Browsing by Author "Jordanova, Elena (57224171953)"

Background/Aim. In the past three decades, focal seg-mental glomerulosclerosis (FSGS) was commonly regarded as a part of obesity-related glomerulopathy (ORG), a dis-tinct entity featuring proteinuria, glomerulomegaly, progres-sive glomerulosclerosis, and a decline of renal function. The present study aimed to evaluate the glomerular morphome-try, clinical features, and a two-year outcome in the obese and non-obese FSGS patients. Methods. The study includ-ed 35 FSGS patients (23 males, aged 46.5 ± 15.2 years) di-vided into two groups: Obese [body mass index (BMI) ≥ 27 kg/m2 (18 patients, aged 47.2 ± 15.5 years)] and non-obese [BMI < 27 kg/m2 (17 patients, aged 45.7 ± 15.2 years)]. The serum concentrations of proteins, albumin, cholesterol, tri-glyceride, and creatinine were determined at the time of the biopsy, and 6, 12, and 24 months after the biopsy. Cock-croft-Gault (BMI < 27 kg/m2) and Cockcroft-GaultLBW (BMI ≥ 27 kg/m2) formulas were calculated. Glomerular radius (GR), glomerular volume (GV), and glomerular den-sity (GD) were compared morphometrically between the two groups. Results. At the time of the kidney biopsy and 6 months later, the obese had significantly lower glomerular filtration rate (GFR) compared to the non-obese. After 24 months of follow-up, there were not any differences be-tween the groups. The obese had a significantly higher GR (109.44 ± 6.03 μm vs. 98.53 ± 14.38 μm) and GV (3.13 ± 0.49 × 106 μm3 vs. 2.26 ± 0.83 × 106 μm3), and only slightly lower GD (1.91 ± 0.39/mm2 vs. 1.95 ± 0.61/mm2) compared to the non-obese. A significant positive associa-tion between GV and BMI (r = 0.439) was found. After 12 months of follow-up, a significantly higher percentage of the non-obese patients reached complete remission com-pared to the obese (71.4% vs. 37.5%, respectively; p = 0.041), but after 24 months there were no significant differences. Conclusion. Obese patients, at the time of the kidney biopsy and 6 months later, had already a significantly lower kidney function compared to the non-obese ones. However, 12 and 24 months after, this difference was not statistically significant. Also, 24 months after, there was no significant difference between the two groups in the per-centage of patients with complete remission of the nephrot-ic syndrome. © 2021 Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved.

Background Fractal dimension is an indirect indicator of signal complexity. The aim was to evaluate the fractal and textural analysis parameters of glomeruli in obese and non-obese patients with glomerular diseases and association of these parameters with clinical features. Methods The study included 125 patients mean age 46 ± 15.2 years: obese (BMI ≥ 27 kg/m2—63 patients) and non-obese (BMI < 27 kg/m2—62 patients). Serum concentration of creatinine, protein, albumin, cholesterol, trygliceride, and daily proteinuria were measured. Formula Chronic Kidney Disease Epidemiology Colaboration (CKD-EPI) equation was calculated. Fractal (fractal dimension, lacunarity) and textural (angular second moment (ASM), textural correlation (COR), inverse difference moment (IDM), textural contrast (CON), variance) analysis parameters were compared between two groups. Results Obese patients had higher mean value of variance (t = 1.867), ASM (t = 1.532) and CON (t = 0.394) but without significant difference (P > 0.05) compared to non-obese. Mean value of COR (t = 0.108) and IDM (t = 0.185) were almost the same in two patient groups. Obese patients had higher value of lacunarity (t = 0.499) in comparison with non-obese, the mean value of fractal dimension (t = 0.225) was almost the same in two groups. Significantly positive association between variance and creatinine concentration (r = 0.499, P < 0.01), significantly negative association between variance and CKD-EPI (r = -0.448, P < 0.01), variance and sex (r = -0.339, P < 0.05) were found. Conclusions Variance showed significant correlation with serum creatinine concentration, CKD-EPI and sex. CON and IDM were significantly related to sex. Fractal and textural analysis parameters of glomeruli could become a supplement to histopathologic analysis of kidney tissue. © 2022 The Authors

Background Fractal dimension is an indirect indicator of signal complexity. The aim was to evaluate the fractal and textural analysis parameters of glomeruli in obese and non-obese patients with glomerular diseases and association of these parameters with clinical features. Methods The study included 125 patients mean age 46 ± 15.2 years: obese (BMI ≥ 27 kg/m2—63 patients) and non-obese (BMI < 27 kg/m2—62 patients). Serum concentration of creatinine, protein, albumin, cholesterol, trygliceride, and daily proteinuria were measured. Formula Chronic Kidney Disease Epidemiology Colaboration (CKD-EPI) equation was calculated. Fractal (fractal dimension, lacunarity) and textural (angular second moment (ASM), textural correlation (COR), inverse difference moment (IDM), textural contrast (CON), variance) analysis parameters were compared between two groups. Results Obese patients had higher mean value of variance (t = 1.867), ASM (t = 1.532) and CON (t = 0.394) but without significant difference (P > 0.05) compared to non-obese. Mean value of COR (t = 0.108) and IDM (t = 0.185) were almost the same in two patient groups. Obese patients had higher value of lacunarity (t = 0.499) in comparison with non-obese, the mean value of fractal dimension (t = 0.225) was almost the same in two groups. Significantly positive association between variance and creatinine concentration (r = 0.499, P < 0.01), significantly negative association between variance and CKD-EPI (r = -0.448, P < 0.01), variance and sex (r = -0.339, P < 0.05) were found. Conclusions Variance showed significant correlation with serum creatinine concentration, CKD-EPI and sex. CON and IDM were significantly related to sex. Fractal and textural analysis parameters of glomeruli could become a supplement to histopathologic analysis of kidney tissue. © 2022 The Authors

Background/Aim. Different surgical interventions have been proposed, including trabeculectomy associated with antiproliferative agents because silicone oil (SO) removal cannot necessarily provide intraocular pressure (IOP) control. The aim of the study was to determine the effi-cacy of trabeculectomy with mitomycin C (MMC) for lowering IOP in patients with open-angle glaucoma (OAG) secondary to emulsified SO after pars plana vitrec-tomy. Methods. A single-center, prospective study was conducted, from December 2014 to December 2019, on 56 consecutive patients with an uncontrolled elevation of IOP after SO removal who were subjected to trabeculec-tomy with mitomycin MMC in that period. The primary end-point was the IOP at the three-year follow-up visit. Complete surgical success was defined as an IOP ranging from 7 mmHg to 18 mmHg without glaucoma medica-tion. Qualified success was defined as IOP ≤ 21 mmHg with one or two topical medications. Results. Fifty-six patients with a mean age of 53.6 [standard deviation (SD)15.5] years had a mean baseline IOP of 42.3 (39.3 to 45.3) mmHg, which reduced to 18.6 (17.9 to 19.3) mmHg three years after surgery (p < 0.0001). Seventeen (30.4%) eyes were classified as a complete success, 21 (37,5%) as a qualified success, and 18 (32.1%) as a fail-ure. In all successfully treated patients, the number of an-tiglaucoma medications was significantly reduced from 2.85 (SD 0.77) to 1.63 (SD 0.62), p < 0.0001. Conclu-sion. Trabeculectomy with MMC may be an option for lowering IOP in patients with OAG secondary to emulsi-fied SO after pars plana vitrectomy, which was not con-trolled with maximum antiglaucomatous medical treat-ment. © 2022 Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved.