Browsing by Author "Colovic, M. (21639151700)"

[No abstract available]

[No abstract available]

Purpose: To test some hypotheses concerning risk factors for Hodgkin's disease (HD). Material and methods: A case-control study conducted in Beograd from 1993 to 1996 enrolled 100 patients with histologically confirmed HD and 100 hospitalized non-cancer patients (controls), individually matched by sex, age (±2 years) and place of residence. A number of risk factors was evaluated, in the analysis of which the McNemar's test and univariate and multivariate logistic regression analyses were used. Results: According to multivariate analysis the following factors were significantly related to HD: white collar occupation, daily consumption of milk, cheese and fruit, use of lard for food preparation, age difference between participant and first older sibling >3 years and possession of pets. Conclusion: The results obtained support the hypothesis that, in addition to other factors, some dietary components influence the occurrence of HD.

Purpose: To test some hypotheses concerning risk factors for Hodgkin's disease (HD). Material and methods: A case-control study conducted in Beograd from 1993 to 1996 enrolled 100 patients with histologically confirmed HD and 100 hospitalized non-cancer patients (controls), individually matched by sex, age (±2 years) and place of residence. A number of risk factors was evaluated, in the analysis of which the McNemar's test and univariate and multivariate logistic regression analyses were used. Results: According to multivariate analysis the following factors were significantly related to HD: white collar occupation, daily consumption of milk, cheese and fruit, use of lard for food preparation, age difference between participant and first older sibling >3 years and possession of pets. Conclusion: The results obtained support the hypothesis that, in addition to other factors, some dietary components influence the occurrence of HD.

[No abstract available]

Introduction. A 26-yr-old male patient with mixed phenotype acute leukemia of T/myeloid type with prominent leukemic cell heterogeneity, and the presence of a so far unreported karyotype aberration in this type of acute leukemia 45,XY, dic(11;17)(11qter→11p11.2::17p11.2→17qter) is presented. Methods. Flow immunocytometry was performed by direct multicolor immunofluorescent technique on bone marrow aspirates. Cytogenetic analyses were performed using G-banding method by direct preparation of unstimulated bone marrow cells and following 24hours of culture in RPMI 1540 culture medium with 25% fetal calf serum at 37°C Results. The flow immunocytometry of bone marrow nucleated cells revealed the existance of three distinct blast cell populations with overlapping immunophenotypes. Predominant blast cell population had an early myeloid phenotype and aberrant expression of CD7 antigen (HLA-DR +, CD34 +, anti-MPO +, CD117 +, CD33 +, CD13 +, CD7 +low, cyCD3 -, TdT -). The other two blast cell populations, smaller in cell diameter and less sizable in cell proportion, both shared the T-lymphoid features. The patient was treated with ADE protocol (etoposide, cytarabine and doxorubicine). A complete remission was achieved and lasted 5months. Conclusion. A case of MPAL with complex biological features, 45,XY, dic(11;17)(11qter→11p11.2::17p11.2→17qter) karyotype and an aggressive, therapy-resistant clinical course, is presented. © 2011 Blackwell Publishing Ltd.

Introduction. A 26-yr-old male patient with mixed phenotype acute leukemia of T/myeloid type with prominent leukemic cell heterogeneity, and the presence of a so far unreported karyotype aberration in this type of acute leukemia 45,XY, dic(11;17)(11qter→11p11.2::17p11.2→17qter) is presented. Methods. Flow immunocytometry was performed by direct multicolor immunofluorescent technique on bone marrow aspirates. Cytogenetic analyses were performed using G-banding method by direct preparation of unstimulated bone marrow cells and following 24hours of culture in RPMI 1540 culture medium with 25% fetal calf serum at 37°C Results. The flow immunocytometry of bone marrow nucleated cells revealed the existance of three distinct blast cell populations with overlapping immunophenotypes. Predominant blast cell population had an early myeloid phenotype and aberrant expression of CD7 antigen (HLA-DR +, CD34 +, anti-MPO +, CD117 +, CD33 +, CD13 +, CD7 +low, cyCD3 -, TdT -). The other two blast cell populations, smaller in cell diameter and less sizable in cell proportion, both shared the T-lymphoid features. The patient was treated with ADE protocol (etoposide, cytarabine and doxorubicine). A complete remission was achieved and lasted 5months. Conclusion. A case of MPAL with complex biological features, 45,XY, dic(11;17)(11qter→11p11.2::17p11.2→17qter) karyotype and an aggressive, therapy-resistant clinical course, is presented. © 2011 Blackwell Publishing Ltd.

[No abstract available]

We present two cases of an unusual localised extramedullary plasmacytoma with a long survival period: a 42-year-old woman with left temporal and a 25-year-old woman with left parietal intracranial plasmacytoma. The tumor masses were totally removed in both patients and their histological, histochemical (PAS and methyl green pyronin positive granules) and immunohistochemical (positive light chains mostly λ, and negative stains for GFAP, NSE and S-100 protein) properties showed that the tumor tissues consisted of monoclonal population of plasma cells. Our cases were diagnosed as solitary cerebral plasmacytomas since the presence of underlying multiple myeloma has been ruled out by the clinical, laboratory, radiographic and immunological investigations. Postoperatively the patients were given 40 Gy to the whole cranium and additional 20 Gy focused on the tumor site. Complete remissions were achieved 7.5 and 5.5 years, respectively.

We present two cases of an unusual localised extramedullary plasmacytoma with a long survival period: a 42-year-old woman with left temporal and a 25-year-old woman with left parietal intracranial plasmacytoma. The tumor masses were totally removed in both patients and their histological, histochemical (PAS and methyl green pyronin positive granules) and immunohistochemical (positive light chains mostly λ, and negative stains for GFAP, NSE and S-100 protein) properties showed that the tumor tissues consisted of monoclonal population of plasma cells. Our cases were diagnosed as solitary cerebral plasmacytomas since the presence of underlying multiple myeloma has been ruled out by the clinical, laboratory, radiographic and immunological investigations. Postoperatively the patients were given 40 Gy to the whole cranium and additional 20 Gy focused on the tumor site. Complete remissions were achieved 7.5 and 5.5 years, respectively.

[No abstract available]