Browsing by Author "Dragojević, Svetlana (57205032707)"

[No abstract available]

[No abstract available]

Endometrial sonographic and color doppler features can be used to predict the occurrence of pregnancy in natural or stimulated cycles. Implantation will usually only take place if the endometrium has reach a certain stage of vascularisation and development. The aim of this study was to evaluate endometrial development -- endometrial thickness and reflectivity , subendometrial, endometrial and uterine perfusion, after hyperbaric oxygenation, using transvaginal color doppler. During a three years period 32 women with unexplained infertility were entered into a randomised study. The patients were treated in multiplaced HAUX chamber at pressure of 2.3 ATA during 70 minutes, 7 days consecutively beginning with day 5th of menstrual cycle.The evaluation of effects of hyperbaric oxygen therapy was carried out by transvaginal color doppler sonography which was continuously used starting from 8th day of menstrual cycle until the ovulation in the cycles when the therapy was applied , one month before and one month after the therapy. Folliculometry in the cycles when hyperbaric oxygen therapy at 2.3 ATA was applied, indicated an excellent response of endometrium. Thickness of endometrium at the time of ovulation was 11.0 +/- 2.6 mm. Desirable quality of endometrium was significantly better in the cycle when HBO therapy had been applied (p< 0.001). The doppler flowmetry of the uterine arteries indicated that the uterine blood vessel resistance was slightly higher than expected. Mapping of subendometrial blood vessels in the cycles covered by hyperbaric oxygen therapy showed the intensive capillary network of endometrium with low resistance Ri< 0.45. The oxygen used under higher pressure -- oxygen as a drug , may have an extraordinary significance for better outcome of pregnancy implantation by improving endometrial receptivity. If endometrial receptivity is conditioned by adequate vascularisation and oxygenation, then hyperbaric oxygen therapy is the treatment of choice.

Hypogonadotropic hypogonadism is one of the causes of infertility. In women with hypogonadotropic hypogonadism both follicle-stimulating hormone and luteinizing hormone are required to induce optimal follicular growth and steroidogenesis. We described a case of singleton pregnancy in a 38-year-old patient, presenting with primary hypogonadotropic amenorrhea and empty sella syndrome, treated with human menopausal gonadotropins and performing intrauterine insemination in first attempt. This therapy led to maturation of two follicles and one of them was fertilized. A singleton pregnancy ensued and a normal infant was delivered by cesarean section. © 2006 Blackwell Munksgaard.

Hypogonadotropic hypogonadism is one of the causes of infertility. In women with hypogonadotropic hypogonadism both follicle-stimulating hormone and luteinizing hormone are required to induce optimal follicular growth and steroidogenesis. We described a case of singleton pregnancy in a 38-year-old patient, presenting with primary hypogonadotropic amenorrhea and empty sella syndrome, treated with human menopausal gonadotropins and performing intrauterine insemination in first attempt. This therapy led to maturation of two follicles and one of them was fertilized. A singleton pregnancy ensued and a normal infant was delivered by cesarean section. © 2006 Blackwell Munksgaard.

Introduction Hepatic pregnancy is an extremely rare form of ectopic pregnancy, and represents a difficult challenge for both diagnostics and treatment. Case outline A 40-year-old gravida 0 para 0 patient in 6 + 0 gestational weeks was admitted to the hospital with lower abdominal pain, positive bHCG values, and presence of free intra-abdominal fluid. She had a history of infertility, and also a previous surgery due to pelvic endometriosis. Urgent open surgery was performed due to signs of hypovolemic shock. We discovered a rupture of the left ovarian corpus luteum cyst. Bleeding management was achieved with preservation of ovarian tissue. Patient recovered, bHCG levels continued to rise, and five days after surgery free intra-abdominal fluid reappeared with upper abdominal pain and tenderness. After transferring patient to abdominal surgery clinic, second surgery was performed, where we confirmed the presence of hepatic pregnancy. After this procedure, patient fully recovered. Conclusion The method of choice for an ectopic pregnancy treatment is laparoscopic surgery, but when laparoscopy is not possible, the site of ectopic pregnancy could be difficult to diagnose. Prolonged time for making accurate diagnosis increases the risk of ectopic pregnancy complications. © 2020, Serbia Medical Society. All rights reserved.

Introduction: Post-menopause androgens are the essential precursors for estrogen synthesis through their conversion in peripheral tissues. The main postmenopausal estrogen is estrone, which is also peripherally converted into estradiol. Concentrations of these two estrogens are directly proportional in circulation. We wanted to establish whether there is a direct correlation between body mass and postmenopausal symptoms in surgically castrated women. Materials and methods: We analyzed 30 patients with artificially induced menopause, 3-12 months after the operation (hysterectomy and bilateral adnexectomy). Prior to being put on hormone substitution therapy the following was obtained from the patients: Body Mass Index-BMI (kg/m 2 ), measurement of estradiol (E 2 ) by RIA method, and 12 subjective symptoms analyzed according to intensity and frequency. The relationship between BMI, E 2 level and subjective symptoms were assessed. Results: By analyzing the correlation coefficient it was shown that there was statistically significant causal-consequential connection between the E 2 level and BMI (R 2 =0.1647, p<0.05). There is no strong correlation between BMI and symptoms (R 2 =0.004, p<0.05). However, E 2 level correlated with subjective symptoms (R 2 =0.2123, p<0.05). Conclusions: Estrogen production in postmenopause is dependent on the substrate availability, and thus with adiposity. Therefore, we were surprised by the lack of correlation between BMI and symptoms. This suggests that estrogen metabolism and biological effects are not primarily affected by BMI, and that expression of postmenopausal symptoms does not depend only on estrogen level. © Springer-Verlag 2004.