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Browsing by Author "Abera, Semaw Ferede (57205180598)"

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    Publication
    Erratum: Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 (The Lancet (2016) 388(10053) (1725–1774)(S0140673616315756)(10.1016/S0140-6736(16)31575-6))
    (2017)
    Wang, Haidong (16507828100)
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    Bhutta, Zulfiqar A (24342648300)
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    Coates, Matthew M (57211076754)
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    Coggeshall, Megan (56132969600)
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    Dandona, Lalit (7007017243)
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    Diallo, Khassoum (6701577865)
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    Franca, Elisabeth Barboza (16031258100)
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    Fraser, Maya (57202561859)
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    Fullman, Nancy (57211064970)
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    Gething, Peter W (57193559189)
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    Hay, Simon I (7101875313)
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    Kinfu, Yohannes (12770281900)
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    Kita, Maaya (57208149285)
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    Kulikoff, Xie Rachel (57191837748)
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    Larson, Heidi J (57202559142)
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    Liang, Juan (57198351058)
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    Liang, Xiaofeng (26662590300)
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    Lim, Stephen S (7404081544)
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    Lind, Margaret (57189271761)
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    Lopez, Alan D (7401455668)
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    Lozano, Rafael (7102198442)
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    Mensah, George A (57196028147)
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    Mikesell, Joseph B (57202572280)
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    Mokdad, Ali H (7004813962)
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    Mooney, Meghan D (57216598823)
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    Naghavi, Mohsen (57207906323)
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    Nguyen, Grant (57191591002)
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    Rakovac, Ivo (57201180617)
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    Salomon, Joshua A (56745638600)
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    Silpakit, Naris (57202401404)
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    Sligar, Amber (57190284582)
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    Sorensen, Reed J D (24170882700)
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    Vos, Theo (57223885848)
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    Zhu, Jun (56215097100)
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    Abajobir, Amanuel Alemu (57203613441)
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    Abate, Kalkidan Hassen (57207943858)
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    Abbas, Kaja M (57190285707)
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    Abd-Allah, Foad (36503428900)
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    Abdulle, Abdishakur M (6603592018)
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    Abera, Semaw Ferede (57205180598)
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    Aboyans, Victor (56214736500)
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    Abraham, Biju (57202568691)
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    Abubakar, Ibrahim (57220174401)
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    Abu-Raddad, Laith J (14032724700)
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    Abu-Rmeileh, Niveen M E (57216675148)
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    Abyu, Gebre Yitayih (57190277969)
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    Achoki, Tom (57202561099)
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    Adebiyi, Akindele Olupelumi (57203334499)
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    Adedeji, Isaac Akinkunmi (57208456508)
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    Adelekan, Ademola Lukman (57216109261)
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    Adou, Arsène Kouablan (56531895000)
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    Agarwal, Arnav (56865159500)
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    Ajala, Oluremi N (57218094659)
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    Akinyemiju, Tomi F (57202561503)
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    Akseer, Nadia (57207801968)
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    Alam, Khurshid (57203681299)
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    Alam, Noore K M (57202437697)
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    Alasfoor, Deena (57211114684)
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    Aldridge, Robert William (57209842885)
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    Alegretti, Miguel Angel (56276408300)
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    Alemu, Zewdie Aderaw (57202557784)
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    Ali, Raghib (57196506541)
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    Alkerwi, Ala’a (57197724313)
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    Alla, François (6701580827)
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    Al-Raddadi, Rajaa (57219673720)
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    Alsharif, Ubai (57211633255)
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    Altirkawi, Khalid A (57202762923)
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    Alvarez Martin, Elena (15070257300)
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    Alvis-Guzman, Nelson (57210741239)
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    Amare, Azmeraw T (57202220009)
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    Amberbir, Alemayehu (57202564972)
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    Amegah, Adeladza Kofi (55542401600)
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    Ameh, Emmanuel A (7006356993)
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    Ammar, Walid (57208159281)
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    Amrock, Stephen Marc (57211220414)
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    Andersen, Hjalte H (57203517540)
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    Anderson, Gregory M (57199931084)
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    Antonio, Carl Abelardo T (55247644500)
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    Ärnlöv, Johan (6602512227)
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    Artaman, Al (57217223811)
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    Asayesh, Hamid (55334322800)
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    Asghar, Rana Jawad (57209013760)
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    Assadi, Reza (57203677411)
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    Atique, Suleman (56505419100)
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    Avokpaho, Euripide Frinel G Arthur (57209842037)
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    Awasthi, Ashish (58420926700)
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    Ayala Quintanilla, Beatriz Paulina (55598298700)
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    Bacha, Umar (57200173721)
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    Badawi, Alaa (57216776029)
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    Balakrishnan, Kalpana (7103222725)
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    Banerjee, Amitava (57208560645)
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    Banigbe, Bolanle F (56263444600)
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    Barac, Aleksandra (55550748700)
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    Barber, Ryan M (57202560423)
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    Barker-Collo, Suzanne L (57193065514)
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    Bärnighausen, Till (23011726900)
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    Barrero, Lope H (57208560675)
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    Bayou, Tigist Assefa (57199665742)
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    Bayou, Yibeltal Tebekaw (57202895869)
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    Bazargan-Hejazi, Shahrzad (57205912040)
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    Beardsley, Justin (57207800229)
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    Bedi, Neeraj (57988442200)
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    Bekele, Tolesa (57195086149)
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    Bell, Michelle L (7401466450)
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    Bello, Aminu K (12759638700)
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    Bennett, Derrick A (57650836400)
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    Bensenor, Isabela M (7004830338)
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    Berhane, Adugnaw (57200410735)
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    Bernabé, Eduardo (57194696150)
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    Betsu, Balem Demtsu (57196316128)
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    Beyene, Addisu Shunu (57209036705)
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    Bhatt, Samir (57203665130)
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    Biadgilign, Sibhatu (57195448180)
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    Bikbov, Boris (57219957158)
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    Birlik, Sait Mentes (57190275478)
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    Bisanzio, Donal (57196394991)
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    Bjertness, Espen (7004026306)
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    Blore, Jed D (57202562230)
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    Bourne, Rupert R A (7103377631)
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    Brainin, Michael (7006405278)
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    Brazinova, Alexandra (57216996405)
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    Breitborde, Nicholas J K (6603260895)
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    Brown, Alexandria (57190271927)
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    Buckle, Geoffrey Colin (57202771556)
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    Burch, Michael (7005588453)
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    Butt, Zahid A (57202522739)
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    Campos-Nonato, Ismael Ricardo (57203424784)
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    Campuzano, Julio Cesar (57203629478)
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    Cárdenas, Rosario (57216482927)
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    Carpenter, David O (7201795413)
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    Carrero, Juan Jesus (16834646800)
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    Carter, Austin (57201756395)
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    Casey, Daniel C (56844735100)
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    Castañeda-Orjuela, Carlos A (35769124700)
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    Castillo Rivas, Jacqueline (57197814657)
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    Castro, Ruben Estanislao (57216814152)
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    Catalá-López, Ferrán (57202553733)
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    Cercy, Kelly (57208777587)
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    Chang, Hsing-Yi (7407523087)
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    Chang, Jung-Chen (57202568248)
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    Chibueze, Chioma Ezinne (57244744000)
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    Chisumpa, Vesper Hichilombwe (56761895800)
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    Choi, Jee-Young Jasmine (57209706428)
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    Chowdhury, Rajiv (57216138475)
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    Christopher, Devasahayam Jesudas (57209863533)
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    Ciobanu, Liliana G (57201603453)
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    Colquhoun, Samantha M (57205178937)
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    Cooper, Cyrus (36041345700)
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    Cornaby, Leslie (57191837051)
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    Damtew, Solomon Abrha (58991324800)
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    Danawi, Hadi (57201079895)
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    Dandona, Rakhi (57203043697)
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    Das Neves, José (57208073193)
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    Davis, Adrian C (7404296836)
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    de Jager, Pieter (55445666600)
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    De Leo, Diego (7006128644)
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    Degenhardt, Louisa (7004040033)
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    Deribe, Kebede (57193912587)
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    Deribew, Amare (25625914400)
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    Des Jarlais, Don C (56990451200)
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    Deveber, Gabrielle A (57204345472)
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    Dharmaratne, Samath D (57216324802)
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    Dhillon, Preet K (57201002943)
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    Ding, Eric L (54413849800)
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    Doshi, Pratik Pinal (57202595536)
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    Doyle, Kerrie E (55693710800)
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    Duan, Leilei (56150781400)
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    Dubey, Manisha (57219898654)
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    Ebrahimi, Hedyeh (57195329214)
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    Ellingsen, Christian Lycke (7801360950)
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    Elyazar, Iqbal (6506894785)
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    Endries, Aman Yesuf (57216324852)
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    Ermakov, Sergey Petrovich (7006796196)
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    Eshrati, Babak (16030619200)
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    Esteghamati, Alireza (11240321100)
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    Faraon, Emerito Jose Aquino (57195414019)
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    Farid, Talha A (57226213785)
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    Farinha, Carla Sofia E Sa (57190279273)
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    Faro, André (36770969600)
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    Farvid, Maryam S (57216534761)
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    Farzadfar, Farshad (57195049611)
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    Fereshtehnejad, Seyed-Mohammad (57202557520)
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    Fernandes, Joao C (35274726800)
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    Fischer, Florian (55508208800)
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    Fitchett, Joseph R A (57219697690)
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    Foigt, Nataliya (57216998893)
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    Franklin, Richard C (7201428429)
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    Friedman, Joseph (57202895428)
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    Fürst, Thomas (57208431345)
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    Gambashidze, Ketevan (13610194000)
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    Gamkrelidze, Amiran (6506029209)
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    Ganguly, Parthasarathi (57193832815)
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    Gebre, Teshome (57202565005)
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    Gebrehiwot, Tsegaye Tewelde (57216482917)
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    Gebremedhin, Amanuel Tesfay (57202566187)
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    Gebru, Alemseged Aregay (57196196083)
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    Geleijnse, Johanna M (35195702500)
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    Gessner, Bradford D (7005779769)
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    Ginawi, Ibrahim Abdelmageem Mohamed (57192378390)
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    Giref, Ababi Zergaw (57219994468)
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    Gishu, Melkamu Dedefo (57202568734)
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    Gomez-Dantes, Hector (57202555692)
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    Gona, Philimon (57219703762)
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    Goodridge, Amador (55801980200)
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    Gopalani, Sameer Vali (57190277891)
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    Goto, Atsushi (36339255500)
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    Gouda, Hebe N (57202432343)
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    Gugnani, Harish Chander (7005567008)
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    Guo, Yuming (55712472800)
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    Gupta, Rahul (56453686300)
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    Gupta, Rajeev (55705295300)
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    Gupta, Vipin (57199940653)
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    Gyawali, Bishal (56237046200)
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    Haagsma, Juanita A (57202571125)
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    Hafezi-Nejad, Nima (57216814261)
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    Haile, Demewoz (40861134200)
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    Hailu, Alemayehu Desalegne (57225733572)
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    Hailu, Gessessew Bugssa (57219637263)
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    Hamadeh, Randah Ribhi (57202769526)
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    Hamidi, Samer (24366336000)
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    Hancock, Jamie (57202975481)
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    Handal, Alexis J (57208977398)
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    Hankey, Graeme J (7102816661)
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    Harb, Hilda L (57221443122)
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    Harikrishnan, Sivadasanpillai (57202524069)
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    Harun, Kimani M (57190281262)
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    Havmoeller, Rasmus (59842723800)
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    Hay, Roderick J (56785229200)
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    Heredia-Pi, Ileana Beatriz (36941085200)
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    Hoek, Hans W (57202570421)
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    Horino, Masako (57195769276)
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    Horita, Nobuyuki (57217110823)
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    Hosgood, H. Dean (56353204400)
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    Hotez, Peter J (7004958298)
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    Hoy, Damian G (57216593652)
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    Hsairi, Mohamed (57209033943)
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    Hu, Guoqing (57218106596)
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    Huang, Cheng (57216683566)
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    Huang, John J (56135699200)
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    Huang, Hsiang (57202278530)
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    Huiart, Laetitia (6602208431)
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    Huynh, Chantal (57202556112)
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    Iburg, Kim Moesgaard (57216814160)
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    Idrisov, Bulat T (57208773503)
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    Innos, Kaire (57217314902)
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    Jacobsen, Kathryn H (26029163100)
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    Jahanmehr, Nader (57203122718)
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    Javanbakht, Mehdi (57204619886)
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    Jayatilleke, Achala Upendra (57204797176)
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    Jee, Sun Ha (16039275900)
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    Jeemon, Panniyammakal (57216324831)
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    Jha, Vivekanand (7005119423)
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    Jiang, Guohong (56984997300)
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    Jiang, Ying (57216138470)
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    Jibat, Tariku (57212368830)
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    Jin, Ye (56648601200)
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    Jonas, Jost B (7202492953)
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    Kabir, Zubair (57207901718)
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    Kalkonde, Yogeshwar (57200250807)
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    Kamal, Ritul (57203177242)
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    Kan, Haidong (7101602991)
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    Kang, Gagandeep (57202656584)
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    Karch, André (57223444197)
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    Karema, Corine Kakizi (57202557522)
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    Kasaeian, Amir (57195540738)
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    Kaul, Anil (16156995700)
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    Kawakami, Norito (35377339000)
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    Kayibanda, Jeanne Françoise (57200737035)
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    Kazanjan, Konstantin (57193091626)
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    Keiyoro, Peter Njenga (57203177260)
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    Kemp, Andrew Haddon (57218313462)
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    Kengne, Andre Pascal (7801322838)
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    Keren, Andre (7005620132)
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    Kereselidze, Maia (55659152900)
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    Kesavachandran, Chandrasekharan Nair (57218000521)
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    Khader, Yousef Saleh (55654192600)
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    Khalil, Ibrahim A (58255049500)
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    Khan, Abdur Rahman (55520620000)
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    Khan, Ejaz Ahmad (57218791274)
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    Khang, Young-Ho (57198904674)
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    Khonelidze, Irma (57202287317)
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    Khubchandani, Jagdish (57211720011)
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    Kim, Cho-Il (57199973023)
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    Kim, Daniel (57223019104)
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    Kim, Yun Jin (57211086375)
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    Kissoon, Niranjan (7006364038)
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    Kivipelto, Miia (6701347410)
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    Knibbs, Luke D (16313525200)
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    Kokubo, Yoshihiro (56155004000)
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    Kosen, Soewarta (57211346192)
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    Koul, Parvaiz A (14022262900)
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    Koyanagi, Ai (57197741912)
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    Kuate Defo, Barthelemy (6602271655)
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    Kucuk Bicer, Burcu (57204528360)
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    Kudom, Andreas A (36442735400)
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    Kumar, G. Anil (57139550500)
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    Kutz, Michael J (57195617315)
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    Kyu, Hmwe H (57217040073)
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    Lal, Dharmesh Kumar (57222488984)
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    Lalloo, Ratilal (57189334553)
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    Lam, Hilton (35484312600)
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    Lam, Jennifer O (57201997930)
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    Lansingh, Van C (57194598546)
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    Larsson, Anders (56381985300)
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    Leigh, James (7202089604)
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    Leung, Ricky (56276497100)
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    Li, Yichong (57218426673)
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    Li, Yongmei (56147667800)
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    Lindsay, M Patrice (57222114807)
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    Liu, Patrick Y (56170368200)
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    Liu, Shiwei (57209574351)
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    Lloyd, Belinda K (55313086800)
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    Lo, Warren D (8964933400)
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    Logroscino, Giancarlo (7004888005)
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    Low, Nicola (7006432437)
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    Lunevicius, Raimundas (57216165063)
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    Lyons, Ronan A (55574561400)
    ;
    Ma, Stefan (7403723389)
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    Magdy Abd El Razek, Hassan (57195948985)
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    Magdy Abd El Razek, Mohammed (57201191366)
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    Mahdavi, Mahdi (57190276959)
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    Majdan, Marek (36147855100)
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    Majeed, Azeem (7102027801)
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    Malekzadeh, Reza (7005197760)
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    Mapoma, Chabila C (57208956832)
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    Marcenes, Wagner (7005668102)
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    Martinez-Raga, Jose (57202861191)
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    Marzan, Melvin Barrientos (57200737144)
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    Masiye, Felix (57216327983)
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    McGrath, John J (57202560550)
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    Meaney, Peter A (57208635601)
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    Mehari, Alem (57211114616)
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    Mehndiratta, Man Mohan (57202557864)
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    Mekonnen, Alemayehu B (57200179648)
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    Melaku, Yohannes Adama (57203122720)
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    Memiah, Peter (57217207827)
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    Memish, Ziad A (7005059350)
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    Mendoza, Walter (57216905642)
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    Meretoja, Atte (12775885500)
    ;
    Meretoja, Tuomo J (57202554188)
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    Mhimbira, Francis Apolinary (57207789910)
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    Miller, Ted R (7403948600)
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    Mills, Edward J (57205301363)
    ;
    Mirarefin, Mojde (57222113397)
    ;
    Misganaw, Awoke (57202808713)
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    Mock, Charles N (7005790549)
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    Mohammad, Karzan Abdulmuhsin (57205300378)
    ;
    Mohammadi, Alireza (58896815600)
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    Mohammed, Shafiu (57838689000)
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    Monasta, Lorenzo (7801520497)
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    Montañez Hernandez, Julio Cesar (57203977041)
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    Montico, Marcella (57202563609)
    ;
    Moore, Ami R (57216303682)
    ;
    Moradi-Lakeh, Maziar (35617421300)
    ;
    Morawska, Lidia (7004773965)
    ;
    Mori, Rintaro (57072757600)
    ;
    Mueller, Ulrich O (8512347500)
    ;
    Murphy, Georgina A V (57191839770)
    ;
    Murthy, Srinivas (36247670800)
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    Nachega, Jean B (6701544088)
    ;
    Naheed, Aliya (57202560989)
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    Naidoo, Kovin S (35564549000)
    ;
    Naldi, Luigi (7004954781)
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    Nand, Devina (55575672100)
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    Nangia, Vinay (57201490837)
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    Neupane, Subas (57215632313)
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    Newton, Charles R (35465836500)
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    Newton, John N (57210543772)
    ;
    Ng, Marie (36155754200)
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    Ngalesoni, Frida Namnyak (57219463339)
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    Nguhiu, Peter (36028406600)
    ;
    Nguyen, Quyen Le (57223642100)
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    Nisar, Muhammad Imran (57191774461)
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    Nkamedjie Pete, Patrick Martial (57194583820)
    ;
    Norheim, Ole F (7004082597)
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    Norman, Rosana E (57194839077)
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    Ogbo, Felix Akpojene (57200737136)
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    Oh, In-Hwan (57204090669)
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    Ojelabi, Foluke Adetola (57202561682)
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    Olivares, Pedro R (7003510190)
    ;
    Olusanya, Bolajoko Olubukunola (57218504682)
    ;
    Olusanya, Jacob Olusegun (57222488860)
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    Oren, Eyal (36815569400)
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    Ota, Erika (57202554474)
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    Mahesh, P.A. (57202421244)
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    Park, Eun-Kee (57216814178)
    ;
    Park, Hye-Youn (57190283947)
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    Parsaeian, Mahboubeh (57196467994)
    ;
    Paternina Caicedo, Angel J (35769665400)
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    Yebyo, Henock Gebremedhin (57204699309)
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    Yoon, Seok-Jun (24823148900)
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    Younis, Mustafa Z (8549393000)
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    Yu, Chuanhua (57208140344)
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    Zaidi, Zoubida (57197376721)
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    Zaki, Maysaa El Sayed (57203666922)
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    Zeeb, Hajo (57203073012)
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    Zhang, Hao (59062050200)
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    Zhao, Yong (59798995400)
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    Zheng, Yingfeng (58918045300)
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    Zhou, Maigeng (57054557200)
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    Zodpey, Sanjay (7003415080)
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    Murray, Christopher J L (55481130700)
    GBD 2015 Child Mortality Collaborators. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388: 1725–74—In this Article, Mohsen Naghavi, Michael J Kutz, Chantal Huynh, Samer Hamidi, Addisu Shunu Beyene, and Stephen S Lim should have been listed as authors. The affiliation details for Simon I Hay have been updated. The funding statement for Simon I Hay has been added. These corrections have been made to the online version as of Jan 5, 2017. © 2017 Elsevier Ltd
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    Evolution and patterns of global health financing 1995-2014: Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries
    (2017)
    Dieleman, Joseph (54891678100)
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    Campbell, Madeline (57192869720)
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    Chapin, Abigail (57159731300)
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    Eldrenkamp, Erika (57194530102)
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    Fan, Victoria Y. (9737474800)
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    Haakenstad, Annie (56079498000)
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    Kates, Jennifer (7006961170)
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    Liu, Yingying (57194531196)
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    Matyasz, Taylor (57194529771)
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    Micah, Angela (57193064978)
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    Reynolds, Alex (57216683497)
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    Sadat, Nafis (57219687343)
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    Schneider, Matthew T. (35332956100)
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    Sorensen, Reed (57196918748)
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    Evans, Tim (7401454148)
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    Evans, David (57193990382)
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    Kurowski, Christoph (6602392515)
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    Tandon, Ajay (7103281804)
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    Abbas, Kaja M. (57190285707)
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    Abera, Semaw Ferede (57205180598)
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    Ahmad Kiadaliri, Aliasghar (57199100665)
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    Ahmed, Kedir Yimam (57190386244)
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    Ahmed, Muktar Beshir (57207802317)
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    Alam, Khurshid (57203681299)
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    Alizadeh-Navaei, Reza (36024974700)
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    Alkerwi, Ala'a (57197724313)
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    Amini, Erfan (35073393800)
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    Ammar, Walid (57208159281)
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    Amrock, Stephen Marc (57211220414)
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    Antonio, Carl Abelardo T. (55247644500)
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    Atey, Tesfay Mehari (57209784978)
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    Avila-Burgos, Leticia (8530790100)
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    Awasthi, Ashish (57200155811)
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    Barac, Aleksandra (55550748700)
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    Bernal, Oscar Alberto (44060935600)
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    Beyene, Addisu Shunu (57209036705)
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    Beyene, Tariku Jibat (57201181881)
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    Birungi, Charles (57195448297)
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    Bizuayehu, Habtamu Mellie (56507519700)
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    Breitborde, Nicholas J.K. (6603260895)
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    Cahuana-Hurtado, Lucero (57207890731)
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    Castro, Ruben Estanislao (55798606600)
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    Catalá-López, Ferran (57202553733)
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    Dalal, Koustuv (23469128200)
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    Dandona, Lalit (7007017243)
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    Dandona, Rakhi (57203043697)
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    De Jager, Pieter (55445666600)
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    Farinha, Carla Sofia E. Sa (57190279273)
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    Faro, Andre (36770969600)
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    Fischer, Florian (55508208800)
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    Fitchett, Joseph Robert Anderson (57219697690)
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    Foigt, Nataliya (57216998893)
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    Giref, Ababi Zergaw (57219994468)
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    Gupta, Rahul (57204120071)
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    Hamidi, Samer (24366336000)
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    Harb, Hilda L. (57221443122)
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    Hay, Simon I. (7101875313)
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    Hendrie, Delia (6602071966)
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    Horino, Masako (57195769276)
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    Jürisson, Mikk (55547524800)
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    Jakovljevic, Mihajlo B. (14318929700)
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    Javanbakht, Mehdi (57204619886)
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    John, Denny (57194230095)
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    Jonas, Jost B. (7202492953)
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    Karimi, Seyed M. (57220096578)
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    Khang, Young-Ho (57198904674)
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    Kim, Yun Jin (57211086375)
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    Kinge, Jonas M. (56133084600)
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    Krohn, Kristopher J. (57194138806)
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    Kumar, G. Anil (57139550500)
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    Magdy Abd El Razek, Hassan (57195948985)
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    Magdy Abd El Razek, Mohammed (57201191366)
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    Rai, Rajesh Kumar (51864423900)
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    Ram, Usha (26653819000)
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    Ranabhat, Chhabi Lal (56719695500)
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    Roba, Hirbo Shore (57200684844)
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    Salama, Joseph (57202975625)
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    Savic, Miloje (57204524150)
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    Sepanlou, Sadaf G. (36248136000)
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    Shrime, Mark G. (57204703404)
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    Talongwa, Roberto Tchio (57195568335)
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    Te Ao, Braden J. (55480837300)
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    Tediosi, Fabrizio (6603388399)
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    Tesema, Azeb Gebresilassie (57194530110)
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    Thomson, Alan J. (57969994200)
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    Tobe-Gai, Ruoyan (57209276611)
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    Topor-Madry, Roman (57211182892)
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    Undurraga, Eduardo A. (57204092789)
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    Vasankari, Tommi (57189653936)
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    Violante, Francesco S. (7003555890)
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    Werdecker, Andrea (57208964895)
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    Wijeratne, Tissa (14051317700)
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    Xu, Gelin (57203583113)
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    Yonemoto, Naohiro (57204947657)
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    Younis, Mustafa Z. (8549393000)
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    Yu, Chuanhua (57201889726)
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    Zaidi, Zoubida (57197376721)
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    El Sayed Zaki, Maysaa (57203666922)
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    Murray, Christopher J.L. (55481130700)
    Background: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, types of services purchased, and development assistance for health disbursed change with economic development. We also identify countries that deviate from the trends. Methods: We estimated national health spending by type of care and by source, including development assistance for health, based on a diverse set of data including programme reports, budget data, national estimates, and 964 National Health Accounts. These data represent health spending for 184 countries from 1995 through 2014. We converted these data into a common inflation-adjusted and purchasing power-adjusted currency, and used non-linear regression methods to model the relationship between health financing, time, and economic development. Findings: Between 1995 and 2014, economic development was positively associated with total health spending and a shift away from a reliance on development assistance and out-of-pocket (OOP) towards government spending. The largest absolute increase in spending was in high-income countries, which increased to purchasing power-adjusted $5221 per capita based on an annual growth rate of 3.0%. The largest health spending growth rates were in upper-middle-income (5.9) and lower-middle-income groups (5.0), which both increased spending at more than 5% per year, and spent $914 and $267 per capita in 2014, respectively. Spending in low-income countries grew nearly as fast, at 4.6%, and health spending increased from $51 to $120 per capita. In 2014, 59.2% of all health spending was financed by the government, although in low-income and lower-middle-income countries, 29.1% and 58.0% of spending was OOP spending and 35.7% and 3.0% of spending was development assistance. Recent growth in development assistance for health has been tepid; between 2010 and 2016, it grew annually at 1.8%, and reached US$37.6 billion in 2016. Nonetheless, there is a great deal of variation revolving around these averages. 29 countries spend at least 50% more than expected per capita, based on their level of economic development alone, whereas 11 countries spend less than 50% their expected amount. Interpretation: Health spending remains disparate, with low-income and lower-middle-income countries increasing spending in absolute terms the least, and relying heavily on OOP spending and development assistance. Moreover, tremendous variation shows that neither time nor economic development guarantee adequate prepaid health resources, which are vital for the pursuit of universal health coverage. © The Author(s). Published by Elsevier Ltd.
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    Future and potential spending on health 2015-40: Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries
    (2017)
    Dieleman, Joseph L. (54891678100)
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    Campbell, Madeline (57192869720)
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    Chapin, Abigail (57159731300)
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    Eldrenkamp, Erika (57194530102)
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    Fan, Victoria Y. (9737474800)
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    Haakenstad, Annie (56079498000)
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    Kates, Jennifer (7006961170)
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    Li, Zhiyin (57194530861)
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    Matyasz, Taylor (57194529771)
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    Micah, Angela (57193064978)
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    Reynolds, Alex (57216683497)
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    Sadat, Nafis (57219687343)
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    Schneider, Matthew T. (35332956100)
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    Sorensen, Reed (57196918748)
    ;
    Abbas, Kaja M. (57190285707)
    ;
    Abera, Semaw Ferede (57205180598)
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    Ahmad Kiadaliri, Aliasghar (57199100665)
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    Ahmed, Muktar Beshir (57207802317)
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    Alam, Khurshid (57203681299)
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    Alizadeh-Navaei, Reza (36024974700)
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    Alkerwi, Ala'a (57197724313)
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    Amini, Erfan (35073393800)
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    Ammar, Walid (57208159281)
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    Antonio, Carl Abelardo T. (55247644500)
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    Atey, Tesfay Mehari (57209784978)
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    Avila-Burgos, Leticia (8530790100)
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    Awasthi, Ashish (57200155811)
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    Barac, Aleksandra (55550748700)
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    Berheto, Tezera Moshago (56382955400)
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    Beyene, Addisu Shunu (57209036705)
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    Beyene, Tariku Jibat (57201181881)
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    Birungi, Charles (57195448297)
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    Bizuayehu, Habtamu Mellie (56507519700)
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    Breitborde, Nicholas J.K. (6603260895)
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    Cahuana-Hurtado, Lucero (57207890731)
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    Castro, Ruben Estanislao (55798606600)
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    Catalá-López, Ferran (57202553733)
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    Dalal, Koustuv (23469128200)
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    Dandona, Lalit (7007017243)
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    Dharmaratne, Rakhi Dandona Samath D. (57197827278)
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    Dubey, Manisha (57219898654)
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    Faro, Andé (36770969600)
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    Feigl, Andrea B. (57202461042)
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    Fischer, Florian (55508208800)
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    Fitchett, Joseph R. Anderson (57219697690)
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    Foigt, Nataliya (57216998893)
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    Giref, Ababi Zergaw (57219994468)
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    Gupta, Rahul (57204120071)
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    Hamidi, Samer (24366336000)
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    Harb, Hilda L. (57221443122)
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    Hay, Simon I. (7101875313)
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    Hendrie, Delia (6602071966)
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    Horino, Masako (57195769276)
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    Jürisson, Mikk (55547524800)
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    Jakovljevic, Mihajlo B. (14318929700)
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    Javanbakht, Mehdi (57204619886)
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    John, Denny (57194230095)
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    Jonas, Jost B. (7202492953)
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    Karimi, Seyed M. (57220096578)
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    Khang, Young-Ho (57198904674)
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    Khubchandani, Jagdish (57211720011)
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    Kim, Yun Jin (57211086375)
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    Kinge, Jonas M. (56133084600)
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    Krohn, Kristopher J. (57194138806)
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    Kumar, G. Anil (57139550500)
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    Leung, Ricky (56276497100)
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    Magdy Abd El Razek, Hassan (57195948985)
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    Magdy Abd El Razek, Mohammed (57201191366)
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    Majeed, Azeem (7102027801)
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    Malekzadeh, Reza (7005197760)
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    Malta, Deborah Carvalho (15835283500)
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    Meretoja, Atte (12775885500)
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    Miller, Ted R. (7403948600)
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    Mirrakhimov, Erkin M. (57216202888)
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    Mohammed, Shafiu (57838689000)
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    Molla, Gedefaw (57197832200)
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    Nangia, Vinay (57201490837)
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    Olgiati, Stefano (56372296100)
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    Owolabi, Mayowa O. (57222581892)
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    Patel, Tejas (57207871841)
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    Paternina Caicedo, Angel J. (35769665400)
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    Pereira, David M. (57200690024)
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    Perelman, Julian (22938580800)
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    Polinder, Suzanne (12766122200)
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    Rafay, Anwar (57212263323)
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    Rahimi-Movaghar, Vafa (6507646446)
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    Rai, Rajesh Kumar (51864423900)
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    Ram, Usha (26653819000)
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    Ranabhat, Chhabi Lal (56719695500)
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    Roba, Hirbo Shore (57200684844)
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    Savic, Miloje (57204524150)
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    Sepanlou, Sadaf G. (36248136000)
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    Te Ao, Braden J. (55480837300)
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    Tesema, Azeb Gebresilassie (57194530110)
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    Thomson, Alan J. (57969994200)
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    Tobe-Gai, Ruoyan (57209276611)
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    Topor-Madry, Roman (57211182892)
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    Undurraga, Eduardo A. (57204092789)
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    Vargas, Veronica (14018617400)
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    Vasankari, Tommi (57200592416)
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    Violante, Francesco S. (7003555890)
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    Wijeratne, Tissa (14051317700)
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    Xu, Gelin (57203583113)
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    Yonemoto, Naohiro (57204947657)
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    Younis, Mustafa Z. (8549393000)
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    Yu, Chuanhua (57201889726)
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    Zaidi, Zoubida (57197376721)
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    El Sayed Zaki, Maysaa (57203666922)
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    Murray, Christopher J.L. (55481130700)
    Background: The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study, we estimate future gross domestic product (GDP), all-sector government spending, and health spending disaggregated by source, and we compare expected future spending to potential future spending. Methods: We extracted GDP, government spending in 184 countries from 1980-2015, and health spend data from 1995-2014. We used a series of ensemble models to estimate future GDP, all-sector government spending, development assistance for health, and government, out-of-pocket, and prepaid private health spending through 2040. We used frontier analyses to identify patterns exhibited by the countries that dedicate the most funding to health, and used these frontiers to estimate potential health spending for each low-income or middle-income country. All estimates are inflation and purchasing power adjusted. Findings: We estimated that global spending on health will increase from US$9.21 trillion in 2014 to $24.24 trillion (uncertainty interval [UI] 20.47-29.72) in 2040. We expect per capita health spending to increase fastest in upper-middle-income countries, at 5.3% (UI 4.1-6.8) per year. This growth is driven by continued growth in GDP, government spending, and government health spending. Lower-middle income countries are expected to grow at 4.2% (3.8-4.9). High-income countries are expected to grow at 2.1% (UI 1.8-2.4) and low-income countries are expected to grow at 1.8% (1.0-2.8). Despite this growth, health spending per capita in low-income countries is expected to remain low, at $154 (UI 133-181) per capita in 2030 and $195 (157-258) per capita in 2040. Increases in national health spending to reach the level of the countries who spend the most on health, relative to their level of economic development, would mean $321 (157-258) per capita was available for health in 2040 in low-income countries. Interpretation: Health spending is associated with economic development but past trends and relationships suggest that spending will remain variable, and low in some low-resource settings. Policy change could lead to increased health spending, although for the poorest countries external support might remain essential. © The Author(s).
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    Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
    (2015)
    Naghavi, Mohsen (57207906323)
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    Wang, Haidong (16507828100)
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    Lozano, Rafael (7102198442)
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    Davis, Adrian (7404296836)
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    Liang, Xiaofeng (26662590300)
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    Zhou, Maigeng (57054557200)
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    Vollset, Stein Emil (57196315778)
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    Abbasoglu Ozgoren, Ayse (56133944200)
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    Abdalla, Safa (7005715928)
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    Abu-Rmeileh, Niveen M.E. (57216675148)
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    Chen, Jian Sheng (56541894700)
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    Ebel, Beth E. (7003709059)
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    Temesgen, A.M. (56541894900)
    Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specific causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65·3 years (UI 65·0-65·6) in 1990, to 71·5 years (UI 71·0-71·9) in 2013, while the number of deaths increased from 47·5 million (UI 46·8-48·2) to 54·9 million (UI 53·6-56·3) over the same interval. Global progress masked variation by age and sex: for children, average absolute differences between countries decreased but relative differences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative differences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10·7%, from 4·3 million deaths in 1990 to 4·8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specific mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade. Funding Bill & Melinda Gates Foundation. © 2015 Elsevier Ltd.
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    Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016
    (2017)
    Naghavi, Mohsen (57207906323)
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    Zegeye, Elias Asfaw (57209171278)
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    Zenebe, Zerihun Menlkalew (57200737185)
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    Zerfu, Taddese Alemu (55358278900)
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    Zhang, Anthony Lin (56391112900)
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    Zhang, Xueying (56283378700)
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    Zodpey, Sanjay (7003415080)
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    Lopez, Alan D. (7401455668)
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    Murray, Christopher J.L. (55481130700)
    Background: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specifc mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. Methods: We estimated cause-specifc deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specifc causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specifc deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016. Findings: The quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72·3% (95% uncertainty interval [UI] 71·2-73·2) of deaths in 2016 with 19·3% (18·5-20·4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8·43% (8·00-8·67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006-16 - age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1·80 million deaths (95% UI 1·59 million to 1·89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176-181) increase in deaths in ages 90-94 years and a 210% (208-212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL signifcantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2·89%); the median annualised rate of change for all other causes was lower (a decrease of 1·59%) during the same interval. Globally, the fve leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a fner level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations. Other leading causes of YLLs for which YLLs were notably lower than expected included neonatal preterm birth complications in many locations in both south Asia and southeast Asia, and cerebrovascular disease in western Europe. Interpretation: The past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages suggests success in reducing many causes of early death. YLLs have increased globally for causes such as diabetes mellitus or some neoplasms, and in some locations for causes such as drug use disorders, and confict and terrorism. Increasing levels of YLLs might refect outcomes from conditions that required high levels of care but for which efective treatments remain elusive, potentially increasing costs to health systems. Copyright © 2017 The Author(s). Published by Elsevier Ltd.
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    Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
    (2017)
    Gakidou, Emmanuela (57202567277)
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    Afshin, Ashkan (57217465455)
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    Abajobir, Amanuel Alemu (57203613441)
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    Abbafati, Cristiana (54917122400)
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    Abbas, Kaja M. (57190285707)
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    Abd-Allah, Foad (36503428900)
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    Abdulle, Abdishakur M. (6603592018)
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    Abera, Semaw Ferede (57205180598)
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    Aboyans, Victor (56214736500)
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    Abu-Rmeileh, Niveen M.E. (57216675148)
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    Abyu, Gebre Yitayih (57190277969)
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    Adedeji, Isaac Akinkunmi (57208456508)
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    Afarideh, Mohsen (56227034300)
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    Van Boven, Job F.M. (53464198500)
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    Van Donkelaar, Aaron (15926418500)
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    Varughese, Santosh (22942817500)
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    Veerman, Lennert J. (8222114200)
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    Venkateswaran, Vidhya (59829999400)
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    Venketasubramanian, Narayanaswamy (56804702100)
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    Vollset, Stein Emil (57196315778)
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    Wallin, Mitchell T. (57201573668)
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    Wang, Yuan-Pang (8576812100)
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    Woldeyes, Belete Getahun (57195329524)
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    Wolfe, Charles D.A. (57202754705)
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    Woodbrook, Rachel (57200298006)
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    Workicho, Abdulhalik (56720337100)
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    Wulf Hanson, Sarah (57212263269)
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    Xavier, Denis (55403963100)
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    Xu, Gelin (57203583113)
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    Yadgir, Simon (57192837280)
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    Yakob, Bereket (57203811497)
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    Yan, Lijing L. (57198311895)
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    Yaseri, Mehdi (23029507000)
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    Yimam, Hassen Hamid (57196325590)
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    Yip, Paul (7102503720)
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    Yonemoto, Naohiro (57204947657)
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    Yoon, Seok-Jun (24823148900)
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    Yotebieng, Marcel (26325950800)
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    Younis, Mustafa Z. (8549393000)
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    Zaidi, Zoubida (57197376721)
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    El Sayed Zaki, Maysaa (57203666922)
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    Zavala-Arciniega, Luis (57196083471)
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    Zhang, Xueying (56283378700)
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    Zimsen, Stephanie Raman M. (57196078433)
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    Zipkin, Ben (57200737130)
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    Zodpey, Sanjay (7003415080)
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    Lim, Stephen S. (57201800433)
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    Murray, Christopher J.L. (55481130700)
    Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. Methods: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2016. This study included 481 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk (RR) and exposure estimates from 22 717 randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources, according to the GBD 2016 source counting methods. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. Finally, we explored four drivers of trends in attributable burden: population growth, population ageing, trends in risk exposure, and all other factors combined. Findings: Since 1990, exposure increased significantly for 30 risks, did not change significantly for four risks, and decreased significantly for 31 risks. Among risks that are leading causes of burden of disease, child growth failure and household air pollution showed the most significant declines, while metabolic risks, such as body-mass index and high fasting plasma glucose, showed significant increases. In 2016, at Level 3 of the hierarchy, the three leading risk factors in terms of attributable DALYs at the global level for men were smoking (124.1 million DALYs [95% UI 111.2 million to 137.0 million]), high systolic blood pressure (122.2 million DALYs [110.3 million to 133.3 million], and low birthweight and short gestation (83.0 million DALYs [78.3 million to 87.7 million]), and for women, were high systolic blood pressure (89.9 million DALYs [80.9 million to 98.2 million]), high body-mass index (64.8 million DALYs [44.4 million to 87.6 million]), and high fasting plasma glucose (63.8 million DALYs [53.2 million to 76.3 million]). In 2016 in 113 countries, the leading risk factor in terms of attributable DALYs was a metabolic risk factor. Smoking remained among the leading five risk factors for DALYs for 109 countries, while low birthweight and short gestation was the leading risk factor for DALYs in 38 countries, particularly in sub-Saharan Africa and South Asia. In terms of important drivers of change in trends of burden attributable to risk factors, between 2006 and 2016 exposure to risks explains an 9.3% (6.9-11.6) decline in deaths and a 10.8% (8.3-13.1) decrease in DALYs at the global level, while population ageing accounts for 14.9% (12.7-17.5) of deaths and 6.2% (3.9-8.7) of DALYs, and population growth for 12.4% (10.1-14.9) of deaths and 12.4% (10.1-14.9) of DALYs. The largest contribution of trends in risk exposure to disease burden is seen between ages 1 year and 4 years, where a decline of 27.3% (24.9-29.7) of the change in DALYs between 2006 and 2016 can be attributed to declines in exposure to risks. Interpretation: Increasingly detailed understanding of the trends in risk exposure and the RRs for each risk-outcome pair provide insights into both the magnitude of health loss attributable to risks and how modification of risk exposure has contributed to health trends. Metabolic risks warrant particular policy attention, due to their large contribution to global disease burden, increasing trends, and variable patterns across countries at the same level of development. GBD 2016 findings show that, while it has huge potential to improve health, risk modification has played a relatively small part in the past decade. © The Author(s). Published by Elsevier Ltd.
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    Publication
    Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
    (2017)
    Soriano, Joan B. (7101973935)
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    Abajobir, Amanuel Alemu (57203613441)
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    Abate, Kalkidan Hassen (57207943858)
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    Abera, Semaw Ferede (57205180598)
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    Agrawal, Anurag (35214460700)
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    Ahmed, Muktar Beshir (57207802317)
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    Aichour, Amani Nidhal (57195486768)
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    Aichour, Ibtihel (57195485980)
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    Eddine Aichour, Miloud Taki (57204418341)
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    Alam, Khurshid (57203681299)
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    Alam, Noore (57202437697)
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    Alkaabi, Juma M. (57202957220)
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    Al-Maskari, Fatma (25824744400)
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    Alvis-Guzman, Nelson (57210741239)
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    Antó, Josep M. (56196020900)
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    Hedayati, Mohammad T. (23979915700)
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    Jakovljevic, Mihajlo Michael B. (14318929700)
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    James, Spencer Lewis (57202557998)
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    Kasaeian, Amir (57195540738)
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    Leshargie, Cheru Tesema (57195295462)
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    Liang, Xiaofeng (26662590300)
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    Miller, Ted R. (7403948600)
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    Mohammad, Karzan Abdulmuhsin (57205300378)
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    Mohammed, Kedir Endris (57216551957)
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    Mohammed, Shafiu (57838689000)
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    Mokdad, Ali H. (7004813962)
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    Naghavi, Mohsen (57207906323)
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    Nguyen, Cuong Tat (56531347200)
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    Nguyen, Grant (57191591002)
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    Nguyen, Quyen Le (57223642100)
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    Nguyen, Trang Huyen (59142352200)
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    Ningrum, Dina Nur Anggraini (57195329470)
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    Nong, Vuong Minh (55507077200)
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    Obi, Jennifer Ifeoma (57195484240)
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    Odeyemi, Yewande E. (56786402700)
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    Ogbo, Felix Akpojene (57200737136)
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    Mahesh, P.A. (57202421244)
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    Park, Eun-Kee (57216814178)
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    Patton, George C. (7102184358)
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    Paulson, Katherine (57203437789)
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    Qorbani, Mostafa (24831040300)
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    Quansah, Reginald (14825606700)
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    Rafay, Anwar (57212263323)
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    Rahman, Mohammad Hifz Ur (57208867497)
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    Rai, Rajesh Kumar (51864423900)
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    Rawaf, Salman (6602475959)
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    Reinig, Nik (57208577401)
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    Sarmiento-Suarez, Rodrigo (57204744430)
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    Sartorius, Benn (12788526800)
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    Shigematsu, Mika (23968093000)
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    Smith, Mari (57195484737)
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    Tadese, Fentaw (57190805861)
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    Thurston, George D. (7102270013)
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    Topor-Madry, Roman (57211182892)
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    Tran, Bach Xuan (57209107515)
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    Ukwaja, Kingsley Nnanna (57202824584)
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    van Boven, Job F. M. (53464198500)
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    Vlassov, Vasiliy Victorovich (57211633239)
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    Vollset, Stein Emil (57196315778)
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    Wan, Xia (57197110584)
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    Werdecker, Andrea (57208964895)
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    Hanson, Sarah Wulf (57212263269)
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    Yano, Yuichiro (57196965200)
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    Yimam, Hassen Hamid (57196325590)
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    Yonemoto, Naohiro (57204947657)
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    Yu, Chuanhua (57208140344)
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    Zaidi, Zoubida (57197376721)
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    Sayed Zaki, Maysaa El (57203666922)
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    Lopez, Alan D. (7401455668)
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    Murray, Christopher J. L. (55481130700)
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    Vos, Theo (57223885848)
    Background Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 study. The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year. Methods We estimated numbers of deaths due to COPD and asthma using the GBD Cause of Death Ensemble modelling (CODEm) tool. First, we analysed data from vital registration and verbal autopsy for the aggregate category of all chronic respiratory diseases. Subsequently, models were run for asthma and COPD relying on covariates to predict rates in countries that have incomplete or no vital registration data. Disease estimates for COPD and asthma were based on systematic reviews of published papers, unpublished reports, surveys, and health service encounter data from the USA. We used the Global Initiative of Chronic Obstructive Lung Disease spirometry-based definition as the reference for COPD and a reported diagnosis of asthma with current wheeze as the definition of asthma. We used a Bayesian meta-regression tool, DisMod-MR 2.1, to derive estimates of prevalence and incidence. We estimated population-attributable fractions for risk factors for COPD and asthma from exposure data, relative risks, and a theoretical minimum exposure level. Results were stratified by Socio-demographic Index (SDI), a composite measure of income per capita, mean years of education over the age of 15 years, and total fertility rate. Findings In 2015, 3·2 million people (95% uncertainty interval [UI] 3·1 million to 3·3 million) died from COPD worldwide, an increase of 11·6% (95% UI 5·3 to 19·8) compared with 1990. There was a decrease in age-standardised death rate of 41·9% (37·7 to 45·1) but this was counteracted by population growth and ageing of the global population. From 1990 to 2015, the prevalence of COPD increased by 44·2% (41·7 to 46·6), whereas age-standardised prevalence decreased by 14·7% (13·5 to 15·9). In 2015, 0·40 million people (0·36 million to 0·44 million) died from asthma, a decrease of 26·7% (−7·2 to 43·7) from 1990, and the age-standardised death rate decreased by 58·8% (39·0 to 69·0). The prevalence of asthma increased by 12·6% (9·0 to 16·4), whereas the age-standardised prevalence decreased by 17·7% (15·1 to 19·9). Age-standardised DALY rates due to COPD increased until the middle range of the SDI before reducing sharply. Age-standardised DALY rates due to asthma in both sexes decreased monotonically with rising SDI. The relation between with SDI and DALY rates due to asthma was attributed to variation in years of life lost (YLLs), whereas DALY rates due to COPD varied similarly for YLLs and years lived with disability across the SDI continuum. Smoking and ambient particulate matter were the main risk factors for COPD followed by household air pollution, occupational particulates, ozone, and secondhand smoke. Together, these risks explained 73·3% (95% UI 65·8 to 80·1) of DALYs due to COPD. Smoking and occupational asthmagens were the only risks quantified for asthma in GBD, accounting for 16·5% (14·6 to 18·7) of DALYs due to asthma. Interpretation Asthma was the most prevalent chronic respiratory disease worldwide in 2015, with twice the number of cases of COPD. Deaths from COPD were eight times more common than deaths from asthma. In 2015, COPD caused 2·6% of global DALYs and asthma 1·1% of global DALYs. Although there are laudable international collaborative efforts to make surveys of asthma and COPD more comparable, no consensus exists on case definitions and how to measure disease severity for population health measurements like GBD. Comparisons between countries and over time are important, as much of the chronic respiratory burden is either preventable or treatable with affordable interventions. Funding Bill & Melinda Gates Foundation. © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
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    Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
    (2017)
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    Uthman, Olalekan A. (23026328100)
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    Uzochukwu, Benjamin S. Chudi (57211633289)
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    Van Boven, Job F. M. (53464198500)
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    Varughese, Santosh (22942817500)
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    Vasankari, Tommi (57200592416)
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    Veerman, Lennert J. (8222114200)
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    Venkatesh, S. (57201538443)
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    Venketasubramanian, Narayanaswamy (56804702100)
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    Vidavalur, Ramesh (57201445172)
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    Vijayakumar, Lakshmi (57202973343)
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    Violante, Francesco S. (7003555890)
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    Vishnu, Abhishek (36515938100)
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    Vladimirov, Sergey K. (57195959162)
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    Vlassov, Vasiliy Victorovich (57211633239)
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    Vollset, Stein Emil (57196315778)
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    Vos, Theo (57223885848)
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    Wadilo, Fiseha (57194049305)
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    Wakayo, Tolassa (57205609717)
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    Wallin, Mitchell T. (57201573668)
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    Wang, Yuan-Pang (8576812100)
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    Weichenthal, Scott (57202555239)
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    Weiderpass, Elisabete (57205018947)
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    Weintraub, Robert G. (7006079405)
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    Weiss, Daniel J. (8609275600)
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    Werdecker, Andrea (57208964895)
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    Westerman, Ronny (57218361023)
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    Whiteford, Harvey A. (55906494000)
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    Wijeratne, Tissa (14051317700)
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    Williams, Hywel C. (23500447000)
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    Wiysonge, Charles Shey (6507441509)
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    Woldeyes, Belete Getahun (57195329524)
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    Wolfe, Charles D. A. (57202754705)
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    Woodbrook, Rachel (57200298006)
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    Woolf, Anthony D. (7102882171)
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    Workicho, Abdulhalik (56720337100)
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    Xavier, Denis (55403963100)
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    Xu, Gelin (57203583113)
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    Yadgir, Simon (57192837280)
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    Yaghoubi, Mohsen (56402926900)
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    Yakob, Bereket (57203811497)
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    Yan, Lijing L. (57198311895)
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    Yano, Yuichiro (57196965200)
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    Ye, Pengpeng (57202839295)
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    Yihdego, Mahari Gidey (57194541914)
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    Yimam, Hassen Hamid (57196325590)
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    Yip, Paul (7102503720)
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    Yonemoto, Naohiro (57204947657)
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    Yoon, Seok-Jun (24823148900)
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    Yotebieng, Marcel (26325950800)
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    Younis, Mustafa Z. (8549393000)
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    Yu, Chuanhua (57201889726)
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    Zaidi, Zoubida (57197376721)
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    Zaki, Maysaa El Sayed (57203666922)
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    Zegeye, Elias Asfaw (57209171278)
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    Zenebe, Zerihun Menlkalew (57200737185)
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    Zhang, Xueying (56283378700)
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    Zheng, Yingfeng (58918045300)
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    Zhou, Maigeng (57054557200)
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    Zipkin, Ben (57200737130)
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    Zodpey, Sanjay (7003415080)
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    Zoeckler, Leo (57203905510)
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    Zuhlke, Liesl Joanna (57209027746)
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    Murray, Christopher J. L. (55481130700)
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    Adedji, I.A. (57207919805)
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    Murdoch, M.E. (57202097865)
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    Bryane, C.E.G. (57207920084)
    Background: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). Methods: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE difered from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. Findings: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and 1·96 years (1·69-2·13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2·3% [-5·9 to 0·9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs ofset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the fve lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16·1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally. Interpretation: At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs ofset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention eforts, and development assistance for health, including fnancial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support. © The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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    Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
    (2014)
    Murray, Christopher J.L. (55481130700)
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    Ortblad, Katrina F. (57190076688)
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    Guinovart, Caterina (23024511900)
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    Lim, Stephen S. (7404081544)
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    Wolock, Timothy M. (57210784314)
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    Roberts, D. Allen (57188657365)
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    Dansereau, Emily A. (57203833128)
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    Dicker, Daniel (57196026676)
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    Dandona, Lalit (7007017243)
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    Salomon, Joshua A. (56745638600)
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    Heuton, Kyle R. (57202568555)
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    Abubakar, Ibrahim (57220174401)
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    Abu-Raddad, Laith J. (14032724700)
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    Achoki, Tom (57202561099)
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    Adeyemo, Austine Olufemi (56276318500)
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    Al Kahbouri, Mazin J. (56132885900)
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    Alasfoor, Deena (57211114684)
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    Albittar, Mohammed I. (56276571900)
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    Alcalá-Cerra, Gabriel (35769097100)
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    Alegretti, Miguel Angel (56276408300)
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    Alfonso-Cristancho, Rafael (26326133000)
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    Alhabib, Samia (57194933167)
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    Ali, Raghib (57196506541)
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    Alla, Francois (6701580827)
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    Allen, Peter J. (58444261300)
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    Alsharif, Ubai (57211633255)
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    Alvarez, Elena (57216675106)
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    Amankwaa, Adansi A. (57202564178)
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    Amini, Hassan (57202568400)
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    Anderson, Benjamin O. (22937050900)
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    Arsic Arsenijevic, Valentina S. (6507940363)
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    Artaman, Ali (57217223811)
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    Assadi, Reza (57201282579)
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    Atkins, Lydia S. (56132848600)
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    Balakrishnan, Kalpana (7103222725)
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    Banerjee, Amitava (57208560645)
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    Basu, Sanjay (9335409500)
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    Beardsley, Justin (57207800229)
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    Bekele, Tolesa (57195086149)
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    Bell, Michelle L. (7401466450)
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    Bernabe, Eduardo (57194696150)
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    Beyene, Tariku Jibat (57201181881)
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    Bhala, Neeraj (15759186000)
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    Bhalla, Ashish (57202555305)
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    Bhutta, Zulfiqar A. (24342648300)
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    Bin Abdulhak, Aref (57201757922)
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    Binagwaho, Agnes (8314417100)
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    Blore, Jed D. (57202562230)
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    Bose, Dipan (57205255835)
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    Brainin, Michael (7006405278)
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    Breitborde, Nicholas (6603260895)
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    Castañeda-Orjuela, Carlos A. (35769124700)
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    Catalá-López, Ferrán (57202553733)
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    Chadha, Vineet K. (57208775362)
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    Chang, Jung-Chen (57202568248)
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    Chiang, Peggy Pei-Chia (59846886500)
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    Chuang, Ting-Wu (6603108974)
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    Colomar, Mercedes (57218434254)
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    Cooper, Leslie Trumbull (15754277900)
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    Cooper, Cyrus (36041345700)
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    Courville, Karen J. (56133151600)
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    Cowie, Benjamin C. (57202566182)
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    Criqui, Michael H. (7005209601)
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    Dandona, Rakhi (57203043697)
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    Dayama, Anand (57202564137)
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    De Leo, Diego (7006128644)
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    Degenhardt, Louisa (7004040033)
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    Del Pozo-Cruz, Borja (42061354100)
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    Deribe, Kebede (57193912587)
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    Des Jarlais, Don C. (56990451200)
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    Dessalegn, Muluken (57192148714)
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    Dharmaratne, Samath D. (57216324802)
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    Dilmen, Uur (57213612668)
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    Ding, Eric L. (54413849800)
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    Driscoll, Tim R. (7005928308)
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    Durrani, Adnan M. (57202572082)
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    Ellenbogen, Richard G. (7007098380)
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    Ermakov, Sergey Petrovich (7006796196)
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    Esteghamati, Alireza (11240321100)
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    Faraon, Emerito Jose A. (57195414019)
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    Farzadfar, Farshad (57195049611)
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    Fereshtehnejad, Seyed-Mohammad (57202557520)
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    Fijabi, Daniel Obadare (56133163100)
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    Forouzanfar, Mohammad H. (55882758900)
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    Paleo, Urbano Fra. (15053114000)
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    Gaffikin, Lynne (6701866671)
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    Gamkrelidze, Amiran (6506029209)
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    Gankpé, Fortuné Gbètoho (57201341525)
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    Geleijnse, Johanna M. (35195702500)
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    Gessner, Bradford D. (7005779769)
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    Gibney, Katherine B. (57202564104)
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    Ginawi, Ibrahim Abdelmageem Mohamed (57192378390)
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    Glaser, Elizabeth L. (56133254300)
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    Gona, Philimon (57219703762)
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    Goto, Atsushi (36339255500)
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    Gouda, Hebe N. (57202432343)
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    Gugnani, Harish Chander (7005567008)
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    Gupta, Rajeev (55705295300)
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    Gupta, Rahul (56453686300)
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    Hafezi-Nejad, Nima (57216814261)
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    Hamadeh, Randah Ribhi (57202769526)
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    Hankey, Graeme J. (7102816661)
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    Harb, Hilda L. (57221443122)
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    Haro, Josep Maria (57215877903)
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    Havmoeller, Rasmus (57212075728)
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    Hay, Simon I. (7101875313)
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    Hedayati, Mohammad T. (23979915700)
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    Heredia Pi, Ileana B. (36941085200)
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    Hoek, Hans W. (57202570421)
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    Hornberger, John C. (56825487700)
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    Hosgood, H. Dean (56353204400)
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    Hotez, Peter J. (7004958298)
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    Hoy, Damian G. (8553772600)
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    Huang, John J. (56135699200)
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    Iburg, Kim M. (57216814160)
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    Idrisov, Bulat T. (57208773503)
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    Innos, Kaire (57217314902)
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    Jacobsen, Kathryn H. (26029163100)
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    Jeemon, Panniyammakal (57216324831)
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    Jensen, Paul N. (57224209864)
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    Jha, Vivekanand (7005119423)
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    Jiang, Guohong (56984997300)
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    Jonas, Jost B. (7202492953)
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    Juel, Knud (7005077250)
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    Kan, Haidong (7101602991)
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    Kankindi, Ida (56276481400)
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    Karam, Nadim E. (57221993192)
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    Karch, André (55917217700)
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    Karema, Corine Kakizi (57202557522)
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    Kaul, Anil (16156995700)
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    Kawakami, Norito (35377339000)
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    Kazi, Dhruv S. (57216814161)
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    Kemp, Andrew H. (57218313462)
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    Kengne, Andre Pascal (7801322838)
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    Keren, Andre (7005620132)
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    Kereselidze, Maia (55659152900)
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    Khader, Yousef Saleh (55654192600)
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    Khalifa, Shams Eldin Ali Hassan (59831217100)
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    Khan, Ejaz Ahmed (57218791274)
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    Khang, Young-Ho (57198904674)
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    Khonelidze, Irma (57202287317)
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    Kinfu, Yohannes (12770281900)
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    Kinge, Jonas M. (56133084600)
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    Kumar, Kaushalendra (59070501700)
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    De Lima, Graça Maria Ferreira (56133968700)
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    Lin, Hsien-Ho (39061859200)
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    Lipshultz, Steven E. (7006950713)
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    Liu, Shiwei (57209574351)
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    Lloyd, Belinda K. (55313086800)
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    Lotufo, Paulo A. (7003331101)
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    Mejia-Rodriguez, Fabiola (56013641600)
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    Memish, Ziad A. (7005059350)
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    Mendoza, Walter (57216905642)
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    Miller, Ted R. (7403948600)
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    Mills, Edward J. (7102584704)
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    Mokdad, Ali H. (7004813962)
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    Newton, Charles R. (35465836500)
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    Uzun, Selen Begüm (57200327315)
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    Vallely, Andrew J. (21744114400)
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    Vasankari, Tommi J. (57189653936)
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    Venketasubramanian, N. (56804702100)
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    Vlassov, Vasiliy Victorovich (57211633239)
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    Waller, Stephen (57201445180)
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    Wilkinson, James D. (57207903571)
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    Williams, Thomas Neil (35430527200)
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    Woldeyohannes, Solomon Meseret (57195461619)
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    Wong, John Q. (56491997300)
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    Xu, Gelin (14049536200)
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    Yano, Yuichiro (57196965200)
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    Yentur, Gokalp Kadri (57211728019)
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    Yip, Paul (7102503720)
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    Yonemoto, Naohiro (57204947657)
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    Yoon, Seok-Jun (24823148900)
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    Younis, Mustafa (8549393000)
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    Yu, Chuanhua (57201889726)
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    Jin, Kim Yun (57211086375)
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    El Sayed Zaki, Maysaa (57203666922)
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    Zhao, Yong (59798995400)
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    Zheng, Yingfeng (58918045300)
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    Zhou, Maigeng (57054557200)
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    Zhu, Jun (56215097100)
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    Zou, Xiao Nong (57216284159)
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    Lopez, Alan D. (7401455668)
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    Vos, Theo (57223885848)
    Background The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration. Methods To estimate incidence and mortality for HIV, we used the UNAIDS Spectrum model appropriately modifi ed based on a systematic review of available studies of mortality with and without antiretroviral therapy (ART). For concentrated epidemics, we calibrated Spectrum models to fi t vital registration data corrected for misclassifi cation of HIV deaths. In generalised epidemics, we minimised a loss function to select epidemic curves most consistent with prevalence data and demographic data for all-cause mortality. We analysed counterfactual scenarios for HIV to assess years of life saved through prevention of mother-to-child transmission (PMTCT) and ART. For tuberculosis, we analysed vital registration and verbal autopsy data to estimate mortality using cause of death ensemble modelling. We analysed data for corrected case-notifi cations, expert opinions on the case-detection rate, prevalence surveys, and estimated cause-specifi c mortality using Bayesian meta-regression to generate consistent trends in all parameters. We analysed malaria mortality and incidence using an updated cause of death database, a systematic analysis of verbal autopsy validation studies for malaria, and recent studies (2010-13) of incidence, drug resistance, and coverage of insecticide-treated bednets. Findings Globally in 2013, there were 1·8 million new HIV infections (95% uncertainty interval 1·7 million to 2·1 million), 29·2 million prevalent HIV cases (28·1 to 31·7), and 1·3 million HIV deaths (1·3 to 1·5). At the peak of the epidemic in 2005, HIV caused 1·7 million deaths (1·6 million to 1·9 million). Concentrated epidemics in Latin America and eastern Europe are substantially smaller than previously estimated. Through interventions including PMTCT and ART, 19·1 million life-years (16·6 million to 21·5 million) have been saved, 70·3% (65·4 to 76·1) in developing countries. From 2000 to 2011, the ratio of development assistance for health for HIV to years of life saved through intervention was US$4498 in developing countries. Including in HIV-positive individuals, all-form tuberculosis incidence was 7·5 million (7·4 million to 7·7 million), prevalence was 11·9 million (11·6 million to 12·2 million), and number of deaths was 1·4 million (1·3 million to 1·5 million) in 2013. In the same year and in only individuals who were HIV-negative, all-form tuberculosis incidence was 7·1 million (6·9 million to 7·3 million), prevalence was 11·2 million (10·8 million to 11·6 million), and number of deaths was 1·3 million (1·2 million to 1·4 million). Annualised rates of change (ARC) for incidence, prevalence, and death became negative after 2000. Tuberculosis in HIV-negative individuals disproportionately occurs in men and boys (versus women and girls); 64·0% of cases (63·6 to 64·3) and 64·7% of deaths (60·8 to 70·3). Globally, malaria cases and deaths grew rapidly from 1990 reaching a peak of 232 million cases (143 million to 387 million) in 2003 and 1·2 million deaths (1·1 million to 1·4 million) in 2004. Since 2004, child deaths from malaria in sub-Saharan Africa have decreased by 31·5% (15·7 to 44·1). Outside of Africa, malaria mortality has been steadily decreasing since 1990. Interpretation Our estimates of the number of people living with HIV are 18·7% smaller than UNAIDS's estimates in 2012. The number of people living with malaria is larger than estimated by WHO. Incidence rates for HIV, tuberculosis, and malaria have all decreased since 2000. At the global level, upward trends for malaria and HIV deaths have been reversed and declines in tuberculosis deaths have accelerated. 101 countries (74 of which are developing) still have increasing HIV incidence. Substantial progress since the Millennium Declaration is an encouraging sign of the effect of global action. Funding Bill & Melinda Gates Foundation.
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    Publication
    Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
    (2017)
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    Thomas, Katie E. (56239717800)
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    Thrift, Amanda G. (7004824524)
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    Tiruye, Tenaw Yimer (57194055872)
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    Tobe-Gai, Ruoyan (57209276611)
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    Tollanes, Mette C. (16833860000)
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    Tonelli, Marcello (7103102534)
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    Topor-Madry, Roman (57211182892)
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    Tortajada, Miguel (16242320900)
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    Touvier, Mathilde (8877033300)
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    Tran, Bach Xuan (57209107515)
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    Tripathi, Suryakant (57225821627)
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    Troeger, Christopher (57195223624)
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    Truelsen, Thomas (57202824565)
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    Tsoi, Derrick (57196074984)
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    Tuem, Kald Beshir (57216106503)
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    Tuzcu, Emin Murat (7005951350)
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    Tyrovolas, Stefanos (57207793475)
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    Ukwaja, Kingsley N. (57202824584)
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    Undurraga, Eduardo A. (57204092789)
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    Uneke, Chigozie Jesse (57202824589)
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    Updike, Rachel (57204698680)
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    Uthman, Olalekan A. (23026328100)
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    Uzochukwu, Benjamin S. Chudi (57211633289)
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    Van Boven, Job F.M. (53464198500)
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    Varughese, Santosh (22942817500)
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    Vasankari, Tommi (23096834700)
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    Venkatesh, S. (57201538443)
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    Venketasubramanian, Narayanaswamy (56804702100)
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    Vidavalur, Ramesh (57201445172)
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    Violante, Francesco S. (7003555890)
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    Vladimirov, Sergey K. (57195959162)
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    Vlassov, Vasiliy Victorovich (57211633239)
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    Vollset, Stein Emil (57196315778)
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    Wadilo, Fiseha (57194049305)
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    Wakayo, Tolassa (57205609717)
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    Wang, Yuan-Pang (8576812100)
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    Weaver, Marcia (7201548872)
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    Weichenthal, Scott (57202555239)
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    Weiderpass, Elisabete (57205018947)
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    Weintraub, Robert G. (7006079405)
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    Werdecker, Andrea (57208964895)
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    Westerman, Ronny (57218361023)
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    Whiteford, Harvey A. (55906494000)
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    Wijeratne, Tissa (14051317700)
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    Wiysonge, Charles Shey (6507441509)
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    Wolfe, Charles D.A. (57202754705)
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    Woodbrook, Rachel (57200298006)
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    Woolf, Anthony D. (7102882171)
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    Workicho, Abdulhalik (56720337100)
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    Wulf Hanson, Sarah (57212263269)
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    Xavier, Denis (55403963100)
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    Xu, Gelin (57203583113)
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    Yadgir, Simon (57192837280)
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    Yaghoubi, Mohsen (56402926900)
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    Yakob, Bereket (57203811497)
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    Yan, Lijing L. (35933756700)
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    Yano, Yuichiro (57196965200)
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    Ye, Pengpeng (57202839295)
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    Yimam, Hassen Hamid (57196325590)
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    Yip, Paul (7102503720)
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    Yonemoto, Naohiro (57204947657)
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    Yoon, Seok-Jun (24823148900)
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    Yotebieng, Marcel (26325950800)
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    Younis, Mustafa Z. (8549393000)
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    Zaidi, Zoubida (57197376721)
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    Zaki, Maysaa El Sayed (57203666922)
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    Zegeye, Elias Asfaw (57209171278)
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    Zenebe, Zerihun Menlkalew (57200737185)
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    Zhang, Xueying (56283378700)
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    Zhou, Maigeng (57054557200)
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    Zipkin, Ben (57200737130)
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    Zodpey, Sanjay (7003415080)
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    Zuhlke, Liesl Joanna (57209027746)
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    Murray, Christopher J.L. (55481130700)
    Background As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. Methods We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8-75·9 million [7·2%, 6·0-8·3]), 45·1 million (29·0-62·8 million [5·6%, 4·0-7·2]), 36·3 million (25·3-50·9 million [4·5%, 3·8-5·3]), 34·7 million (23·0-49·6 million [4·3%, 3·5-5·2]), and 34·1 million (23·5-46·0 million [4·2%, 3·2-5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3-3·1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10·4% (95% UI 9·0-11·8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout were the main conditions contributing to higher YLD rates in women. Men had higher age-standardised rates of substance use disorders, diabetes, cardiovascular diseases, cancers, and all injuries apart from sexual violence. Globally, we noted much less geographical variation in disability than has been documented for premature mortality. In 2016, there was a less than two times difference in age-standardised YLD rates for all causes between the location with the lowest rate (China, 9201 YLDs per 100 000, 95% UI 6862-11943) and highest rate (Yemen, 14 774 YLDs per 100 000, 11 018-19 228). Interpretation The decrease in death rates since 1990 for most causes has not been matched by a similar decline in age-standardised YLD rates. For many large causes, YLD rates have either been stagnant or have increased for some causes, such as diabetes. As populations are ageing, and the prevalence of disabling disease generally increases steeply with age, health systems will face increasing demand for services that are generally costlier than the interventions that have led to declines in mortality in childhood or for the major causes of mortality in adults. Up-todate information about the trends of disease and how this varies between countries is essential to plan for an adequate health-system response. © The Author(s). Published by Elsevier Ltd.
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    Publication
    Global, regional, and national levels and causes of maternal mortality during 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
    (2014)
    Kassebaum, Nicholas J. (55522621100)
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    Bertozzi-Villa, Amelia (57192900191)
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    Coggeshall, Megan S. (56132969600)
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    Shackelford, Katya A. (57202959163)
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    Steiner, Caitlyn (57205358084)
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    Heuton, Kyle R. (57202568555)
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    Gonzalez-Medina, Diego (57202595524)
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    Ding, Eric L. (54413849800)
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    Fereshtehnejad, Seyed-Mohammad (57202557520)
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    Pi, Ileana B. Heredia (56133570600)
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    Hoek, Hans W. (57202570421)
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    Inoue, Manami (8889234100)
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    Jacobsen, Kathryn H. (26029163100)
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    Jahangir, Eiman (22634545400)
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    Jee, Sun Ha (16039275900)
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    Jensen, Paul N. (57224209864)
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    Jonas, Jost B. (7202492953)
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    Juel, Knud (7005077250)
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    Kan, Haidong (7101602991)
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    Kemp, Andrew H. (57218313462)
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    Khalifa, Shams Eldin Ali Hassan (59831217100)
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    Khan, Ejaz Ahmed (57218791274)
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    Khang, Young-Ho (57198904674)
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    Knibbs, Luke (16313525200)
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    Defo, Barthelemy Kuate (6602271655)
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    Kulkarni, Chanda (59869378300)
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    Kulkarni, Veena S. (57200084922)
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    Kumar, G. Anil (57139550500)
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    Kumar, Kaushalendra (59070501700)
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    Kumar, Ravi B. (59600303400)
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    Kwan, Gene (57194535368)
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    Lai, Taavi (57196395162)
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    Lam, Hilton (35484312600)
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    Larsson, Anders (36818888800)
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    Lee, Jong-Tae (57196083400)
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    Leigh, James (7202089604)
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    Leinsalu, Mall (6603447541)
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    Leung, Ricky (56276497100)
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    Li, Xiaohong (36627308700)
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    Li, Yichong (57218426673)
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    Li, Yongmei (56147667800)
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    Liang, Juan (57198351058)
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    Liang, Xiaofeng (26662590300)
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    Lim, Stephen S. (7404081544)
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    Lipshultz, Steven E. (7006950713)
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    London, Stephanie J. (56988756100)
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    Lotufo, Paulo A. (7003331101)
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    Shakh-Nazarova, Marina (56133525500)
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    Sheikhbahaei, Sara (57219637352)
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    Shibuya, Kenji (8948057900)
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    Shin, Hwashin Hyun (56132914500)
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    Shiue, Ivy (35811219800)
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    Sigfusdottir, Inga Dora (57195363778)
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    Silberberg, Donald H. (57223420256)
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    Silva, Andrea P. (59594831400)
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    Singh, Jasvinder A. (7404421736)
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    Skirbekk, Vegard (57202564482)
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    Sliwa, Karen (57207223988)
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    Soshnikov, Sergey S. (57195195606)
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    Sposato, Luciano A. (25640261000)
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    Sreeramareddy, Chandrashekhar T. (57212263335)
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    Stroumpoulis, Konstantinos (57211777127)
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    Sturua, Lela (37662283900)
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    Sykes, Bryan L. (57211183396)
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    Tabb, Karen M. (51162023700)
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    Talongwa, Roberto Tchio (57195568335)
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    Tan, Feng (56429971500)
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    Teixeira, Carolina Maria (56133286100)
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    Tenkorang, Eric Yeboah (57216997115)
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    Thorne-Lyman, Andrew L. (57194437700)
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    Tirschwell, David L. (7003788101)
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    Towbin, Jeffrey A. (7102520568)
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    Tran, Bach X. (57209107515)
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    Tsilimbaris, Miltiadis (6701721894)
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    Uchendu, Uche S. (56328470200)
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    Ukwaja, Kingsley N. (57202824584)
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    Undurraga, Eduardo A. (57204092789)
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    Uzun, Selen Begüm (57200327315)
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    Vallely, Andrew J. (21744114400)
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    Van Gool, Coen H. (57217153933)
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    Vasankari, Tommi J. (57189653936)
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    Vavilala, Monica S. (7004076648)
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    Venketasubramanian, N. (56804702100)
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    Villalpando, Salvador (7005159171)
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    Violante, Francesco S. (7003555890)
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    Vlassov, Vasiliy Victorovich (57211633239)
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    Vos, Theo (57223885848)
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    Waller, Stephen (57201445180)
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    Wang, Haidong (16507828100)
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    Wang, Linhong (59088832100)
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    Wang, Xiao Rong (59881699400)
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    Wang, Yanping (57215440165)
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    Weichenthal, Scott (57202555239)
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    Weiderpass, Elisabete (57205018947)
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    Weintraub, Robert G. (7006079405)
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    Westerman, Ronny (57218361023)
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    Wilkinson, James D. (57207903571)
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    Woldeyohannes, Solomon Meseret (57195461619)
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    Wong, John Q. (56491997300)
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    Wordofa, Muluemebet Abera (57211398351)
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    Xu, Gelin (14049536200)
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    Yang, Yang C. (39763666500)
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    Yano, Yuichiro (57196965200)
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    Yentur, Gokalp Kadri (57211728019)
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    Yip, Paul (7102503720)
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    Yonemoto, Naohiro (57204947657)
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    Yoon, Seok-Jun (24823148900)
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    Younis, Mustafa Z. (8549393000)
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    Yu, Chuanhua (57201889726)
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    Jin, Kim Yun (57211086375)
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    El Sayed Zaki, Maysaa (57203666922)
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    Zhao, Yong (59798995400)
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    Zheng, Yingfeng (58918045300)
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    Zhou, Maigeng (57054557200)
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    Zhu, Jun (56215097100)
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    Zou, Xiao Nong (57216284159)
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    Lopez, Alan D. (7401455668)
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    Naghavi, Mohsen (57207906323)
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    Murray, Christopher J.L. (55481130700)
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    Lozano, Rafael (7102198442)
    Background The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100 000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery. Methods We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basis of a systematic review of the relative risk of dying during pregnancy for HIV-positive women compared with HIV-negative women. We also estimated the fraction of these deaths aggravated by pregnancy on the basis of a systematic review. To estimate the numbers of maternal deaths due to nine diff erent causes, we identified 61 sources from a systematic review and 943 site-years of vital registration data. We also did a systematic review of reports about the timing of maternal death, identifying 142 sources to use in our analysis. We developed estimates for each country for 1990-2013 using Bayesian meta-regression. We estimated 95% uncertainty intervals (UIs) for all values. Findings 292 982 (95% UI 261 017-327 792) maternal deaths occurred in 2013, compared with 376 034 (343 483-407 574) in 1990. The global annual rate of change in the MMR was -0.3% (-1.1 to 0.6) from 1990 to 2003, and -2.7% (-3.9 to -1.5) from 2003 to 2013, with evidence of continued acceleration. MMRs reduced consistently in south, east, and southeast Asia between 1990 and 2013, but maternal deaths increased in much of sub-Saharan Africa during the 1990s. 2070 (1290-2866) maternal deaths were related to HIV in 2013, 0.4% (0.2-0.6) of the global total. MMR was highest in the oldest age groups in both 1990 and 2013. In 2013, most deaths occurred intrapartum or postpartum. Causes varied by region and between 1990 and 2013. We recorded substantial variation in the MMR by country in 2013, from 956.8 (685.1-1262.8) in South Sudan to 2.4 (1.6-3.6) in Iceland. Interpretation Global rates of change suggest that only 16 countries will achieve the MDG 5 target by 2015. Accelerated reductions since the Millennium Declaration in 2000 coincide with increased development assistance for maternal, newborn, and child health. Setting of targets and associated interventions for after 2015 will need careful consideration of regions that are making slow progress, such as west and central Africa. Funding Bill & Melinda Gates Foundation.
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    Publication
    Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: A systematic analysis for the Global Burden of Disease Study 2016
    (2017)
    Wang, Haidong (16507828100)
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    Zenebe, Zerihun Menlkalew (57200737185)
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    Zerfu, Taddese Alemu (55358278900)
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    Zhang, Anthony Lin (56391112900)
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    Zhang, Xueying (56283378700)
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    Zodpey, Sanjay (7003415080)
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    Zuhlke, Liesl Joanna (57209027746)
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    Lopez, Alan D. (7401455668)
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    Murray, Christopher J.L. (55481130700)
    Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods: We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0.5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Socio-demographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. Findings: Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates - a measure of relative inequality - increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86.9 years (95% UI 86.7-87.2), and for men in Singapore, at 81.3 years (78.8-83.7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, and the gap between male and female life expectancy increased with progression to higher levels of SDI. Some countries with exceptional health performance in 1990 in terms of the difference in observed to expected life expectancy at birth had slower progress on the same measure in 2016. Interpretation Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both level and rate of changes in age-specific mortality; increases in mortality for certain age groups occurred in some locations. We found evidence that the absolute gap between countries in age-specific death rates has declined, although the relative gap for some age-sex groups increased. Countries that now lead in terms of having higher observed life expectancy than that expected on the basis of development alone, or locations that have either increased this advantage or rapidly decreased the deficit from expected levels, could provide insight into the means to accelerate progress in nations where progress has stalled. Copyright © The Author(s).
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    Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015
    (2016)
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    Murray, Christopher J L (55481130700)
    Background Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time. Methods Drawing from analytical approaches developed and refined in previous iterations of the GBD study, we generated updated estimates of child mortality by age group (neonatal, post-neonatal, ages 1–4 years, and under 5) for 195 countries and territories and selected subnational geographies, from 1980–2015. We also estimated numbers and rates of stillbirths for these geographies and years. Gaussian process regression with data source adjustments for sampling and non-sampling bias was applied to synthesise input data for under-5 mortality for each geography. Age-specific mortality estimates were generated through a two-stage age–sex splitting process, and stillbirth estimates were produced with a mixed-effects model, which accounted for variable stillbirth definitions and data source-specific biases. For GBD 2015, we did a series of novel analyses to systematically quantify the drivers of trends in child mortality across geographies. First, we assessed observed and expected levels and annualised rates of decrease for under-5 mortality and stillbirths as they related to the Soci-demographic Index (SDI). Second, we examined the ratio of recorded and expected levels of child mortality, on the basis of SDI, across geographies, as well as differences in recorded and expected annualised rates of change for under-5 mortality. Third, we analysed levels and cause compositions of under-5 mortality, across time and geographies, as they related to rising SDI. Finally, we decomposed the changes in under-5 mortality to changes in SDI at the global level, as well as changes in leading causes of under-5 deaths for countries and territories. We documented each step of the GBD 2015 child mortality estimation process, as well as data sources, in accordance with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, 5·8 million (95% uncertainty interval [UI] 5·7–6·0) children younger than 5 years died in 2015, representing a 52·0% (95% UI 50·7–53·3) decrease in the number of under-5 deaths since 1990. Neonatal deaths and stillbirths fell at a slower pace since 1990, decreasing by 42·4% (41·3–43·6) to 2·6 million (2·6–2·7) neonatal deaths and 47·0% (35·1–57·0) to 2·1 million (1·8-2·5) stillbirths in 2015. Between 1990 and 2015, global under-5 mortality decreased at an annualised rate of decrease of 3·0% (2·6–3·3), falling short of the 4·4% annualised rate of decrease required to achieve MDG4. During this time, 58 countries met or exceeded the pace of progress required to meet MDG4. Between 2000, the year MDG4 was formally enacted, and 2015, 28 additional countries that did not achieve the 4·4% rate of decrease from 1990 met the MDG4 pace of decrease. However, absolute levels of under-5 mortality remained high in many countries, with 11 countries still recording rates exceeding 100 per 1000 livebirths in 2015. Marked decreases in under-5 deaths due to a number of communicable diseases, including lower respiratory infections, diarrhoeal diseases, measles, and malaria, accounted for much of the progress in lowering overall under-5 mortality in low-income countries. Compared with gains achieved for infectious diseases and nutritional deficiencies, the persisting toll of neonatal conditions and congenital anomalies on child survival became evident, especially in low-income and low-middle-income countries. We found sizeable heterogeneities in comparing observed and expected rates of under-5 mortality, as well as differences in observed and expected rates of change for under-5 mortality. At the global level, we recorded a divergence in observed and expected levels of under-5 mortality starting in 2000, with the observed trend falling much faster than what was expected based on SDI through 2015. Between 2000 and 2015, the world recorded 10·3 million fewer under-5 deaths than expected on the basis of improving SDI alone. Interpretation Gains in child survival have been large, widespread, and in many places in the world, faster than what was anticipated based on improving levels of development. Yet some countries, particularly in sub-Saharan Africa, still had high rates of under-5 mortality in 2015. Unless these countries are able to accelerate reductions in child deaths at an extraordinary pace, their achievement of proposed SDG targets is unlikely. Improving the evidence base on drivers that might hasten the pace of progress for child survival, ranging from cost-effective intervention packages to innovative financing mechanisms, is vital to charting the pathways for ultimately ending preventable child deaths by 2030. Funding Bill & Melinda Gates Foundation. © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license.
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    Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: A novel analysis from the global burden of disease study 2015
    (2017)
    Barber, Ryan M. (57202560423)
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    Fullman, Nancy (57211064970)
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    Sorensen, Reed J.D. (57196918748)
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    Abd-Allah, Foad (36503428900)
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    Abdulle, Abdishakur M. (6603592018)
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    Abdurahman, Ahmed Abdulahi (56677630600)
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    Abraham, Biju (57202568691)
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    Abreha, Girmatsion Fisseha (6504124710)
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    Mock, Charles N. (57222417202)
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    Workicho, Abdulhalik (56720337100)
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    Wubshet, Mamo (54409732600)
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    Xavier, Denis (55403963100)
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    Xu, Gelin (57203583113)
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    Yadav, Ajit Kumar (57197675591)
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    Yaghoubi, Mohsen (56402926900)
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    Yakob, Bereket (57203811497)
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    Yan, Lijing L. (57198311895)
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    Yano, Yuichiro (57196965200)
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    Yaseri, Mehdi (23029507000)
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    Yimam, Hassen Hamid (57196325590)
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    Yip, Paul (7102503720)
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    Yonemoto, Naohiro (57204947657)
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    Yoon, Seok-Jun (24823148900)
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    Younis, Mustafa Z. (8549393000)
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    Yu, Chuanhua (57201889726)
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    Zaidi, Zoubida (57197376721)
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    El Sayed Zaki, Maysaa (57203666922)
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    Zambrana-Torrelio, Carlos (57193255530)
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    Zapata, Tomas (57194968519)
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    Zenebe, Zerihun Menlkalew (57200737185)
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    Zodpey, Sanjay (7003415080)
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    Zoeckler, Leo (57203905510)
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    Zuhlke, Liesl Joanna (57209027746)
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    Murray, Christopher J.L. (55481130700)
    Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015. Methods We mapped the most widely used list of causes amenable to personal health care developed by Nolte and McKee to 32 GBD causes. We accounted for variations in cause of death certification and misclassifications through the extensive data standardisation processes and redistribution algorithms developed for GBD. To isolate the effects of personal health-care access and quality, we risk-standardised cause-specific mortality rates for each geography-year by removing the joint effects of local environmental and behavioural risks, and adding back the global levels of risk exposure as estimated for GBD 2015. We employed principal component analysis to create a single, interpretable summary measure-the Healthcare Quality and Access (HAQ) Index-on a scale of 0 to 100. The HAQ Index showed strong convergence validity as compared with other health-system indicators, including health expenditure per capita (r=0·88), an index of 11 universal health coverage interventions (r=0·83), and human resources for health per 1000 (r=0·77). We used free disposal hull analysis with bootstrapping to produce a frontier based on the relationship between the HAQ Index and the Socio-demographic Index (SDI), a measure of overall development consisting of income per capita, average years of education, and total fertility rates. This frontier allowed us to better quantify the maximum levels of personal health-care access and quality achieved across the development spectrum, and pinpoint geographies where gaps between observed and potential levels have narrowed or widened over time. Findings Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. Of 195 geographies, 167 had statistically significant increases in HAQ Index levels since 1990, with South Korea, Turkey, Peru, China, and the Maldives recording among the largest gains by 2015. Performance on the HAQ Index and individual causes showed distinct patterns by region and level of development, yet substantial heterogeneities emerged for several causes, including cancers in highest-SDI countries; chronic kidney disease, diabetes, diarrhoeal diseases, and lower respiratory infections among middle-SDI countries; and measles and tetanus among lowest-SDI countries. While the global HAQ Index average rose from 40·7 (95% uncertainty interval, 39·0-42·8) in 1990 to 53·7 (52·2-55·4) in 2015, far less progress occurred in narrowing the gap between observed HAQ Index values and maximum levels achieved; at the global level, the difference between the observed and frontier HAQ Index only decreased from 21·2 in 1990 to 20·1 in 2015. If every country and territory had achieved the highest observed HAQ Index by their corresponding level of SDI, the global average would have been 73·8 in 2015. Several countries, particularly in eastern and western sub-Saharan Africa, reached HAQ Index values similar to or beyond their development levels, whereas others, namely in southern sub-Saharan Africa, the Middle East, and south Asia, lagged behind what geographies of similar development attained between 1990 and 2015. Interpretation This novel extension of the GBD Study shows the untapped potential for personal health-care access and quality improvement across the development spectrum. Amid substantive advances in personal health care at the national level, heterogeneous patterns for individual causes in given countries or territories suggest that few places have consistently achieved optimal health-care access and quality across health-system functions and therapeutic areas. This is especially evident in middle-SDI countries, many of which have recently undergone or are currently experiencing epidemiological transitions. The HAQ Index, if paired with other measures of health-system characteristics such as intervention coverage, could provide a robust avenue for tracking progress on universal health coverage and identifying local priorities for strengthening personal health-care quality and access throughout the world. Copyright © The Author(s). Published by Elsevier Ltd.
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    Publication
    The global burden of tuberculosis: results from the Global Burden of Disease Study 2015
    (2018)
    Kyu, Hmwe H (57217040073)
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    Maddison, Emilie R (57196084094)
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    Henry, Nathaniel J (57196076616)
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    Mumford, John Everett (57221821974)
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    Barber, Ryan (57202560423)
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    Shields, Chloe (57196083232)
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    Brown, Jonathan C (57212760159)
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    Nguyen, Grant (57191591002)
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    Carter, Austin (57201756395)
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    Wolock, Timothy M (57210784314)
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    Wang, Haidong (57208732268)
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    Liu, Patrick Y (56170368200)
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    Reitsma, Marissa (57208766315)
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    Ross, Jennifer M (56895463600)
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    Abajobir, Amanuel Alemu (57203613441)
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    Abate, Kalkidan Hassen (57207943858)
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    Endries, Aman (57216324852)
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    Fischer, Florian (55508208800)
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    Gebrehiwot, Tsegaye Tewelde (57216482917)
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    Haghparast-Bidgoli, Hassan (36647510000)
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    Hailu, Gessessew Bugssa (57219637263)
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    Hassen, Hamid Yimam (57188660707)
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    Hilawe, Esayas (55842959800)
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    Horita, Nobuyuki (57217110823)
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    Jacobsen, Kathryn H (26029163100)
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    Jonas, Jost B (7202492953)
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    Kasaeian, Amir (57195540738)
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    Kemmer, Laura (57205017265)
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    Khader, Yousef (55654192600)
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    Khan, Ejaz (57218791274)
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    Khang, Young-Ho (57198904674)
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    Khoja, Abdullah T (57194229795)
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    Kim, Yun Jin (57211086375)
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    Koul, Parvaiz (14022262900)
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    Koyanagi, Ai (57197741912)
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    Krohn, Kristopher J (57194138806)
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    Anil Kumar, G. (57139550500)
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    Kutz, Michael (57195617315)
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    Lodha, Rakesh (7007019609)
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    Magdy Abd El Razek, Hassan (57195948985)
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    Majdzadeh, Reza (9246620000)
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    Manyazewal, Tsegahun (55414403100)
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    Memish, Ziad (7005059350)
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    Mendoza, Walter (57216905642)
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    Mezgebe, Haftay Berhane (57222113213)
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    Mohammed, Shafiu (57838689000)
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    Oh, In-Hwan (57204090669)
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    Oren, Eyal (36815569400)
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    Plass, Dietrich (57217142114)
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    Rafay, Anwar (57212263323)
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    Rai, Rajesh Kumar (51864423900)
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    Rao, Puja C (57191835613)
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    Ray, Sarah E (57196078769)
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    Reiner, Robert (57203229088)
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    Reinig, Nickolas (57208577401)
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    Safiri, Saeid (56009654100)
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    Salomon, Joshua A (56745638600)
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    Sandar, Logan (57202561352)
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    Sartorius, Benn (12788526800)
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    Shamsizadeh, Morteza (57195940127)
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    Shey, Muki (10138820000)
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    Markos Shifti, Desalegn (57204795705)
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    Shore, Hirbo (57200684844)
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    Singh, Jasvinder (7404421736)
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    Sreeramareddy, Chandrashekhar T (57212263335)
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    Swaminathan, Soumya (7102380757)
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    Swartz, Scott J (57196350745)
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    Tadese, Fentaw (57190805861)
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    Tedla, Bemnet Amare (57211142920)
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    Tegegne, Balewgizie Sileshi (57216997287)
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    Tessema, Belay (20735503600)
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    Topor-Madry, Roman (57211182892)
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    Ukwaja, Kingsley Nnanna (57202824584)
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    Uthman, Olalekan A (23026328100)
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    Vlassov, Vasiliy (57211633239)
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    Vollset, Stein Emil (57196315778)
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    Wakayo, Tolassa (57205609717)
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    Weldegebreal, Solomon (57203681037)
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    Westerman, Ronny (57218361023)
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    Workicho, Abdulhalik (56720337100)
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    Yonemoto, Naohiro (57204947657)
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    Yoon, Seok-Jun (24823148900)
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    Yotebieng, Marcel (26325950800)
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    Naghavi, Mohsen (57207906323)
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    Hay, Simon I (7101875313)
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    Vos, Theo (57223885848)
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    Murray, Christopher J L (55481130700)
    Background: An understanding of the trends in tuberculosis incidence, prevalence, and mortality is crucial to tracking of the success of tuberculosis control programmes and identification of remaining challenges. We assessed trends in the fatal and non-fatal burden of tuberculosis over the past 25 years for 195 countries and territories. Methods: We analysed 10 691 site-years of vital registration data, 768 site-years of verbal autopsy data, and 361 site-years of mortality surveillance data using the Cause of Death Ensemble model to estimate tuberculosis mortality rates. We analysed all available age-specific and sex-specific data sources, including annual case notifications, prevalence surveys, and estimated cause-specific mortality, to generate internally consistent estimates of incidence, prevalence, and mortality using DisMod-MR 2.1, a Bayesian meta-regression tool. We assessed how observed tuberculosis incidence, prevalence, and mortality differed from expected trends as predicted by the Socio-demographic Index (SDI), a composite indicator based on income per capita, average years of schooling, and total fertility rate. We also estimated tuberculosis mortality and disability-adjusted life-years attributable to the independent effects of risk factors including smoking, alcohol use, and diabetes. Findings: Globally, in 2015, the number of tuberculosis incident cases (including new and relapse cases) was 10·2 million (95% uncertainty interval 9·2 million to 11·5 million), the number of prevalent cases was 10·1 million (9·2 million to 11·1 million), and the number of deaths was 1·3 million (1·1 million to 1·6 million). Among individuals who were HIV negative, the number of incident cases was 8·8 million (8·0 million to 9·9 million), the number of prevalent cases was 8·9 million (8·1 million to 9·7 million), and the number of deaths was 1·1 million (0·9 million to 1·4 million). Annualised rates of change from 2005 to 2015 showed a faster decline in mortality (−4·1% [−5·0 to −3·4]) than in incidence (−1·6% [−1·9 to −1·2]) and prevalence (−0·7% [−1·0 to −0·5]) among HIV-negative individuals. The SDI was inversely associated with HIV-negative mortality rates but did not show a clear gradient for incidence and prevalence. Most of Asia, eastern Europe, and sub-Saharan Africa had higher rates of HIV-negative tuberculosis burden than expected given their SDI. Alcohol use accounted for 11·4% (9·3–13·0) of global tuberculosis deaths among HIV-negative individuals in 2015, diabetes accounted for 10·6% (6·8–14·8), and smoking accounted for 7·8% (3·8–12·0). Interpretation: Despite a concerted global effort to reduce the burden of tuberculosis, it still causes a large disease burden globally. Strengthening of health systems for early detection of tuberculosis and improvement of the quality of tuberculosis care, including prompt and accurate diagnosis, early initiation of treatment, and regular follow-up, are priorities. Countries with higher than expected tuberculosis rates for their level of sociodemographic development should investigate the reasons for lagging behind and take remedial action. Efforts to prevent smoking, alcohol use, and diabetes could also substantially reduce the burden of tuberculosis. Funding: Bill & Melinda Gates Foundation. © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license
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    Trends in HIV/AIDS morbidity and mortality in Eastern Mediterranean countries, 1990–2015: findings from the Global Burden of Disease 2015 study
    (2018)
    Mokdad, Ali H. (7004813962)
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    El Bcheraoui, Charbel (25027689700)
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    Wang, Haidong (16507828100)
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    Khalil, Ibrahim (58255049500)
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    Afshin, Ashkan (57217465455)
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    Collison, Michael (57202309052)
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    Daoud, Farah (57201079837)
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    Chew, Adrienne (57209171085)
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    Krohn, Kristopher J. (57194138806)
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    Carter, Austin (57201756395)
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    Foreman, Kyle J. (57209064414)
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    He, Fei (59031207400)
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    Kassebaum, Nicholas J. (57202562224)
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    Kutz, Michael (57195617315)
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    Mirarefin, Mojde (57222113397)
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    Nguyen, Grant (57191591002)
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    Silpakit, Naris (57202401404)
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    Sligar, Amber (57190284582)
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    Larson, Heidi J. (57202559142)
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    Vollset, Stein Emil (57196315778)
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    Vos, Theo (57223885848)
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    Hay, Simon I. (7101875313)
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    Naghavi, Mohsen (57207906323)
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    Murray, Christopher J. L. (55481130700)
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    Rawaf, David Laith (57209228052)
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    Rawaf, Salman (6602475959)
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    Charara, Raghid (56514085300)
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    Moradi-Lakeh, Maziar (35617421300)
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    Abajobir, Amanuel Alemu (57203613441)
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    Abate, Kalkidan Hassen (57207943858)
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    Gebrehiwot, Tsegaye Tewelde (57216482917)
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    Gesesew, Hailay Abrha (56412148300)
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    Wakayo, Tolassa (57205609717)
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    Workicho, Abdulhalik (56720337100)
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    Abbas, Kaja M. (57190285707)
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    Abd-Allah, Foad (36503428900)
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    Abera, Semaw Ferede (57205180598)
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    Adane, Kelemework (57202841698)
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    Agarwal, Arnav (57214768208)
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    Kiadaliri, Aliasghar Ahmad (57199100665)
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    Ahmadi, Alireza (56336080700)
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    Ahmed, Muktar Beshir (57207802317)
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    Al Lami, Faris Hasan (57200737005)
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    Alam, Khurshid (57203681299)
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    Mekonnen, Alemayehu B. (57200179648)
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    Alasfoor, Deena (57211114684)
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    Alizadeh-Navaei, Reza (57226214128)
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    Al-Maskari, Fatma (25824744400)
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    Al-Raddadi, Rajaa (57219673720)
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    Altirkawi, Khalid A. (57202762923)
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    Sobaih, Badr H. A. (57202564080)
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    Temsah, Mohamad-Hani (56115852000)
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    Alvis-Guzman, Nelson (57210741239)
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    Ammar, Walid (57208159281)
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    Harb, Hilda L. (57221443122)
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    Anber, Nahla (57202351369)
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    Antonio, Carl Abelardo T. (55247644500)
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    Anwari, Palwasha (57217465526)
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    Asayesh, Hamid (55334322800)
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    Asghar, Rana Jawad (57209013760)
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    Atey, Tesfay Mehari (57209784978)
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    Hailu, Gessessew Bugssa (57219637263)
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    Mezgebe, Haftay Berhane (57222113213)
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    Yalew, Ayalnesh Zemene (57190286375)
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    Arthur Avokpaho, Euripide Frinel G. (57202307726)
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    Ayele, Tadesse Awoke (55431232600)
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    Tesssema, Belay (57195294962)
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    Azzopardi, Peter (56861081000)
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    Bacha, Umar (57200173721)
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    Barac, Aleksandra (55550748700)
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    Bärnighausen, Till (23011726900)
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    Bazargan-Hejazi, Shahrzad (57205912040)
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    Bedi, Neeraj (57202557520)
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    Bensenor, Isabela M. (7004830338)
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    Berhane, Adugnaw (57200410735)
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    Bessong, Pascal Obong (6506832973)
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    Beyene, Addisu Shunu (57209036705)
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    Bhutta, Zulfiqar A. (24342648300)
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    Birungi, Charles (57195448297)
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    Bidgoli, Hassan Haghparast (57201491554)
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    Butt, Zahid A. (57202522739)
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    Cahuana-Hurtado, Lucero (57207890731)
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    Danawi, Hadi (57201079895)
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    Neves, Josédas (57208073193)
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    Deribe, Kebede (57193912587)
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    Deribew, Amare (25625914400)
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    Des Jarlais, Don C. (56990451200)
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    Dharmaratne, Samath D. (57226838689)
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    Djalalinia, Shirin (37113718000)
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    Doyle, Kerrie E. (55693710800)
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    Endries, Aman Yesuf (57216324852)
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    Shifa, Girma Temam (57211793093)
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    Hareri, Habtamu Abera (57195292447)
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    Kassaw, Nigussie Assefa (57196473578)
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    Woldu, Minyahil Alebachew (55648411900)
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    Eshrati, Babak (16030619200)
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    Faraon, Emerito Jose Aquino (57195414019)
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    Farvid, Maryam S. (57216534761)
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    Feyissa, Tesfaye Regassa (57222562476)
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    Tekelab, Tesfalidet (56721378300)
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    Fischer, Florian (55508208800)
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    Garcia-Basteiro, Alberto L. (57200187168)
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    Gishu, Melkamu Dedefo (57202568734)
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    Glaser, Elizabeth (56133254300)
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    Gona, Philimon N. (57219703762)
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    Gugnani, Harish Chander (7005567008)
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    Gupta, Rahul (57204120071)
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    Hamadeh, Randah Ribhi (57202769526)
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    Hambisa, Mitiku Teshome (57203666810)
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    Mengesha, Melkamu Merid (57192953602)
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    Roba, Hirbo Shore (7102027801)
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    Hamidi, Samer (24366336000)
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    Horita, Nobuyuki (57217110823)
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    Husseini, Abdullatif (6603689690)
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    Ibrahim, Ahmed (59644932100)
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    James, Spencer Lewis (57202557998)
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    Jonas, Jost B. (7202492953)
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    Kasaeian, Amir (57195540738)
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    Khader, Yousef Saleh (55654192600)
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    Khan, Ejaz Ahmad (57218791274)
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    Khan, Gulfaraz (6701635515)
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    Khoja, Abdullah Tawfih Abdullah (57194229795)
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    Khubchandani, Jagdish (57211720011)
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    Kim, Yun Jin (57211086375)
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    Koyanagi, Ai (59269920500)
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    Defo, Barthelemy Kuate (6602271655)
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    Latif, Asma Abdul (57201620992)
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    Leshargie, Cheru Tesema (57195295462)
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    Tegegne, Teketo Kassaw (57216998561)
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    Lunevicius, Raimundas (57216165063)
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    El Razek, Mohammed Magdy Abd (57216629996)
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    Majdzadeh, Reza (9246620000)
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    Majeed, Azeem (57217722657)
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    Malekzadeh, Reza (7005197760)
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    Roshandel, Gholamreza (14034446800)
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    Sepanlou, Sadaf G. (36248136000)
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    Manyazewal, Tsegahun (57204150906)
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    Markos, Desalegn (57210741352)
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    Farid, Habibolah Masoudi (57191592768)
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    Mehari, Alem (57211114616)
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    Memiah, Peter (57217207827)
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    Memish, Ziad A. (7005059350)
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    Mendoza, Walter (57216905642)
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    Mengistu, Desalegn Tadese (57194776802)
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    Mhimbira, Francis Apolinary (57207789910)
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    Miller, Ted R. (7403948600)
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    Moore, Ami R. (57216303682)
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    Mumtaz, Ghina R. (57191452190)
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    Natarajan, Gopalakrishnan (55804491100)
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    Negin, Joel (25937447400)
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    Obermeyer, Carla Makhlouf (57209300189)
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    Ogbo, Felix Akpojene (57217186813)
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    Oh, In-Hwan (57204090669)
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    Ota, Erika (57202554474)
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    Pereira, David M. (57200690024)
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    Pourmalek, Farshad (8309390500)
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    Qorbani, Mostafa (24831040300)
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    Radfar, Amir (57194428768)
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    Rafay, Anwar (57212263323)
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    Rahimi-Movaghar, Vafa (6507646446)
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    Salamati, Payman (14045860600)
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    Rai, Rajesh Kumar (51864423900)
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    Ram, Usha (26653819000)
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    Renzaho, Andre M. N. (6505786588)
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    Rezaei, Satar (55791003000)
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    Rezai, Mohammad Sadegh (55273796300)
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    Safdarian, Mahdi (57203849024)
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    Safiri, Saeid (56009654100)
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    Sahraian, Mohammad Ali (55886074600)
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    Samy, Abdallah M. (36973661300)
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    Sartorius, Benn (12788526800)
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    Shaikh, Masood Ali (57203122601)
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    Shamsizadeh, Morteza (57195940127)
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    Sibamo, Ephrem Lejore Sibamo (57195508024)
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    Wadilo, Fiseha (57194049305)
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    Workie, Shimelash Bitew (57191837199)
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    Singh, Jasvinder A. (7404421736)
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    Soshnikov, Sergey (57195195606)
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    Sufiyan, Muawiyyah Babale (58294633600)
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    Sykes, Bryan L. (57218362022)
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    Taveira, Nuno (6602731390)
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    Tehrani-Banihashemi, Arash (57204006020)
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    Topor-Madry, Roman (57211182892)
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    Ukwaja, Kingsley Nnanna (57202824584)
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    Uthman, Olalekan A. (23026328100)
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    Yaghoubi, Mohsen (56402926900)
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    Yimam, Hassen Hamid (57196325590)
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    Yonemoto, Naohiro (57204947657)
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    Yoon, Seok-Jun (24823148900)
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    Yotebieng, Marcel (26325950800)
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    Younis, Mustafa Z. (8549393000)
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    Zaki, Maysaa El Sayed (57203666922)
    ;
    Jumaan, Aisha O. (6603612494)
    Objectives: We used the results of the Global Burden of Disease 2015 study to estimate trends of HIV/AIDS burden in Eastern Mediterranean Region (EMR) countries between 1990 and 2015. Methods: Tailored estimation methods were used to produce final estimates of mortality. Years of life lost (YLLs) were calculated by multiplying the mortality rate by population by age-specific life expectancy. Years lived with disability (YLDs) were computed as the prevalence of a sequela multiplied by its disability weight. Results: In 2015, the rate of HIV/AIDS deaths in the EMR was 1.8 (1.4–2.5) per 100,000 population, a 43% increase from 1990 (0.3; 0.2–0.8). Consequently, the rate of YLLs due to HIV/AIDS increased from 15.3 (7.6–36.2) per 100,000 in 1990 to 81.9 (65.3–114.4) in 2015. The rate of YLDs increased from 1.3 (0.6–3.1) in 1990 to 4.4 (2.7–6.6) in 2015. Conclusions: HIV/AIDS morbidity and mortality increased in the EMR since 1990. To reverse this trend and achieve epidemic control, EMR countries should strengthen HIV surveillance, and scale up HIV antiretroviral therapy and comprehensive prevention services. © 2017, The Author(s).

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