Browsing by Author "Lazovic, Milica (23497397400)"
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Publication Clinoptilolite for treatment of dyslipidemia: Preliminary efficacy study(2017) ;Cutovic, Milisav (23495402400) ;Lazovic, Milica (23497397400) ;Vukovic-Dejanovic, Vesna (56442699500) ;Nikolic, Dejan (26023650800) ;Petronic-Markovic, Ivana (57192176867)Cirovic, Dragana (25121527800)Objectives: A tribomechanically activated clinoptilolite (natural aluminosilicate mineral) has been used to increase growth in meat-producing animals, as an adjuvant in cancer therapy, and a heavy metal remover in humans. Because of its unique cation exchanging and chelating properties, we hypothesized that clinoptilolite may be beneficial for the treatment of dyslipidemia in the manner similar to bile acid sequestrants. Thus, specific aims of this pilot study were to orally administer clinoptilolite in different doses and granule size combinations to determine magnitude and time profile of changes in blood lipids. Design: A phase I/IIa prospective, open-label, uncontrolled, dose/granule size-ranging study (treatment phase 8 weeks, follow-up 6 weeks). Blood lipids were examined every 2 weeks. Settings: Outpatient clinic of a university-affiliated hospital. Subjects: Forty-one subjects (all white, mean age 57.6 ± 6.8 years, 17 women) with blood lipids above the normative limits divided into three groups. Intervention: A tribomechanically activated clinoptilolite was administered in three dose/grind combinations: 6 g/day of fine grind (6gF), 6 g/day of coarse grind (6gC), and 9 g/day of coarse grind (9gC). Outcome measures: Blood concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc), and triglycerides (TG). Results: For the 3 groups combined, all lipid fractions significantly improved after 8 weeks of treatment (20-25%, p < 0.001), which reversed to baseline after 6 weeks of clinoptilolite withdrawal. Early (week 2) and the most pronounced decrease in TC and LDLc was observed in the 6gF group (19% and 23% in week 8, respectively), with no difference in HDLc and TG between the three dose/grind groups. No side effects were reported. Conclusions: These pilot results suggest that oral administration of clinoptilolite may improve lipid profile in individuals with dyslipidemia, which warrants further investigations. © Copyright 2017, Mary Ann Liebert, Inc. - Some of the metrics are blocked by yourconsent settings
Publication Comorbidity impact on social functioning after hip fracture: The role of rehabilitation(2016) ;Radosavljevic, Natasa (55245822900) ;Nikolic, Dejan (26023650800) ;Lazovic, Milica (23497397400) ;Hrkovic, Marija (56191243000)Ilic-Stojanovic, Olivera (24401526100)Objective: To analyze the impact of rehabilitation treatment on social functioning in elderly patients after hip fracture during a rehabilitation program. Methods: This study included 203 patients with hip fracture. Four groups were analyzed on rehabilitation: Group 1, at admission, Group 2, at discharge, Group 3, three months after discharge and Group 4, six months after discharge. The analyzed parameters included: Musculoskeletal, neurological and cognitive impairments. Impairment severity was graded by cumulative index rating scale for geriatrics (CIRS-G). Evaluation of social functioning was completed by social functioning component (SFC) from quality of life (SF-36) questionnaire. Results: There was a significant improvement in SF-36 SFC values for observed impairments from admission to six months after discharge for each severity degree (p < 0.01), except for CIRS-G severity degree 4 for cognitive impairment, where significance was p < 0.05. For the group of patients with musculoskeletal impairment, there was a significant difference between the values of SF-36 SFC concerning different severity degrees of CIRS-G only at six months after discharge (p < 0.05). Patients with neurological or cognitive impairments have shown significant differences between the values of SF-36 SFC in regard to severity degrees of CIRS-G in all observational groups. Conclusion: Different degrees of observed impairments influence the degree of social functioning recovery in the elderly after hip fracture. - Some of the metrics are blocked by yourconsent settings
Publication Comorbidity impact on social functioning after hip fracture: The role of rehabilitation(2016) ;Radosavljevic, Natasa (55245822900) ;Nikolic, Dejan (26023650800) ;Lazovic, Milica (23497397400) ;Hrkovic, Marija (56191243000)Ilic-Stojanovic, Olivera (24401526100)Objective: To analyze the impact of rehabilitation treatment on social functioning in elderly patients after hip fracture during a rehabilitation program. Methods: This study included 203 patients with hip fracture. Four groups were analyzed on rehabilitation: Group 1, at admission, Group 2, at discharge, Group 3, three months after discharge and Group 4, six months after discharge. The analyzed parameters included: Musculoskeletal, neurological and cognitive impairments. Impairment severity was graded by cumulative index rating scale for geriatrics (CIRS-G). Evaluation of social functioning was completed by social functioning component (SFC) from quality of life (SF-36) questionnaire. Results: There was a significant improvement in SF-36 SFC values for observed impairments from admission to six months after discharge for each severity degree (p < 0.01), except for CIRS-G severity degree 4 for cognitive impairment, where significance was p < 0.05. For the group of patients with musculoskeletal impairment, there was a significant difference between the values of SF-36 SFC concerning different severity degrees of CIRS-G only at six months after discharge (p < 0.05). Patients with neurological or cognitive impairments have shown significant differences between the values of SF-36 SFC in regard to severity degrees of CIRS-G in all observational groups. Conclusion: Different degrees of observed impairments influence the degree of social functioning recovery in the elderly after hip fracture. - Some of the metrics are blocked by yourconsent settings
Publication Effect of short-term exercise training in patients following acute myocardial infarction treated with primary percutaneous coronary intervention(2016) ;Andjic, Mojsije (57190173631) ;Spiroski, Dejan (57190161724) ;Ilic Stojanovic, Olivera (24401526100) ;Vidakovic, Tijana (57190179703) ;Lazovic, Milica (23497397400) ;Babic, Dragan (56197715200) ;Ristic, Arsen (7003835406) ;Mazic, Sanja (6508115084) ;Zdravkovic, Marija (24924016800)Otasevic, Petar (55927970400)BACKGROUND: Exercise-based rehabilitation is an important part of treatment patients following acute myocardial infarction (MI). However, data are scarce on the efffects of short-term exercise programs in patients with acute MI treated with primary percutaneous coronary intervention (PPCI). AIM: To evaluate the effect of short-term exercise training on cardiopulmonary exercise testing (CPET) parameters in patients suffering acute MI treated with PPCI. STUDY DESIGN: Observational longitudinal study. SETTING: Inpatient cardiac rehabilitation. POPULATION: Sixty consecutive patients with MI treated with PPCI referred for rehabilitation. METHODS: We studied 60 consecutive patients with MI treated with PPCI reffered for rehabilitation to our institution. The study population consisted of 54 men and 6 women (age 52.0±8.4 years, left ventricular ejection fraction 54.1±8.1%), who participated in a 3-week clinical cardiac rehabilitation program. The program consisted of cycling for 7 times/week, and daily walking for 45 minutes at an intensity of 70-80% of the individual maximal heart rate. All patients performed symptom-limited CPET on a bicycle ergometer with a ramp protocol of 10 w/min. The CPET was also performed after cardiac rehabilitation programs. RESULTS: After 3 weeks of exercise-based cardiac rehabilitation program improved exercise tolerance as compared to baseline (peak workload 119.28±20.45 vs. 104.35±22.01 watts, respectively, P<0.001), as well as peak respiratory exchage ratio (1.10±0.14 vs. 1.04±0.01, respectively, P<0.001). Peak heart rate at rest, peak and after 1 minute of rest were also improved. Most importantly, peak V02 (19.27±4.16 vs. 17.27±3.34 ml/kg/min, respectively, P<0.001), peak VC02 (1.83±0.38 vs. 1.58±0.30, respectively, P<0.001), peak ventilatory exchange (53.73Ü2.47 vs. 45.50±11.32 L/min, respectively, P<0.001) and peak breathing reserve (55.20±12.36 vs. 60.18±14.19%, respectively, P<0.001) were also improved. No major adverse cardiac events were noted during the rehabilitation program. CONCLUSIONS: Our data indicate that short-term exercise training in patients with acute MI treated with PPCI is safe and improves functional capacity, as well as test duration, work load and heart rate response. CLINICAL REHABILITATION IMPACT: It appears that three week cardiac rehabilitation is an effective approach to improve exercise capacity in patients with acute MI treated with PPCI. © 2016 EDIZIONI MINERVA MEDICA. - Some of the metrics are blocked by yourconsent settings
Publication Effect of short-term exercise training in patients following acute myocardial infarction treated with primary percutaneous coronary intervention(2016) ;Andjic, Mojsije (57190173631) ;Spiroski, Dejan (57190161724) ;Ilic Stojanovic, Olivera (24401526100) ;Vidakovic, Tijana (57190179703) ;Lazovic, Milica (23497397400) ;Babic, Dragan (56197715200) ;Ristic, Arsen (7003835406) ;Mazic, Sanja (6508115084) ;Zdravkovic, Marija (24924016800)Otasevic, Petar (55927970400)BACKGROUND: Exercise-based rehabilitation is an important part of treatment patients following acute myocardial infarction (MI). However, data are scarce on the efffects of short-term exercise programs in patients with acute MI treated with primary percutaneous coronary intervention (PPCI). AIM: To evaluate the effect of short-term exercise training on cardiopulmonary exercise testing (CPET) parameters in patients suffering acute MI treated with PPCI. STUDY DESIGN: Observational longitudinal study. SETTING: Inpatient cardiac rehabilitation. POPULATION: Sixty consecutive patients with MI treated with PPCI referred for rehabilitation. METHODS: We studied 60 consecutive patients with MI treated with PPCI reffered for rehabilitation to our institution. The study population consisted of 54 men and 6 women (age 52.0±8.4 years, left ventricular ejection fraction 54.1±8.1%), who participated in a 3-week clinical cardiac rehabilitation program. The program consisted of cycling for 7 times/week, and daily walking for 45 minutes at an intensity of 70-80% of the individual maximal heart rate. All patients performed symptom-limited CPET on a bicycle ergometer with a ramp protocol of 10 w/min. The CPET was also performed after cardiac rehabilitation programs. RESULTS: After 3 weeks of exercise-based cardiac rehabilitation program improved exercise tolerance as compared to baseline (peak workload 119.28±20.45 vs. 104.35±22.01 watts, respectively, P<0.001), as well as peak respiratory exchage ratio (1.10±0.14 vs. 1.04±0.01, respectively, P<0.001). Peak heart rate at rest, peak and after 1 minute of rest were also improved. Most importantly, peak V02 (19.27±4.16 vs. 17.27±3.34 ml/kg/min, respectively, P<0.001), peak VC02 (1.83±0.38 vs. 1.58±0.30, respectively, P<0.001), peak ventilatory exchange (53.73Ü2.47 vs. 45.50±11.32 L/min, respectively, P<0.001) and peak breathing reserve (55.20±12.36 vs. 60.18±14.19%, respectively, P<0.001) were also improved. No major adverse cardiac events were noted during the rehabilitation program. CONCLUSIONS: Our data indicate that short-term exercise training in patients with acute MI treated with PPCI is safe and improves functional capacity, as well as test duration, work load and heart rate response. CLINICAL REHABILITATION IMPACT: It appears that three week cardiac rehabilitation is an effective approach to improve exercise capacity in patients with acute MI treated with PPCI. © 2016 EDIZIONI MINERVA MEDICA. - Some of the metrics are blocked by yourconsent settings
Publication Estimation of functional recovery in patients after hip fracture by Berg Balance Scale regarding the sex, age and comorbidity of participants(2013) ;Radosavljevic, Natasa (55245822900) ;Nikolic, Dejan (26023650800) ;Lazovic, Milica (23497397400) ;Petronic, Ivana (25121756800) ;Milicevic, Vera (55292831900) ;Radosavljevic, Zoran (56107375600) ;Potic, Jelena (55293803000) ;Ilic-Stojanovic, Olivera (24401526100)Jeremic, Aleksandar (6701360652)Aim: To evaluate the functional status measured by Berg Balance Scale (BBS) in elderly aged more than 65years after hip fractures, and to evaluate the influence of sex, age and comorbidity on balance function improvement. Methods: The study included 203 patients with hip fractures. Functional status was evaluated by BBS: at admission (Group 1), at discharge (Group 2) and 3months after discharge (Group 3). We analyzed three age groups: Group65-74, Group75-84 and Group85-up; female and male sex separately; and for severity index value (SI; total cumulative illness rating scale for geriatrics score divided by number of endorsed categories): group between 0-1.99 (SI1) and group ≥2 (SI2). Results: BBS values significantly declined in all male groups and female Group 2 and Group 3 in SI2 (P<0.01). Group65-74 and Group85-up had a significant BBS values decline in Group 2 and Group 3, whereas Group75-84 had a significant decline in all groups in the SI2 group (P<0.01). Females and males had a significant BBS values increase in the SI1 groups (P<0.01), and non-significant BBS values increase between Group 2/Group 3 for SI2. Group85-up had a significant BBS values increase in SI1 (Group 1/Group 2 and Group 1/Group 3; P<0.01); a non-significant increase between Group 1/Group 2 and Group 1/Group 3, and a non-significant decline between Group 2/Group 3 in SI2. Conclusions: Male sex, increased comorbidity and age more than 85years could be considered with lower functional recovery capacity potential after hip fracture, and thus should be individually assessed and continuously monitored. Functional status estimation by BBS could be taken as a sensitive predictive value for the evaluation of functional improvement in these patients. © 2012 Japan Geriatrics Society. - Some of the metrics are blocked by yourconsent settings
Publication Estimation of functional recovery in patients after hip fracture by Berg Balance Scale regarding the sex, age and comorbidity of participants(2013) ;Radosavljevic, Natasa (55245822900) ;Nikolic, Dejan (26023650800) ;Lazovic, Milica (23497397400) ;Petronic, Ivana (25121756800) ;Milicevic, Vera (55292831900) ;Radosavljevic, Zoran (56107375600) ;Potic, Jelena (55293803000) ;Ilic-Stojanovic, Olivera (24401526100)Jeremic, Aleksandar (6701360652)Aim: To evaluate the functional status measured by Berg Balance Scale (BBS) in elderly aged more than 65years after hip fractures, and to evaluate the influence of sex, age and comorbidity on balance function improvement. Methods: The study included 203 patients with hip fractures. Functional status was evaluated by BBS: at admission (Group 1), at discharge (Group 2) and 3months after discharge (Group 3). We analyzed three age groups: Group65-74, Group75-84 and Group85-up; female and male sex separately; and for severity index value (SI; total cumulative illness rating scale for geriatrics score divided by number of endorsed categories): group between 0-1.99 (SI1) and group ≥2 (SI2). Results: BBS values significantly declined in all male groups and female Group 2 and Group 3 in SI2 (P<0.01). Group65-74 and Group85-up had a significant BBS values decline in Group 2 and Group 3, whereas Group75-84 had a significant decline in all groups in the SI2 group (P<0.01). Females and males had a significant BBS values increase in the SI1 groups (P<0.01), and non-significant BBS values increase between Group 2/Group 3 for SI2. Group85-up had a significant BBS values increase in SI1 (Group 1/Group 2 and Group 1/Group 3; P<0.01); a non-significant increase between Group 1/Group 2 and Group 1/Group 3, and a non-significant decline between Group 2/Group 3 in SI2. Conclusions: Male sex, increased comorbidity and age more than 85years could be considered with lower functional recovery capacity potential after hip fracture, and thus should be individually assessed and continuously monitored. Functional status estimation by BBS could be taken as a sensitive predictive value for the evaluation of functional improvement in these patients. © 2012 Japan Geriatrics Society. - Some of the metrics are blocked by yourconsent settings
Publication Evidence based position paper on Physical and Rehabilitation Medicine practice for people with muscular dystrophies(2021) ;Lazovic, Milica (23497397400) ;Nikolic, Dejan (26023650800) ;Boyer, François C. (8933818800) ;Borg, Kristian (7005626444) ;Ceravolo, Maria G. (6701635825) ;Zampolini, Mauro (57202997816)Kiekens, Carlotte (6603408343)Muscular dystrophies present a group of inherited degenerative disorder that are characterized by progressive muscular weakness. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section. The aim of the paper is to evaluate the role of the physical and rehabilitation medicine (PRM) physician and PRM practice for people with muscular dystrophies. Asystematic review of the literature and a consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMSPRM Section. The systematic literature review is reported together with thirty-three recommendations resulting from the Delphi procedure. The role of the PRM physician is to assess the functional status of persons with muscular dystrophy and to plan, monitor and lead PRM program in an interdisciplinary setting within a multiprofessional team. © 2021 Edizioni Minerva Medica. All rights reserved. - Some of the metrics are blocked by yourconsent settings
Publication Evidence based position paper on Physical and Rehabilitation Medicine practice for people with muscular dystrophies(2021) ;Lazovic, Milica (23497397400) ;Nikolic, Dejan (26023650800) ;Boyer, François C. (8933818800) ;Borg, Kristian (7005626444) ;Ceravolo, Maria G. (6701635825) ;Zampolini, Mauro (57202997816)Kiekens, Carlotte (6603408343)Muscular dystrophies present a group of inherited degenerative disorder that are characterized by progressive muscular weakness. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section. The aim of the paper is to evaluate the role of the physical and rehabilitation medicine (PRM) physician and PRM practice for people with muscular dystrophies. Asystematic review of the literature and a consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMSPRM Section. The systematic literature review is reported together with thirty-three recommendations resulting from the Delphi procedure. The role of the PRM physician is to assess the functional status of persons with muscular dystrophy and to plan, monitor and lead PRM program in an interdisciplinary setting within a multiprofessional team. © 2021 Edizioni Minerva Medica. All rights reserved. - Some of the metrics are blocked by yourconsent settings
Publication Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice for people with cardiovascular conditions. the European PRM position (UEMS PRM Section)(2018) ;Juocevicius, Alvydas (35784604300) ;Oral, Aydan (7006521429) ;Lukmann, Aet (57194753164) ;TAKǎč, Peter (7004605267) ;Tederko, Piotr (16837625600) ;Haznere, Ilze (57202887870) ;Aguiar-Branco, Catarina (55821487700) ;Lazovic, Milica (23497397400) ;Negrini, Stefano (16307641300) ;Varela Donoso, Enrique (36474074400)Christodoulou, Nicolas (35361449400)Cardiovascular conditions are significant causes of mortality and morbidity leading to substantial disability. The aim of the paper is to improve Physical and Rehabilitation Medicine (PRM) physicians' professional practice for people with cardiovascular conditions in order to promote their functioning and to reduce activity limitations and/or participation restrictions. A systematic review of the literature and a Consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section. The systematic literature review is reported together with thirty recommendations resulting from the Delphi procedure. The professional role of PRM physicians having expertise in the rehabilitation of cardiovascular conditions is to lead cardiac rehabilitation programs in multiprofessional teams, working in collaboration with other disciplines in a variety of settings to improve functioning of people with cardiovascular conditions. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section and designates the professional role of PRM physicians in persons with cardiovascular conditions. © 2017 EDIZIONI MINERVA MEDICA. - Some of the metrics are blocked by yourconsent settings
Publication Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice for people with cardiovascular conditions. the European PRM position (UEMS PRM Section)(2018) ;Juocevicius, Alvydas (35784604300) ;Oral, Aydan (7006521429) ;Lukmann, Aet (57194753164) ;TAKǎč, Peter (7004605267) ;Tederko, Piotr (16837625600) ;Haznere, Ilze (57202887870) ;Aguiar-Branco, Catarina (55821487700) ;Lazovic, Milica (23497397400) ;Negrini, Stefano (16307641300) ;Varela Donoso, Enrique (36474074400)Christodoulou, Nicolas (35361449400)Cardiovascular conditions are significant causes of mortality and morbidity leading to substantial disability. The aim of the paper is to improve Physical and Rehabilitation Medicine (PRM) physicians' professional practice for people with cardiovascular conditions in order to promote their functioning and to reduce activity limitations and/or participation restrictions. A systematic review of the literature and a Consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section. The systematic literature review is reported together with thirty recommendations resulting from the Delphi procedure. The professional role of PRM physicians having expertise in the rehabilitation of cardiovascular conditions is to lead cardiac rehabilitation programs in multiprofessional teams, working in collaboration with other disciplines in a variety of settings to improve functioning of people with cardiovascular conditions. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section and designates the professional role of PRM physicians in persons with cardiovascular conditions. © 2017 EDIZIONI MINERVA MEDICA. - Some of the metrics are blocked by yourconsent settings
Publication Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice for people with respiratory conditions. the European PRM position (UEMS PRM Section)(2018) ;Oral, Aydan (7006521429) ;Juocevicius, Alvydas (35784604300) ;Lukmann, Aet (57194753164) ;TAKǎč, Peter (7004605267) ;Tederko, Piotr (16837625600) ;Haznere, Ilze (57202887870) ;Aguiar-Branco, Catarina (55821487700) ;Lazovic, Milica (23497397400) ;Negrini, Stefano (16307641300) ;Donoso, Enrique Varela (55658149300)Christodoulou, Nicolas (35361449400)Chronic respiratory conditions are among the top causes of death and disability. The aim of the paper was to improve Physical and Rehabilitation Medicine (PRM) physicians' professional practice for people with chronic respiratory conditions in order to promote their functioning and to reduce activity limitations and/or participation restrictions. A systematic review of the literature and a Consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section. The systematic literature review is reported together with twenty-three recommendations resulting from the Delphi procedure. The professional role of PRM physicians having expertise in the rehabilitation of chronic respiratory conditions is to lead pulmonary rehabilitation programs in multiprofessional teams, working in collaboration with other disciplines in a variety of settings to improve functioning of people with chronic respiratory conditions. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section and designates the professional role of PRM physicians for people with respiratory conditions. © 2017 EDIZIONI MINERVA MEDICA. - Some of the metrics are blocked by yourconsent settings
Publication Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice for people with respiratory conditions. the European PRM position (UEMS PRM Section)(2018) ;Oral, Aydan (7006521429) ;Juocevicius, Alvydas (35784604300) ;Lukmann, Aet (57194753164) ;TAKǎč, Peter (7004605267) ;Tederko, Piotr (16837625600) ;Haznere, Ilze (57202887870) ;Aguiar-Branco, Catarina (55821487700) ;Lazovic, Milica (23497397400) ;Negrini, Stefano (16307641300) ;Donoso, Enrique Varela (55658149300)Christodoulou, Nicolas (35361449400)Chronic respiratory conditions are among the top causes of death and disability. The aim of the paper was to improve Physical and Rehabilitation Medicine (PRM) physicians' professional practice for people with chronic respiratory conditions in order to promote their functioning and to reduce activity limitations and/or participation restrictions. A systematic review of the literature and a Consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section. The systematic literature review is reported together with twenty-three recommendations resulting from the Delphi procedure. The professional role of PRM physicians having expertise in the rehabilitation of chronic respiratory conditions is to lead pulmonary rehabilitation programs in multiprofessional teams, working in collaboration with other disciplines in a variety of settings to improve functioning of people with chronic respiratory conditions. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section and designates the professional role of PRM physicians for people with respiratory conditions. © 2017 EDIZIONI MINERVA MEDICA. - Some of the metrics are blocked by yourconsent settings
Publication Evidence-based position paper on Physical and Rehabilitation Medicine practice for people with amyotrophic lateral sclerosis(2022) ;Lazovic, Milica (23497397400) ;Nikolic, Dejan (26023650800) ;Boyer, François C. (8933818800) ;Borg, Kristian (7005626444) ;Ceravolo, Maria G. (6701635825) ;Zampolini, Mauro (57202997816)Kiekens, Carlotte (6603408343)Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that affects both upper and lower motor neurons and is fatal in its course. This evidence-based position paper represents the official position of the UEMS PRM Section. The aim of the paper is to define the role of the physical and rehabilitation medicine (PRM) physician and PRM professional practice for people with ALS. A systematic review of the literature and a consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section. The systematic literature review is reported together with thirty-two recommendations resulting from the Delphi procedure. The responsibility of the PRM physician is functional assessment of persons with ALS and delivering the optimal and most effective PRM program of care. The rehabilitation program of patients with ALS should be delivered and monitored by the multiprofessional team, with the PRM physician as principal coordinator. © 2021 EDIZIONI MINERVA MEDICA. - Some of the metrics are blocked by yourconsent settings
Publication Evidence-based position paper on Physical and Rehabilitation Medicine practice for people with amyotrophic lateral sclerosis(2022) ;Lazovic, Milica (23497397400) ;Nikolic, Dejan (26023650800) ;Boyer, François C. (8933818800) ;Borg, Kristian (7005626444) ;Ceravolo, Maria G. (6701635825) ;Zampolini, Mauro (57202997816)Kiekens, Carlotte (6603408343)Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that affects both upper and lower motor neurons and is fatal in its course. This evidence-based position paper represents the official position of the UEMS PRM Section. The aim of the paper is to define the role of the physical and rehabilitation medicine (PRM) physician and PRM professional practice for people with ALS. A systematic review of the literature and a consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section. The systematic literature review is reported together with thirty-two recommendations resulting from the Delphi procedure. The responsibility of the PRM physician is functional assessment of persons with ALS and delivering the optimal and most effective PRM program of care. The rehabilitation program of patients with ALS should be delivered and monitored by the multiprofessional team, with the PRM physician as principal coordinator. © 2021 EDIZIONI MINERVA MEDICA. - Some of the metrics are blocked by yourconsent settings
Publication Factors associated with poor self-reported function and quality of life in patients with end-stage knee or hip osteoarthritis immediately prior to total joint arthroplasty(2021) ;Kocic, Mirjana (23497434000) ;Milenkovic, Marina (57191626903) ;Nikolic, Dejan (26023650800) ;Lazovic, Milica (23497397400) ;Grbic, Rade (56925109400) ;Colovic, Hristina (12774005700)Stojanovic, Zorica (57191632071)Introduction: The aim was to evaluate patients' perception of function and physical and mental dimensions of health-related quality of life (HRQoL) in patients with end-stage knee or hip osteoarthritis (OA) immediately prior to surgery and to identify the factors associated with the outcomes. Material and methods: The study included 200 patients with end-stage OA (100 knee OA and 100 hip OA patients). Self-reported physical function was assessed using the Oxford Knee Score or Oxford Hip Score. Physical and mental dimensions of HRQoL were assessed using the physical and mental component summary scores of the 36-Item Short-Form Health Survey. Multivariate linear regression analysis was used to identify the sociodemographic, clinical and psychological factors associated with self-reported function and physical and mental dimensions of HRQoL. Results: End-stage knee or hip OA patients had poor function and physical dimension of HRQoL, while the mental dimension of HRQoL was not impaired. In knee OA, pain, flexion range of motion (ROM), catastrophizing, and anxiety were significantly associated with self-reported function (explained 56% of the variance), whereas catastrophizing explained 10% of the variance of the physical dimension of HRQoL. In hip OA, flexion ROM, catastrophizing and being employed were significantly associated with self-reported function (explained 44% of the variance), whereas catastrophizing and flexion ROM explained 34% of the variance of the physical dimension of HRQoL. Conclusions: Many investigated factors were associated with poor self-reported function and HRQoL in knee and hip OA. However, the most important factors for both knee and hip OA were catastrophizing and flexion ROM. © Termedia & Banach. - Some of the metrics are blocked by yourconsent settings
Publication Functional status measured by Levine questionnaire in surgically and conservatively treated patients with carpal tunnel syndrome regarding nerve conduction studies(2016) ;Hrkovic, Marija (56191243000) ;Lazovic, Milica (23497397400) ;Nikolic, Dejan (26023650800) ;Nikcevic, Ljubica (56233258300) ;Ilic-Stojanovic, Olivera (24401526100)Filipovic, Tamara (57191260384)AIM: To evaluate and compare the functional status in surgically treated patients with Carpal tunnel syndrome (CTS) compared with those treated conservatively by Levine Questionnaire (LQ) in relation to electroneurographic findings. METHODS: The prospective study included 80 patients with diagnosed CTS. Patients were assessed clinically and electrophysiologically. The main outcome measures were sensory latency of median nerve (SL II), and terminal (distal) motor latency of median nerve (TML). For the assessment of functional status we performed Levine Questionnaire (LQ) scoring examination which was divided in two sections: symptoms severity scale (SSS) and functional status scale (FSS). Regarding treatment options patients were divided into 2 groups: group that underwent surgical procedure (Group A) and group that underwent only conservative treatment (Group B). Patients were assessed neurophysiologically twice: before treatment and 12 months after treatment. RESULTS: There is significant increase in LQ-FSS (p=0.021) and LQ-SSS (p=0.038) scores for increased TML and significant increase of LQ-SSS scores (p=0.027) for increased SL II for Group A, while in Group B, LQ-FSS (p=0.034) and LQ-SSS (p=0.018) were significantly increased in patients with increased SL II. After treatment there was significant increase in LQ-FSS (p=0.037) and LQ-SSS (p=0.041) scores for increased SL II for Group B, while in Group A after treatment, we have noticed non-significant differences both regarding TML and SL II values. CONCLUSION: We have demonstrated the benefits of surgical treatment and better functional improvement with symptoms reduction particularly in more severe cases of patients with CTS. - Some of the metrics are blocked by yourconsent settings
Publication Influence of fear of movement on total knee arthroplasty outcome(2015) ;Kocic, Mirjana (23497434000) ;Stankovic, Anita (36629404400) ;Lazovic, Milica (23497397400) ;Dimitrijevic, Lidija (24168136600) ;Stankovic, Ivona (54987130800) ;Spalevic, Marija (55554020000) ;Stojiljkovic, Predrag (23487321000) ;Milenkovic, Marina (57191626903) ;Stojanovic, Zorica (57191632071)Nikolic, Dejan (26023650800)AIM: The aim of the study was to investigate the occurence of postoperative fear of movement in total knee arthroplasty (TKA) patients and to determine the association of fear of movement with established outcome measures. METHODS: A prospective study included 78 patients with primary TKA for osteorthritis. The occurence of fear of movement was assessed by Tampa Scale of Kinesiophobia (TSK). The patients were assessed at three time points: 2 weeks, 4 weeks and 6 months after the surgery. Pain and flexion were measured at all the three time points while function according to the Oxford knee score 1 was evaluated only at 6 month after surgery. RESULTS: Fear of movement occurred in 17 patients (21.8%). Patients with a high degree of fear of movement showed significantly poorer results compared to those with a low degree in terms of pain, flexion and function. Improvement in pain and flexion over time was achieved in both groups but it was significantly greater in the low degree fear of movement group. DISCUSSION: Our study showed that postoperative fear of movement was significantly associated with pain, flexion and function. Other authors found that preoperative level of fear of movement was a predictor of postoperative functional limitations. CONCLUSIONS: Fear of movement occurred in a substantial proportion of patients after TKA and it was associated with knee pain, flexion and function. According to our results fear of movement may represent a risk for poor TKA outcome. - Some of the metrics are blocked by yourconsent settings
Publication Morphogenetic variability and hypertension in ischemic stroke patients—preliminary study(2018) ;Savic, Milan (57206453158) ;Cvjeticanin, Suzana (55924655300) ;Lazovic, Milica (23497397400) ;Nikcevic, Ljubica (56233258300)Nikolic, Dejan (26023650800)In this study, we evaluated and compared the morphogenetic variability and the degree of recessive homozygosity in patients with manifested ischemic stroke compared to healthy controls. We have evaluated 120 patients with manifested ischemic stroke, of which 64 did not have hypertension and 56 have hypertension. For comparison, we additionally tested 194 healthy individuals without manifested ischemic stroke (controls). For the estimation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. There was a significant difference in the individual variations of 19 HRCs between the controls and patients with manifested ischemic stroke (2 = 60.162, p < 0.01). The mean values of the tested HRCs significantly differed between the controls and group with manifested ischemic stroke (Controls − 5.71 ± 1.61, Ischemic stroke group − 6.25 ± 1.54, p = 0.012). For the tested individuals with hypertension, the mean values of HRCs did not significantly differ between the controls and those that had manifested ischemic stroke (Controls − 5.28 ± 1.75, Ischemic stroke group − 5.64 ± 1.48, p = 0.435). We found a significant difference in the frequencies of HRCs between those with and without hypertension for controls (p < 0.003) and for those with manifested ischemic stroke (p < 0.001). There are increased degrees of recessive homozygosity along with decreased variability in patients with manifested ischemic stroke compared to controls. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. - Some of the metrics are blocked by yourconsent settings
Publication Postacute Rehabilitation Impact on Functional Recovery Outcome and Quality of Life in Stroke Survivors: Six Month Follow-Up(2022) ;Bisevac, Emir (57224485277) ;Lazovic, Milica (23497397400) ;Nikolic, Dejan (26023650800) ;Mahmutovic, Elvis (57195362657) ;Dolicanin, Zana (25924848600)Jurisic-Skevin, Aleksandra (37072707300)Background and Objectives: This study aimed to examine the impact of postacute rehabilitation duration on the outcome of the functional recovery and patients’ quality of life after the stroke. Materials and Methods: One hundred patients (52 females, 48 males, mean age: 66.5 ± 7.3; range 53 to 79 years) who experienced a stroke (50 with ischemic stroke (IS) and 50 with intracranial hemorrhage (ICH)) took part in the study. Patients (treated with postacute rehabilitation measures for six months) were examined after one, three, and six months of postacute rehabilitation. Functional independence was measured using the functional independence measure (FIM) test, while the EQ-5D-3L questionnaire was used to assess the quality of life. Results: Patients with ICH had a slightly lower FIM score (FIM motor = 29.8 ± 11.8; FIM cognitive = 14.4 ± 4.6) on admission compared to patients with IS (FIM motor = 41.8 ± 18.8; FIM cognitive = 18.7 ± 6.3), but, after six months of postacute rehabilitation, patients with ICH reached an approximate level of functional independence (FIM motor = 53.8 ± 14.4; FIM cognitive = 25.8 ± 4.7), as did patients with IS (FIM motor = 67.6 ± 16.4; FIM cognitive = 29.2 ± 4.0). The motor and cognitive FIM, as well as quality of life, was statistically significantly increased at all four measurement points (p < 0.001). Furthermore, there is a statistically significant connection between functional independence and quality of life at all tested times. Conclusion: Patients achieved the highest degree of functional independence after six months. Furthermore, our findings point out that inpatient rehabilitation as well as outpatient rehabilitation are effective in functionality and quality of life improvement after a stroke; thus, both should be emphasized and regularly implemented. © 2022 by the authors.
