Browsing by Author "Goertsches, R. (55882530700)"

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IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis
(2011)
Malhotra, S. (50262475300)
;
Morcillo-Suárez, C. (24465436500)
;
Brassat, D. (55666405000)
;
Goertsches, R. (55882530700)
;
Lechner-Scott, J. (6603311349)
;
Urcelay, E. (10639601200)
;
Fernández, O. (7102560044)
;
Drulovic, J. (55886929900)
;
García-Merino, A. (6602178754)
;
Martinelli Boneschi, F. (57202042750)
;
Chan, A. (7403168324)
;
Vandenbroeck, K. (7003943780)
;
Navarro, A. (35477108400)
;
Bustamante, M.F. (36647223700)
;
Río, J. (7006734684)
;
Akkad, D.A. (12787505100)
;
Giacalone, G. (37037407500)
;
Sánchez, A.J. (37665880200)
;
Leyva, L. (6602303467)
;
Alvarez-Lafuente, R. (13411081600)
;
Zettl, U.K. (7004582854)
;
Oksenberg, J. (7005749242)
;
Montalban, X. (7007177960)
;
Comabella, M. (6701491362)
Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n = 281) and non-responders (n = 307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients. © 2011 Elsevier B.V.
Some of the metrics are blocked by your
consent settings
IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis
(2011)
Malhotra, S. (50262475300)
;
Morcillo-Suárez, C. (24465436500)
;
Brassat, D. (55666405000)
;
Goertsches, R. (55882530700)
;
Lechner-Scott, J. (6603311349)
;
Urcelay, E. (10639601200)
;
Fernández, O. (7102560044)
;
Drulovic, J. (55886929900)
;
García-Merino, A. (6602178754)
;
Martinelli Boneschi, F. (57202042750)
;
Chan, A. (7403168324)
;
Vandenbroeck, K. (7003943780)
;
Navarro, A. (35477108400)
;
Bustamante, M.F. (36647223700)
;
Río, J. (7006734684)
;
Akkad, D.A. (12787505100)
;
Giacalone, G. (37037407500)
;
Sánchez, A.J. (37665880200)
;
Leyva, L. (6602303467)
;
Alvarez-Lafuente, R. (13411081600)
;
Zettl, U.K. (7004582854)
;
Oksenberg, J. (7005749242)
;
Montalban, X. (7007177960)
;
Comabella, M. (6701491362)
Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n = 281) and non-responders (n = 307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients. © 2011 Elsevier B.V.