Browsing by Author "Milutinovic, Katarina (55445911400)"

Inflammation plays an important role in all stages of atherosclerosis — from endothelial dysfunction, to formation of fatty streaks and atherosclerotic plaque, and its progression to serious complications, such as atherosclerotic plaque rupture. Although dyslipidemia is a key driver of atherosclerosis, pathogenesis of atherosclerosis is now considered interplay between cholesterol and inflammation, with the significant role of the immune system and immune cells. Despite modern therapeutic approaches in primary and secondary cardiovascular prevention, cardiovascular diseases remain the leading cause of mortality worldwide. In order to reduce residual cardiovascular risk, despite the guidelines-guided optimal medical therapy, novel therapeutic strategies are needed for prevention and management of coronary artery disease. One of the innovative and promising approaches in atherosclerotic cardiovascular disease might be inflammation-targeted therapy. Numerous experimental and clinical studies are seeking into metabolic pathways underlying atherosclerosis, in order to find the most suitable pathway and inflammatory marker/s that should be the target for anti-inflammatory therapy. Many anti-inflammatory drugs have been tested, from the well-known broad range anti-inflammatory agents, such as colchicine, allopurinol and methotrexate, to targeted monoclonal antibodies specifically inhibiting a molecule included in inflammatory pathway, such as canakinumab and tocilizumab. To date, there are no approved anti-inflammatory agents specifically indicated for silencing inflammation in patients with coronary artery disease. The most promising results came from the studies which tested colchicine, and studies where the inflammatory-target was NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome/interleukin-1 beta (IL-1β)/interleukin-6 (IL-6)/C-reactive protein (CRP) pathway. A growing body of evidence, along with the ongoing clinical studies, suggest that the anti-inflammatory therapy might become an additional strategy in treating atherosclerotic cardiovascular disease. Herein we present an overview of the role of inflammation in atherosclerosis, the most important inflammatory markers chosen as targets of anti-inflammatory therapy, along with the critical review of the major clinical trials which tested non-targeted and targeted anti-inflammatory drugs in patients with atherosclerotic cardiovascular disease. © 2023 The Author(s). Published by IMR Press.

Background: Doctoral programmes are an important pillar of medical education, and although many universities award the best theses, the criteria for selection of awardees and the topics of their doctoral theses are seldom analysed. Objectives: To analyse the landscape of doctoral research through assessing the temporal trends in the criteria related to recognising the best theses. Methods: A total of 55 award-winning doctoral theses, from those submitted to the Faculty of Medicine, University of Belgrade, over 7 years (2016–2022), were examined, focusing on the number of awardees, publications based on the theses, research subfields, and keywords. Results: The awardees comprised 36 women (65%) and 19 men (35%). The number of award-winning theses per year in clinical medicine and public health increased over the years (P < .05 for both the fields). The awardees had published a total of 134 articles based on their theses before the thesis defence, and half of these were published in open-access journals. The journals that each published at least 4 of these articles were PLOS One, Experimental and Molecular Pathology, and Oxidative Medicine and Cellular Longevity. The cumulative impact factor of these publications showed no significant increase (P > .05). The subfields that accounted for at least 5 of the publications were molecular medicine (13 publications) among the basic or translational fields, cardiology (5) among clinical medicine, and epidemiology (7) among public health. Mapping the co-occurrence of keywords from all the dissertations identified some research hotspots, which included cancer, oxidative stress, Parkinsonism, risk factors, genetic polymorphisms, and biomarkers. Conclusion: The increasing number of award-winning theses reflects the rising quality of doctoral research and the growing motivation of candidates to choose indexed journals as outlets for papers based on the theses. This approach can serve as a basis for strategic evaluation of the practices for evaluating PhD theses and for identifying strong and weak spots in the research landscape of medical schools to guide future doctoral research and the competitiveness of doctoral programmes. © 2025 the authors.

Background: Doctoral programmes are an important pillar of medical education, and although many universities award the best theses, the criteria for selection of awardees and the topics of their doctoral theses are seldom analysed. Objectives: To analyse the landscape of doctoral research through assessing the temporal trends in the criteria related to recognising the best theses. Methods: A total of 55 award-winning doctoral theses, from those submitted to the Faculty of Medicine, University of Belgrade, over 7 years (2016–2022), were examined, focusing on the number of awardees, publications based on the theses, research subfields, and keywords. Results: The awardees comprised 36 women (65%) and 19 men (35%). The number of award-winning theses per year in clinical medicine and public health increased over the years (P < .05 for both the fields). The awardees had published a total of 134 articles based on their theses before the thesis defence, and half of these were published in open-access journals. The journals that each published at least 4 of these articles were PLOS One, Experimental and Molecular Pathology, and Oxidative Medicine and Cellular Longevity. The cumulative impact factor of these publications showed no significant increase (P > .05). The subfields that accounted for at least 5 of the publications were molecular medicine (13 publications) among the basic or translational fields, cardiology (5) among clinical medicine, and epidemiology (7) among public health. Mapping the co-occurrence of keywords from all the dissertations identified some research hotspots, which included cancer, oxidative stress, Parkinsonism, risk factors, genetic polymorphisms, and biomarkers. Conclusion: The increasing number of award-winning theses reflects the rising quality of doctoral research and the growing motivation of candidates to choose indexed journals as outlets for papers based on the theses. This approach can serve as a basis for strategic evaluation of the practices for evaluating PhD theses and for identifying strong and weak spots in the research landscape of medical schools to guide future doctoral research and the competitiveness of doctoral programmes. © 2025 the authors.