Browsing by Author "Diklic, A.D. (6601959320)"

Background: Thyroid cancer is relatively rare, but it is the most frequent cancer among malignancies of the endocrine system. To evaluate the association between thyroid cancer and potential risk factors. Material and methods: A case-control study was conducted in Central Serbia, Yugoslavia. The case group consisted of 100 newly diagnosed patients with histologically confirmed thyroid cancer. The controls (100 patients with injuries) were individually matched with cases by sex, age and place of residence. McNemar's test and conditional logistic regression were used in the analysis. Results: According to logistic regression analysis the following factors were independently related with the occurrence of thyroid cancer: diagnostic X- ray during childhood and/or youth goiter, history of residence in endemic goiter area, anemia in personal history, history of previous malignant tumors, family history of any malignant tumor, spontaneous abortion and use of oral contraceptives. Conclusion: The present study supports the hypothesis that besides other risk factors, thyroid cancer in women is affected by some reproductive and probably hormonal factors.

Background: Anaplastic thyroid carcinoma (ATC) is relatively rare and represents one of the most aggressive tumours with poor prognosis, despite therapy. The aim of the study was to analyse demographic and clinical characteristics of ATC patients, and to identify survival rates and prognostic factors. Methods: In a retrospective study (1995-2005) ATC was found in 150 patients treated at our institution. Survival was calculated by Kaplan-Meier curve and log-rank test. Potential prognostic factors affecting survival were compared by Cox univariate and multivariate analyses. Results: Mean survival time was 56 weeks; median survival time was 16 weeks and 1 and 5-year survival were 17% and 8%. More than 10% died during the first month and 50% died up to the fourth month. Multivariate analysis showed that age, goitre and surgery were independent prognostic factors of survival in all ATC patients. Among operated patients, the extent of tumour resection, distant metastasis and multicentricity were independent prognostic risk factors of survival. Postoperative radiotherapy was a protective factor. Conclusions: There is still no successful treatment of ATC that can guarantee long term survival. Younger patients with pre-existing goitre, who undergo complete resection of unilocular early stage ATC without distant metastasis and with postoperative external radiotherapy, stand a better chance of long-term survival. © Acta Chirurgica Belgica.