Browsing by Author "Leurs, C.E. (56866079400)"

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Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study
(2020)
Leurs, C.E. (56866079400)
;
Twaalfhoven, H.A.M. (26533533200)
;
Lissenberg-Witte, B.I. (57204744042)
;
van Pesch, V. (15847200900)
;
Dujmovic, I. (6701590899)
;
Drulovic, J. (55886929900)
;
Castellazzi, M. (57190160648)
;
Bellini, T. (7004337741)
;
Pugliatti, M. (6603827112)
;
Kuhle, J. (8937520800)
;
Villar, L.M. (35518965300)
;
Alvarez-Cermeño, J.C. (7004605927)
;
Alvarez-Lafuente, R. (13411081600)
;
Hegen, H. (57202373490)
;
Deisenhammer, F. (7004758773)
;
Walchhofer, L.M. (57194580116)
;
Thouvenot, E. (35325407800)
;
Comabella, M. (6701491362)
;
Montalban, X. (7007177960)
;
Vécsei, L. (35452449900)
;
Rajda, C. (6603645376)
;
Galimberti, D. (6701617660)
;
Scarpini, E. (57210771033)
;
Altintas, A. (7006317905)
;
Rejdak, K. (8284992700)
;
Frederiksen, J.L. (7102315536)
;
Pihl-Jensen, G. (56568478300)
;
Jensen, P.E.H. (57214664093)
;
Khalil, M. (55628524072)
;
Voortman, M.M. (57195917900)
;
Fazekas, F. (7102945505)
;
Saiz, A. (56213393300)
;
La Puma, D. (56422282100)
;
Vercammen, M. (6602461163)
;
Vanopdenbosch, L. (6602558181)
;
Uitdehaag, B.M.J. (57243388200)
;
Killestein, J. (7004423164)
;
Bridel, C. (6508071655)
;
Teunissen, C. (6701704380)
Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2–138.1). The cut-off for the LFLC index was 6.9 (95% CI = 4.5–22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85–0.90) was higher than OCB (0.82; 95%CI = 0.79–0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78–0.88) was lower (OCB = 0.92; 95% CI = 0.89–0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. © The Author(s), 2019.
Some of the metrics are blocked by your
consent settings
Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study
(2020)
Leurs, C.E. (56866079400)
;
Twaalfhoven, H.A.M. (26533533200)
;
Lissenberg-Witte, B.I. (57204744042)
;
van Pesch, V. (15847200900)
;
Dujmovic, I. (6701590899)
;
Drulovic, J. (55886929900)
;
Castellazzi, M. (57190160648)
;
Bellini, T. (7004337741)
;
Pugliatti, M. (6603827112)
;
Kuhle, J. (8937520800)
;
Villar, L.M. (35518965300)
;
Alvarez-Cermeño, J.C. (7004605927)
;
Alvarez-Lafuente, R. (13411081600)
;
Hegen, H. (57202373490)
;
Deisenhammer, F. (7004758773)
;
Walchhofer, L.M. (57194580116)
;
Thouvenot, E. (35325407800)
;
Comabella, M. (6701491362)
;
Montalban, X. (7007177960)
;
Vécsei, L. (35452449900)
;
Rajda, C. (6603645376)
;
Galimberti, D. (6701617660)
;
Scarpini, E. (57210771033)
;
Altintas, A. (7006317905)
;
Rejdak, K. (8284992700)
;
Frederiksen, J.L. (7102315536)
;
Pihl-Jensen, G. (56568478300)
;
Jensen, P.E.H. (57214664093)
;
Khalil, M. (55628524072)
;
Voortman, M.M. (57195917900)
;
Fazekas, F. (7102945505)
;
Saiz, A. (56213393300)
;
La Puma, D. (56422282100)
;
Vercammen, M. (6602461163)
;
Vanopdenbosch, L. (6602558181)
;
Uitdehaag, B.M.J. (57243388200)
;
Killestein, J. (7004423164)
;
Bridel, C. (6508071655)
;
Teunissen, C. (6701704380)
Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2–138.1). The cut-off for the LFLC index was 6.9 (95% CI = 4.5–22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85–0.90) was higher than OCB (0.82; 95%CI = 0.79–0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78–0.88) was lower (OCB = 0.92; 95% CI = 0.89–0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. © The Author(s), 2019.