Browsing by Author "Mitrović-Jovanović, Milica (56257450700)"

Introduction Primary Non-Hodgkin lymphoma of the liver is an extremely rare disease. It most often occurs as a diffuse large B-cell type. Case outline We present the case of a 75-year-old patient who was admitted to our clinic with rightsided subcostal pain accompanied by malaise, weakness, and elevated body temperature. Laboratory analyzes were within normal limits. Ultrasonography and computed tomography findings showed a sharply marginated inhomogeneous lesion in the right liver lobe with central necrosis. Intraoperatively and pathohistologically, it was confirmed that it was diffuse large B-cell lymphoma of the liver. Surgery, chemotherapy, radiotherapy and their combination are the methods of treatment. Conclusion Surgical treatment with chemotherapy allows for a significantly higher survival rate. © 2025, Serbia Medical Society. All rights reserved.

Introduction Malignant melanoma is a tumor of the melanocytes and is one of the most aggressive tumors. In most cases, the first symptoms appear in the metastatic phase of the disease. In clinical practice, malignant melanoma very rarely metastasizes to the gallbladder. Modern diagnostic methods include 18F-fluorodeoxyglucose positron emission tomography, new computed tomography protocols, new nuclear magnetic resonance for melanoma protocols, and contrast-enhanced ultrasound. The article aims to emphasize the necessity of radical surgical treatment of metastatic melanoma of the gallbladder. Case outline We present a rare case of metastatic malignant melanoma of the gallbladder, which was treated with cholecystectomy and radical surgical excision of all metastatic lesions. Conclusion All patients with a positive anamnesis for malignant melanoma require to be checked for the spread of the disease to the gallbladder and subsequent surgical treatment. © 2024, Serbia Medical Society. All rights reserved.

Introduction Primary, “pure” squamous cell carcinoma (SCC) is an exceptionally rare pancreatic malignancy that has been described in sporadic case reports. The appearance of this rare entity created a diagnostic dilemma for us, therefore, in this case report, we are focused on the radiological detection and characterization, pathogenesis, and therapeutic options of pure pancreatic SCC. Case outline In an 80-year-old female patient, a partially necrotic mass in the tail of the pancreas was detected by computed tomography, which is the rarest localization of this tumor. On the performed imaging, the tumor showed predominantly malignant features with a surprising definitive histopathological diagnosis in the direction of pure SCC. Distal pancreatectomy with splenectomy was performed because of the infiltration of lienal vascular structures. Conclusion Due to the very aggressive form of this tumor and poor prognosis, early detection, risk factors control, genetic burden, and optimization of surgical and therapeutic management can improve the quality of life and prolong the overall survival period. © 2024, Serbia Medical Society. All rights reserved.

Introduction Spontaneous cholecystoduodenal fistula is a rare complication of the gallbladder calculosis. Bowel obstruction is the complication in less than 1% of these patients. The pathognomonic triad (Rigler triad) of pneumobilia, small-bowel distention, and ectopic gallstones is typical for gallstone ileus. In only 1–3% of the patients with bowel obstruction by ectopic gallstone the localization of obstruction is in the duodenum, and it is called Bouveret syndrome. The rarest complication is a floating non-obstructing gallstone trapped in the stomach. Outline of cases We present three elderly female patients with persistent abdominal pain and known gallbladder calculosis in the patients’ histories. Plain radiography of the thorax and abdomen and ultrasound were performed as the first choice and contrast-enhanced computer tomography (CT) was done subsequently. In the first patient, CT and magnetic resonance imaging (MRI) showed signs of pneumobilia, cholecystoduodenal fistula, and the presence of the gallstone in the stomach. The iodine contrast X-ray swallow test revealed a cholecysto-duodenal bulb fistula and floating calculus in the stomach, confirmed by endoscopy. In the second patient with persistent abdominal pain, CT and barium swallow test showed signs of pneumobilia, cholecystoduodenal fistula, and two ectopic gallstones obstructing duodenum – Bouveret syndrome. The third case showed signs of the Rigler triad – typical signs of gallstone ileus. Conclusion Spontaneous cholecystoduodenal fistula is a rare condition with possible complications such as Bouveret syndrome, gallstone ileus and floating, non-obstructive gallstones in the stomach, as the rarest possible complication. CT, MRI with magnetic resonance cholangiopancreatography, as well as the contrast X-ray swallow test can be very helpful in the detection of the bilio-enteric fistula and ectopic gallstones. © 2019, Serbia Medical Society. All rights reserved.