Browsing by Author "Karapandžić, Vesna Plešinac (36092731000)"

[No abstract available]

Introduction. Angiosarcomas (ASs) arising from vascu-lar tissue, account for 3.3% of all sarcomas and have a poor prognosis. Radiation-induced AS is a rare late com-plication of radiotherapy (RT) treatment and is character-ized by a gene expression profile such as amplification of the MYC oncogene, by which we can distinguish primary from secondary induced tumor. Case report. For a 77-year-old female patient with early-stage endometrial ade-nocarcinoma, a radical hysterectomy with bilateral sal-pingo-oophorectomy was initially done. According to pathological risk factors, the postoperative external beam conformal RT (CRT) of the pelvis was administered with concomitant brachytherapy. Six years after the treatment, on the anterior abdominal wall, in the region of the postoperative irradiation field and surgical scar, an infil-trative AS of the skin and subcutaneous adipose tissue was histologically confirmed. The patient received six cy-cles of mono-adriamycin chemotherapy with verified par-tial regression. Additional immunohistochemical analysis (IHC) of c-MYC, Ki67, and CD34 expression showed a high proliferative index (Ki67 around 60%) and c-MYC positivity indicating the molecular pattern of radiation-induced AS. Furthermore, the high proliferative index could explain the positive response to chemotherapy. Conclusion. The novel postoperative RT techniques provide better survival and local control in risk-endometrial cancer groups with a decrease in irradiation complications. These patients with longer survival are at a higher risk of developing radiation-induced tumors as late side-effects of RT. When assessing the probability of radiation-induced AS, IHC analysis of c-MYC expression could distinguish secondary from other AS if Cahan's cri-teria are fulfilled. © 2022 Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved.