Browsing by Author "Milić, Marija (57202972248)"

Background: Undernutrition disorder is a prevalent comorbidity (up to 25%) in type 2 diabetes (T2D) patients which significantly compromises their health. We aimed to assess the association between single nucleotide poly-morphysms (SNPs) adiponectin (ADIPOQ) +276 (G/T) and resistin (RETN)-420 (C/G) with the risk of developing T2D and undernutrition in patients with T2D. Methods: The research was conducted as prospective case-control study among 106 patients with T2D and 106 healthy control individuals in the territory of the Bosnia and Herzegovina from Sep 1st 2022 to May 1st 2023. For assessing the nutritional status, the mini nutritional assessment (MNA) was used. DNA analysis was carried out by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. The data were analyzed using chi-square test, t-test for independent samples and binary multivariate logistic regression. Results: The research included 212 subjects of which 124 (58.5%) were male. The mean age of the subjects was 68.48±4,67 yr. Almost 20% of subjects were undernourished, significantly more T2D patients when compared to controls (33% vs. 6.6%; P<0.001). ADIPOQ +276 GT genotype was identified as significant predictor of T2D (OR: 3.454; 95% CI: 1.400-8.521; P=0.007) and undernutrition disorder (OR: 3.453; 95% CI: 1.331-8.961; P=0.011) in T2D population, while the presence of RETN-420 CG genotype had protective effect against occur-rence of T2D (OR: 0.353; 95% CI: 0.144-0.867; P=0.023). However, RETN genotypes were not associated with undernutrition disorder. Conclusion: ADIPOQ +276 gene polymorphism represent a significant predictor for development of T2D and undernutrition disorder in T2D population, while RETN-420 gene polymorphism was identified as a significant factor associated with a reduced risk for T2D, but was not associated with undernutrition. © 2025 Vuković et al.

Background/Aim. The fundamental objective of primary percutaneous coronary intervention (PCI) in myocardial infarction is to provide early, complete, and sustained flow in the occluded artery that has led to myocardial ischemia or necrosis. The aim of this study was to determine the predictive power of a combination of GRACE, SYNTAX I, and SYNTAX II scores in predicting major adverse cardiovascular events (MACE) and one-year mortality in patients with ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) after primary PCI. Methods. The study included 400 patients who had their first acute myocardial infarction and underwent PCI. The patients were treated and followed for one year at the Clinical Hospital Center Zvezdara at the Department of Interventional Cardiology. By monitoring the defined clinical parameters, a comparative analysis of risk scores GRACE, SYNTAX I, and SYNTAX II was performed. Their sensitivity, specificity as well as predictive possibilities in predicting adverse outcomes were determined. Results. The incidence of MACE in our sample was 12.8%. Patients with STEMI entity had significantly higher values of GRACE, SYNTAX I, and SYNTAX II scores. The highest value for predicting the occurrence of MACE was shown by the SYNTAX II score (score value 29.3), with a sensitivity of 88.2% and a specificity of 76.8%. The GRACE score was a significant predictor of SYNTAX I and SYNTAX II scores. A two-way correlation was observed between the high score values of all three scores. Conclusion. The presented scores for the assessment of clinical and angiographic indicators showed good predictive power in assessing the outcome of adverse cardiovascular events in both clinical entities of acute myocardial infarction during one-year follow-up. By using the proposed scores to assess MACE, we can single out high-risk patients in order to prevent adverse events and reduce mortality. This suggests its suitability for clinical use in this patient population. © 2022 Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved.

Objective – To examine health-related quality of life (HRQoL) among Serbian students who study in the northern Kosovo province and to explore potential differences in HRQoL relative to students’ region of origin. Materials and Methods – This study was conducted from April to June 2015. A total of 514 students from the University of Priština temporarily settled in Kosovska Mitrovica were enrolled in the study. The students completed the socio-demographic and lifestyle questionnaire, Beck Depression Inventory (BDI) and the generic HRQoL questionnaire Short Form-36 (SF-36). The region of origin was classified based on the area in which the students were originally from: Republic of Serbia vs. North Kosovo vs. Southern enclaves. Results – The highest scores were observed for Physical Functioning and the lowest for Vitality. No difference in HRQoL was observed between students from the Republic of Serbia, North Kosovo and Southern enclaves. Compared to females, males scored better on Bodily Pain, General Health, Social Functioning and Mental Health. They also had better Physical and Mental Composite scores and Total HRQoL than females. Worse depressive symptoms were consistently associated with poorer HRQoL across all three groups of students. Conclusion – The HRQoL among Serbian students in the northern Kosovo province does not differ based on their region of origin. Health care services for university students should prioritize prevention, early recognition and treatment of depressive symptoms. © 2021 by the University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.