Browsing by Author "Miljuš, Dragan (24169622800)"

Background/Aim. Nasopharyngeal carcinoma (NPC) is a relatively rare malignant disease, of which 80 000 individuals become ill around the world annually, which amounts to 0.7% of all carcinomas. The aim of this descriptive study was to analyze NPC incidence in Belgrade (the capital city of Serbia, with about 1.6 milion inhabitants) during the period 1991-2005. Methods. In data analysis, crude rates age and sex specific rates, and standardized incidence rates were used. Standardization was performed by a direct method, using world population as the standard. Results. In Belgrade, during the observed 15-year-period, the number of new NPC patients totaled 118, of which 86 (72.9%) were male and 32 (27.1%) were female. The average standardized incidence rate for men was 0.52 per 100 000 and for women 0.16 per 100 000. In both sexes the incidence was very low before 40 years of age. In men, the greatest incidence rate of NPC was in the 50-59 years age group, and in women in those 60 and more years old. Furthermore, undifferentiated carcinoma of nasopharyngeal type was 3.6 times more often in comparison to squamous cell carcinoma. Conclusion. Belgrade belongs to a region with a low incidence rate of NPC. Further investigations are needed to explain higher frequency of undifferentiated carcinoma of nasopharyngeal type than squamous cell carcinoma.

This study aimed to explore the set of variables related to skeletal muscle mass (SMM) in both sexes, and to create age-and sex-related models of changes in SMM, using the most representative indicator of muscular status. Body composition was assessed in 8733 subjects (♀= 3370 and ♂= 5363), allocated into subsamples according to age: 18–29.9, 30–39.9, 40–49.9, 50–59.9, 60–69.9, and 70.0–79.9 years. Nine variables were used: protein mass, protein percent, protein mass index, SMM, percent of SMM, SMM index, fat-free mass, fat-free mass index, and protein/fat index. Univariate and multivariate analysis of variance (ANOVA and MANOVA) were used to determine between-and within-sex difference in all variables by age. Correlation analysis established the relationship between age and muscularity variables. Principal Component Analysis extracted the variables that loaded highest in explaining muscularity, while regression analysis determined the linearity of association between the age and indicators of muscular status. Variables SMMI and PSMM were extracted as the most sensitive to age, with SMMI being gender-independent while showing the parabolic and sinusoidal form of change as function of ageing in males and females, respectively; and PSMM being sex-dependent while showing a linear trend of decrease in both sexes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

This study aimed to explore the set of variables related to skeletal muscle mass (SMM) in both sexes, and to create age-and sex-related models of changes in SMM, using the most representative indicator of muscular status. Body composition was assessed in 8733 subjects (♀= 3370 and ♂= 5363), allocated into subsamples according to age: 18–29.9, 30–39.9, 40–49.9, 50–59.9, 60–69.9, and 70.0–79.9 years. Nine variables were used: protein mass, protein percent, protein mass index, SMM, percent of SMM, SMM index, fat-free mass, fat-free mass index, and protein/fat index. Univariate and multivariate analysis of variance (ANOVA and MANOVA) were used to determine between-and within-sex difference in all variables by age. Correlation analysis established the relationship between age and muscularity variables. Principal Component Analysis extracted the variables that loaded highest in explaining muscularity, while regression analysis determined the linearity of association between the age and indicators of muscular status. Variables SMMI and PSMM were extracted as the most sensitive to age, with SMMI being gender-independent while showing the parabolic and sinusoidal form of change as function of ageing in males and females, respectively; and PSMM being sex-dependent while showing a linear trend of decrease in both sexes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Background/Aim: Prehypertension and hypertension are an important public health problem worldwide and although they can be modified, they are often a risk for cardiovascular diseases. The aim of this study was to determine the prevalence of prehypertension and hypertension and associated risk factors in the adult population (15+ years) of Serbia. Methods: The cross-sectional study covered 14,623 adult respondents, but 14,422 volunteered to measure their blood pressure according to a pre-defined protocol. A stratified two-stage national representative random sampling approach was used for the selection of the survey sample. Results: In 2013, 17.7% of Serbian population, aged 15 and over, was normotensive, every third (33.1%) person had prehypertension, and every second (49.3%) had hypertension. The standardized prevalence of prehypertension and hypertension was 40.6% and 34.5%, respectively; 57.8% of the hypertensive population were receiving medical treatment. Among those receiving medical treatment, 35.2% (36.4% males and 33.2% females) had a blood pressure within the normal range. According to the results of multivariate logistic regression analysis, independently significant risk factors for hypertension compared to persons with normotension were older age (50 and more) (p < 0.001), overweight (p < 0.001) and obesity (p < 0.001), moderate (p < 0.001) and large (p < 0.001) waist circumference in both sexes, and nonurban place of residence in females (p = 0.006). In females, independently significant risk factors for prehypertension compared to persons with normotension were older age (50 and more) (p < 0.001), overweight (p < 0.001) and obesity (p < 0.001), moderate (p < 0.001) and large (p < 0.001) waist circumference, but high level of physical activity was significantly protective (p = 0.014). In males, overweight (p < 0.001) and obesity (p < 0.001) were independently significant risk factors for prehypertension. Conclusion: Serbia belongs to countries with a high prevalence of prehypertension and hypertension. Our results emphasize the need for a new public health strategy for the prevention, detection and treatment of prehypertension and hypertension. © 2020 Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved.