Browsing by Author "Kocev, N. (6602672952)"

Purpose: Dietary factors have been suggested as having a major role in the etiology of prostate cancer. The purpose of this study was to investigate whether there are differences in the dietary factors between younger and older men with prostate cancer. Materials and methods: A case-control study was conducted in two towns of Serbia without provinces. The case group consisted of 101 patients with histologically confirmed prostate cancer and the control group of 202 hospital patients with no neoplastic disorders (for each case two controls were chosen). Cases and controls were individualy matched by age (± 2 years), time of hospital admission and place of residence. Univariate and multivariate logistic regression methods were used for result anlayses. Results: After adjustment for a variety of confounding variables, a significant relationship between prostate cancer and vitamin B 12 (odds ratio - OR = 4.77; 95% confidence interval - 95% C.I. = 1.74-13.07) and potassium (OR = 0.18; 95% C.I. = 0.07-0.49) was found in men ≤ 70 years old. In men > 70 years old daily intake of retinol and atocopherol were independently significantly related to prostate cancer (OR = 3.20; 95% C.I. = 1.38-7.43 and OR = 0.42; 95% C.I. = 0.18-0.99, respectively). Conclusion: Differences between younger and older men in the dietary factors related to prostate cancer (retinol and a-tocopherol) are in line with the existing literature data. The relationship of prostate cancer with vitamin B12 and potassium should be corroborated by other authors.

Purpose: Dietary factors have been suggested as having a major role in the etiology of prostate cancer. The purpose of this study was to investigate whether there are differences in the dietary factors between younger and older men with prostate cancer. Materials and methods: A case-control study was conducted in two towns of Serbia without provinces. The case group consisted of 101 patients with histologically confirmed prostate cancer and the control group of 202 hospital patients with no neoplastic disorders (for each case two controls were chosen). Cases and controls were individualy matched by age (± 2 years), time of hospital admission and place of residence. Univariate and multivariate logistic regression methods were used for result anlayses. Results: After adjustment for a variety of confounding variables, a significant relationship between prostate cancer and vitamin B 12 (odds ratio - OR = 4.77; 95% confidence interval - 95% C.I. = 1.74-13.07) and potassium (OR = 0.18; 95% C.I. = 0.07-0.49) was found in men ≤ 70 years old. In men > 70 years old daily intake of retinol and atocopherol were independently significantly related to prostate cancer (OR = 3.20; 95% C.I. = 1.38-7.43 and OR = 0.42; 95% C.I. = 0.18-0.99, respectively). Conclusion: Differences between younger and older men in the dietary factors related to prostate cancer (retinol and a-tocopherol) are in line with the existing literature data. The relationship of prostate cancer with vitamin B12 and potassium should be corroborated by other authors.

The objective of the work was to study blood pressure and some anthropometric characteristics in children. The study design included the prevalence study at Belgrade, Serbia and Montenegro. The study comprised 1651 subjects (809 boys and 842 girls) aged 7-14 years, that is, 2.6% of all relevant population. The average levels of systolic and diastolic blood pressures (SBP and DBF) were 113.4/70.3 mmHg in boys and 114.6/71.1 mmHg in girls. High SBP was present in 4.7% of boys and in 5.3% of girls. High DBP was found in 5.6% of boys and in 4.8% of girls. According to multivariate regression analysis, in boys SBP and DBP were significantly associated with age, body mass index (BMI) and subscapular skinfold, SBP was also associated with body weight, and DBP with triceps skinfold. In girls, SBP was significantly related to BMI, suprailiac skinfold and body height, and DBP was significantly associated with BMI, suprailiac and subscapular skinfolds. The results of the present study support the opinion that BMI is a significant predictor of blood pressure in children and point out to suprailiac skinfold in girls as a possible predictor of blood pressure.

A new robust modified generalized likelihood ratio algorithm, which enables the changes of mortality rates to be detected automatically, is applied. The procedure is based on the calculation of discrimination function using robust least squares estimates of AR mortality rates residuals. The feasibility of the approach is demonstrated with experimental data concerning infant mortality rate in Serbia. © 1997, The authors.

A new robust modified generalized likelihood ratio algorithm, which enables the changes of mortality rates to be detected automatically, is applied. The procedure is based on the calculation of discrimination function using robust least squares estimates of AR mortality rates residuals. The feasibility of the approach is demonstrated with experimental data concerning infant mortality rate in Serbia. © 1997, The authors.

The aim of the study was to evaluate association of type 1 diabetes in children and adolescents with positive family history of type 1 diabetes, type 2 diabetes, and thyroid, adrenal, rheumatic, allergic, celiac and some other diseases. A case-control study was conducted in Belgrade. The case group comprised 105 subjects ≤16 years old who were for the first time hospitalized because of type 1 diabetes during the period 1994-1997. For each case, two controls were chosen among children and adolescents treated for skin diseases. Cases and controls were individually matched by age (± one year), sex and place of residence (all were from Belgrade). In the statistical analysis we used X2 test, Fisher's exact test and univariate and multivariate logistic regressions. According to multivariate logistic regression analysis, risk of type 1 diabetes was significantly associated with a positive family history for type 1 diabetes (OR=8.58; 95% CI, 3.28-22.46), type 2 diabetes (OR=4.04; 95% CI, 2.31-7.07), allergic diseases (OR=3.32; 95% CI, 1.63-6.76), celiac and Crohn's diseases (OR=11.02; 95% CI, 1.14-106.89) and other diseases (thrombocytopenia, alopecia areata, psoriasis, chronic uveitis and pernicious anemia; OR=3.63; 95% CI, 1.05-12.48).

The aim of the study was to evaluate association of type 1 diabetes in children and adolescents with positive family history of type 1 diabetes, type 2 diabetes, and thyroid, adrenal, rheumatic, allergic, celiac and some other diseases. A case-control study was conducted in Belgrade. The case group comprised 105 subjects ≤16 years old who were for the first time hospitalized because of type 1 diabetes during the period 1994-1997. For each case, two controls were chosen among children and adolescents treated for skin diseases. Cases and controls were individually matched by age (± one year), sex and place of residence (all were from Belgrade). In the statistical analysis we used X2 test, Fisher's exact test and univariate and multivariate logistic regressions. According to multivariate logistic regression analysis, risk of type 1 diabetes was significantly associated with a positive family history for type 1 diabetes (OR=8.58; 95% CI, 3.28-22.46), type 2 diabetes (OR=4.04; 95% CI, 2.31-7.07), allergic diseases (OR=3.32; 95% CI, 1.63-6.76), celiac and Crohn's diseases (OR=11.02; 95% CI, 1.14-106.89) and other diseases (thrombocytopenia, alopecia areata, psoriasis, chronic uveitis and pernicious anemia; OR=3.63; 95% CI, 1.05-12.48).

Marketing principles in health care delivery systems, reducing financial funds for health institutions and permanently increasing costs of medical equipment are responsible for the growing influence of management on physician's autonomy and working satisfaction. A questionnaire research was carried out in order to determine the best method of examination of this influence in Belgrade. All tested persons were medical doctors working in a primary health centers for 7 hours per day, who examined about 26 patients every day. More than a half of physician improved their knowledge by reading professional publications 6 hours per week. In spite of the fact that they all worked in the same institution, they expressed different opinions regarding the organisation. In the physicians' opinion clinical freedom and working satisfaction were at the high level, and partly connected with management practice. At the same time they were very unsatisfactory with personal income and budgetary distribution in the institution. It is evident that the method described in this article is useful in the analysis of the present situation related to management and physician's practice in the country.

Influence of factors which fluctuate in time is usually described in term of residuals present in general linear or nonlinear models. The aim of this paper has been to identify relationship between mortality rates and major social and economic factors and to compare three methods in detecting (hidden) relations between them. Data on frequencies for all causes of death, e.g. mortality rates have been collected for Central Serbia for 21 years, from 1973. until 1993. We have used two models based on the general linear model, variance-covariance regression and correlation and Box-Jenkins time series method and one nonlinear model based on neural networks. The relationship has been established, according to our results. Among presented methods we consider the analysis based on multilayer neural networks techniques has several advantages over classical approach. © The authors 1996.

Influence of factors which fluctuate in time is usually described in term of residuals present in general linear or nonlinear models. The aim of this paper has been to identify relationship between mortality rates and major social and economic factors and to compare three methods in detecting (hidden) relations between them. Data on frequencies for all causes of death, e.g. mortality rates have been collected for Central Serbia for 21 years, from 1973. until 1993. We have used two models based on the general linear model, variance-covariance regression and correlation and Box-Jenkins time series method and one nonlinear model based on neural networks. The relationship has been established, according to our results. Among presented methods we consider the analysis based on multilayer neural networks techniques has several advantages over classical approach. © The authors 1996.

Pancreatic cancer is characterized by high incidence and high mortality rates in developed countries and low ones in developing countries. To analyse pancreatic cancer mortality in Belgrade population and it's secular trend. Material and Methods: Age-adjusted death rates per 100,000 population were calculated separately for males and females, using the direct method of standardization and the world population as the standard. The least square method was used to fit mortality rates to different trend curves. During the period 1975-1994 increasing mortality trends for cancer of pancreas were established in Belgrade population in both sexes. The increase of mortality was parallel to the increased consumption of coffee, alcohol and tobacco. The observed trend is in agreement with the increasing mortality of pancreatic cancer registered almost everywhere in the world.

BACKGROUND: Identification of preoperative factors that indicate difficulties in the operation are in the function of primary prevention of intraoperative complications and require selection of an experienced surgical team, planning of operating program and timely provision of information to patients about the increased likelihood of conversion. AIM: Identification of preoperative factors of operative difficulties by analysis of routine clinical parameters. PATIENTS AND METHODS: A prospective cohort study of patients who underwent laparoscopic cholecystectomy from February 2005 to December 2009. All patients were operated by the same surgeon. There were 369 operated patients. Conversion was done in 10 patients. Main outcome measures were: duration of stages of laparoscopic cholecystectomy and conversion; identification of predictive parameters; assesment of their predictive value; assesment of the predictive value of individual parameters in respect to the duration of stages of laparoscopic cholecystectomy; correlation of parameter predictive value and duration of laparoscopic cholecystectomy stage. RESULTS: Multivariate stepwise linear regression analysis showed that previous history of acute cholecystitis, gallbladder wall thickness □ 4 mm, acute cholecystitis to admission, size of calculus < 2 cm, < 5 attacks of pain that lasted longer of 4 hours, diabetes mellitus, duration of symptoms longer then 36 months and pericholecystic fluid collection were significant for prediction of difficulties of laparoscopic cholecystectomy. CONCLUSIONS: Based on clinical, laboratory and ultrasonographic parameters without the use of highly sophisticated diagnostic procedures and increasing medical costs it is possible to predict difficulties in the laparoscopic cholecystectomy.

Objectives - The aim of this investigation was to evaluate factors that might influence the health-related quality of life (HRQoL) in multiple sclerosis (MS) patients in Serbia. Materials and methods - This cross-sectional study was performed on a group of 156 patients with MS. HRQoL was assessed by using the SF-36 questionnaire. Expanded Disability Status Scale (EDSS) and Beck Depression Inventory (BDI) scale were assessed as variables affecting the HRQoL of MS patients. Results - EDSS score correlated negatively with all SF-36 health dimensions, and the highest statistically significant coefficients were for physical functioning (r = -0.682), and social and role functioning (r = -0.407 and -0.405 respectively). BDI correlated statistically significantly negatively (P < 0.01) with all SF-36 health dimensions. Conclusions - Our findings suggest that both disability and depression significantly influence the HRQoL in Serbian MS patients, with depressive symptoms having the major influence. © 2007 The Authors.

Objectives - The aim of this investigation was to evaluate factors that might influence the health-related quality of life (HRQoL) in multiple sclerosis (MS) patients in Serbia. Materials and methods - This cross-sectional study was performed on a group of 156 patients with MS. HRQoL was assessed by using the SF-36 questionnaire. Expanded Disability Status Scale (EDSS) and Beck Depression Inventory (BDI) scale were assessed as variables affecting the HRQoL of MS patients. Results - EDSS score correlated negatively with all SF-36 health dimensions, and the highest statistically significant coefficients were for physical functioning (r = -0.682), and social and role functioning (r = -0.407 and -0.405 respectively). BDI correlated statistically significantly negatively (P < 0.01) with all SF-36 health dimensions. Conclusions - Our findings suggest that both disability and depression significantly influence the HRQoL in Serbian MS patients, with depressive symptoms having the major influence. © 2007 The Authors.

[No abstract available]