Browsing by Author "Jeremić, Ana (57225983983)"

Due to the recognized harmful effects of some trace elements on fetal development after long-term exposures, it is first important to address their basic/physiological levels before monitoring toxicological effects and clinical outcomes on prenatal and postnatal health. This research aimed to define, for the first time, reference values for multiple (ultra) trace elements in umbilical cord blood (UCB) plasma samples of a notable number of healthy pregnant women (n = 125). All samples were collected during 2020–2021 and all participants were from Belgrade and two regions (Šumadija and Podunavlje). Following trace elements were enrolled in this study: essential (Mn, Co, Cu, Zn, Se, Mo), toxic (Be, Al, Ni, As, Rb, Sr, Ag, Cd, Sb, Ba, Tl, Pb, Th, U), rare earth (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm), and noble metals (Ru, Rh, Pd, Re, Ir, Os, Pt). UCB plasma samples were diluted with suitable solvents and analyzed by inductively coupled plasma-mass spectrometry. The analytical technique used was validated by the standard addition method and using certified reference materials. Zn was found in the highest amount and Tm in the least amount. Be, Co, Ag, Sb, La, and Ce exhibited statistically significant differences in the four age groups (20 to 41 years), whereas Ag and Ce showed a tendency to increase with age. Furthermore, our participants had notably higher As, Ni, and Co, levels and lower Zn levels compared to other populations. This is the first study that, in addition to analyzing essential and toxic trace elements, also provided an analysis of noble and rare earth elements in UCB plasma samples. Presented results can be used as a starting point or database for further studies, in terms of predicting the pregnancy outcome and postnatal development. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.

Due to the recognized harmful effects of some trace elements on fetal development after long-term exposures, it is first important to address their basic/physiological levels before monitoring toxicological effects and clinical outcomes on prenatal and postnatal health. This research aimed to define, for the first time, reference values for multiple (ultra) trace elements in umbilical cord blood (UCB) plasma samples of a notable number of healthy pregnant women (n = 125). All samples were collected during 2020–2021 and all participants were from Belgrade and two regions (Šumadija and Podunavlje). Following trace elements were enrolled in this study: essential (Mn, Co, Cu, Zn, Se, Mo), toxic (Be, Al, Ni, As, Rb, Sr, Ag, Cd, Sb, Ba, Tl, Pb, Th, U), rare earth (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm), and noble metals (Ru, Rh, Pd, Re, Ir, Os, Pt). UCB plasma samples were diluted with suitable solvents and analyzed by inductively coupled plasma-mass spectrometry. The analytical technique used was validated by the standard addition method and using certified reference materials. Zn was found in the highest amount and Tm in the least amount. Be, Co, Ag, Sb, La, and Ce exhibited statistically significant differences in the four age groups (20 to 41 years), whereas Ag and Ce showed a tendency to increase with age. Furthermore, our participants had notably higher As, Ni, and Co, levels and lower Zn levels compared to other populations. This is the first study that, in addition to analyzing essential and toxic trace elements, also provided an analysis of noble and rare earth elements in UCB plasma samples. Presented results can be used as a starting point or database for further studies, in terms of predicting the pregnancy outcome and postnatal development. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.

Exposure to certain metals has been recognized as a risk factor for numerous complications in vulnerable population groups, particularly pregnant women. This investigation evaluated the levels of essential (Cr, Mn, Co, Cu, Zn, Se, Mo) and nonessential trace metals with recognized toxicity (Be, Al, Ti, V, Ni, Ga, As, Rb, Sr, Cd, Sb, Ba, Tl, Hg, Pb, Bi, Th, U), together with rare earth elements (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Lu), and noble metals (Ru, Rh, Pd, Re, Os, Ir, Pt, Au, Ag) in the placental tissues of healthy pregnant women (n = 105). The selection of participants was undertaken with special reference to specific confounding factors that could influence the trace element profiles. Among trace elements, Zn was the most abundant and Lu was the least abundant. Cd and Os placental levels show a tendency to increase with women's age. Compared with literature data, high levels of Ni were found. This is the first study that provides the composition levels of essential and toxic trace elements, rare earth elements, and noble metals in human placental tissues. Also, for the first time, normal (reference) ranges for 50 (ultra)trace elements in placental tissues are proposed. Reference ranges are especially important in biomonitoring studies, which nowadays give increasing importance to the analysis of solid tissues instead of body fluids. Overall, the information provided in this study can serve as a starting point for further clinical trials and/or prediction of potential risks to pregnancy. © 2021 Elsevier Ltd

Exposure to certain metals has been recognized as a risk factor for numerous complications in vulnerable population groups, particularly pregnant women. This investigation evaluated the levels of essential (Cr, Mn, Co, Cu, Zn, Se, Mo) and nonessential trace metals with recognized toxicity (Be, Al, Ti, V, Ni, Ga, As, Rb, Sr, Cd, Sb, Ba, Tl, Hg, Pb, Bi, Th, U), together with rare earth elements (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Lu), and noble metals (Ru, Rh, Pd, Re, Os, Ir, Pt, Au, Ag) in the placental tissues of healthy pregnant women (n = 105). The selection of participants was undertaken with special reference to specific confounding factors that could influence the trace element profiles. Among trace elements, Zn was the most abundant and Lu was the least abundant. Cd and Os placental levels show a tendency to increase with women's age. Compared with literature data, high levels of Ni were found. This is the first study that provides the composition levels of essential and toxic trace elements, rare earth elements, and noble metals in human placental tissues. Also, for the first time, normal (reference) ranges for 50 (ultra)trace elements in placental tissues are proposed. Reference ranges are especially important in biomonitoring studies, which nowadays give increasing importance to the analysis of solid tissues instead of body fluids. Overall, the information provided in this study can serve as a starting point for further clinical trials and/or prediction of potential risks to pregnancy. © 2021 Elsevier Ltd