Browsing by Author "Marinkovic, Dragoslav (7006275625)"

In this population-genetic study, we compared morphological and genetic variability of a control group of individuals with that of developing and elite water polo players from Serbia, using a test of determination of homozygously recessive characteristics in humans (HRC-test). Comparisons of the frequencies of ABO and Rh blood types were also made for the groups examined. The degree of genetic homozygosity showed not only statistically significant differences in the mean values obtained for the studied samples (control group 5.1 ± 0.2; emerging water polo players 3.5 ± 0.1; elite water polo players 1.9 ± 0.3 HRCs, out of 20 analysed characteristics), but also differences in the type of distribution, as well as the presence of specific combinations of such traits. During identification of swimming talents, the degree of genetic homozygosity showed a significant decrease, from 4.8 ± 0.3 in the group of pre-competitive young boys, to 2.7 ± 0.3 in selected adult team members, to only 1.9 ± 0.3 in elite water polo players. In the group of pre-competitive young individuals, all characteristics tested also had homo-recessive combinations, while in the group of elite water polo players only 8 of 20 traits were expressed as homozygously recessive. In the group of elite water polo players, who were World and European champions as well as Olympic champions, the frequencies of the A and B blood types were low, AB was absent, and the frequency of the O blood type was high at 72.2% (i.e. almost twice the expected percentage).

In this population-genetic study, we compared morphological and genetic variability of a control group of individuals with that of developing and elite water polo players from Serbia, using a test of determination of homozygously recessive characteristics in humans (HRC-test). Comparisons of the frequencies of ABO and Rh blood types were also made for the groups examined. The degree of genetic homozygosity showed not only statistically significant differences in the mean values obtained for the studied samples (control group 5.1 ± 0.2; emerging water polo players 3.5 ± 0.1; elite water polo players 1.9 ± 0.3 HRCs, out of 20 analysed characteristics), but also differences in the type of distribution, as well as the presence of specific combinations of such traits. During identification of swimming talents, the degree of genetic homozygosity showed a significant decrease, from 4.8 ± 0.3 in the group of pre-competitive young boys, to 2.7 ± 0.3 in selected adult team members, to only 1.9 ± 0.3 in elite water polo players. In the group of pre-competitive young individuals, all characteristics tested also had homo-recessive combinations, while in the group of elite water polo players only 8 of 20 traits were expressed as homozygously recessive. In the group of elite water polo players, who were World and European champions as well as Olympic champions, the frequencies of the A and B blood types were low, AB was absent, and the frequency of the O blood type was high at 72.2% (i.e. almost twice the expected percentage).

Acting on the assumption that susceptibility to alcohol dependence is genetically controlled, we have developed a hypothesis that a generally increased homozygosity level, as well as a changed variability in the group of alcoholics, could be a population genetic parameter for predicting this dependence. A morphophysiological test was used to identify the proportion of homozygously recessive characteristics (HRC test), so that the comparison of presence and distribution of the 25 selected homorecessive traits was carried out between the group of 100 cured alcoholics (the A group), and a control group consisting of 100 non-alcoholics (the C group). This population genetic study revealed not only a statistically significant difference in the mean values of genetic homozygosity (A: 9.3 ± 0.2, C: 8.2 ± 0.2), but also the differences in the distribution type, as well as in the variances of presence of certain specific combinations of such traits. In 18 of the 25 observed characteristics, recessive homozygosity was expressed to a greater degree among the group of alcoholics, while for 10 of the traits this level of difference was statistically significant. The fact that the genes controlling such qualitative recessive traits are distributed in different human chromosomes as their visible markers, could indicate that the genetic homozygosity degrees are visibly higher in the sample of alcohol dependents when compared to the group of individuals free from such dependence. Further application of the HRC testing as an easy procedure may have its practical use in identifying the presence of such indicators in young individuals in order to detect a possible future inclination to alcoholism.