Browsing by Author "Bajkin, Branislav (24767346200)"

Background/Aim. There is no scientific evidence that the prophylactic use of antibiotics as a part of the mandib-ular third molar surgery is effective in suppressing postop-erative pain, edema, trismus, and dry socket. The aim of the study was to investigate the effects of antibiotics from the fluoroquinolone (moxifloxacin) and cephalosporin (cefixime) groups in reducing postoperative inflammatory sequelae (pain, edema, and trismus), as well as in possibly reducing the incidence of dry socket after mandibular third molar surgery. Methods. This double-blind study was completed by 157 subjects, comprising two study groups (who received the aforementioned antibiotics) and a con-trol group, who received placebo tablets. Subjects were as-sessed on the first, second, and seventh day following sur-gery. In the postoperative course, patients were monitored for the occurrence, intensity, and duration of postopera-tive inflammatory sequelae and dry socket. Results. Both antibiotics, especially moxifloxacin, had a pronounced ef-fect on reducing all inflammatory sequelae (pain, edema, and trismus) as the most common postoperative com-plaints following mandibular third molar surgery, and also contributed to reducing the incidence of dry socket. Con-clusion. Antibiotic prophylaxis with cefixime and, espe-cially moxifloxacin, reduced the occurrence of postopera-tive inflammatory sequelae and alleviated discomfort. It is interesting, that both antibiotics, especially moxifloxacin, also contributed to reducing the incidence of postopera-tive dry socket, which is not provoked by inflammation. Therefore, further research into the underlying mecha-nisms behind such an effect is warranted. © 2022 Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved.

Introduction/Objective The aim of the present study was to investigate the effects of moxifloxacin and cefixime in preventing postoperative infection following mandibular third molar surgery. Methods Double-blind study was completed by 157 patients undergoing surgical removal of mandibular third molars. The patients were randomly assigned to the following three groups: moxifloxacin (M), cefixime (C), and placebo (P). Patients in each group were classified into two subgroups: subgroup (a), without previous history of pericoronitis, and subgroup (b), with previous history of pericoronitis. All the patients were evaluated at the postoperative follow-ups on the first, second, and seventh postoperative day. Results Postoperative infections were registered only in patients with a history of pericoronitis. Antibiotic prophylaxis with cefixime and moxifloxacin reduced the occurrence of postoperative infection. Overall incidence of postoperative infections was 6.4%. All postoperative infections were registered in the placebo-group, where the incidence of postoperative infection was 19.2%. Microbiological tests verified the clinically obtained results. Isolated microflora was resistant to penicillin-derived antibiotics in 50% of the cases. Conclusion Prophylactic use of antibiotics after third molar surgery should be weighed against potential risks and benefits and could be considered in cases with previous history of pericoronitis, when compli-cated surgical extraction is performed. © 2022, Serbia Medical Society. All rights reserved.