Browsing by Author "Honig, Asaf (55654048600)"

In the published article, the reference for (17) was incorrectly written as Strambo D. Acute bihemispheric stroke from a single carotid source: risk factors, mechanism and outcome. J Vasc Interv Neurol. (2021) 12:24–33. It should be Scoppettuolo P, Strambo D, Nannoni S, Dunet V, Sirimarco G, Michel P. Acute bihemispheric stroke from a single carotid source: risk factors, mechanism and outcome. J Vasc Interv Neurol. (2021) 12:24–33. 10.5281/zenodo.10391282. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. Copyright © 2024 Filioglo, Simaan, Honig, Heldner, Pezzini, Martinez-Majander, Padjen, Baumgartner, Papanagiotou, Salerno, Nolte, Nordanstig, Engelter, Zini, Zedde, Marto, Arnold, Magoni, Gensicke, Cohen and Leker.

In the published article, the reference for (17) was incorrectly written as Strambo D. Acute bihemispheric stroke from a single carotid source: risk factors, mechanism and outcome. J Vasc Interv Neurol. (2021) 12:24–33. It should be Scoppettuolo P, Strambo D, Nannoni S, Dunet V, Sirimarco G, Michel P. Acute bihemispheric stroke from a single carotid source: risk factors, mechanism and outcome. J Vasc Interv Neurol. (2021) 12:24–33. 10.5281/zenodo.10391282. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. Copyright © 2024 Filioglo, Simaan, Honig, Heldner, Pezzini, Martinez-Majander, Padjen, Baumgartner, Papanagiotou, Salerno, Nolte, Nordanstig, Engelter, Zini, Zedde, Marto, Arnold, Magoni, Gensicke, Cohen and Leker.

Introduction: After positive findings in clinical trials the time window for endovascular thrombectomy (EVT) for patients with an acute ischemic stroke has been expanded up to 24 h from symptom onset or last seen well (LSW). We aimed to compare EVT patients’ characteristics and outcomes in the early versus extended time window and to compare outcomes with the DAWN and DEFUSE 3 trial results. Patients and methods: Consecutive EVT patients from 16 mostly European comprehensive stroke centers from the EVA-TRISP cohort were included. We compared rates of 90-day good functional outcomes (Modified Rankin Scale 0–2), symptomatic intracranial hemorrhage (sICH), and 90-day mortality between patients treated in the early (<6 h after onset or LSW) versus extended (6–24 h after onset or LSW) time windows. Results: We included 9313 patients, of which 6876 were treated in the early and 2437 in the extended time window. National Institutes of Health Stroke Scale (NIHSS) score at presentation was lower in patients treated in the extended time window (median 13 [IQR 7–18] vs 15 [IQR 9–19], p < 0.001). The percentage of patients with good functional outcome was slightly lower in the extended time window (37.4% vs 42.2%, p < 0.001). However, rates of successful recanalization, sICH, and mortality were similar. Good functional outcome rates after EVT were slightly lower for patients in the extended window in the EVA-TRISP cohort as compared to DAWN and DEFUSE 3. Discussion and conclusion: According to this large multicenter cohort study reflecting daily clinical practice, EVT use in the extended time window appears safe and effective. © European Stroke Organisation 2024.

Background: Patients with stroke secondary to isolated anterior cerebral artery (ACA) occlusions have poor outcomes. Whether tandem occlusions (TO) of the extracranial internal carotid (ICA) and the ACA carry even worse outcomes that remain unknown. Methods: Patients with TO involving ICA and ACA occlusions were identified from 14 participating centers from the EndoVascular treatment And ThRombolysis in Ischemic Stroke Patients (EVATRISP) project which is a multicenter, observational, cohort study with prospective accrual of data followed by retrospective data analysis. Patients with isolated ACA stroke served as controls. Results: Included were 92 patients with isolated ACA and 16 patients with ICA-ACA TO stroke. On univariate analyses, patients with TO had more severe strokes on admission [median NIHSS (IQR) 13.5 (9–21) vs. 8 (5–12), p = 0.003] and were more often treated with thrombectomy (81 vs. 40%, p = 0.002). Mortality rates were higher among TO patients (31 vs. 11%, p = 0.03). Rates of favorable functional outcomes were numerically lower among TO patients (38 vs. 60%) but the difference was not statistically significant (p = 0.09). On multivariate analyses, the presence of TO did not modify the chances for favorable outcomes. Conclusion: TO stroke with ICA and isolated ACA involvement is rare and results in more severe initial neurological deficits and higher mortality compared to those seen in patients with isolated ACA stroke. Copyright © 2022 Filioglo, Simaan, Honig, Heldner, Pezzini, Martinez-Majander, Padjen, Baumgartner, Papanagiotou, Salerno, Nolte, Nordanstig, Engelter, Zini, Zedde, Marto, Arnold, Magoni, Gensicke, Cohen and Leker.

Background: Patients with stroke secondary to isolated anterior cerebral artery (ACA) occlusions have poor outcomes. Whether tandem occlusions (TO) of the extracranial internal carotid (ICA) and the ACA carry even worse outcomes that remain unknown. Methods: Patients with TO involving ICA and ACA occlusions were identified from 14 participating centers from the EndoVascular treatment And ThRombolysis in Ischemic Stroke Patients (EVATRISP) project which is a multicenter, observational, cohort study with prospective accrual of data followed by retrospective data analysis. Patients with isolated ACA stroke served as controls. Results: Included were 92 patients with isolated ACA and 16 patients with ICA-ACA TO stroke. On univariate analyses, patients with TO had more severe strokes on admission [median NIHSS (IQR) 13.5 (9–21) vs. 8 (5–12), p = 0.003] and were more often treated with thrombectomy (81 vs. 40%, p = 0.002). Mortality rates were higher among TO patients (31 vs. 11%, p = 0.03). Rates of favorable functional outcomes were numerically lower among TO patients (38 vs. 60%) but the difference was not statistically significant (p = 0.09). On multivariate analyses, the presence of TO did not modify the chances for favorable outcomes. Conclusion: TO stroke with ICA and isolated ACA involvement is rare and results in more severe initial neurological deficits and higher mortality compared to those seen in patients with isolated ACA stroke. Copyright © 2022 Filioglo, Simaan, Honig, Heldner, Pezzini, Martinez-Majander, Padjen, Baumgartner, Papanagiotou, Salerno, Nolte, Nordanstig, Engelter, Zini, Zedde, Marto, Arnold, Magoni, Gensicke, Cohen and Leker.