Browsing by Author "Marinkovic, J.M. (7004611210)"

Objectives: This study aims to investigate whether overweight and obesity are related to the clinical (C) category of clinical, etiologic, anatomic and pathophysiologic (CEAP) classification of chronic venous disease (CVD). Design: A cross-sectional study. Materials and methods: The study was conducted in Serbia, in the year 2011. Men and women aged >18 years, consecutively coming to venous specialists because of venous problems in the legs, were included in the study. Patients demographic, anthropometric and clinical data were collected. For the analysis, univariate and multivariate logistic regressions were used. Results: The study comprised 1116 subjects with primary CVD, 384 (34.4%) men and 732 (65.6%) women. Among them 464 (41.6%) were normal-weight patients (body mass index (BMI) < 25.0 kg m-2), 476 (42.7%) were overweight (BMI = 25.0-29.9 kg m-2) and 176 (15.8%) were obese (BMI ≥ 30.0 kg m-2). According to multivariate analysis, the CEAP C category of CVD was significantly more advanced in overweight and obese patients, the association being more pronounced in obese. Compared groups did not differ in the presence of venous reflux. In univariate analysis, venous obstruction was related to overweight and obesity but this association did not substantially affect the relationship between obesity and CEAP C categories of CVD. Conclusion: The CEAP C categories of CVD were significantly related to overweight and obesity, and this association was independent of age, sex and some other postulated risk factors.© 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

In this study, we investigated whether the occurrence and intensity of leg pain are related to C class of the clinical, etiological, anatomical, and pathophysiological (CEAP) classification for chronic venous disease (CVeD). This cross-sectional study, conducted in Serbia, included 2841 patients: 2027 (71.3%) women and 814 (28.7%) men with CVeD diagnosed by general practitioners. For the first time, the Numeric Rating Scale of 0 to 5 units was used to assess the intensity of pain. For the analysis, univariate and multivariate logistic and linear regressions were applied. Pain in the legs was reported by 90.5% of the patients. The occurrence of pain significantly (P <.001) increased with increasing C class. Of the patients who reported pain in the legs, 42.0% had moderate pain, 23.7% had moderate to severe pain, 22.8% had light pain, 11.2% had severe pain, and 0.3% had very severe pain. Severity of pain differed significantly (P <.001) according to C class. Light and moderate pain gradually decreased and severe pain gradually increased from C0 to C6 class. These associations remained significant after adjustment for age, body mass index, and family history of CVeD. © SAGE Publications.

The aim of this study was to assess the risk factors for basal cell carcinoma (BCC). A case-control study, carried out in two towns in Yugoslavia, comprised 200 BCC cases and 399 controls. For statistical analysis, univariate and multivariate logistic regressions were used. The risk factors found for BCC were: freckling before the age 15, seven or more weeks per year spent at the seaside during holidays (lifetime average), outdoor work during summer-time, occupational exposure to organic and non-organic dissolvents and organophosphatic compounds, use of tar for cosmetic purposes, and previous BCC in personal history. Subjects who tended to burn and not to tan after sun exposure also showed a significantly higher risk for BCC. Brown eyes and history of acne had a protective effect. This study confirmed the role of both constitutional and environmental factors in the development of BCC.

Background: Thyroid cancer is relatively rare, but it is the most frequent cancer among malignancies of the endocrine system. To evaluate the association between thyroid cancer and potential risk factors. Material and methods: A case-control study was conducted in Central Serbia, Yugoslavia. The case group consisted of 100 newly diagnosed patients with histologically confirmed thyroid cancer. The controls (100 patients with injuries) were individually matched with cases by sex, age and place of residence. McNemar's test and conditional logistic regression were used in the analysis. Results: According to logistic regression analysis the following factors were independently related with the occurrence of thyroid cancer: diagnostic X- ray during childhood and/or youth goiter, history of residence in endemic goiter area, anemia in personal history, history of previous malignant tumors, family history of any malignant tumor, spontaneous abortion and use of oral contraceptives. Conclusion: The present study supports the hypothesis that besides other risk factors, thyroid cancer in women is affected by some reproductive and probably hormonal factors.

[No abstract available]