Browsing by Author "Micic, J. (58399975000)"

[No abstract available]

The bad state of diabetes, its duration and time of occurrence, age and sex are important factors for the development of vascular disease. Vascular disease was found most frequently in patients over 50 yr, whose diabetes had existed for more than 5 yr duration. Special attention must be paid to the prevention of vascular manifestations. The best way of postponing and prevention of the vascular disease during the diabetes is frequent and good control of the disease, body weight reduction, treatment of hypertension, physical activity and giving up of smoking.

The bad state of diabetes, its duration and time of occurrence, age and sex are important factors for the development of vascular disease. Vascular disease was found most frequently in patients over 50 yr, whose diabetes had existed for more than 5 yr duration. Special attention must be paid to the prevention of vascular manifestations. The best way of postponing and prevention of the vascular disease during the diabetes is frequent and good control of the disease, body weight reduction, treatment of hypertension, physical activity and giving up of smoking.

[No abstract available]

[No abstract available]

In 2005 diabetics treated during 10 years, 95 cases of diabetic nephropathy were found. Of 95 observed patients 57 were females and 38 males in the age group of more than 50 years (83.1%). The duration of diabetes was 1-30 yrs, mostly 6-30 yr (82 patients). In 86.2% cases it was a maturity onset diabetes. Most of them were treated with insulin and diet (78.4%). Most patients (68.4%) were under bad control. Clinically in 36 patients edemas were found. In 75.8% the diastolic blood pressure was more than 95. Laboratory findings showed hypoproteinemia in 30 patients. Albuminuria till 3 g/l was found in 70, more than 3 g/l in 23, pathological findings in urine sediment in 89 patients. Azotaemia was found in 58 patients. Decreased creatinine clearance was found in 80 (84.2%) patients. Kidney biopsy was not done. It can be concluded, that in observed patients the occurrence of diabetic nephropathy is in close connection with inadequate treatment and long duration of diabetes. (Journal received: June 1976)

In 2005 diabetics treated during 10 years, 95 cases of diabetic nephropathy were found. Of 95 observed patients 57 were females and 38 males in the age group of more than 50 years (83.1%). The duration of diabetes was 1-30 yrs, mostly 6-30 yr (82 patients). In 86.2% cases it was a maturity onset diabetes. Most of them were treated with insulin and diet (78.4%). Most patients (68.4%) were under bad control. Clinically in 36 patients edemas were found. In 75.8% the diastolic blood pressure was more than 95. Laboratory findings showed hypoproteinemia in 30 patients. Albuminuria till 3 g/l was found in 70, more than 3 g/l in 23, pathological findings in urine sediment in 89 patients. Azotaemia was found in 58 patients. Decreased creatinine clearance was found in 80 (84.2%) patients. Kidney biopsy was not done. It can be concluded, that in observed patients the occurrence of diabetic nephropathy is in close connection with inadequate treatment and long duration of diabetes. (Journal received: June 1976)

Corticosteroid hormones administered into the organism for therapeutic purposes have a certain effect on different organs and systems, especially on the endocrine system. It was interesting to find out the effect of corticosteroid therapy of different duration on the sympathetic adrenal system i.e. on urinary elimination of norepinephrine. The examination concerned 28 patients with systemic diseases and 8 healthy individuals who never were given corticosteroids. The patients were divided into 3 groups: 1). group on a short therapy; 2). group on a long therapy and 3). group on a prolonged therapy. The amount of norepinephrine in urine was determined by spectrophotofluorometric method. A multiphasic urinary elimination of norepinephrine was registered. After a short therapy corticosteroids provoked a decreased norepinephrine elimination i.e. a decreased activity of the sympathetic nervous system. After a several-month-therapy the elimination of norepinephrine returned to normal. However, after a prolonged corticosteroid therapy a definite decrease of sympathetic activity was observed. The result showed a positive correlation between norepinephrine excretion and administered dose of Pronison. The greatest fall of sympathetic activity was observed during small, suppressive doses of Pronison (5 mg daily). A prolonged administration of 80 mg doses increased urinary elimination of norepinephrine. This is possibly due to a central stimulating activity of corticosteroids on the sympathicus. It is concluded that a prolonged corticosteroid therapy provoked a fluctuation of sympathetic activity. Therefore the therapy should be intermittent. It is known that a prolonged corticosteroid treatment, especially a synthetic corticosteroid therapy, can provoke hypertension which is the consequence not only of water and salt retention, but also of increased sympathetic activity.

[No abstract available]

[No abstract available]

[No abstract available]

[No abstract available]

[No abstract available]

[No abstract available]

[No abstract available]

Thrombocyte aggregation was investigated in 15 diabetic patients with clinically pronounced vascular complications and with hyperlipoproteinemia type IV. By means of an aggregometer (type 'Mustard') the maximum amplitude of the decreased optical density and the degree of speed of the decreased optical density in a given unit of time were determined after adding 2 micrograms of ADP to the thrombocyte rich plasma. In comparison with 13 healthy subjects from the control group, a statistically significant higher maximum amplitude of the decreased optical density and a greater degree of the speed of the decreased optical density were noted among diabetics. Considering these facts, the authors suggest a possible influence of hyperlipoproteinemia upon the increased thrombocyte aggregation in diabetics with vascular complications.

Thrombocyte aggregation was investigated in 15 diabetic patients with clinically pronounced vascular complications and with hyperlipoproteinemia type IV. By means of an aggregometer (type 'Mustard') the maximum amplitude of the decreased optical density and the degree of speed of the decreased optical density in a given unit of time were determined after adding 2 micrograms of ADP to the thrombocyte rich plasma. In comparison with 13 healthy subjects from the control group, a statistically significant higher maximum amplitude of the decreased optical density and a greater degree of the speed of the decreased optical density were noted among diabetics. Considering these facts, the authors suggest a possible influence of hyperlipoproteinemia upon the increased thrombocyte aggregation in diabetics with vascular complications.

[No abstract available]