Browsing by Author "Milošević, Branislav (57207556704)"

Background and Objectives: Cervical squamous cell carcinoma (SCC) usually showed an infiltrative growth pattern into endocervical stroma. In rare cases, SCC spreads superficially as an intraepithelial lesion to proximal uterine segments, and more rarely, involves invasive and more aggressive behavior on secondary sites. Materials and Methods: In this study, we present the case of an interesting form of cervical SCC growth and we discuss the possible reasons for that presentation. Results: After clinical examination and repeated histomorphological analysis, we found remarkable cervical epithelial dysplasia (a high-grade squamous intraepithelial lesion-H-SIL). A histopathology report after conization and hysterectomy showed squamocellular carcinoma with microinvasive focuses. Interestingly, squamocellular carcinoma was found in the proximal uterine and adnexal structure, as well as intraepithelial and microinvasive lesions. Conclusions: Our study described a rare presentation of primary cervical SCC with unusual adnexal involvement. This pattern of tumor growth should be especially considered for patients who are proposed for sparing surgical procedures. A detailed and multidisciplinary approach for every patient is very important because unpredictable cases are present. However, they are rare.

Introduction/Objective Coronavirus pandemic caused most hospitals in the world to suspend regular activities. The aim of this study was to analyze pandemic influence on patients who underwent hysterectomy with classical (abdominal) and minimally invasive surgery (laparoscopic and vaginal approach) at the Clinic for Gynecology and Obstetrics of the University Medical Centre of Serbia. Methods There were 2446 hysterectomies for five-year period. The study analyzed number and types of hysterectomies before and during COVID-19 pandemic. Results The total number of operated patients was most decreased in the first year of the pandemic. During pandemic, the number of vaginal and laparoscopic hysterectomies did not change, whereas there was an increase in the number of abdominal hysterectomies. Statistical significance (p < 0.01) was found between abdominal and vaginal as well as between abdominal and endoscopic hysterectomies. Conclusion The global pandemic impact on care of symptomatic patients with COVID-19 has led to the redeployment of staff and resources, which has significantly reduced the total number of operations in many hospitals around the world. © 2024, Serbia Medical Society. All rights reserved.

Introduction/Objective Cesarean section birth rate has been constantly increasing worldwide over the last decades. The complications of cesarean section that require relaparotomy are rather serious and relatively rare. The aim of this paper is to present the incidence of surgical complications after Cesarean section at the Clinic of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia, during a three-year period (2013–2015). Methods This is a retrospective study. Data obtained from the medical records/histories were used and processed according to descriptive statistical methods. Results During the observed period, relaparotomy was necessary in 29 (0.44%) women who had a CS. Relaparotomy was performed due to clinically and ultrasonographically evidenced hematoma of the anterior abdominal wall, retroperitoneal hematoma, hemoperitoneum, and development of hemorrhagic shock, complete wound dehiscence or diffuse peritonitis. There were no lethal outcomes after CS followed by these complications at the Clinic of Gynecology and Obstetrics, Clinical Center of Serbia in Belgrade. Conclusion The incidence of relaparotomy in our study is similar to other tertiary institutions, as well as the indications for relaparotomy. While generally observed mortality rate after post-cesarean relaparotomy in developed countries is 2.7%, in our study there were no lethal outcomes. © 2019, Serbia Medical Society. All rights reserved.

Background and Objectives: Mutations in succinate dehydrogenase (SDH) and fumarate hydratase (FH) give rise to various familial cancer syndromes, with these alterations being characteristic of certain types of histomorphologically specific leiomyomas that hold significant predictive value. Materials and Methods: This study presents two cases of uterine leiomyomas exhibiting rare histomorphological and genetic characteristics, which are crucial for prognosis and further treatment. Results: Distinct histopathological features such as marked nuclear atypia, intracellular eosinophilic globules, and abnormal intratumoral vessels raise suspicion for specific leiomyoma subtypes, which carry predictive significance for additional hereditary cancer syndromes. Immunohistochemical analysis confirmed FH/SDH deficiency in both patients, who underwent careful follow-up. Conclusions: This study describes two cases involving unusual leiomyomas, the histopathological characteristics of which may easily go unrecognized. These features hold predictive significance because their specific mutations point to additional hereditary cancer syndromes, highlighting the need for further examinations. © 2024 by the authors.