Browsing by Author "Batinić, Borjanka (26428017500)"

Objective: Trazodone is an effective antidepressant. The present study was designed as a non-interventional open-label, multi-centre, post-marketing study. The aim of the study was to evaluate the therapeutic effectiveness and tolerability of trazodone retard formulation (Trittico® retard) in everyday clinical practice. Methods: Two hundred and forty-two patients with depressive disorder from 19 different centres were included in the study. The antidepressant and anxyolitic effects were assessed using Hamilton anxiety rating scale 14 items version, Hamilton depression rating scale 14 items version and Clinical Global Impression Severity scale. Results: After only two weeks of therapy, a statistically significant improvement in the HAM-D score, was observed. This observation was maintained over the whole study period, up to the day 56. Conclusions: Our study points toward clinical effectiveness of the prolonged-release formulation of trazodone in the treatment of unselected depressed patients in real-world practice. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Background: The aim of the study was to examine the frequency and class of life events, as well as social support, in patients with panic disorder (with/without agoraphobia) (PD/PDA) in a 1-year period preceding the onset of panic attacks. Subjects and methods: The study sample included 40 patients (PD/PDA) (of an average age of 39.25, SD 6.96), and 40 matched healthy controls (M 37.50, SD 8.05). The following instruments were applied: DSM-IV criteria for PD/PDA, Stressful Life Events Scale, Social Support Index (SSI), Family Coping Coherence Index (FCCI), Relative and Friend Support (RFS) and Family Hardiness Index (FHI). The study was retrospective. Results: Patients with PD/PDA compared to the healthy controls, had significantly increased ftequency of negative life events (M 3.8, min 0, max 11) (p<0.05). With respect to the class of life events, PD/PDA patients reported significantly more frequently: mild somatic illness, serious somatic illness, conflict with a member of the extended family, separation from a significant person (p<0.05) and frequent marital conflicts (p<0.01). The patients compared to the healthy controls, had significantly lower level of social support by SS1, FH1, and FCCI (p<0.001). By RFS, there were no significant differences between the two groups. Conclusion: Increased frequency of negative life events (particularly somatic illness, interpersonal conflicts and separation), combined with absence of the most part of the supportive quality of the environment (particularly family support), precede the development of PD/PDA in vulnerable persons. © Medicinska naklada - Zagreb.