Browsing by Author "Bumbaširević, Uroš (36990205400)"

The remarkable variability in clinical behaviour of prostate cancer necessitates an individualized approach to therapy. The reliance on conventional clinico pathological variables, including prostate-specific antigen, has proven insufficient in addressing the complexities of this oncopathology. As a result, a significant number of novel, promising biomarkers have been developed and are now being utilized in all domains of prostate cancer management. The utilization of OncotypeDx, Decipher and Ki-67 has the potential to improve the process of decision-making for patients diagnosed with localized prostate cancer, including both curative and adjuvant therapy. The integration of combination therapy has engendered a significant shift in a therapeutic paradigm of metastatic hormone-sensitive prostate cancer underpinning the need for new biomarkers including TP53, RB1 and PTEN aberrations, along with SPOP mutation and molecular subtypes of prostate cancer as possible candidates. The use of liquid biopsies and next-generation sequencing techniques has a promising role in metastatic castration-resistant prostate cancer. The validation and improvement of existing biomarkers, the development of innovative and more accurate biomarkers, with the integration of clinical and multiomics data have the potential to provide considerable advancements in the field of precision oncology of prostate cancer. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

The remarkable variability in clinical behaviour of prostate cancer necessitates an individualized approach to therapy. The reliance on conventional clinico pathological variables, including prostate-specific antigen, has proven insufficient in addressing the complexities of this oncopathology. As a result, a significant number of novel, promising biomarkers have been developed and are now being utilized in all domains of prostate cancer management. The utilization of OncotypeDx, Decipher and Ki-67 has the potential to improve the process of decision-making for patients diagnosed with localized prostate cancer, including both curative and adjuvant therapy. The integration of combination therapy has engendered a significant shift in a therapeutic paradigm of metastatic hormone-sensitive prostate cancer underpinning the need for new biomarkers including TP53, RB1 and PTEN aberrations, along with SPOP mutation and molecular subtypes of prostate cancer as possible candidates. The use of liquid biopsies and next-generation sequencing techniques has a promising role in metastatic castration-resistant prostate cancer. The validation and improvement of existing biomarkers, the development of innovative and more accurate biomarkers, with the integration of clinical and multiomics data have the potential to provide considerable advancements in the field of precision oncology of prostate cancer. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

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Introduction. Juxtaglomerular cell tumor (JGCT) or reninoma is a very rare cause of curable hypertension among young people. The early diagnosis is the most important based on the clinical presentation, hormonal and radiological findings observed on computed tomography (CT) and/or magnetic resonance imaging (MRI). The final confirmation of the JGCT is the lateralization of the plasma renin activity (PRA) during the selective renal venous sampling. Case report. This report presents a typical case of young women with JGCT which was manifested for the first time with severe hypertension during the pregnancy and was the reason of fetal death. After the miscarriage, the diagnosis of JGCT was made by the CT scanning and confirmed by the selective renal venous sampling. After the partial nephrectomy, the blood pressure and serum potassium normalized without the medications. Conclusion. Reninoma should be considered in the differential diagnosis as a cause of severe hypertension in pregnancy and also should be suspected in young hipertensives (especially females) with hypokalemia and secondary hyperaldosteronism after the exclusion of other causes particularly renal artery stenosis. A dynamic contrastenhanced CT, MRI and selective renal venous sampling are the most important tools in the diagnosis of JGCT. © 2017, Institut za Vojnomedicinske Naucne Informacije/Documentaciju. All Rights Reserved.