Browsing by Author "Jovanovic, Tomislav (57214419559)"

Objective: To investigate whether hyperbaric oxygenation (HBO) can improve the recovery of motor functions in rats after suction ablation of the right sensorimotor cortex. Methods: The experimental paradigm implies the following groups: Control animals (C), ControlHBO (CHBO), Sham controls (S), Sham controlHBO (SHBO), Lesion group (L), right sensorimotor cortex was removed by suction, LesionHBO (LHBO). Hyperbaric protocol: pressure applied 2.5 atmospheres absolute, for 60minutes, once a day for 10 days. A beam walking test and grip strength meter were used to evaluate the recovery of motor functions. Expression profiles of growth-associated protein 43 (GAP43) and synaptophysin (SYP) were detected using immunohistochemistry. Results: The LHBO group achieved statistically superior scores in the beam walking test compared to the L group. Additionally, the recovery of muscle strength of the affected hindpaw was significantly enhanced after HBO treatment. Hyperbaric oxygenation induced over-expression of GAP43 and SYP in the neurons surrounding the lesion site. Conclusions: Data presented suggest that hyperbaric oxygen therapy can intensify neuroplastic responses by promoting axonal sprouting and synapse remodelling, which contributes to the recovery of locomotor performances in rats. This provides the perspective for implementation of HBO in clinical strategies for treating traumatic brain injuries. © 2012 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Objective: To investigate whether hyperbaric oxygenation (HBO) can improve the recovery of motor functions in rats after suction ablation of the right sensorimotor cortex. Methods: The experimental paradigm implies the following groups: Control animals (C), ControlHBO (CHBO), Sham controls (S), Sham controlHBO (SHBO), Lesion group (L), right sensorimotor cortex was removed by suction, LesionHBO (LHBO). Hyperbaric protocol: pressure applied 2.5 atmospheres absolute, for 60minutes, once a day for 10 days. A beam walking test and grip strength meter were used to evaluate the recovery of motor functions. Expression profiles of growth-associated protein 43 (GAP43) and synaptophysin (SYP) were detected using immunohistochemistry. Results: The LHBO group achieved statistically superior scores in the beam walking test compared to the L group. Additionally, the recovery of muscle strength of the affected hindpaw was significantly enhanced after HBO treatment. Hyperbaric oxygenation induced over-expression of GAP43 and SYP in the neurons surrounding the lesion site. Conclusions: Data presented suggest that hyperbaric oxygen therapy can intensify neuroplastic responses by promoting axonal sprouting and synapse remodelling, which contributes to the recovery of locomotor performances in rats. This provides the perspective for implementation of HBO in clinical strategies for treating traumatic brain injuries. © 2012 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

As the Higgs boson could be a key to unlocking mysteries regarding our Universe, melatonin, a somewhat mysterious substance secreted by the pineal gland primarily at night, might be a crucial factor in regulating numerous processes in human reproduction. Melatonin is a powerful antioxidant which has an essential role in controlling several physiological reactions, as well as biological rhythms throughout human reproductive life. Melatonin, which is referred to as a hormone, but also as an autocoid, a chronobiotic, a hypnotic, an immunomodulator and a biological modifier, plays a crucial part in establishing homeostatic, neurohumoral balance and circadian rhythm in the body through synergic actions with other hormones and neuropeptides. This paper aims to analyze the effects of melatonin on the reproductive function, as well as to shed light on immunological and oncostatic properties of one of the most powerful hormones. © 2014 Informa UK Ltd.

As the Higgs boson could be a key to unlocking mysteries regarding our Universe, melatonin, a somewhat mysterious substance secreted by the pineal gland primarily at night, might be a crucial factor in regulating numerous processes in human reproduction. Melatonin is a powerful antioxidant which has an essential role in controlling several physiological reactions, as well as biological rhythms throughout human reproductive life. Melatonin, which is referred to as a hormone, but also as an autocoid, a chronobiotic, a hypnotic, an immunomodulator and a biological modifier, plays a crucial part in establishing homeostatic, neurohumoral balance and circadian rhythm in the body through synergic actions with other hormones and neuropeptides. This paper aims to analyze the effects of melatonin on the reproductive function, as well as to shed light on immunological and oncostatic properties of one of the most powerful hormones. © 2014 Informa UK Ltd.

Background: Cases of blunt diaphragmatic rupture are not as common as other thoracoabdominal injuries and may pose a diagnostic challenge. Depending upon the size of the right hemidiaphragmatic rupture, herniation of liver may be partial, as progressive hepatothorax. The diagnosis of progressive hepatothorax coincides with the onset of the first symptoms of herniation. Case Study: In the patient presented here, the interval between the original injury and the onset of symptoms related to the herniation of the abdominal cavity organs in the thorax was 26 years. Herniation of abdominal organs into the thorax was apparently rather slow and asymptomatic. The first symptoms, 26 years after trauma, included epigastric pain, meteorism, nausea, and vomiting, and all of them were due to gastrothorax and elongated gaster. These symptoms were nonspecific and therefore interpreted as acute alcoholic gastritis. With deterioration of the patient's condition, they were subsequently interpreted as subileus due to the strangulation of a portion of the elongated and dilated stomach. Conclusion: Laparoscopy proved to be the most reliable diagnostic method in this case.

Background Polycystic ovarian syndrome (PCOS) constitutes the most common endocrinopathy of women of reproductive age. Infertility due to the PCOS is a complex and specific condition but the majority of the problem is the ovulatory dysfunction. Aims Evaluation of the therapy choice and reproductive therapy possibilities in PCOS infertility patients. Make it easier for clinicians. Methods Clinical experience based on review of the literature. Results The syndromes heterogeneity is reflected in the different response to the various ovulation inducting drugs. Management of anovulatory infertility associated with PCOS is based on the overall clinical picture. Lifestyle change programs, weight reduction diet and exercise, have been shown to be very effective in improving reproductive as well as metabolic characteristics of overweight and obese patients with PCOS. In women with anovulatory infertility, the first line of treatment for induction of ovulation is clomiphene citrate. Aromatase inhibitors have been suggested as an alternative treatment to clomiphene therapy. Gonadotropin treatment is effective, but there is a risk of ovarian hyperstimulation syndrome. Surgery, such as laparoscopic ovarian drilling should be considered in some patients. Reconsider a use of metformin and supplements. Conclusion Understanding specific features and metabolic implications of different PCOS patients, may guide us to treat individuals optimally, as well as to develop effective prevention strategies to reduce the risk of long term complications- consequences and improve reproductive outcomes. Individual treatment modalities in PCOS patients are imperative for successful therapy. © 2017, Australasian Medical Journal Pty Ltd. All rights reserved.

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