Browsing by Author "Milenković, Petar (35574505300)"

Objectives: Macroscopic entheseal forms show two main features: predominant signs of bony formation or resorption. To understand the development of these forms, we investigated microarchitectural differences between the macroscopic proliferative and resorptive forms of the gluteus maximus enthesis. Materials and Methods: The macromorphological analysis of entheseal changes (EC) was based on the Villotte, visual scoring system for fibrous entheses. Gluteal tuberosity specimens of different stages of Villote's system were harvested from 16 adult males derived from an archaeological context and scanned using microcomputed tomography. Results: The microarchitectural analyzes of cortical bone demonstrated a trend of higher porosity in the resorptive compared to the proliferative phase in Stage B, whereas a 30% porosity reduction was detected in the resorptive compared to proliferative phase of Stage C. In terms of the trabecular bone between the resorptive and proliferative entheseal phases, there was a trend of increased connectivity density, whereas the structural model index decreased in B and increased in C. The assessment of the entire specimen showed an increase in porosity from the proliferative to the resorptive phase in the Stage B, in contrast to a decrease in the Stage C. Discussion: The results suggest that from an initial flat entheses, two directions of EC development are possible: (a) a bony prominence may form and, subsequently, it is subjected to trabecularization of the cortical bone inside the prominence, such cortical trabecularization can lead to visible porosity on the cortical external surface; (b) the cortical bone defect may develop with the regular underlying cortical bone. © 2020 Wiley Periodicals, Inc.

Objectives: Macroscopic entheseal forms show two main features: predominant signs of bony formation or resorption. To understand the development of these forms, we investigated microarchitectural differences between the macroscopic proliferative and resorptive forms of the gluteus maximus enthesis. Materials and Methods: The macromorphological analysis of entheseal changes (EC) was based on the Villotte, visual scoring system for fibrous entheses. Gluteal tuberosity specimens of different stages of Villote's system were harvested from 16 adult males derived from an archaeological context and scanned using microcomputed tomography. Results: The microarchitectural analyzes of cortical bone demonstrated a trend of higher porosity in the resorptive compared to the proliferative phase in Stage B, whereas a 30% porosity reduction was detected in the resorptive compared to proliferative phase of Stage C. In terms of the trabecular bone between the resorptive and proliferative entheseal phases, there was a trend of increased connectivity density, whereas the structural model index decreased in B and increased in C. The assessment of the entire specimen showed an increase in porosity from the proliferative to the resorptive phase in the Stage B, in contrast to a decrease in the Stage C. Discussion: The results suggest that from an initial flat entheses, two directions of EC development are possible: (a) a bony prominence may form and, subsequently, it is subjected to trabecularization of the cortical bone inside the prominence, such cortical trabecularization can lead to visible porosity on the cortical external surface; (b) the cortical bone defect may develop with the regular underlying cortical bone. © 2020 Wiley Periodicals, Inc.

This is the most intriguing museum specimen of cardiovascular syphilis, collected in the Forensic Museum founded by professor Milovan Milovanović (1884–1948) in 1923, the first professor of Forensic Pathology in the newly established University School of Medicine in Belgrade. We aimed to analyze the specimen of an autopsy case from the year 1929 in which severe thoracic spine erosion occurred due to syphilitic aneurism and to demonstrate findings by multi-detector computed tomography (MDCT). The specimen comprises an en-block-eviscerated heart, thoracic aorta, thoracic spine, and posterior segments of the ribs, with a partial section of the heart and a longitudinal section of the aorta. We performed histology and MDCT analyses almost a century after the autopsy and revised the original case documentation. The conducted analyses confirmed the characteristic pathology. Most importantly, MDCT imaging revealed intriguing destruction of the vertebral bodies by the pulsatile saccular aneurysm of the descending aorta. The calcified aneurysm led to the extensive irregular mechanically caused osteolysis of the anterior segments of the several vertebral corpora. After the analysis and revision of the original case documentation, we discussed these findings, as well as additional characteristic autopsy findings in syphilis-related deaths, some of which might be forgotten. The direct close contact of the syphilitic aortic aneurysm with the thoracic spine was preserved. By utilizing postmortem MDCT and 3D reconstruction, we better visualize the thoracic spine bone resorption and alteration: in the time of Milovanović, only roentgenography was available, providing less detail. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.