Browsing by Author "Filipović, Branka (22934489100)"

Considering the developmental mutuality of the hepatic excretory ducts and pancreas it is possible to anticipate that the total number of the gravidities (artificial abortions + full-term deliveries) are influencing the morphological status of the pancreatic ductal system. Sixty seven women and 40 men underwent ultrasonographic examination that revealed no pathological changes on their biliopancreatic system. The diameters of Wirsung's duct in head, body and tail of pancreas, showed a gradual increasing in the function of the full-term deliveries: in the head diameters averagely ranged from 1.69 (one delivery) to 2.37 mm (three or more deliveries); manifesting same tendencies for the diameters in the body and the tail. The analysis based on the total number of pregnancies evaluated variations between 1.97 (women with two pregnancies) to 2.35 (women with five or more pregnancies). The correlation of the number of pregnancies and full-term deliveries with the change of the diameter of the pancreatic duct was verified by statistical tests of correlation and linear regression. Mentioned methods evaluated the relationship between the obtained parameters in our group of the female examinees although results obtained did not surpass commonly accepted ranges.

Background/Aim. The iliopsoas muscle [musculus (m.) iliopsoas] originates from the Greek word psóa, which means loin and represents the only muscle in the body with anatomical preconditions to simultaneously and directly contribute to the stability and movement of the trunk, pelvis, and legs. M. iliopsoas belongs to the inner thigh muscle group and forms part of the posterior abdominal wall. This muscle is the major flexor of the hip joint, and it is functionally essential for proper posture, walking, running, and other physical activities. The aim of this study was to determine the relationship between the anatomical parameters of the pelvis and nervus (n.) femoralis, as well as the relationship between the same pelvic parameters and m. psoas major. Methods. The study was conducted at the Faculty of Medicine, University of Belgrade, on cadaveric material of the Institute of Anatomy “Niko Miljanić”. For measurement purposes, 14 cadavers were used, seven of which were male and seven female, aged 67–79 years. The measuring instruments used in this study were a ruler and an electronic digital caliper (measuring range 0–500 mm, resolution 0.01 mm). Statistical data processing was performed in the SPSS 11.0 program using the Mann-Whitney U test. Results. The results of this study indicate a significant statistical difference in pelvic width between male and female cadavers, which was observed in the reduction of the bituberal line in females, while the parameters of the bispinal line showed no significant difference between the two genders. The decrease of the bituberal line in females was followed by an increase in the width of the proximal origin with a statistically significant decrease in the length of the proximal origin of the m. psoas major. Furthermore, the vertical distance of n. femoralis from the exit point of the muscle to the bispinal line was significantly reduced in the male cadavers. Conclusion. Based on our results, we can assume that, in most cases, due to the smaller bituberal and bispinal line or narrower pelvis, a shorter proximal attachment of the m. psoas major will occur with greater width (L2–L5 level) in the female than in the male gender, resulting in a longer vertical distance of n. femoralis. Such results indicate a close correlation between the anatomical parameters of the m. psoas major, which may affect the distance of n. femoralis exit from the muscle. © 2023 Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved.

Studies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potentials have also been reported, both in patient related and in animal model-based investigations, and correlated with assessed brain tissue changes. We hypothesized that NAFLD, as a condition, affects the brain tissue and, subsequently, the cognitive state. So we compared findings in 40 NAFLD positive and 36 NAFLD negative patients and correlated their brain tissue volumes with the results of Montreal Cognitive Assessment (MoCA) test. Binomial logistic regression verified the influence of NAFLD state leading to lower cognitive potentials: odds ratio 0.096; 95% confidence interval (CI) 0.032-0.289; p<0.001. Patients with NAFLD had a greater risk to suffer from the cognitive impairment and depression: RR = 3.9; 95% CI 1.815-8.381; p=0.0005 and RR = 1.65; 95% CI 1.16-2.36; p=0.006. NAFLD significantly influenced the cognitive deficit and tissue volume reduction and patients suffering from NAFLD had about four times higher risk of having a cognitive impairment. © 2018 Branka Filipović et al.

Aim To compare the prognostic performance of three major risk scoring systems including global registry for acute coronary events (GRACE), thrombolysis in myocardial infarction (TIMI), and prediction of 30-day major adverse cardiovascular events after primary percutaneous coronary intervention (RISK-PCI). Methods This single-center retrospective study involved 200 patients with acute coronary syndrome (ACS) who underwent invasive diagnostic approach, ie, coronary angiography and myocardial revascularization if appropriate, in the period from January 2014 to July 2014. The GRACE, TIMI, and RISK-PCI risk scores were compared for their predictive ability. The primary endpoint was a composite 30-day major adverse cardiovascular event (MACE), which included death, urgent target-vessel revascularization (TVR), stroke, and non-fatal recurrent myocardial infarction (REMI). Results The c-statistics of the tested scores for 30-day MACE or area under the receiver operating characteristic curve (AUC) with confidence intervals (CI) were as follows: RISK-PCI (AUC = 0.94; 95% CI 1.790-4.353), the GRACE score on admission (AUC = 0.73; 95% CI 1.013-1.045), the GRACE score on discharge (AUC = 0.65; 95% CI 0.999-1.033). The RISK-PCI score was the only score that could predict TVR (AUC = 0.91; 95% CI 1.392-2.882). The RISK-PCI scoring system showed an excellent discriminative potential for 30- day death (AUC = 0.96; 95% CI 1.339-3.548) in comparison with the GRACE scores on admission (AUC = 0.88; 95% CI 1.018-1.072) and on discharge (AUC = 0.78; 95% CI 1.000- 1.058). Conclusions In comparison with the GRACE and TIMI scores, RISK-PCI score showed a non-inferior ability to predict 30-day MACE and death in ACS patients. Moreover, RISK-PCI was the only scoring system that could predict recurrent ischemia requiring TVR.

[No abstract available]

Introduction. Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially life-threatening, hyperinflammatory syndrome caused by severe hypercytokinemia due to a highly stimulated, but ineffective immune response. Case report. We reported a 19-year-old woman presenting with fever, muscle and joint pain and sore throat. After diagnostic procedures we made the diagnosis of hemophagocytic lymphohistiocytosis (7 of 8 HLH-2004 diagnostic criteria) caused by Ebstein-Barr viral infection and trigerred by the intense physical activity. Genetic analysis showed three different sequence changes in Munc-18-2, two splice acceptor side mutations/changes affecting exon 10 (c.795-4 C > T) and exon 15 (c.1247-10 C > T) and a missense mutation c.1375 C > T; p.Arg 459 Trp. All mutations were in heterozygous state and their significance in pathogensis of HLH is not clear. After treatment with corticosteroids and cyclosporin A complete clinical remission was achieved. Conclusion. The presented case history suggests the possibility that mutations of undetermined clinical significance in a gene associated with primary HLH may underlie some cases of secondary HLH, probably by causing a partial, rather than total or subtotal, impairment of encoded protein function. Our case also suggests that strenuous physical activity (in apparent synergy with viral infection) can trigger HLH. © 2017, Institut za Vojnomedicinske Naucne Informacije/Documentaciju. All rights reserved.

Introduction/Objective The objective was to explore whether there is a difference in headache manifestation and level of its intensity in patients with functional dyspepsia and irritable bowel syndrome. Methods We assessed a cohort of 420 participants out of which 300 satisfied the recruiting criterion of the presence of irritable bowel syndrome (148) or functional dyspepsia (152). Diagnoses of irritable bowel syndrome and functional dyspepsia were made according to Rome IV criteria. Intensity of headaches was estimated in irritable bowel syndrome and functional dyspepsia participants using visual analog scale. All the patients underwent subsequent testing by Hamilton’s Depression Inventory and anxiety scale. Results Our results showed that males with headaches are more susceptible to functional dyspepsia, statistical significance in the group of patients with irritable bowel syndrome with high scores on the visual analog scales, in relation to Hamilton’s anxiety scores in the group of patients with irritable bowel syndrome. Gender and visual analogue scale scores were determinants to show whether the patient falls within the group of functional dyspepsia or irritable bowel syndrome. Scores of visual analogue scale where the patient felt the best was statistically borderline (p = 0.061) and its higher values pinpointed which of those patients fall into irritable bowel syndrome group. Conclusion Gender and level of headache intensity as a extraintestinal manifestation showed to be the main variables to make a difference between patients with functional dyspepsia and irritable bowel syndrome where irritable bowel syndrome had higher scores and greater dominance in differential diagnosis if the headache was determining variable. © 2023, Serbia Medical Society. All rights reserved.

Cavum septi pellucidi (CSP), especially when longer than 6 mm, has been recognized as a neurodevelopmental anomaly associated with schizophrenia. The present post-mortem study was designed to determine the importance of linear parameters of CSP and to evaluate the possible differences of CSP in schizophrenic patients (n = 25 out of 110 CSP+ brains) and normal persons (n = 40 out of 110 CSP+ brains). According to our results, schizophrenia patients had significantly longer and wider CSP than normal individuals. Also, statistical analysis revealed a higher suicide rate in CSP-positive patients with schizophrenia.

Cavum septi pellucidi (CSP), especially when longer than 6 mm, has been recognized as a neurodevelopmental anomaly associated with schizophrenia. The present post-mortem study was designed to determine the importance of linear parameters of CSP and to evaluate the possible differences of CSP in schizophrenic patients (n = 25 out of 110 CSP+ brains) and normal persons (n = 40 out of 110 CSP+ brains). According to our results, schizophrenia patients had significantly longer and wider CSP than normal individuals. Also, statistical analysis revealed a higher suicide rate in CSP-positive patients with schizophrenia.

[No abstract available]

Introduction Colorectal cancer is the third most common cancer worldwide. Signet-ring carcinoma is an extremely rare subtype of colorectal cancer, with frequency ranges 0.3–4.6%. The diagnosis of this type of cancer is based on pathohistological analysis. Case outline A 58-year-old patient was admitted due to abdominal pain and abdominal swelling. The physical findings indicated abdomen above the level of the chest, soft, painfully sensitive in the left hemiabdomen, with positive clinical signs of ascites. Laboratory analyzes indicated positive inflammatory syndrome, elevation of D-dimer and CA-19-9. Ascites analysis showed the presence of malignant cells. Computed tomography revealed hepatomegaly, liver steatosis, as well as multiple secondary deposits in the liver, ascites, and peritoneal implants. Colonoscopy showed ulceration of the right colon, which was covered with fibrin. The pathohistological findings indicated poorly differentiated, invasive adenocarcinoma of the signet ring carcinoma type. The patient was treated with analgesics, diuretics, proton pump inhibitors, beta 2 blockers, angiotensin-converting enzyme inhibitors, low-molecular-weight heparin, antibiotics, and supportive therapy. The patient was discharged after 10 days of hospitalization. He was presented to the multidisciplinary team, which decided on further symptomatic therapy. Conclusion Signet-ring colon cancer is a rare, aggressive tumor with a poor prognosis. Although it is most often localized in the stomach, it is necessary to think about the colorectal localization of this tumor in the differential diagnosis of patients with colonic complaints, especially if they have “alarm symptoms” and if they are younger. © 2024, Serbia Medical Society. All rights reserved.