sub-Saharan Africa and southeast Asia, whereas several countries in Latin America and elsewhere saw progress stagnate after experiencing considerable advances in the HAQ Index between 1990 and 2000. Striking subnational disparities emerged in personal health-care access and quality, with China and India having particularly large gaps between locations with the highest and lowest scores in 2016. In China, performance ranged from 91·5 (89·1-93·6) in Beijing to 48·0 (43·4-53·2) in Tibet (a 43·5-point difference), while India saw a 30·8-point disparity, from 64·8 (59·6-68·8) in Goa to 34·0 (30·3-38·1) in Assam. Japan recorded the smallest range in subnational HAQ performance in 2016 (a 4·8-point difference), whereas differences between subnational locations with the highest and lowest HAQ Index values were more than two times as high for the USA and three times as high for England. State-level gaps in the HAQ Index in Mexico somewhat narrowed from 1990 to 2016 (from a 20·9-point to 17·0-point difference), whereas in Brazil, disparities slightly increased across states during this time (a 17·2-point to 20·4-point difference). Performance on the HAQ Index showed strong linkages to overall development, with high and high-middle SDI countries generally having higher scores and faster gains for non-communicable diseases. Nonetheless, countries across the development spectrum saw substantial gains in some key health service areas from 2000 to 2016, most notably vaccine-preventable diseases. Overall, national performance on the HAQ Index was positively associated with higher levels of total health spending per capita, as well as health systems inputs, but these relationships were quite heterogeneous, particularly among low-to-middle SDI countries. Interpretation GBD 2016 provides a more detailed understanding of past success and current challenges in improving personal health-care access and quality worldwide. Despite substantial gains since 2000, many low-SDI and middle- SDI countries face considerable challenges unless heightened policy action and investments focus on advancing access to and quality of health care across key health services, especially non-communicable diseases. Stagnating or minimal improvements experienced by several low-middle to high-middle SDI countries could reflect the complexities of re-orienting both primary and secondary health-care services beyond the more limited foci of the Millennium Development Goals. Alongside initiatives to strengthen public health programmes, the pursuit of universal health coverage hinges upon improving both access and quality worldwide, and thus requires adopting a more comprehensive view - and subsequent provision - of quality health care for all populations. Copyright © 2018 The Author(s). Published by Elsevier Ltd.
