Browsing by Author "Dotlic, R. (6603869546)"

Asymptomatic genital Herpesvirus hominis (HVH) infection in a group of 100 pregnant women with normal and high risk pregnancy was examined. Vaginal and cervical HVH shedding was diagnosed by the method of immunofluorescence. The results of cervical and vaginal swabs taken from the same patients, showed that in both groups of pregnant women examined, the presence of HVH infection in the vagina and cervix was not always simultaneous. Asymptomatic vaginal HVH type 1 infection was found more often in high risk pregnancy, and the difference in reference to the normal pregnancy was statistically significant. Asymptomatic cervical infection was more caused of HVH type 2 both in normal and high risk pregnancy.

[No abstract available]

A randomized group of 101 oligospermic men, with low or normal serum follicle-stimulating hormone levels and infertile marriages of more than 2 years were studied with and without clomiphene citrate. For 6 to 9 months 56 patients were treated with 50 mg. clomiphene citrate daily and 45 men were given no treatment. Significant improvement in volume, sperm density and sperm motility was observed in the treated group but not in the control group. Sperm density greater than 20 times 106 per ml. was obtained in 18 men and there were 7 pregnancies in the treated group. In the control group 3 men had a sperm count greater than 20 times 106 per ml. and there was no pregnancy. This study showed statistically significant improvement of sperm parameters in the treated group but not in the untreated patients.

A possible etiologic relationship between maternal asymptomatic genital HVH infection and pre-term labor was discussed on the base of the results of the investigation performed in this study. Latent HVH infection was diagnosed by the test of microneutralization. Asymptomatic HVH vaginal and cervical shedding was investigated by indirect immunofluorescence and cytologically. The incidence of latent HVH type 2 infection was higher in women with previous pre-term labor than in the control group. The difference appeared to be statistically significant. The comparison of HVH type 2 asymptomatic cervical infection of the examined and the control group shows that it lies on the boundary of statistical significance. It means that further research of the subject is needed including prospective virologic investigations with the aim of detecting active HVH infections at the time of pre-term labor. Concerning the increasing significance of genital HVH infections in our environment, it seems reasonable to aim diagnostic efforts at the determination of both latent and active HVH infections, in order to reduce the incidence of pre-term labor and the perinatal morbidity and mortality rates by use of appropriate preventive and therapeutic measures.

A randomised group of 90 men with idiopathic oligoasthenozoospermia was subjected to control study with pentoxifylline. Pentoxifylline was given to 51 men 1200 mg daily for 3 months. The other group of 39 infertile men was followed during the same period of time. Significant improvement was observed, in treated group, in percentage of motile sperms and normal shaped sperms after 3 months treatment. This study emphasizes that pentoxifylline is a relatively good drug for restoring sperm motility and morphology in oligoasthenozoospermic men.