Browsing by Author "Ille, Mihailo (35078546700)"

[No abstract available]

Introduction Ankylosing spondylitis is a chronic progressive autoimmune inflammatory disorder involving mainly the axial skeleton and larger peripheral joints that progressively limits spinal mobility and may lead to irreversible structural changes and consequently to impaired physical function and reduced quality of life. Objective The aim of this study was to assess functional disability and quality of life of patients with ankylosing spondylitis and determine the correlation between functional disability and quality of life. Methods The study enrolled 74 patients with ankylosing spondylitis (16 females and 58 males). The demographic data of the patients were collected. Functional disability was assessed with the Bath Ankylosing Functional Index (BASFI). Quality of life was assessed by the Short-Form 36 (SF-36) and the European Quality of Life Questionnaire (EuroQoL/EQ-5D). Results In our study, the mean age was 48.5±10.3 years. BASFI was negatively correlated with the SF-36 physical function subscale (p<0.001), physical role (p=0.002), bodily pain (p=0.003), general health (p<0.001), vitality (p=0.012) and mental health (p=0.010) subscale. There was a significantly inverse correlation between the BASFI score and the rating scale of EQ-5D (p=0.001). In the regression model, the BASFI score (p=0.000) showed an independent association with the physical function domain of SF-36. Conclusion In conclusion, the BASFI index was associated with physical function, physical role, bodily pain, general health, vitality and mental health domains of SF-36 and also with the rating scale of EQ-5D.

Introduction/Objective When choosing the appropriate treatment for Achilles tendon rupture, there may be a dilemma when choosing the optimal treatment. The objective of this study was analyzing groups of patients with acute closed Achilles tendon injury, comparing early recovery and functional parameters in relation to treatment and first choice treatment suggestion. Methods The prospective study included 80 patients with acute Achilles tendon rupture. The treatment was surgery or immobilization. Results There is a difference in the mechanism of injury between surgically and non-surgically treated (p = 0.026). In total, 50 (62.5%) patients were operated and 30 (37.5%) patients were treated with circu-lar plaster. The difference (p = 0.000) between the groups in the duration of treatment, The American Orthopaedic Foot and Ankle Society (AOFAS) score and Visual Analogue Scale of pain (VAS) was shown. Patients undergoing surgery in the first two days had better clinical results in terms of The Achilles tendon Total Rupture score (ATRS), AOFAS and VAS. Higher satisfaction was achieved in younger people (p = 0.036). Patients whose treatment lasted shorter were more satisfied with their status (p = 0.001). ATRS and AOFAS score are higher in patients who are more satisfied with their own status (ATRS p = 0.301; AOFAS score p = 0.001). Six months after the treatment, 78.75% (63/80) of patients were fully functional. Conclusion The therapy of choice in the treatment of acute Achilles tendon rupture is surgical, as surgical treatment is shorter; rehabilitation is faster and shorter, and the total costs associated with treatment and absence from work are lower. © 2020, Serbia Medical Society. All rights reserved.

[No abstract available]

The aim of this study was to assess spinal mobility status and Quality of life (QoL) of patients with ankylosing spondylitis (AS) and determine the relationship between spinal mobility and measures of clinical condition including QoL. A total of 74 patients with AS were included in this study. Disease specific instruments Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were applied, and mobility testing: occiput-wall distance and chest expansion. QoL was assessed by the Short Form-36 (SF-36). The mean age was 48.5 years; there were significant correlations between BASMI score and age (P < 0.001), disease duration (P < 0.001), symptoms duration (P < 0.001) and BASFI (P < 0.001). BASMI was negatively correlated with SF-36 physical function subscale (P < 0.001) and general health subscale (P = 0.029). In multivariate regression analysis, BASFI score (P < 0.001) was independently associated factor with physical function domain of SF-36. This study showed that in AS spinal mobility measures are associated with physical function, general health, emotional role and mental health domains of QoL. © 2009 Springer-Verlag.

The aim of this study was to assess spinal mobility status and Quality of life (QoL) of patients with ankylosing spondylitis (AS) and determine the relationship between spinal mobility and measures of clinical condition including QoL. A total of 74 patients with AS were included in this study. Disease specific instruments Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were applied, and mobility testing: occiput-wall distance and chest expansion. QoL was assessed by the Short Form-36 (SF-36). The mean age was 48.5 years; there were significant correlations between BASMI score and age (P < 0.001), disease duration (P < 0.001), symptoms duration (P < 0.001) and BASFI (P < 0.001). BASMI was negatively correlated with SF-36 physical function subscale (P < 0.001) and general health subscale (P = 0.029). In multivariate regression analysis, BASFI score (P < 0.001) was independently associated factor with physical function domain of SF-36. This study showed that in AS spinal mobility measures are associated with physical function, general health, emotional role and mental health domains of QoL. © 2009 Springer-Verlag.

Three distinct approaches are currently used in assessing acid-base disorders: the traditional - physiological or bicarbonate-centered approach, the base-excess approach, and the “modern” physicochemical approach proposed by Peter Stewart, which uses the strong ion difference (particularly the sodium chloride difference) and the concentration of nonvolatile weak acids (particularly albumin) and partial pressure of carbon dioxide (pCO2) as independent variables in the assessment of acid-base status. The traditional approach developed from the pioneering work of Henderson and Hasselbalch and the base-excess are still most widely used in clinical practice, even though there are a number of problems identified with this approach. The approach works well clinically and is recommended for use whenever serum total protein, albumin and phosphate concentrations are normal. Although Stewart’s approach has been largely ignored by physiologists, it is increasingly used by anesthesiologists and intensive care specialists, and is recommended for use whenever serum’s total protein, albumin or phosphate concentrations are markedly abnormal, as in critically ill patients. Although different in their concepts, the traditional and modern approaches can be seen as complementary, giving in principle, the same information about the acid-base status. © 2015 Medical Association of Zenica-Doboj Canton. All rights reserved.

Introduction/Objective Increased fracture risk was previously associated with alcohol-associated liver disease (AALD), but contemporary literature lacks the assessment of the micro-fracture healing events (microcalli) in these individuals. We aimed to quantify microcalli in a trabecular compartment of lumbar vertebrae obtained from individuals with pathohistological confirmation of AALD. Methods We used high-resolution micro-computed tomography scanning to evaluate the density of trabecular microcalli in the anterior mid-transverse portion of lumbar vertebral bodies collected from 32 male adult cadaveric donors (age range: 33–75 years), divided into the AALD group (n = 13) and the control group (n = 19). Pathohistological analysis indicated that seven individuals had the initial AALD stage (fatty liver disease), while six individuals had end-stage AALD (alcoholic liver cirrhosis). Results A declining trend in the density of trabecular microcalli was noted in the AALD group (1.8 ± 1.7/mm3) compared to the control (3.3 ± 2.6/mm3), but without reaching statistical significance (p = 0.080, Student’s t-test). The density of trabecular microcalli was not significantly different between initial and end-stage AALD (p > 0.05; ANOVA with Bonferroni correction). Pearson correlation indicated that a decreasing trend in the density of trabecular microcalli was associated with the deteriorated trabecular microarchitecture of the AALD group. Conclusions The density of trabecular microcalli was not significantly altered in the lumbar vertebrae of men with different stages of AALD, suggesting that AALD does not have a substantial impact on the healing process of trabecular micro-fractures and the formation of trabecular microcalli in the lumbar vertebrae. However, future studies are required to confirm our findings. © 2025, Serbia Medical Society. All rights reserved.