Browsing by Author "Gal, Vera (6603730785)"

Background/Aim. There are only several studies on the acute effect of alcoholic drinks intake on heart rhythm and this phenomenon is still not well understood. We wanted to examine whether linear and nonlinear measures of RR in-terval and QT interval series could quantify the effect of be-er in healthy subjects. Methods. Eighteen young volunteers drank 500 mL of beer (21 g of ethanol). Electrocardiogram (ECG) recordings were taken in supine position: 20 minutes before (relaxation) and 60 minutes after drink intake. The RR interval series and the QT interval series were extracted from ECG and we calculated short-term (α1) and long-term (α2) scaling exponents and sample entropy (SampEn) for both series; low frequency (LF) and high frequency (HF) spectral components from RR interval series and QT variability (QTV). Blood pressure was measured every 10 minutes. Results. It was shown that beer induced changes in variability and correlation properties of these series. Im-mediate effect of beer intake was detected as a transient inc-rease in the QT variability, heart rate and blood pressure. Delayed effects of beer were shortening of the RR and QT intervals and reduction of the HF spectral component. Beer intake also increased short-term scaling exponent (α1) of the RR time series and long-term scaling exponent (α2) of the QT time series. Conclusion. Our results suggest that acute effects of beer are reduced parasympathetic control of the heart and changed dynamic complexity of the ventricular repolarization. © 2017, Inst. Sci. inf., Univ. Defence in Belgrade. All Rights Reserved.

The origin of heart rate variability (HRV) is largely in parasympathetic activity. The direct influence of sympathetic activity and other control mechanisms, especially at an increased HR, is not well understood. The objectives of the study were to investigate the influence of increasing HR on the properties of heartbeat interval (RR) series in young healthy subjects. ECG was recorded in 9 trained and 11 untrained young men during supine rest, standing, incremental running exercise and relaxation. During exercise, a breath-to-breath gas exchange was monitored. The RR time series analysis included the spectral analysis, detrended fluctuations analysis method and sample entropy (SampEn) calculation. During exercise, spectral powers were reduced dramatically in both groups. The dependence of short-term scaling exponent (α1) on the RR included a characteristic maximum, while SampEn for the same value of the RR had a minimum. The value of HR corresponding to the maximum of α1 and minimum of SampEn (IHR) corresponded to the intrinsic HR obtained by an autonomic blockade. In trained subjects, the curves α1 versus RR and SampEn versus RR were moved toward larger RR, compared with control. For HR values higher than IHR, α1 decreased and SampEn increased. These results reveal that the complexity of the heart rhythm above intrinsic HR decreases with an increase in HR. We suggest that at the highest HR intrinsic heart control is reflected in the heart rhythm. We point out the possibility of developing a new non-invasive method for the determination of intrinsic HR from the curve α1 versus RR. © 2008 Institute of Physics and Engineering in Medicine.

The origin of heart rate variability (HRV) is largely in parasympathetic activity. The direct influence of sympathetic activity and other control mechanisms, especially at an increased HR, is not well understood. The objectives of the study were to investigate the influence of increasing HR on the properties of heartbeat interval (RR) series in young healthy subjects. ECG was recorded in 9 trained and 11 untrained young men during supine rest, standing, incremental running exercise and relaxation. During exercise, a breath-to-breath gas exchange was monitored. The RR time series analysis included the spectral analysis, detrended fluctuations analysis method and sample entropy (SampEn) calculation. During exercise, spectral powers were reduced dramatically in both groups. The dependence of short-term scaling exponent (α1) on the RR included a characteristic maximum, while SampEn for the same value of the RR had a minimum. The value of HR corresponding to the maximum of α1 and minimum of SampEn (IHR) corresponded to the intrinsic HR obtained by an autonomic blockade. In trained subjects, the curves α1 versus RR and SampEn versus RR were moved toward larger RR, compared with control. For HR values higher than IHR, α1 decreased and SampEn increased. These results reveal that the complexity of the heart rhythm above intrinsic HR decreases with an increase in HR. We suggest that at the highest HR intrinsic heart control is reflected in the heart rhythm. We point out the possibility of developing a new non-invasive method for the determination of intrinsic HR from the curve α1 versus RR. © 2008 Institute of Physics and Engineering in Medicine.

To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut ratD́s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions. © 2013 Elsevier Ltd.

To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut ratD́s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions. © 2013 Elsevier Ltd.

The aim of this study was to compare the dependence of heart rate variability (HRV) on heart period (RR interval length) under different physiological and pathological states in order to detect changes in HR modulation. The dependence of HRV on the RR interval length in healthy elderly subjects, congestive heart failure (CHF) patients and one patient with a transplanted heart (T) was compared with healthy young subjects. Spectral powers, sample entropy (SampEn) and short-term fractal scaling exponent (α1) were determined from 24 h free-running recordings. For the same HR, HRV measures were different in different groups. In healthy subjects HRV measures depended on RR interval length and all spectral powers were highly correlated, although reduced in elderly subjects. SampEn at high HR was the most sensitive quantity to changes induced by aging. In disease, CHF and T, an achievable HR range was decreased, all spectral powers were reduced, but correlated, and the dependence of HRV measures on RR was lost. There was an evident difference in the dependence of nonlinear on linear measures between young subjects and all the other studied groups. In disease the reduction in autonomic control was associated with the decrease in short-range correlation and regularity in RR series. We have concluded that the analysis of HRV measures as functions of RR interval length can reveal important aspects of HR control that might be lost in averaging. © 2006 IOP Publishing Ltd.

The aim of this study was to compare the dependence of heart rate variability (HRV) on heart period (RR interval length) under different physiological and pathological states in order to detect changes in HR modulation. The dependence of HRV on the RR interval length in healthy elderly subjects, congestive heart failure (CHF) patients and one patient with a transplanted heart (T) was compared with healthy young subjects. Spectral powers, sample entropy (SampEn) and short-term fractal scaling exponent (α1) were determined from 24 h free-running recordings. For the same HR, HRV measures were different in different groups. In healthy subjects HRV measures depended on RR interval length and all spectral powers were highly correlated, although reduced in elderly subjects. SampEn at high HR was the most sensitive quantity to changes induced by aging. In disease, CHF and T, an achievable HR range was decreased, all spectral powers were reduced, but correlated, and the dependence of HRV measures on RR was lost. There was an evident difference in the dependence of nonlinear on linear measures between young subjects and all the other studied groups. In disease the reduction in autonomic control was associated with the decrease in short-range correlation and regularity in RR series. We have concluded that the analysis of HRV measures as functions of RR interval length can reveal important aspects of HR control that might be lost in averaging. © 2006 IOP Publishing Ltd.

Background: Reduction of heart rate variability as a consequence of heart disease and postural change has been well documented. However, the data on the effect of postural change in pediatric patients are incomplete and the effect is not fully understood. The aim of the study was to investigate effect of postural change on heart rate variability in relation to the extent of severity of heart disease. Methods: The dependence of heart rate variability on posture in 41 children and young adults (8-20 years) with heart disease has been investigated and compared with control. Short-term electrocardiograms (ECGs) were assessed in supine rest and active standing, and spectral measures of heart rate variability were determined. Results: Two types of response to the change of supine to standing posture were determined in both healthy and diseased subjects. In majority of subjects, the increased heart rate induced by standing was accompanied by a decrease in high-frequency power. However, in about 30% of all subjects, increased heart rate during standing was accompanied by an increased high-frequency power. Independently of posture and disease, high-frequency and low-frequency power were positively correlated. In subjects characterized by a reduction of heart rate variability in standing, the high-frequency power in both postures is reduced in diseased subjects compared to control. Conclusions: These results demonstrate that in this age range, the response to posture is not unique because of the difference in high-frequency power, which implies a variety of vagal modulations of heart rate. © 2004 Elsevier Ireland Ltd. All rights reserved.

Previous results on heart rate variability (HRV) analysis in anorexia nervosa (AN) include some apparently conflicting data. In order to find out the reason for different results and to improve understanding of autonomic control in AN we compare HRV in acute and chronic AN. Spectral powers, fractal scaling exponent and sample entropy were computed from 24 h RR series derived from Holter ECG recordings in 17 anorexic patients, nine chronic and eight healthy women. We found that all linear and non-linear HRV measures change in different direction in acute and chronic AN. Acute AN is characterized by decreased HR and increased HRV. In chronic AN, HR is increased, HRV reduced and the difference between awake and sleeping values is high. HRV measures are associated with body mass index only in chronic AN. As HRV measures are significantly different between acute and chronic AN, we propose that HRV analysis might provide additional data in clinical practice. © 2006 Blackwell Publishing Ltd.

Previous results on heart rate variability (HRV) analysis in anorexia nervosa (AN) include some apparently conflicting data. In order to find out the reason for different results and to improve understanding of autonomic control in AN we compare HRV in acute and chronic AN. Spectral powers, fractal scaling exponent and sample entropy were computed from 24 h RR series derived from Holter ECG recordings in 17 anorexic patients, nine chronic and eight healthy women. We found that all linear and non-linear HRV measures change in different direction in acute and chronic AN. Acute AN is characterized by decreased HR and increased HRV. In chronic AN, HR is increased, HRV reduced and the difference between awake and sleeping values is high. HRV measures are associated with body mass index only in chronic AN. As HRV measures are significantly different between acute and chronic AN, we propose that HRV analysis might provide additional data in clinical practice. © 2006 Blackwell Publishing Ltd.

In this study we investigated nonlinear and linear characteristics of heart period variability with aging in supine and standing posture. Sixty healthy subjects (8-61 years) divided in three age groups participated in the study. Heart period variability was assessed by measurement of short-term scaling exponent, sample entropy, largest Lyapunov exponent and spectral low-frequency and high-frequency power. In standing, there was significant increase in short-term scaling exponent and largest Lyapunov exponent in all subjects, and significant decrease in sample entropy in children (< 15 years) and young adults (15-39 years). Increasing age is associated with reduction in sample entropy in supine posture. Mutual effect of aging and postural change was reflected on heart rate and sample entropy. Correlation between low-frequency-to-high-frequency power ratio and short-term scaling exponent was found in supine posture. In standing both low-frequency and high-frequency powers are correlated with short-term scaling exponent and sample entropy. These results show that posture, standing compared to supine, has significant effect on nonlinear properties of heart period variability in healthy subjects while the influence of healthy aging is less pronounced. The findings indicate that intrinsic properties of heart period dynamics, reflected on nonlinear measures, are altered only by robust changes of autonomic modulation of heart rate.

In this study we investigated nonlinear and linear characteristics of heart period variability with aging in supine and standing posture. Sixty healthy subjects (8-61 years) divided in three age groups participated in the study. Heart period variability was assessed by measurement of short-term scaling exponent, sample entropy, largest Lyapunov exponent and spectral low-frequency and high-frequency power. In standing, there was significant increase in short-term scaling exponent and largest Lyapunov exponent in all subjects, and significant decrease in sample entropy in children (< 15 years) and young adults (15-39 years). Increasing age is associated with reduction in sample entropy in supine posture. Mutual effect of aging and postural change was reflected on heart rate and sample entropy. Correlation between low-frequency-to-high-frequency power ratio and short-term scaling exponent was found in supine posture. In standing both low-frequency and high-frequency powers are correlated with short-term scaling exponent and sample entropy. These results show that posture, standing compared to supine, has significant effect on nonlinear properties of heart period variability in healthy subjects while the influence of healthy aging is less pronounced. The findings indicate that intrinsic properties of heart period dynamics, reflected on nonlinear measures, are altered only by robust changes of autonomic modulation of heart rate.

The measures of nonlinear properties of RR interval and QT interval time series are sensitive to physiologically- or pathologically-induced complexity/regularity changes, but were not used to estimate the effect of alcohol intake. We wanted to examine the potential of these measures to quantify the acute effect of a low dose of red wine in healthy subjects. In separate experiments, fourteen young volunteers drank 200ml of red wine and a control drink with equal concentration of ethanol. ECG in supine position was recorded 20min before and 60min after drink intake. RR interval and QT interval series were extracted from ECG and we calculated variability, scaling exponents (α 1 and α 2 ) and sample entropy (SampEn) for both series. Systolic and diastolic blood pressures (BP) were measured every 10min. The immediate effect of both the drinks was equal: HR, BP and QT variability exhibited a sudden increase and then a decrease. However, the prolonged effect of wine and the control drink was different. Wine decreased both BP (p<0.05) and reduced complexity of RR and QT series (increased scaling exponents and decreased SampEn). The control drink prolonged QT and RR intervals (p<0.05). These results point out that the nonlinear properties of RR and QT interval series could be used to differentiate the effect of wine and ethanol. Changes in RR and QT interval series induced by a low dose of red wine are more detectable by methods that quantify the structure of the series than by methods that quantify their variability. © 2014 Elsevier Ltd.

The measures of nonlinear properties of RR interval and QT interval time series are sensitive to physiologically- or pathologically-induced complexity/regularity changes, but were not used to estimate the effect of alcohol intake. We wanted to examine the potential of these measures to quantify the acute effect of a low dose of red wine in healthy subjects. In separate experiments, fourteen young volunteers drank 200ml of red wine and a control drink with equal concentration of ethanol. ECG in supine position was recorded 20min before and 60min after drink intake. RR interval and QT interval series were extracted from ECG and we calculated variability, scaling exponents (α 1 and α 2 ) and sample entropy (SampEn) for both series. Systolic and diastolic blood pressures (BP) were measured every 10min. The immediate effect of both the drinks was equal: HR, BP and QT variability exhibited a sudden increase and then a decrease. However, the prolonged effect of wine and the control drink was different. Wine decreased both BP (p<0.05) and reduced complexity of RR and QT series (increased scaling exponents and decreased SampEn). The control drink prolonged QT and RR intervals (p<0.05). These results point out that the nonlinear properties of RR and QT interval series could be used to differentiate the effect of wine and ethanol. Changes in RR and QT interval series induced by a low dose of red wine are more detectable by methods that quantify the structure of the series than by methods that quantify their variability. © 2014 Elsevier Ltd.

The aim of this study was to examine the dependence of heart rate variability (HRV) measures on RR interval length and to find out relationships between linear and nonlinear measures. The spectral powers in very low (VLF), low (LF) and high (HF) frequency regions, short-term scaling exponent α1 and sample entropy (SampEn) were determined. All spectral powers increased with increasing RR interval length until they reached a plateau. Neighbouring spectral powers were strongly correlated. The largest fraction of the spectrum consisted of VLF (from about 40 to 95%) and the smallest of HF, although HF was most sensitive to changes in RR interval length. SampEn is also increased with increasing RR interval, reaching a plateau. The dependence of α1 on RR showed a deflection point at 0.5 s. Nonlinear measures can be expressed by spectral powers: α1 by a linear function of ln(LF/HF) and SampEn by a quadratic function of ln HF. We concluded that during the day an increase of HR up to 120 beats min-1 was reflected in a reduction in HF and LF and to a smaller extent in VLF and by decreased complexity and increased correlation in RR interval series. In sleep, HRV measures are at a plateau. We suggest that below intrinsic value, HR is regulated mainly by changes of parasympathetic activity, reflected in linear and nonlinear HRV measures. © 2006 IOP Publishing Ltd.

The aim of this study was to examine the dependence of heart rate variability (HRV) measures on RR interval length and to find out relationships between linear and nonlinear measures. The spectral powers in very low (VLF), low (LF) and high (HF) frequency regions, short-term scaling exponent α1 and sample entropy (SampEn) were determined. All spectral powers increased with increasing RR interval length until they reached a plateau. Neighbouring spectral powers were strongly correlated. The largest fraction of the spectrum consisted of VLF (from about 40 to 95%) and the smallest of HF, although HF was most sensitive to changes in RR interval length. SampEn is also increased with increasing RR interval, reaching a plateau. The dependence of α1 on RR showed a deflection point at 0.5 s. Nonlinear measures can be expressed by spectral powers: α1 by a linear function of ln(LF/HF) and SampEn by a quadratic function of ln HF. We concluded that during the day an increase of HR up to 120 beats min-1 was reflected in a reduction in HF and LF and to a smaller extent in VLF and by decreased complexity and increased correlation in RR interval series. In sleep, HRV measures are at a plateau. We suggest that below intrinsic value, HR is regulated mainly by changes of parasympathetic activity, reflected in linear and nonlinear HRV measures. © 2006 IOP Publishing Ltd.

In war, many people are not directly hurt, but they feel fear of various intensities for a long time. The response of the cardiovascular autonomic system to these conditions, produced by the bombardment of Yugoslav cities by NATO for 78 days in spring 1999, was investigated. A group of 12 active medical professionals was examined 1 and 5 weeks after the beginning of bombardment and 10 days after the end of bombardment by spectral analysis of heart rate variability. Two types of cardiovascular autonomic responses emerged. One type included a fast reaction and then adaptation; the increased activity of symphaticus compared to parasymphaticus in the beginning of war was followed by a balance of these activities after 1 month and a small increase immediately after the end of bombardment. The other type did not show an increased activity of symphaticus compared to parasymphaticus during the war, but at the end of bombardment the prevalence of vagal tone was observed. Copyright (C) 2000 Elsevier Science B.V.

In war, many people are not directly hurt, but they feel fear of various intensities for a long time. The response of the cardiovascular autonomic system to these conditions, produced by the bombardment of Yugoslav cities by NATO for 78 days in spring 1999, was investigated. A group of 12 active medical professionals was examined 1 and 5 weeks after the beginning of bombardment and 10 days after the end of bombardment by spectral analysis of heart rate variability. Two types of cardiovascular autonomic responses emerged. One type included a fast reaction and then adaptation; the increased activity of symphaticus compared to parasymphaticus in the beginning of war was followed by a balance of these activities after 1 month and a small increase immediately after the end of bombardment. The other type did not show an increased activity of symphaticus compared to parasymphaticus during the war, but at the end of bombardment the prevalence of vagal tone was observed. Copyright (C) 2000 Elsevier Science B.V.