Browsing by Author "Maksimović, Ž. (26537806600)"

Objectives: The pathogenesis of venous ulceration is not completely understood. The aim of this research was to measure and compare various parameters in ulcers caused by abnormalities in superficial venous (SU) versus deep venous flow (DU), to determine possible differences in their pathogenesis. Methods: Analysis of venous blood gases and levels of anaerobic metabolites from the ulcer site were measured in SU (n=8) and DU patients (n=8) and compared with control samples from the contralateral healthy limb. Histological examination via electron microscopy was also performed in tissue samples from the ulcer sites in SU (n=2) and DU (n=2) patients. Results: The SU group had significantly lower values of partial oxygen pressure (pO 2) and oxygen saturation (sO 2), and significantly higher values of partial pressure of carbon dioxide, bicarbonate concentration and total carbon dioxide versus control samples. The DU group had significantly higher values of pO 2 and sO 2 versus controls. Elevated levels of pyruvate (P <0.01) and lactate (P <0.05) were found in DU ulcer blood samples taken after 30 min of passive standing (static shear), as compared with control blood samples. However, no significant histological differences between SU and DU samples could be distinguished via electron microscopy. Conclusions: Differences in levels of venous blood gases and anaerobic metabolites indicate a potential difference in the causation and development of superficial versus deep venous caused ulcers. This may have clinical significance for the diagnosis and treatment of these conditions. © 2007 Royal Society of Medicine Press.

Introduction: Deep vein thrombosis (DVT) is present in 10.6% patients after operative treatment for ovarian malignancy. We undertook the present study to find the risk factors for venous thromboembolism (VTE) after surgical treatment for ovarian cancer and to clarify the prognostic value of D-dimer and a positive PTP test (Wells score) in these patients. Material and Methods: A total of 31 consecutive patients with histologically confirmed ovarian cancer after surgery, clinically suspicious for DVT were followed from January 2006 to December 2008. All patients were operatively treated at the Clinical Center of Serbia. Study variables included age, cardiovascular disease, FIGO stage, histology, BMI, presence of massive ascites and tumor size, D-dimer level and Wells score. All patients were postoperatively administered anticoagulant therapy. Results: DVT was found in nine of 31 patients (29.0%). High BMI and presence of massive ascites were significantly associated with DVT D-dimer (DD) levels were high in 27 of out 31 patients (87.1%). Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 100, 18.2, 33.3 and 100%. Results of the PTP test (according to Wells score) was positive in 20 out of 31 patients (64.5%). PTP score was not significantly different in patients with or without VTE (p = 0.606). Sensitivity, specificity, PPV and NPV were 66.7, 36.4, 30.0 and 72.7%, respectively. Conclusion: Incidence of VTE after gynecological operations for ovarian cancer in our study was similar to other investigators. Obesity and the massive ascites are statistically significant risk factors. Measurement of DD level and ultrasonography could become the standard in predicting VTE in ovarian cancer surgery. The use of Wells score is not satisfying in these patients. Prediction of VTE after gynecological surgery needs further confirmation in randomized controlled trials.

Aim. The aim of this paper was to determine the role of ultrasonographic examination in acute progressive thrombophlebitis (APT) of great saphenous vein (GSV) and its impact in considering indications for urgent surgical treatment. Methods. In this retrospective study, out of 141 consecutive patients operated due to APT of GSV above the knee, 63 were examined by ultrasonography prior surgery. Results. Out of 63 operated patients, in 38 duplex ultrasonography (DUS) revealed that proximal level of phlebitic process was more than 5 cm higher than the one found during physical examination (60.3%). In this group, the mean difference between DUS and clinical finding was 8.5±3.5 cm. In 25 patients there were no differences greater than 5 cm found between DUS and physical examination (39.7%). There was statistically highly significant difference between DUS and physical examination findings (χ 2=6.5, P<0.01). Conclusion. This study revealed significant difference between ultrasonographic and physical findings in patients with APT of GSV. DUS presented as reliable diagnostic method in examining, course-following and making decision for operative treatment of these patients.