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Browsing by Author "Davidovic, Lazar (7006821504)"

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    A deceitful case of spinal cord malperfusion presented as an acute limb ischemia
    (2014)
    Banzic, Igor (36518108700)
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    Ilić, Nikola (7006245465)
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    Dragaš, Marko (25027673300)
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    Končar, Igor (19337386500)
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    Sladojevic, Milos (35184234700)
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    Tomic, Ivan (54928165800)
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    Davidovic, Lazar (7006821504)
    We present an interesting case of a patient with spinal cord ischemia presented with physical and angiographic findings of acute right leg ischemia 6 days after abdominal aortic aneurysm open repair. After unsuccessful transpopliteal thrombectomy, patient was treated with spinal cord drainage. Cause of this complication might be ischemic lumbal plexopathy. © 2014 Elsevier Inc. All rights reserved.
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    A proposal for a predictive model of paraplegia prevention during thoracic endovascular aortic repair
    (2013)
    Ilić, Nikola (7006245465)
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    Končar, Igor (19337386500)
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    Dragaš, Marko (25027673300)
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    Pejkic, Sinisa (57189038513)
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    Maksimovic, Zivan (26537806600)
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    Davidovic, Lazar (7006821504)
    [No abstract available]
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    A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks
    (2014)
    Radak, Djordje (7004442548)
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    Davidovic, Lazar (7006821504)
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    Tanaskovic, Slobodan (25121572000)
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    Banzic, Igor (36518108700)
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    Matic, Predrag (25121600300)
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    Babic, Srdjan (26022897000)
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    Kostic, Dusan (7007037165)
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    Isenovic, Esma R. (14040488600)
    Background To present outcomes following an operative approach of extracranial carotid artery aneurysm (ECAAs) based on anatomic types and associated kinks. Methods This study represents retrospective analysis of anatomic type based approach to operative repair of 84 patients with ECAA from 1994 to 2011, 28 (33.3%) with associated kinking. Patients were followed for neurological ischemic events, hematoma, cranial nerve injury, myocardial infarction, neurological, and overall mortality. The results are presented as early, within 30 days after the surgery, and long term during the follow-up. Results In the early postoperative period, there were no strokes or mortalities, cranial nerve injury rate was 2.4% while 1 patient had myocardial infarction (1.2%). During the follow-up, 4 patients (4.8%) had stroke, out of which 2 patients died (2.3%), while overall mortality was 4.6%. The average 5-year survival rate was 96 ± 3%. Conclusion Excellent outcomes can be obtained with surgical repair of ECAA, which should be tailored to the anatomic types and presence of kinks. © 2014 Elsevier Inc. All rights reserved.
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    Abdominal Aortic Surgery in the Presence of Inferior Vena Cava Anomalies: A Case Series
    (2017)
    Dimic, Andreja (55405165000)
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    Markovic, Miroslav (7101935751)
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    Cvetkovic, Slobodan (7006158672)
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    Cinara, Ilijas (6602522444)
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    Koncar, Igor (19337386500)
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    Davidovic, Lazar (7006821504)
    Background Left-sided inferior vena cava (LIVC) and duplicated inferior vena cava (DIVC) are rare asymptomatic congenital abnormalities. Unrecognized, these anomalies can be the source of major injuries and cause serious life-threatening bleeding complications especially during abdominal aortic surgery. Methods Retrospective data for patients with 2 major inferior vena cava (IVC) anomalies that underwent aortic surgery over a 13-year period were collected. Patient demographics, type of aortic disease and caval anomaly, surgical approach, type of aortic reconstruction associated with procedure on caval vein, postoperative complications, and in-hospital mortality were recorded. Results There were 9 patients with inferior vena cava (IVC) anomalies who underwent aortic surgery. All of them were men, with a median age of 66.2 years. Seven had an LIVC and 2 had DIVC. Five patients were operated on due to abdominal aortic aneurysm and 4 due to aortoiliac occlusive disease. In all patients, a midline transperitoneal aortic approach was performed. In 5 cases, the left IVC had to be temporarily resected and later reconstructed, and in the other 4 it was just mobilized. There were no postoperative complications except in one patient who developed deep vein thrombosis in the left calf; this was successfully treated with anticoagulant therapy. Conclusion Due to favorable results and low incidence of perioperative complications and in the absence of other associated abdominal pathology, we propose the midline transperitoneal approach with mobilization or temporary resection of LIVC. © 2016 Elsevier Inc.
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    Acute kidney injury in patients undergoing endovascular or open repair of juxtarenal or pararenal aortic aneurysms
    (2024)
    Zlatanovic, Petar (57201473730)
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    Davidovic, Lazar (7006821504)
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    Mascia, Daniele (54890325100)
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    Ancetti, Stefano (56703428400)
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    Yeung, Kak Khee (15926593800)
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    Jongkind, Vincent (22937335300)
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    Viitala, Herman (58034571600)
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    Venermo, Maarit (24485029300)
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    Wiersema, Arno (55131269100)
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    Chiesa, Roberto (7005309682)
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    Gargiulo, Mauro (7005882364)
    Background: The aim of this cohort study was to report the proportion of patients who develop periprocedural acute kidney injury (AKI) after endovascular repair (ER) and open surgery (OS) in patients with juxta/pararenal abdominal aortic aneurysm and to assess potential risk factors for AKI. The study also aimed to report the short- and long-term outcomes of patients with and without AKI. Methods: This was a multicenter cohort study of five European academic high-volume centers (>50 OS or 50 ER infrarenal AAA repairs, plus >15 complex AAA repairs per year). All consecutively treated patients were extracted from a prospective vascular surgical registry and the data were scrutinized retrospectively. The primary end point for this study was the development of AKI. AKI was diagnosed when there is a two-fold increase of serum creatinine or decrease of glomerular filtration rate of >50% within 1 week of AAA repair. Secondary end points included long-term mortality and end-stage renal disease (ESRD). Results: AKI occurred in 16.6% of patients in the ER group vs 30.3% in the OS group (P <.001). The 30-day mortality rate was higher among patients with AKI in both ER (15.4% vs 3.1%; P =.006) and OS (13.2% vs 5.3%; P =.001) groups. Age, chronic kidney disease, presence of significant thrombus burden in the pararenal region, >1000 mL blood loss in ER group were associated with development of AKI. Age, diabetes mellitus, chronic kidney disease, presence of significant thrombus burden in the pararenal region, and a proximal clamping time of >30 minutes in the OS group were associated with the development of AKI, whereas renal perfusion during clamping was the protective factor against AKI development. After a median follow-up of 91 months, AKI was associated with higher mortality rates in both the ER group (58.9% vs 29.7%; P <.001) and the OS group (61.5% vs 27.3%; P <.001). After the same follow-up period, AKI was associated with a higher incidence of ESRD in both the ER group (12.8% vs 3.6%; P =.009) and the OS group (9.9% vs 2.9%; P <.001). Conclusions: The current study identified important pre and postoperative factors associated with AKI after juxta/pararenal abdominal aortic aneurysm repair. Patients with postoperative AKI had significantly higher short- and long term mortality and higher incidence of ESRD than patients without AKI. © 2024 Society for Vascular Surgery
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    An Isolated Aneurysm of the Abdominal Aorta in a Patient with Marfan Syndrome—A Case Report
    (2020)
    Mutavdzic, Perica (56321930600)
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    Dragas, Marko (25027673300)
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    Kukic, Biljana (6506390933)
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    Stevanovic, Ksenija (57376155800)
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    Končar, Igor (19337386500)
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    Ilić, Nikola (7006245465)
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    Tomic, Ivan (54928165800)
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    Sladojevic, Milos (35184234700)
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    Davidovic, Lazar (7006821504)
    We present a case of successfully treated abdominal aortic aneurysm in a 24-year-old patient with Marfan syndrome. After initial physical and ultrasound examination, the multislice computed tomography (MSCT) scan revealed infrarenal aortic aneurysm of 6 cm in diameter, 10 cm long, along with slightly dilated iliac arteries. However, dimensions of aortic root, aortic arch, and descending suprarenal aorta were within normal limits. Further on, because the patient presented with signs of impending rupture, an urgent surgical intervention was performed. The patient was discharged in good general medical condition 7 days after surgery. After 6 months of follow-up, the patient's condition was satisfying and no MSCT signs of further aortic dissection/aneurysm were identified. To the best of our knowledge, a case of successful management of a patient with Marfans syndrome and truly isolated infrarenal and symptomatic abdominal aortic aneurysm has not been described in the literature before. © 2019 Elsevier Inc.
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    Analysis of Lower Extremity Amputations from the SerbVasc Registry
    (2023)
    Tanaskovic, Slobodan (25121572000)
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    Ilijevski, Nenad (57209017323)
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    Koncar, Igor (19337386500)
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    Matejevic, David (57657574700)
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    Popovic, Miroslava (58611962900)
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    Stefanovic, Zvezdan (35085639500)
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    Babic, Aleksandar (57340398100)
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    Lazic, Aleksandar (57394252100)
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    Knezevic, Dragan (57201430785)
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    Damnjanovic, Zoran (19433895100)
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    Pesic, Slobodan (58525670300)
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    Stankovic, Jelena (58561379800)
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    Marjanovic, Ivan (36928024700)
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    Davidovic, Lazar (7006821504)
    Background: Peripheral arterial disease (PAD) and diabetes are the major causes of lower extremity amputations (LEAs) worldwide. Morbidity and mortality in patients with LEAs are high with an associated significant burden on the global health system. The aim of this article is to report the overall morbidity and mortality rates after major and minor LEAs from the Serbian Vascular Registry (SerbVasc), with an analysis of predictive factors that influenced adverse outcomes. Materials and methods: SerbVasc was created in 2019 as a part of the Vascunet collaboration that is aiming to include all vascular procedures from 21 hospitals in Serbia. Prevalence of diabetes among patients with LEAs, previous revascularization procedures, the degree and the type of foot infection and tissue loss, and overall morbidity and mortality rates were analyzed, with a special reference to mortality predictors. Results: In the period from January 2020 to December 2022, data on 702 patients with LEAs were extracted from the SerbVasc registry, mean age of 69.06±10.63 years. Major LEAs were performed in 59%, while minor LEAs in 41% of patients. Diabetes was seen in 65.1% of the patients, with 44% of them being on insulin therapy. Before LEA, only 20.3% of patients had previous peripheral revascularization. Soft tissue infection, irreversible acute ischemia, and Fontaine III and IV grade ischemia were the most common causes of above-the-knee amputations while diabetic foot was the most common cause of transphalangeal and toe amputations. The infection rate was 3.7%, the re-amputation rate was 5.7%, and the overall mortality rate was 6.9%, with intrahospital mortality in patients with above-the-knee amputation of 11.1%. The most significant intrahospital mortality predictors were age >65 years (p<0.001), chronic kidney disease (CKD) (p<0.001), ischemic heart disease (IHD) (p=0.001), previous myocardial revascularization (p=0.017), emergency type of admission (p<0.001), not using aspirin (p=0.041), using previous anticoagulation therapy (p=0.003), and postoperative complications (p<0.001). Conclusions: The main predictors of increased mortality after LEAs from the SerbVasc registry are age >65 years, CKD, IHD, previous myocardial revascularization, emergency type of admission, not using aspirin, using previous anticoagulation therapy, and postoperative complications. Taking into account high mortality rates after LEAs and a small proportion of previous peripheral revascularization, the work should be done on early diagnosis and timely treatment of PAD hopefully leading to decreased number of LEAs and overall mortality. Clinical Impact: Mortality after lower limb amputation from the SerbVasc register is high. A small number of previously revascularized patients is of particular clinical importance, bearing in mind that the main reasons for above-the-knee amputations were irreversible ischemia, Fontaine III and Fontaine IV grade ischemia. Lack of diagnostics procedures and late recognition of patients with PAD, led to subsequent threating limb ischemia and increased amputation rates. The work should be done on early diagnosis and timely treatment of PAD in Serbia, hopefully leading to an increased number of PAD procedures, decreased number of LEAs, and lower overall mortality. © The Author(s) 2023.
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    Carotid replacement with Dacron graft in 292 patients
    (2016)
    Koncar, Igor (19337386500)
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    Ribac, Jelena Z (57191845324)
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    Ilic, Nikola S (7006245465)
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    Dragas, Marko (25027673300)
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    Mutavdzic, Perica (56321930600)
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    Tomic, Ivan Z (54928165800)
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    Ristanovic, Natasa (56716304700)
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    Kostic, Dusan (7007037165)
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    Davidovic, Lazar (7006821504)
    Introduction: In case of highly atherosclerotic carotid process, carotid graft replacement might be a potential solution for successful procedure. Many studies evaluated the results of vein and polytetrafluorethilen (PTFE) graft usage at the carotid bifurcation, while the experience on the Dacron graft due to extensive atherosclerotic process is missing. The aim of our study was to evaluate 30-day and long-term results of the Dacron graft on carotid artery used in patients with extensive atherosclerotic disease. Material and methods: This retrospective study analysed early and long-term neurological outcome as well as Dacron graft patency in patients operated with carotid reconstruction. Early results were confirmed by follow-up clinical examination, whereas late results were assessed by follow-up clinical examination as well as duplex sonographic examination at least 1 year after the surgery. As for statistical methods we used descriptive analysis tests, Chi-square test, and logistic regression. Results: Carotid graft replacement was performed in 292 patients, before endarterectomy in 155 (53.09%), or after already attempted unsuccessful eversion endarterectomy in 137 (46.91%). Nineteen (6.5%) patients had a stroke due to ipsilateral and contralateral ischaemia or haemorrhagic in 17 (5.8%), 1 (0.3%) and 1 (0.3%) patients, respectively. Significantly higher rate of strokes occurred when the graft reconstruction was used after the failure of endarterectomy (8.5% vs. 3.5%, p = 0.029). Stroke and death rate was 7.19%. Factors that increased risk of early stroke were the length of plaque in the internal carotid artery measured intraoperatively (p = 0.025) and the surgical tactic to perform graft reconstruction after attempted extensive endarterectomy (p = 0.029). Conclusion: Low number of patients with carotid stenosis has extensive atherosclerotic process longer than 4 cm that might jeopardise eversion endarterectomy. Carotid graft replacement with Dacron graft provide early results that are comparable with other conduits; however, in such patients reconstruction should be selected individually based on surgical experience and anatomical distribution of stenotic disease. Due to high risk of stroke, only symptomatic patients with such extensive atherosclerotic disease should be operated. © 2016, © The Author(s) 2016.
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    Chimney Versus Fenestrated Endovascular Versus Open Repair for Juxta/Pararenal Abdominal Aortic Aneurysms: Systematic Review and Network Meta-analysis of the Short-term Results
    (2023)
    Zlatanovic, Petar (57201473730)
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    Jovanovic, Aleksa (57216047949)
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    Tripodi, Paolo (57191963001)
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    Davidovic, Lazar (7006821504)
    Introduction: The aim of this systematic review and network meta-analysis was to compare the short-term results of fenestrated endovascular repair (FEVAR), chimney endovascular repair (ChEVAR), and open surgery (OS) for patients with juxta/pararenal abdominal aortic aneurysms (JAAA/PAAA). Materials and methods: MEDLINE, SCOPUS, and Web of Science were searched from inception to 1 July 2022. Any comparative studies investigating the results of two or three treatment strategies (ChEVAR, FEVAR, or OS) on clinical outcomes for patients with JAAA/PAAA were included. Analysed outcomes were 30-day mortality, acute kidney injury (AKI), major adverse cardiovascular events (MACE), and bowel ischaemia (BI). Results: A total of 22 studies with 8853 patients were included in the analysis. FEVAR (OR = 0.58, 95%CrI 0.36–0.82) and ChEVAR (OR = 0.56, 95%CrI 0.28–1.02) were associated with lower 30-day mortality than OS. FEVAR (OR = 0.54, 95%CrI 0.33–0.85) was associated with lower risk of AKI than OS. FEVAR (OR = 0.43, 95%CrI 0.20–0.89) and ChEVAR (OR = 0.34, 95%CrI 0.10–0.93) compared to OS were associated with lower rates of BI. FEVAR (OR = 0.67, 95%CrI 0.49–0.90) and ChEVAR (OR = 0.61, 95%CrI 0.35–1.02) were associated with lower 30-day MACE risk than OS. FEVAR was associated with a higher rate of SCI compared to OS (OR = 4.90, 95%CrI 1.55–19.17). Conclusion: We found a clear benefit for FEVAR and ChEVAR versus OS in terms of reduced 30-day mortality, BI, and MACE, as well as AKI for FEVAR. This suggests that higher-risk patients might benefit from endovascular treatment of JAAA/PAAA; however, should be applied in clinical practice with caution, since long-term outcomes were outside of the scope of this review. © 2022, The Author(s) under exclusive licence to Société Internationale de Chirurgie.
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    Chimney vs. Fenestrated Endovascular vs. Open Repair for Juxta/Pararenal Abdominal Aortic Aneurysms: Systematic Review and Network Meta-Analysis of the Medium-Term Results
    (2022)
    Zlatanovic, Petar (57201473730)
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    Jovanovic, Aleksa (57216047949)
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    Tripodi, Paolo (57191963001)
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    Davidovic, Lazar (7006821504)
    Introduction: This systematic review with network meta-analysis aimed at comparing the medium-term results of open surgery (OS), fenestrated endovascular repair (FEVAR), and chimney endovascular repair (ChEVAR) in patients with juxta/pararenal abdominal aortic aneurysms (JAAAs/PAAAs). Materials and methods: MEDLINE, SCOPUS, and Web of Science were searched from inception date to 1st July 2022. Any studies comparing the results of two or three treatment strategies (ChEVAR, FEVAR, or OS) on medium-term outcomes in patients with JAAAs/PAAAs were included. Primary outcomes were all-cause mortality, aortic-related reintervention, and aortic-related mortality, while secondary outcomes were visceral stent/bypass occlusion/occlusion, major adverse cardiovascular events (MACEs), new onset renal replacement therapy (RRT), total endoleaks, and type I/III endoleak. Results: FEVAR (OR = 1.53, 95%CrI 1.03–2.11) was associated with higher medium-term all-cause mortality than OS. Sensitivity analysis including only studies that analysed JAAA showed that FEVAR (OR = 1.65, 95%CrI 1.08–2.33) persisted to be associated with higher medium-term mortality than OS. Both FEVAR (OR = 8.32, 95%CrI 3.80–27.16) and ChEVAR (OR = 5.95, 95%CrI 2.23–20.18) were associated with a higher aortic-related reintervention rate than OS. No difference between different treatment options was found in terms of aortic-related mortality. FEVAR (OR = 13.13, 95%CrI 2.70–105.2) and ChEVAR (OR = 16.82, 95%CrI 2.79–176.7) were associated with a higher rate of medium-term visceral branch occlusion/stenosis compared to OS; however, there was no difference found between FEVAR and ChEVAR. Conclusions: An advantage of OS compared to FEVAR and ChEVAR after mid-term follow-up aortic-related intervention and vessel branch/bypass stenosis/occlusion was found. This suggests that younger, low-surgical-risk patients might benefit from open surgery of JAAA/PAAA as a first approach. © 2022 by the authors.
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    Combined Impact of Chronic Kidney Disease and Contrast Induced Acute Kidney Injury on Long-term Outcomes in Patients with Acute Lower Limb Ischaemia
    (2018)
    Zlatanovic, Petar (57201473730)
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    Koncar, Igor (19337386500)
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    Dragas, Marko (25027673300)
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    Ilic, Nikola (7006245465)
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    Sladojevic, Milos (35184234700)
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    Mutavdzic, Perica (56321930600)
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    Tomic, Ivan (54928165800)
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    Kostic, Dusan (7007037165)
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    Davidovic, Lazar (7006821504)
    Introduction: Acute lower limb ischaemia (ALI) is the sudden onset of decreased arterial perfusion with imminent threat to limb viability. Contrast induced acute kidney injury (CI-AKI) is one of the complications that increases mortality in patients who undergo contrast imaging in coronary procedures. The goal of this study is to evaluate the impact of chronic kidney disease (CKD) and CI-AKI on long-term clinical outcomes in patients with ALI undergoing lower limb revascularisation. Methods: A total 1017 consecutive patients with acute lower limb ischaemia who were admitted between July 1, 2006, and January 1, 2017, were retrospectively reviewed. Patients who had end stage renal disease, those who had end stage heart and malignant disease and died within 7 days of limb revascularisation, and those who did not undergo angiography were excluded. Thus 546 patients were included in the final analysis. Patients were classified as with or without CKD and were then subdivided according to the presence or absence of the development of CI-AKI, defined as an increase in serum creatinine of ≥0.5 mg/dL or by ≥25% from the baseline value within the first 72 h after contrast exposure. The primary end point was all cause mortality and secondary major adverse limb event (MALE). Results: Both CKD and CI-AKI were associated with the highest rate of all cause mortality (chi square = 55.77, d.f. = 1, p <.01, log rank test) and MALE (chi square = 79.07, d.f. = 1, p <.01, log rank test). The presence of CKD and CI-AKI were significant risk factors associated with long-term all cause mortality (HR = 2.61, p <.01) and MALE (HR = 2.87, p <.01). Conclusion: In patients with ALI undergoing lower limb revascularisation, both CKD and CI-AKI were significantly associated with poor long-term outcomes compared with either CKD or CI-AKI alone. Further studies are required to assess this association and to confirm the combined effect of CKD and CI-AKI on long-term clinical outcomes. © 2018 European Society for Vascular Surgery
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    Comparison of Long Term Outcomes After Endovascular Treatment Versus Bypass Surgery in Chronic Limb Threatening Ischaemia Patients with Long Femoropopliteal Lesions
    (2021)
    Zlatanovic, Petar (57201473730)
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    Mahmoud, Amr A. (57730710900)
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    Cinara, Ilijas (6602522444)
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    Cvetic, Vladimir (57189236266)
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    Lukic, Borivoje (57189238643)
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    Davidovic, Lazar (7006821504)
    Objective: There are currently two treatments available for patients with chronic limb threatening ischaemia (CLTI): open surgical bypass (OSB) and percutaneous transluminal angioplasty with/without stenting (PTA/S). The aim of this study was to compare short and long term outcomes between PTA/S and OSB in CLTI patients with long (GLASS grade III and IV) femoropopliteal disease. Methods: This was a two centre retrospective study including all consecutive patients with CLTI undergoing first time lower extremity intervention at two distinct vascular surgical centres. Between 1 January 2012 and 1 January 2018, 1 545 CLTI consecutive limbs were treated for femoropopliteal GLASS grade III and IV lesions at two vascular surgical centres. Using covariables from baseline and angiographic characteristics, a propensity score was calculated for each limb. Thus, comparable patient cohorts (235 in PTA/S and 235 in OSB group) were identified for further analysis. The primary outcomes were freedom from re-intervention in the treated extremity and major amputation. Secondary outcomes were all hospital complications among the two patient groups. Results: Total overall complication rates were significantly higher in the OSB group (20.42% vs. 5.96%, p <.001), especially wound infection/seroma rate that required prolonged hospitalisation and further treatment (7.65% vs. 0%, p <.001). After the median follow up of 61 months, re-intervention rates were significantly higher in the PTA/S group (log rank test, 44.68% vs. 29.79%, p =.002), but there was no significant difference in terms of major amputation rates between the two group of patients (log rank test, PTA/S 27.23% vs. OSB 22.13%, p =.17). Conclusion: Bypass surgery seems to be superior to PTA/S for GLASS grade III and IV femoropopliteal lesions in patients with CLTI in terms of long term re-intervention rates, but with considerably higher rates of post-operative complications. A larger cohort of patients in currently ongoing randomised trials, as well as prospective cohort studies are necessary to confirm these findings. © 2020 European Society for Vascular Surgery
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    Complete Immediate Paraplegia Reversal after Performing Aorto–Lumbar Bypass on the Patient who Underwent Aortoiliac Reconstruction
    (2016)
    Banzic, Igor (36518108700)
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    Sladojevic, Milos (35184234700)
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    Ilic, Nikola (7006245465)
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    Koncar, Igor (19337386500)
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    Davidovic, Lazar (7006821504)
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    Brankovic, Milos (57188840013)
    Although both internal iliac arteries were saved during operation, the patient developed paraplegia immediately after aortoiliac reconstruction due to the spinal cord ischemia. We report a successfully treated immediate postoperative paraplegia by performing second operation and creating bypass from the bifurcated Dacron graft to the previously detected nonpaired huge lumbar artery. © 2016 Elsevier Inc.
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    Correlation Between Proteolytic Activity and Abdominal Aortic Aneurysm Wall Morphology with Intraluminal Thrombus Volume
    (2022)
    Sladojevic, Milos (35184234700)
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    Koncar, Igor (19337386500)
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    Zlatanovic, Petar (57201473730)
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    Stanojevic, Zeljka (57815573300)
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    Matejevic, David (57657574700)
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    Vidicevic Novakovic, Sasenka (57205259671)
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    Tasic, Jelena (55744333300)
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    Mutavdzic, Perica (56321930600)
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    Tomic, Ivan (54928165800)
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    Isakovic, Aleksandra (57202555421)
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    Davidovic, Lazar (7006821504)
    Background: The aim of this study was to examine the influence of intraluminal thrombus (ILT) volume on the level of proteolytic activity and the content of abdominal aortic aneurysm (AAA) wall. Methods: The research was designed as a cross-sectional study at the Clinic for Vascular and Endovascular Surgery, Clinical Center of Serbia in the period from April 2017 to February 2018. During this period, a total of 155 patients with asymptomatic AAA underwent open surgical treatment and 50 were included in the study based on inclusion and exclusion criteria. Before surgery, patients included in the study were examined by MRI. During the operation, samples of ILT and AAA wall were taken for biochemical analysis. Results: A statistically significant correlation was found between the volume of the ILT and largest AAA diameter (ρ = 0.56; P < 0.001). The correlation of the ILT volume on the anterior wall and the concentration of MMP-9, MMP-2 and NE/ELA in the wall did not find statistical significance. Also, no statistically significant association was found between the volume of ILT and the concentration of ECM proteins (collagen type 3, elastin, proteoglycan) in the corresponding part of the wall. The association of ILT volume with MDA was also of no statistical significance. There was a positive statistical significance found in correlation of volume of ILT and catalase activity in the wall of AAA (ρ = 0.28, P = 0.049). Conclusions: The volume of ILT in the aneurysmal sac seemed not to affect the level of proteolytic activity and the content of the aneurysm wall. However, a positive correlation was found between the ILT and the catalase activity. The effect of ILT on the aneurysm wall and its role in the progression of aneurysmal disease should be examined in future studies. © 2022 Elsevier Inc.
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    Early and long-term results of open repair of inflammatory abdominal aortic aneurysms: Comparison with a propensity score-matched cohort
    (2020)
    Cvetkovic, Slobodan (7006158672)
    ;
    Koncar, Igor (19337386500)
    ;
    Ducic, Stefan (57210976724)
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    Zlatanovic, Petar (57201473730)
    ;
    Mutavdzic, Perica (56321930600)
    ;
    Maksimovic, Dejan (57215427144)
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    Kukic, Biljana (6506390933)
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    Markovic, Dragan (7004487122)
    ;
    Davidovic, Lazar (7006821504)
    Objective: The aim of our study was to compare early and long-term results of open repair of patients with inflammatory abdominal aortic aneurysm (IAAA) with matched cohort of patients with abdominal aortic aneurysm (AAA). Methods: This retrospective single-center cohort study used prospectively collected data from an institutional registry from 1786 patients between 2009 and 2015. Patients with IAAA and AAA were matched by propensity score analysis controlling for demographics, baseline comorbidities, and AAA parameters in a 1:2 ratio. Patients were followed for 5 years. Results: There were 76 patients with IAAA and 152 patients with AAA. Patients with IAAA had more common intraoperative lesion of intraabdominal organs (P =.04), longer in-hospital (P =.035) and intensive care (P =.048) stays and a higher in-hospital mortality rate (P =.012). There were four patients (5.26%) with in-hospital lethal outcome in IAAA there were no deaths in the AAA group. During the follow-up, there was no difference in survival (χ2 = 0.07; DF = 1; P =.80) and overall aortic related complications (χ2 = 1.25; DF = 1; P =.26); however, aortic graft infection was more frequent in IAAA group (P =.04). Conclusions: Open repair of IAAA is challenging and comparing to AAA carries a higher perioperative risk and long-term infection rate, even in high-volume centers. The main causes of complications are intraoperative injury of adjacent organs, bleeding, and coronary events. Patients with AAA in a matched cohort showed equal long-term survival, which should be assessed in bigger registries. © 2019 Society for Vascular Surgery
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    Effect of Intra-operative Intra-arterial Thrombolysis on Long Term Clinical Outcomes in Patients with Acute Popliteal Artery Aneurysm Thrombosis
    (2020)
    Dragas, Marko (25027673300)
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    Zlatanovic, Petar (57201473730)
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    Koncar, Igor (19337386500)
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    Ilic, Nikola (7006245465)
    ;
    Radmili, Oliver (36125483800)
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    Savic, Nebojsa (25121804000)
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    Markovic, Miroslav (7101935751)
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    Davidovic, Lazar (7006821504)
    Objective: Acute lower limb ischaemia (ALI) as a result of popliteal artery aneurysm (PAA) thrombosis represents a significant problem. The aim of this study was to investigate outcome of intra-operative intra-arterial thrombolysis in the treatment of acute ischaemia due to PAA thrombosis in terms of major adverse limb events (MALE), overall survival, and intrahospital complications, especially those associated with bleeding. Methods: A total of 156 patients with Rutherford grade IIa and IIb acute ischaemia resulting from PAA thrombosis were admitted between 1 January 2011 and 1 January 2017. The patients were divided into two groups, those who underwent additional treatment with intra-operative intra-arterial thrombolysis (20 patients), and those who did not (136 patients). By using covariables from baseline and angiographic characteristics, a propensity score was calculated for each patient. Each patient who underwent intra-operative thrombolysis was matched to four patients from the non-thrombolysis group. Thus, comparable patient cohorts (20 in the thrombolysis and 80 in the non-thrombolysis group) were identified for further analysis. The primary end point was MALE and the secondary endpoint all cause mortality. Results: After a median follow up of 55 months, the estimated MALE rate was significantly lower in the thrombolysis group (30% vs. 65%, chi square = 10.86, p < .001, log rank test). Also, patients in the thrombolysis group had a significantly lower mortality rate (20% vs. 42.65%, chi square = 3.65, p = .05, log rank test). The thrombolysis group had wound/haematoma related interventions performed more commonly (25% in thrombolysis vs 8%, in non-thrombolysis group), but the difference was not significant (p=.013). There were no cases of major (intracranial and gastrointestinal) bleeding in either group. Conclusion: The data suggest that intra-operative thrombolysis in the treatment of selected patients with ALI due to PAA thrombosis has long term MALE and overall survival benefits, without a significant risk of major, life threatening bleeding complications. © 2019 European Society for Vascular Surgery
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    Effects of atmospheric pressure dynamics on abdominal aortic aneurysm rupture onset
    (2018)
    Opacic, Dragan (56306450600)
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    Ilic, Nikola (7006245465)
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    Sladojevic, Milos (35184234700)
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    Schönleitner, Patrick (57189026685)
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    Markovic, Dragan (7004487122)
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    Kostic, Dusan (7007037165)
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    Davidovic, Lazar (7006821504)
    Summary: Background: The effect of atmospheric pressure (AP) on the onset of abdominal aorta aneurysm rupture (RAAA) remains an unanswered question. We have investigated the seasonal variation and the effect of AP dynamics on RAAA by analysing the largest series of intraoperatively confirmed RAAA. Patients and methods: To realize this study we have performed a retrospective analysis of 546 patients with RAAA, operated within 503 days at the Clinic for vascular and endovascular surgery CCS between 1.1.2003 and 31.12.2012. AP data for Belgrade city were obtained from meteorological yearbooks published by the Republic Hydrometeorological Service of Serbia measured at the hydrometeorological station “Belgrade Observatory”. Only patients with a residence within the extended Belgrade region, exposed to the similar AP values, were included in the analysis of the AP effect on RAAA. Results: RAAA were observed more frequently during winter and autumn months but without significant difference in comparison to other seasons. Months with higher AP values were associated with a higher RAAA rate (p = 0.0008, R2 = 0.665). A similar trend was observed for the monthly AP variability (p = 0.0311, R2 = 0.374). Average AP values did not differ between days with and without RAAA. However, during the three and seven days periods preceding RAAA AP variability parameters were greater and AP was rising. Conclusions: Although these pressure differences are very small, higher AP values over longer periods of time as well as greater variability are associated with RAAA. The exact mechanism behind this association remains unclear. The postulation that low AP may precipitate RAAA based on the Laplace law should be discarded. © 2018 Hogrefe.
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    Elective and emergent repair of abdominal aortic aneurysm: selection of open or endovascular strategy
    (2021)
    Davidovic, Lazar (7006821504)
    ;
    Koncar, Igor (19337386500)
    Abdominal aortic aneurysm (AAA) is a disease that contemporary medicine cannot treat without intervention. Vascular surgeons are faced with two challenging decisions: how to treat AAA and when to treat asymptomatic AAA? Open repair (OR) as conventional procedure has been performed for 70 years, and the results have been substantially improved in recent decades. Endovascular aneurysm repair (EVAR) is a less invasive method invented 30 years ago and has been improving for decades in terms of its feasibility and durability. If not treated timely and properly, AAA may develop rupture (rAAA). Such a severe complication can be devastating to multiple organs and systems in the human body, frequently causing death. Due to its urgent nature, rAAA brings additional challenges that determine strategy and selection of treatment modality. The possibility of offering both options, OR and EVAR, and a careful choice of treatment strategy is probably the key point in achieving optimal results. In this article, our view on both, open and endovascular repair of ruptured and elective AAA, will be presented. © 2022 Elsevier Inc. All rights reserved.
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    Endovascular Repair of Thoracic Aneurysm After Open Repair of type IV Thoraco-abdominal Aneurysm?
    (2023)
    Mutavdzic, Perica (56321930600)
    ;
    Davidovic, Lazar (7006821504)
    [No abstract available]
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    Endovascular Treatment of Traumatic Pseudoaneurysm of the Superficial Temporal Artery
    (2016)
    Cvetic, Vladimir Zoran (57189236266)
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    Radmili, Oliver (36125483800)
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    Lukic, Borivoje (57189238643)
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    Colic, Momcilo (7005003692)
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    Davidovic, Lazar (7006821504)
    Pseudoaneurysms of the superficial temporal artery (STA) are rare vascular lesions that mainly occur after blunt head trauma. Diagnosis can be made on clinical grounds and is confirmed by ultrasonography. They are usually treated by open surgery procedures, but when the aneurysm is located in inaccessible areas, catheter embolization can be an alternative therapeutic option. We describe a case of a traumatic pseudoaneurysm of the STA which was treated with the vascular plug embolization. We conclude that endovascular embolization can be an option in the treatment of STA pseudoaneurysms. © The Author(s) 2016.
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