Browsing by Author "Abbas, Kaja M. (57190285707)"
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Publication Evolution and patterns of global health financing 1995-2014: Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries(2017) ;Dieleman, Joseph (54891678100) ;Campbell, Madeline (57192869720) ;Chapin, Abigail (57159731300) ;Eldrenkamp, Erika (57194530102) ;Fan, Victoria Y. (9737474800) ;Haakenstad, Annie (56079498000) ;Kates, Jennifer (7006961170) ;Liu, Yingying (57194531196) ;Matyasz, Taylor (57194529771) ;Micah, Angela (57193064978) ;Reynolds, Alex (57216683497) ;Sadat, Nafis (57219687343) ;Schneider, Matthew T. (35332956100) ;Sorensen, Reed (57196918748) ;Evans, Tim (7401454148) ;Evans, David (57193990382) ;Kurowski, Christoph (6602392515) ;Tandon, Ajay (7103281804) ;Abbas, Kaja M. (57190285707) ;Abera, Semaw Ferede (57205180598) ;Ahmad Kiadaliri, Aliasghar (57199100665) ;Ahmed, Kedir Yimam (57190386244) ;Ahmed, Muktar Beshir (57207802317) ;Alam, Khurshid (57203681299) ;Alizadeh-Navaei, Reza (36024974700) ;Alkerwi, Ala'a (57197724313) ;Amini, Erfan (35073393800) ;Ammar, Walid (57208159281) ;Amrock, Stephen Marc (57211220414) ;Antonio, Carl Abelardo T. (55247644500) ;Atey, Tesfay Mehari (57209784978) ;Avila-Burgos, Leticia (8530790100) ;Awasthi, Ashish (57200155811) ;Barac, Aleksandra (55550748700) ;Bernal, Oscar Alberto (44060935600) ;Beyene, Addisu Shunu (57209036705) ;Beyene, Tariku Jibat (57201181881) ;Birungi, Charles (57195448297) ;Bizuayehu, Habtamu Mellie (56507519700) ;Breitborde, Nicholas J.K. (6603260895) ;Cahuana-Hurtado, Lucero (57207890731) ;Castro, Ruben Estanislao (55798606600) ;Catalá-López, Ferran (57202553733) ;Dalal, Koustuv (23469128200) ;Dandona, Lalit (7007017243) ;Dandona, Rakhi (57203043697) ;De Jager, Pieter (55445666600) ;Dharmaratne, Samath D. (57216324802) ;Dubey, Manisha (57219898654) ;Farinha, Carla Sofia E. Sa (57190279273) ;Faro, Andre (36770969600) ;Feigl, Andrea B. (57202461042) ;Fischer, Florian (55508208800) ;Fitchett, Joseph Robert Anderson (57219697690) ;Foigt, Nataliya (57216998893) ;Giref, Ababi Zergaw (57219994468) ;Gupta, Rahul (57204120071) ;Hamidi, Samer (24366336000) ;Harb, Hilda L. (57221443122) ;Hay, Simon I. (7101875313) ;Hendrie, Delia (6602071966) ;Horino, Masako (57195769276) ;Jürisson, Mikk (55547524800) ;Jakovljevic, Mihajlo B. (14318929700) ;Javanbakht, Mehdi (57204619886) ;John, Denny (57194230095) ;Jonas, Jost B. (7202492953) ;Karimi, Seyed M. (57220096578) ;Khang, Young-Ho (57198904674) ;Khubchandani, Jagdish (57211720011) ;Kim, Yun Jin (57211086375) ;Kinge, Jonas M. (56133084600) ;Krohn, Kristopher J. (57194138806) ;Kumar, G. Anil (57139550500) ;Magdy Abd El Razek, Hassan (57195948985) ;Magdy Abd El Razek, Mohammed (57201191366) ;Majeed, Azeem (7102027801) ;Malekzadeh, Reza (7005197760) ;Masiye, Felix (57216327983) ;Meier, Toni (36678887300) ;Meretoja, Atte (12775885500) ;Miller, Ted R. (7403948600) ;Mirrakhimov, Erkin M. (57216202888) ;Mohammed, Shafiu (57838689000) ;Nangia, Vinay (57201490837) ;Olgiati, Stefano (56372296100) ;Osman, Abdalla Sidahmed (57194529575) ;Owolabi, Mayowa O. (57222581892) ;Patel, Tejas (57207871841) ;Paternina Caicedo, Angel J. (35769665400) ;Pereira, David M. (57200690024) ;Perelman, Julian (22938580800) ;Polinder, Suzanne (12766122200) ;Rafay, Anwar (57212263323) ;Rahimi-Movaghar, Vafa (6507646446) ;Rai, Rajesh Kumar (51864423900) ;Ram, Usha (26653819000) ;Ranabhat, Chhabi Lal (56719695500) ;Roba, Hirbo Shore (57200684844) ;Salama, Joseph (57202975625) ;Savic, Miloje (57204524150) ;Sepanlou, Sadaf G. (36248136000) ;Shrime, Mark G. (57204703404) ;Talongwa, Roberto Tchio (57195568335) ;Te Ao, Braden J. (55480837300) ;Tediosi, Fabrizio (6603388399) ;Tesema, Azeb Gebresilassie (57194530110) ;Thomson, Alan J. (57969994200) ;Tobe-Gai, Ruoyan (57209276611) ;Topor-Madry, Roman (57211182892) ;Undurraga, Eduardo A. (57204092789) ;Vasankari, Tommi (57189653936) ;Violante, Francesco S. (7003555890) ;Werdecker, Andrea (57208964895) ;Wijeratne, Tissa (14051317700) ;Xu, Gelin (57203583113) ;Yonemoto, Naohiro (57204947657) ;Younis, Mustafa Z. (8549393000) ;Yu, Chuanhua (57201889726) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922)Murray, Christopher J.L. (55481130700)Background: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, types of services purchased, and development assistance for health disbursed change with economic development. We also identify countries that deviate from the trends. Methods: We estimated national health spending by type of care and by source, including development assistance for health, based on a diverse set of data including programme reports, budget data, national estimates, and 964 National Health Accounts. These data represent health spending for 184 countries from 1995 through 2014. We converted these data into a common inflation-adjusted and purchasing power-adjusted currency, and used non-linear regression methods to model the relationship between health financing, time, and economic development. Findings: Between 1995 and 2014, economic development was positively associated with total health spending and a shift away from a reliance on development assistance and out-of-pocket (OOP) towards government spending. The largest absolute increase in spending was in high-income countries, which increased to purchasing power-adjusted $5221 per capita based on an annual growth rate of 3.0%. The largest health spending growth rates were in upper-middle-income (5.9) and lower-middle-income groups (5.0), which both increased spending at more than 5% per year, and spent $914 and $267 per capita in 2014, respectively. Spending in low-income countries grew nearly as fast, at 4.6%, and health spending increased from $51 to $120 per capita. In 2014, 59.2% of all health spending was financed by the government, although in low-income and lower-middle-income countries, 29.1% and 58.0% of spending was OOP spending and 35.7% and 3.0% of spending was development assistance. Recent growth in development assistance for health has been tepid; between 2010 and 2016, it grew annually at 1.8%, and reached US$37.6 billion in 2016. Nonetheless, there is a great deal of variation revolving around these averages. 29 countries spend at least 50% more than expected per capita, based on their level of economic development alone, whereas 11 countries spend less than 50% their expected amount. Interpretation: Health spending remains disparate, with low-income and lower-middle-income countries increasing spending in absolute terms the least, and relying heavily on OOP spending and development assistance. Moreover, tremendous variation shows that neither time nor economic development guarantee adequate prepaid health resources, which are vital for the pursuit of universal health coverage. © The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Future and potential spending on health 2015-40: Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries(2017) ;Dieleman, Joseph L. (54891678100) ;Campbell, Madeline (57192869720) ;Chapin, Abigail (57159731300) ;Eldrenkamp, Erika (57194530102) ;Fan, Victoria Y. (9737474800) ;Haakenstad, Annie (56079498000) ;Kates, Jennifer (7006961170) ;Li, Zhiyin (57194530861) ;Matyasz, Taylor (57194529771) ;Micah, Angela (57193064978) ;Reynolds, Alex (57216683497) ;Sadat, Nafis (57219687343) ;Schneider, Matthew T. (35332956100) ;Sorensen, Reed (57196918748) ;Abbas, Kaja M. (57190285707) ;Abera, Semaw Ferede (57205180598) ;Ahmad Kiadaliri, Aliasghar (57199100665) ;Ahmed, Muktar Beshir (57207802317) ;Alam, Khurshid (57203681299) ;Alizadeh-Navaei, Reza (36024974700) ;Alkerwi, Ala'a (57197724313) ;Amini, Erfan (35073393800) ;Ammar, Walid (57208159281) ;Antonio, Carl Abelardo T. (55247644500) ;Atey, Tesfay Mehari (57209784978) ;Avila-Burgos, Leticia (8530790100) ;Awasthi, Ashish (57200155811) ;Barac, Aleksandra (55550748700) ;Berheto, Tezera Moshago (56382955400) ;Beyene, Addisu Shunu (57209036705) ;Beyene, Tariku Jibat (57201181881) ;Birungi, Charles (57195448297) ;Bizuayehu, Habtamu Mellie (56507519700) ;Breitborde, Nicholas J.K. (6603260895) ;Cahuana-Hurtado, Lucero (57207890731) ;Castro, Ruben Estanislao (55798606600) ;Catalá-López, Ferran (57202553733) ;Dalal, Koustuv (23469128200) ;Dandona, Lalit (7007017243) ;Dharmaratne, Rakhi Dandona Samath D. (57197827278) ;Dubey, Manisha (57219898654) ;Faro, Andé (36770969600) ;Feigl, Andrea B. (57202461042) ;Fischer, Florian (55508208800) ;Fitchett, Joseph R. Anderson (57219697690) ;Foigt, Nataliya (57216998893) ;Giref, Ababi Zergaw (57219994468) ;Gupta, Rahul (57204120071) ;Hamidi, Samer (24366336000) ;Harb, Hilda L. (57221443122) ;Hay, Simon I. (7101875313) ;Hendrie, Delia (6602071966) ;Horino, Masako (57195769276) ;Jürisson, Mikk (55547524800) ;Jakovljevic, Mihajlo B. (14318929700) ;Javanbakht, Mehdi (57204619886) ;John, Denny (57194230095) ;Jonas, Jost B. (7202492953) ;Karimi, Seyed M. (57220096578) ;Khang, Young-Ho (57198904674) ;Khubchandani, Jagdish (57211720011) ;Kim, Yun Jin (57211086375) ;Kinge, Jonas M. (56133084600) ;Krohn, Kristopher J. (57194138806) ;Kumar, G. Anil (57139550500) ;Leung, Ricky (56276497100) ;Magdy Abd El Razek, Hassan (57195948985) ;Magdy Abd El Razek, Mohammed (57201191366) ;Majeed, Azeem (7102027801) ;Malekzadeh, Reza (7005197760) ;Malta, Deborah Carvalho (15835283500) ;Meretoja, Atte (12775885500) ;Miller, Ted R. (7403948600) ;Mirrakhimov, Erkin M. (57216202888) ;Mohammed, Shafiu (57838689000) ;Molla, Gedefaw (57197832200) ;Nangia, Vinay (57201490837) ;Olgiati, Stefano (56372296100) ;Owolabi, Mayowa O. (57222581892) ;Patel, Tejas (57207871841) ;Paternina Caicedo, Angel J. (35769665400) ;Pereira, David M. (57200690024) ;Perelman, Julian (22938580800) ;Polinder, Suzanne (12766122200) ;Rafay, Anwar (57212263323) ;Rahimi-Movaghar, Vafa (6507646446) ;Rai, Rajesh Kumar (51864423900) ;Ram, Usha (26653819000) ;Ranabhat, Chhabi Lal (56719695500) ;Roba, Hirbo Shore (57200684844) ;Savic, Miloje (57204524150) ;Sepanlou, Sadaf G. (36248136000) ;Te Ao, Braden J. (55480837300) ;Tesema, Azeb Gebresilassie (57194530110) ;Thomson, Alan J. (57969994200) ;Tobe-Gai, Ruoyan (57209276611) ;Topor-Madry, Roman (57211182892) ;Undurraga, Eduardo A. (57204092789) ;Vargas, Veronica (14018617400) ;Vasankari, Tommi (57200592416) ;Violante, Francesco S. (7003555890) ;Wijeratne, Tissa (14051317700) ;Xu, Gelin (57203583113) ;Yonemoto, Naohiro (57204947657) ;Younis, Mustafa Z. (8549393000) ;Yu, Chuanhua (57201889726) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922)Murray, Christopher J.L. (55481130700)Background: The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study, we estimate future gross domestic product (GDP), all-sector government spending, and health spending disaggregated by source, and we compare expected future spending to potential future spending. Methods: We extracted GDP, government spending in 184 countries from 1980-2015, and health spend data from 1995-2014. We used a series of ensemble models to estimate future GDP, all-sector government spending, development assistance for health, and government, out-of-pocket, and prepaid private health spending through 2040. We used frontier analyses to identify patterns exhibited by the countries that dedicate the most funding to health, and used these frontiers to estimate potential health spending for each low-income or middle-income country. All estimates are inflation and purchasing power adjusted. Findings: We estimated that global spending on health will increase from US$9.21 trillion in 2014 to $24.24 trillion (uncertainty interval [UI] 20.47-29.72) in 2040. We expect per capita health spending to increase fastest in upper-middle-income countries, at 5.3% (UI 4.1-6.8) per year. This growth is driven by continued growth in GDP, government spending, and government health spending. Lower-middle income countries are expected to grow at 4.2% (3.8-4.9). High-income countries are expected to grow at 2.1% (UI 1.8-2.4) and low-income countries are expected to grow at 1.8% (1.0-2.8). Despite this growth, health spending per capita in low-income countries is expected to remain low, at $154 (UI 133-181) per capita in 2030 and $195 (157-258) per capita in 2040. Increases in national health spending to reach the level of the countries who spend the most on health, relative to their level of economic development, would mean $321 (157-258) per capita was available for health in 2040 in low-income countries. Interpretation: Health spending is associated with economic development but past trends and relationships suggest that spending will remain variable, and low in some low-resource settings. Policy change could lead to increased health spending, although for the poorest countries external support might remain essential. © The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019(2020) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abbasi, Mohammad (57221004192) ;Abbasifard, Mitra (37053407900) ;Abbasi-Kangevari, Mohsen (57193543882) ;Abbastabar, Hedayat (57212441848) ;Abd-Allah, Foad (36503428900) ;Abdelalim, Ahmed (7801307783) ;Abdollahi, Mohammad (57940559800) ;Abdollahpour, Ibrahim (36997151900) ;Abedi, Aidin (56673854800) ;Abedi, Parisa (57219860997) ;Abegaz, Kedir Hussein (57200726326) ;Abolhassani, Hassan (58597704600) ;Abosetugn, Akine Eshete (57041277200) ;Aboyans, Victor (56214736500) ;Abrams, Elissa M. (53363080800) ;Abreu, Lucas Guimarães (55937631400) ;Abrigo, Michael R.M. (56018773400) ;Abu Haimed, Abdulaziz Khalid (57218875672) ;Abualhasan, Ahmed (57211135523) ;Abu-Gharbieh, Eman (24586714800) ;Abu-Raddad, Laith Jamal (14032724700) ;Abushouk, Abdelrahman I. (57191479876) ;Acebedo, Alyssa (57219861105) ;Ackerman, Ilana N. (8925517400) ;Adabi, Maryam (57190491886) ;Adair, Tim (24480317900) ;Adamu, Abdu A. (57202024381) ;Adebayo, Oladimeji M. (57194329853) ;Adedeji, Isaac Akinkunmi (57208456508) ;Adekanmbi, Victor (53463192900) ;Adelson, Jaimie D. (16678347700) ;Adeoye, Abiodun Moshood (26654031000) ;Adetokunboh, Olatunji O. (56598104300) ;Adham, Davoud (55346682700) ;Advani, Shailesh M. (56841222900) ;Afarideh, Mohsen (56227034300) ;Afshari, Mahdi (55316123300) ;Afshin, Ashkan (57217465455) ;Agardh, Emilie E. (57202373873) ;Agarwal, Gina (57220151944) ;Agasthi, Pradyumna (57201708783) ;Agesa, Kareha M. (57204562362) ;Aghaali, Mohammad (38860949800) ;Aghamir, Seyed Mohammad Kazem (6508244234) ;Agrawal, Anurag (59030333500) ;Ahmad, Tauseef (57214283386) ;Ahmadi, Alireza (56336080700) ;Ahmadi, Keivan (59396073300) ;Ahmadi, Mehdi (16644923000) ;Ahmadieh, Hamid (57203677679) ;Ahmadpour, Ehsan (55067754700) ;Ahmed, Muktar Beshir (57207802317) ;Aji, Budi (55911737200) ;Akalu, Temesgen Yihunie (57203189637) ;Akinyemi, Rufus Olusola (25633566800) ;Akinyemiju, Tomi (57202561503) ;Akombi, Blessing (57192946271) ;Akunna, Chisom Joyqueenet (57214884531) ;Alahdab, Fares (55135922900) ;Al-Aly, Ziyad (9738161500) ;Alam, Khurshid (57203681299) ;Alam, Noore (57202437697) ;Alam, Samiah (57208071722) ;Alam, Tahiya (57205589820) ;Alanezi, Fahad Mashhour (57213607595) ;Alanzi, Turki M. (55978240000) ;Albertson, Samuel B. (57204573505) ;Alcalde-Rabanal, Jacqueline Elizabeth (35749450200) ;Alema, Niguse Meles (57215093011) ;Alemu, Biresaw Wassihun (57202912931) ;Alemu, Yihun Mulugeta (57188818777) ;Alhabib, Khalid F. (6504139629) ;Alhassan, Robert Kaba (55829647800) ;Ali, Muhammad (59277665600) ;Ali, Saqib (7403094290) ;Alicandro, Gianfranco (36766719200) ;Alijanzadeh, Mehran (56236864700) ;Alinia, Cyrus (57210704519) ;Alipour, Vahid (56436629300) ;Alizade, Hesam (55759064300) ;Aljunid, Syed Mohamed (6504304159) ;Alla, François (6701580827) ;Allebeck, Peter (7005187575) ;Almadi, Majid Abdulrahman Hamad (55665024700) ;Almasi, Ali (19433600700) ;Almasi-Hashiani, Amir (42360952700) ;Almasri, Nihad A. (35301840000) ;Al-Mekhlafi, Hesham M. (8625547100) ;Almulhim, Abdulaziz M. (57214888779) ;Alonso, Jordi (7403482329) ;Al-Raddadi, Rajaa M. (57219673720) ;Altirkawi, Khalid A. (57202762923) ;Alumran, Arwa Khalid (55190329900) ;Alvis-Guzman, Nelson (57210741239) ;Alvis-Zakzuk, Nelson J. (57193279948) ;Amare, Azmeraw T. (57202220009) ;Amare, Bekalu (57219376372) ;Amini, Saeed (57210811281) ;Amini-Rarani, Mostafa (55768670300) ;Aminorroaya, Arya (57567919700) ;Amiri, Fatemeh (57201297148) ;Amit, Arianna Maever L. (57211322011) ;Amugsi, Dickson A. (24461463800) ;Amul, Gianna Gayle Herrera (57193319949) ;Anbesu, Etsay Woldu (57219860911) ;Ancuceanu, Robert (35728302200) ;Anderlini, Deanna (57202506549) ;Anderson, Jason A. (57204563525) ;Andrei, Catalina Liliana (36543507200) ;Andrei, Tudorel (24179349400) ;Androudi, Sofia (6603286512) ;Angus, Colin (55601225500) ;Anjomshoa, Mina (57204563282) ;Ansari, Fereshteh (56478531800) ;Ansari, Iman (56576085100) ;Ansari-Moghaddam, Alireza (57192807651) ;Antonazzo, Ippazio Cosimo (57219860691) ;Antonio, Carl Abelardo T. (55247644500) ;Antony, Catherine M. (57218881089) ;Antriyandarti, Ernoiz (57201775415) ;Anvari, Davood (57201259536) ;Anwer, Razique (54416938700) ;Appiah, Seth Christopher Yaw (57204569403) ;Arabloo, Jalal (57208760927) ;Arab-Zozani, Morteza (57210284593) ;Aravkin, Aleksandr Y. (35386103000) ;Arba, Aseb Arba Kinfe (57212216122) ;Aremu, Olatunde (57214958833) ;Ariani, Filippo (36887464400) ;Aripov, Timur (35104283700) ;Armoon, Bahram (57191472455) ;Ärnlöv, Johan (6602512227) ;Arowosegbe, Oluwaseyi Olalekan (57219860799) ;Aryal, Krishna K. (57203859052) ;Arzani, Afsaneh (57094774900) ;Asaad, Malke (57209296864) ;Asadi-Aliabadi, Mehran (58135916600) ;Asadi-Pooya, Ali A. (6603453399) ;Asgari, Samaneh (56010419200) ;Asghari, Babak (56779960900) ;Asghari Jafarabadi, Mohammad (57226675591) ;Ashbaugh, Charlie (57218878439) ;Assmus, Michael (57219860819) ;Atafar, Zahra (35744556700) ;Athari, Seyyed Shamsadin (26653399600) ;Atnafu, Desta Debalkie (57203502301) ;Atout, Maha Moh'd Wahbi (57195251851) ;Atre, Sachin R. (22933845900) ;Atteraya, Madhu Sudhan (55970935700) ;Ausloos, Floriane (55955339900) ;Ausloos, Marcel (7101798907) ;Avila-Burgos, Leticia (8530790100) ;Avokpaho, Euripide Frinel Gbenato Arthur (57209842037) ;Ayala Quintanilla, Beatriz Paulina (55598298700) ;Ayano, Getinet (57189617474) ;Ayanore, Martin Amogre (57070358300) ;Aynalem, Getie Lake (57206777680) ;Aynalem, Yared Asmare (57214332450) ;Ayza, Muluken Altaye (57216492115) ;Azari, Samad (56396696500) ;Azarian, Ghasem (57220306214) ;Azene, Zelalem Nigussie (57210023751) ;Azhar, Gulrez (37107242500) ;Azzopardi, Peter S. (56861081000) ;Darshan, B.B. (36602364600) ;Babaee, Ebrahim (57217157164) ;Badawi, Alaa (57216776029) ;Badiye, Ashish D. (56340201200) ;Bagherzadeh, Mojtaba (59273166400) ;Bagli, Eleni (6506528499) ;Bahrami, Mohammad Amin (57216350683) ;Baig, Atif Amin (49460999600) ;Bairwa, Mohan (50461080100) ;Bakhshaei, Mohammad Hossein (36522223600) ;Bakhtiari, Ahad (56285704100) ;Bakkannavar, Shankar M. 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(57215198193) ;McKee, Martin (7202304775) ;Medina-Solís, Carlo Eduardo (8530789600) ;Meharie, Birhanu Geta (57217083932) ;Mehndiratta, Man Mohan (57202557864) ;Mehrabi Nasab, Entezar (56062744400) ;Mehri, Fereshteh (57211542603) ;Mehrotra, Ravi (7203045563) ;Mehta, Kala M. (7201939418) ;Meitei, Wahengbam Bigyananda (57209140259) ;Mekonnen, Teferi (57215662987) ;Melese, Addisu (56901393600) ;Memiah, Peter T.N. (57217207827) ;Memish, Ziad A. (7005059350) ;Mendoza, Walter (57216905642) ;Menezes, Ritesh G. (55517099900) ;Mengesha, Endalkachew Worku (57216203521) ;Mengesha, Meresa Berwo (57210570181) ;Mensah, George A. (57196028147) ;Mereke, Alibek (57205595662) ;Mereta, Seid Tiku (57203628211) ;Meretoja, Atte (12775885500) ;Meretoja, Tuomo J. (57219008708) ;Mestrovic, Tomislav (6507240107) ;Miazgowski, Bartosz (56857536900) ;Miazgowski, Tomasz (6701404689) ;Michalek, Irmina Maria (56982945900) ;Mihretie, Kebadnew Mulatu (57214781514) ;Miller, Ted R. (7403948600) ;Mills, Edward J. (57205301363) ;Milne, George J. (9434770500) ;Mini, G.K. (12800865800) ;Miri, Mohammad (56938228400) ;Mirica, Andreea (57188983765) ;Mirrakhimov, Erkin M. (57508336100) ;Mirzaei, Hamed (37034594600) ;Mirzaei, Maryam (56902299800) ;Mirzaei, Roya (55745833800) ;Mirzaei-Alavijeh, Mehdi (57201700997) ;Misganaw, Awoke Temesgen (57202808713) ;Mitchell, Philip B. (35354747000) ;Mithra, Prasanna (36018632500) ;Moazen, Babak (57204324006) ;Moghadaszadeh, Masoud (57200791890) ;Mohajer, Bahram (57039225300) ;Mohamad, Osama (36342663600) ;Mohamadi, Efat (57202198397) ;Mohammad, Dara K. (43161421200)Mohammad, Yousef (6603403710)Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license - Some of the metrics are blocked by yourconsent settings
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(57224556036)Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods: GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk–outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk–outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk–outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. Across all six analytical steps, 30 652 distinct data sources were used in the analysis. Uncertainty in each step of the analysis was propagated into the final estimates of attributable burden. Exposure levels for dichotomous, polytomous, and continuous risk factors were summarised with use of the summary exposure value to facilitate comparisons over time, across location, and across risks. Because the entire time series from 1990 to 2019 has been re-estimated with use of consistent data and methods, these results supersede previously published GBD estimates of attributable burden. Findings: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure. Global declines also occurred for tobacco smoking and lead exposure. The largest increases in risk exposure were for ambient particulate matter pollution, drug use, high fasting plasma glucose, and high body-mass index. In 2019, the leading Level 2 risk factor globally for attributable deaths was high systolic blood pressure, which accounted for 10·8 million (95% uncertainty interval [UI] 9·51–12·1) deaths (19·2% [16·9–21·3] of all deaths in 2019), followed by tobacco (smoked, second-hand, and chewing), which accounted for 8·71 million (8·12–9·31) deaths (15·4% [14·6–16·2] of all deaths in 2019). The leading Level 2 risk factor for attributable DALYs globally in 2019 was child and maternal malnutrition, which largely affects health in the youngest age groups and accounted for 295 million (253–350) DALYs (11·6% [10·3–13·1] of all global DALYs that year). The risk factor burden varied considerably in 2019 between age groups and locations. Among children aged 0–9 years, the three leading detailed risk factors for attributable DALYs were all related to malnutrition. Iron deficiency was the leading risk factor for those aged 10–24 years, alcohol use for those aged 25–49 years, and high systolic blood pressure for those aged 50–74 years and 75 years and older. Interpretation: Overall, the record for reducing exposure to harmful risks over the past three decades is poor. Success with reducing smoking and lead exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016(2017) ;Naghavi, Mohsen (57207906323) ;Abajobir, Amanuel Alemu (57203613441) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. 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(7005209601) ;Dandona, Lalit (7007017243) ;Dandona, Rakhi (57203043697) ;Dargan, Paul I. (57212154356) ;Das Neves, José (57208073193) ;Davitoiu, Dragos V. (57202555163) ;Davletov, Kairat (6602803024) ;De Courten, Barbora (57208309416) ;Degenhardt, Louisa (7004040033) ;Deiparine, Selina (57205252200) ;Deribe, Kebede (57193912587) ;Deribew, Amare (25625914400) ;Dey, Subhojit (25958052600) ;Dicker, Daniel (57196026676) ;Ding, Eric L. (54413849800) ;Djalalinia, Shirin (37113718000) ;Do, Huyen Phuc (57200737094) ;Doku, David Teye (36015210300) ;Douwes-Schultz, Dirk (57196081398) ;Driscoll, Tim R. (7005928308) ;Dubey, Manisha (57219898654) ;Duncan, Bruce Bartholow (35476478500) ;Echko, Michelle (57196076782) ;El-Khatib, Ziad Ziad (54908919000) ;Ellingsen, Christian Lycke (7801360950) ;Enayati, Ahmadali (6507139052) ;Erskine, Holly E. (57202798676) ;Eskandarieh, Sharareh (57211720158) ;Esteghamati, Alireza (11240321100) ;Ermakov, Sergey P. (7006796196) ;Estep, Kara (57216550964) ;Sa Farinha, Carla Sofae (57190279273) ;Faro, André (36770969600) ;Farzadfar, Farshad (57195049611) ;Feigin, Valery L. (57203677957) ;Fereshtehnejad, Seyed-Mohammad (57202557520) ;Fernandes, João C (35274726800) ;Ferrari, Alize J. (57195348907) ;Feyissa, Tesfaye Regassa (57222562476) ;Filip, Irina (55570061400) ;Finegold, Samuel (57195558156) ;Fischer, Florian (55508208800) ;Fitzmaurice, Christina (57212628757) ;Flaxman, Abraham D. (6602883567) ;Foigt, Nataliya (57216998893) ;Frank, Tahvi (57195993514) ;Fraser, Maya (57202561859) ;Fullman, Nancy (57211064970) ;Fürst, Thomas (57208431345) ;Furtado, Joao M. (36801755000) ;Gakidou, Emmanuela (57202567277) ;Garcia-Basteiro, Alberto L (57200187168) ;Gebre, Teshome (57202565005) ;Gebregergs, Gebremedhin Berhe (57078990000) ;Gebrehiwot, Tsegaye Tewelde (57216482917) ;Gebremichael, Delelegn Yilma (57015331400) ;Geleijnse, Johanna M. (35195702500) ;Genova-Maleras, Ricard (15070563900) ;Gesesew, Hailay Abrha (56412148300) ;Gething, Peter W. (57193559189) ;Gillum, Richard F. (7103181331) ;Ginawi, Ibrahim Abdelmageem Mohamed (57192378390) ;Giref, Ababi Zergaw (57219994468) ;Giroud, Maurice (7203027541) ;Giussani, Giorgia (57200843076) ;Godwin, William W. (57191841675) ;Gold, Audra L. (57194129483) ;Goldberg, Ellen M. (57191842703) ;Gona, Philimon N. (57219703762) ;Gopalani, Sameer Vali (57190277891) ;Gouda, Hebe N. (57202432343) ;Goulart, Alessandra Carvalho (57201181348) ;Griswold, Max (57191836595) ;Gupta, Prakash C. (58767181900) ;Gupta, Rajeev (55705295300) ;Gupta, Tanush (57219956402) ;Gupta, Vipin (57199940653) ;Haagsma, Juanita A. (57202571125) ;Hafezi-Nejad, Nima (57216814261) ;Hailu, Alemayehu Desalegne (57225733572) ;Hailu, Gessessew Bugssa (57219637263) ;Hamadeh, Randah Ribhi (57202769526) ;Hambisa, Mitiku Teshome (57203666810) ;Hamidi, Samer (24366336000) ;Hammami, Mouhanad (57216961083) ;Hancock, Jamie (57202975481) ;Handal, Alexis J. (57208977398) ;Hankey, Graeme J. (7102816661) ;Hao, Yuantao (57202554333) ;Harb, Hilda L. (57221443122) ;Hareri, Habtamu Abera (57195292447) ;Hassanvand, Mohammad Sadegh (35085056400) ;Havmoeller, Rasmus (57212075728) ;Hay, Simon I. (7101875313) ;He, Fei (59031207400) ;Hedayati, Mohammad T. (23979915700) ;Henry, Nathaniel J. (57196076616) ;Heredia-Pi, Ileana Beatriz (36941085200) ;Herteliu, Claudiu (26035943100) ;Hoek, Hans W. (57202570421) ;Horino, Masako (57195769276) ;Horita, Nobuyuki (57217110823) ;Hosgood, H. Dean (56353204400) ;Hostiuc, Sorin (24829099800) ;Hotez, Peter J. (7004958298) ;Hoy, Damian G. 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(57202562224) ;Katikireddi, Srinivasa Vittal (6508254091) ;Kawakami, Norito (35377339000) ;Keiyoro, Peter Njenga (57203177260) ;Kemmer, Laura (57205017265) ;Kesavachandran, Chandrasekharan Nair (57218000521) ;Khader, Yousef Saleh (55654192600) ;Khan, Ejaz Ahmad (57218791274) ;Khang, Young-Ho (57198904674) ;Khoja, Abdullah Tawfh Abdullah (57194229795) ;Khosravi, Ardeshir (57201190837) ;Khosravi, Mohammad Hossein (56524167000) ;Khubchandani, Jagdish (57211720011) ;Kieling, Christian (57218820714) ;Kievlan, Daniel (55940685500) ;Kim, Daniel (57223019104) ;Kim, Yun Jin (57211086375) ;Kimokoti, Ruth W. (8647554600) ;Kinfu, Yohannes (12770281900) ;Kissoon, Niranjan (7006364038) ;Kivimaki, Mika (7004391239) ;Knudsen, Ann Kristin (57192966362) ;Kopec, Jacek A. (7006284395) ;Kosen, Soewarta (57211346192) ;Koul, Parvaiz A. (14022262900) ;Koyanagi, Ai (57197741912) ;Defo, Barthelemy Kuate (6602271655) ;Kulikof, Xie Rachel (57202024253) ;Kumar, G. Anil (57139550500) ;Kumar, Pushpendra (57208849920) ;Kutz, Michael (57195617315) ;Kyu, Hmwe H. (57217040073) ;Lal, Dharmesh Kumar (57222488984) ;Lalloo, Ratilal (57189334553) ;Lambert, Tea Lallukka Nkurunziza (57208159086) ;Lan, Qing (56682598900) ;Lansingh, Van C. (57194598546) ;Larsson, Anders (56381985300) ;Lee, Paul H. (57200302692) ;Leigh, James (7202089604) ;Leung, Janni (57214397752) ;Levi, Miriam (54893035000) ;Li, Yongmei (56147667800) ;Kappe, Darya Li (57202014108) ;Liang, Xiaofeng (26662590300) ;Liben, Misgan Legesse (57188568119) ;Lim, Stephen S. (57201800433) ;Liu, Angela (57196080772) ;Liu, Patrick Y. (56170368200) ;Liu, Yang (57202561981) ;Lodha, Rakesh (7007019609) ;Logroscino, Giancarlo (7004888005) ;Lorkowski, Stefan (57203677656) ;Lotufo, Paulo A. (7003331101) ;Lozano, Rafael (7102198442) ;Lucas, Timothy C.D. (57216683591) ;Ma, Stefan (7403723389) ;Macarayan, Erlyn Rachelle King (56330601800) ;Maddison, Emilie R. (57196084094) ;Abd El Razek, Mohammed Magdy (57192379650) ;Majdan, Marek (36147855100) ;Majdzadeh, Reza (9246620000) ;Majeed, Azeem (7102027801) ;Malekzadeh, Reza (7005197760) ;Malhotra, Rajesh (7202423297) ;Malta, Deborah Carvalho (15835283500) ;Manguerra, Helena (57208121153) ;Manyazewal, Tsegahun (55414403100) ;Mapoma, Chabila C. (57208956832) ;Marczak, Laurie B. (57200295553) ;Markos, Desalegn (57210741352) ;Martinez-Raga, Jose (57202861191) ;Martins-Melo, Francisco Rogerlândio (57204796807) ;Martopullo, Ira (57193550189) ;McAlinden, Colm (35325278500) ;McGaughey, Madeline (57206867033) ;McGrath, John J. (57202560550) ;Mehata, Suresh (57211773159) ;Meier, Toni (36678887300) ;Meles, Kidanu Gebremariam (57951018400) ;Memiah, Peter (57217207827) ;Memish, Ziad A. (7005059350) ;Mengesha, Melkamu Merid (57192953602) ;Mengistu, Desalegn Tadese (57194776802) ;Menota, Bereket Gebremichael (57195329507) ;Mensah, George A. (57196028147) ;Meretoja, Atte (12775885500) ;Meretoja, Tuomo J. (57202554188) ;Millear, Anoushka (57204879537) ;Miller, Ted R. (7403948600) ;Minnig, Shawn (57193238817) ;Mirarefn, Mojde (57202024712) ;Mirrakhimov, Erkin M. (57216202888) ;Misganaw, Awoke (57202808713) ;Mishra, Shiva Raj (57208010960) ;Mohammad, Karzan Abdulmuhsin (57205300378) ;Mohammadi, Alireza (56720095000) ;Mohammed, Shafu (57838689000) ;Mokdad, Ali H. (7004813962) ;Mola, Glen Liddell D. (57221824056) ;Mollenkopf, Sarah K. (57203646247) ;Molokhia, Mariam (7004121920) ;Monasta, Lorenzo (7801520497) ;Hernandez, Julio C. Montañez (57199371040) ;Montico, Marcella (57202563609) ;Mooney, Meghan D. (57216598823) ;Moradi-Lakeh, Maziar (35617421300) ;Moraga, Paula (46761426800) ;Morawska, Lidia (7004773965) ;Morrison, Shane D. (45661573100) ;Morozof, Chloe (57202020530) ;Mountjoy-Venning, Clif (57210505240) ;Mruts, Kalayu Birhane (57221822877) ;Muller, Kate (57196075658) ;Murthy, Gudlavalleti Venkata Satyanarayana (7101778322) ;Musa, Kamarul Imran (57194536466) ;Nachega, Jean B. (6701544088) ;Naheed, Aliya (57202560989) ;Naldi, Luigi (7004954781) ;Nangia, Vinay (57201490837) ;Nascimento, Bruno Ramos (14424406800) ;Nasher, Jamal T. (56003685800) ;Natarajan, Gopalakrishnan (55804491100) ;Negoi, Ionut (57200640014) ;Ngunjiri, Josephine Wanjiku (57195296110) ;Nguyen, Cuong Tat (56531347200) ;Nguyen, Grant (57191591002) ;Nguyen, Minh (58203329200) ;Nguyen, Quyen Le (57223642100) ;Nguyen, Trang Huyen (59142352200) ;Nichols, Emma (57205756163) ;Ningrum, Dina Nur Anggraini (57195329470) ;Nong, Vuong Minh (55507077200) ;Noubiap, Jean Jacques N. (55490374000) ;Ogbo, Felix Akpojene (57200737136) ;Oh, In-Hwan (57204090669) ;Okoro, Anselm (54682112200) ;Olagunju, Andrew Toyin (26029995700) ;Olsen, Helen E. (57203080494) ;Olusanya, Bolajoko Olubukunola (57218504682) ;Olusanya, Jacob Olusegun (57222488860) ;Ong, Kanyin (57224697159) ;Opio, John Nelson (57200124403) ;Oren, Eyal (36815569400) ;Ortiz, Alberto (7201911399) ;Osman, Majdi (59804857900) ;Ota, Erika (57202554474) ;Mahesh, P.A. (57202421244) ;Pacella, Rosana E. (57194839077) ;Pakhale, Smita (57220937499) ;Pana, Adrian (57191837583) ;Panda, Basant Kumar (57196077672) ;Jonas, Songhomitra (57198344150) ;Papachristou, Christina (7005498635) ;Park, Eun-Kee (57216814178) ;Patten, Scott B. (57201492915) ;Patton, George C. (7102184358) ;Paudel, Deepak (57207871851) ;Paulson, Katherine (57203437789) ;Pereira, David M. (57200690024) ;Perez-Ruiz, Fernando (57190090281) ;Perico, Norberto (56481931200) ;Pervaiz, Aslam (57202521714) ;Petzold, Max (7003628893) ;Phillips, Michael Robert (57202563610) ;Pigott, David M. (55320335600) ;Pinho, Christine (57212482983) ;Plass, Dietrich (57217142114) ;Pletcher, Martin A. (57196075669) ;Polinder, Suzanne (12766122200) ;Postma, Maarten J. (7006296502) ;Pourmalek, Farshad (8309390500) ;Purcell, Caroline (56203575500) ;Qorbani, Mostafa (24831040300) ;Radfar, Amir (57194428768) ;Rafay, Anwar (57212263323) ;Rahimi-Movaghar, Vafa (6507646446) ;Rahman, Mahfuzar (35571661300) ;Ur Rahman, Mohammad Hifz (57202017378) ;Rai, Rajesh Kumar (51864423900) ;Ranabhat, Chhabi Lal (56719695500) ;Rankin, Zane (57200251742) ;Rao, Puja C. (57191835613) ;Rath, Goura Kishor (35444818200) ;Rawaf, Salman (6602475959) ;Ray, Sarah E. (57196078769) ;Rehm, Jürgen (7102718648) ;Reiner, Robert C. (57203229088) ;Reitsma, Marissa B. (57208766315) ;Remuzzi, Giuseppe (56466188600) ;Rezaei, Satar (55273796300) ;Rezai, Mohammad Sadegh (57226200664) ;Rokni, Mohammad Bagher (36119103200) ;Ronfani, Luca (6602565620) ;Roshandel, Gholamreza (14034446800) ;Roth, Gregory A. (55074747400) ;Rothenbacher, Dietrich (7004765162) ;Ruhago, George Mugambage (50761517500) ;Rizwan, S.A. (57195295816) ;Saadat, Soheil (16310355800) ;Sachdev, Perminder S. (7102284091) ;Sadat, Nafs (57219687343) ;Safdarian, Mahdi (57203849024) ;Saf, Sare (57202019735) ;Safiri, Saeid (56009654100) ;Sagar, Rajesh (26643103100) ;Sahathevan, Ramesh (35332739200) ;Salama, Joseph (57202975625) ;Salamati, Payman (14045860600) ;Salomon, Joshua A. (56745638600) ;Samy, Abdallah M. (36973661300) ;Sanabria, Juan Ramon (7006262917) ;Sanchez-Niño, Maria Dolores (57202569015) ;Santomauro, Damian (56912450700) ;Santos, Itamar S. (57198312911) ;Milicevic, Milena M. Santric (57211144346) ;Sartorius, Benn (12788526800) ;Satpathy, Maheswar (57202563691) ;Shahraz, Saeid (57215142060) ;Schmidt, Maria Inês (7404398885) ;Schneider, Ione J.C. (57201292772) ;Schulhofer-Wohl, Sam (14322452700) ;Schutte, Aletta E. (57216814352) ;Schwebel, David C. (6603681532) ;Schwendicke, Falk (55639536600) ;Sepanlou, Sadaf G. (36248136000) ;Servan-Mori, Edson E. (57202594826) ;Shackelford, Katya Anne (57202959163) ;Shaikh, Masood Ali (57203122601) ;Shamsipour, Mansour (57197846052) ;Shamsizadeh, Morteza (57195940127) ;Islam, Sheikh Mohammed Shariful (56400111100) ;Sharma, Jayendra (57195329457) ;Sharma, Rajesh (58228412600) ;She, Jun (57209122131) ;Sheikhbahaei, Sara (57219637352) ;Shey, Muki (10138820000) ;Shi, Peilin (57203064901) ;Shields, Chloe (57196083232) ;Shigematsu, Mika (23968093000) ;Shiri, Rahman (57200737050) ;Shirude, Shreya (57216599051) ;Shiue, Ivy (35811219800) ;Shoman, Haitham (57208324664) ;Shrime, Mark G. (57204703404) ;Sigfusdottir, Inga Dora (57195363778) ;Silpakit, Naris (57202401404) ;Silva, João Pedro (7403023631) ;Singh, Abhishek (59639211800) ;Singh, Jasvinder A. (7404421736) ;Skiadaresi, Eirini (37100428500) ;Sligar, Amber (57190284582) ;Smith, Alison (57191843859) ;Smith, David L. (55574206203) ;Smith, Mari (57195484737) ;Sobaih, Badr H.A. (57202564080) ;Soneji, Samir (57204096389) ;Sorensen, Reed J.D. (57196918748) ;Soriano, Joan B. (7101973935) ;Sreeramareddy, Chandrashekhar T. (57212263335) ;Srinivasan, Vinay (57196077031) ;Stanaway, Jefrey D. (57201210928) ;Stathopoulou, Vasiliki (57209726581) ;Steel, Nicholas (6603791873) ;Stein, Dan J. (55769747595) ;Steiner, Caitlyn (57205358084) ;Steinke, Sabine (57203777687) ;Stokes, Mark Andrew (7102859000) ;Strong, Mark (12783473200) ;Strub, Bryan (57211781720) ;Subart, Michelle (57194140438) ;Sufyan, Muawiyyah Babale (57203947220) ;Sunguya, Bruno F. (57209060557) ;Sur, Patrick J. (57218360398) ;Swaminathan, Soumya (7102380757) ;Sykes, Bryan L. (57211183396) ;Tabarés-Seisdedos, Rafael (6602981102) ;Tadakamadla, Santosh Kumar (57207799926) ;Takahashi, Ken (55741242600) ;Takala, Jukka S. (35425471300) ;Talongwa, Roberto Tchio (57195568335) ;Tarawneh, Mohammed Rasoul (56742235200) ;Tavakkoli, Mohammad (57202524239) ;Taveira, Nuno (6602731390) ;Tegegne, Teketo Kassaw (57216998561) ;Tehrani-Banihashemi, Arash (57204006020) ;Temsah, Mohamad-Hani (56115852000) ;Terkawi, Abdullah Sulieman (57211144258) ;Thakur, J.S. (57204002123) ;Thamsuwan, Ornwipa (55484605700) ;Thankappan, Kavumpurathu Raman (57202955435) ;Thomas, Katie E. (56239717800) ;Thompson, Alex H. (57196083297) ;Thomson, Alan J. (57969994200) ;Thrift, Amanda G. (7004824524) ;Tobe-Gai, Ruoyan (57209276611) ;Topor-Madry, Roman (57211182892) ;Torre, Anna (57196074351) ;Tortajada, Miguel (16242320900) ;Towbin, Jefrey Allen (7102520568) ;Tran, Bach Xuan (57209107515) ;Troeger, Christopher (57195223624) ;Truelsen, Thomas (57202824565) ;Tsoi, Derrick (57196074984) ;Tuzcu, Emin Murat (7005951350) ;Tyrovolas, Stefanos (57207793475) ;Ukwaja, Kingsley N. (57202824584) ;Undurraga, Eduardo A. (57204092789) ;Updike, Rachel (57204698680) ;Uthman, Olalekan A. (23026328100) ;Uzochukwu, Benjamin S. Chudi (57211633289) ;Van Boven, Job F.M. (53464198500) ;Vasankari, Tommi (57200592416) ;Venketasubramanian, Narayanaswamy (56804702100) ;Violante, Francesco S. (7003555890) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Vos, Theo (57223885848) ;Wakayo, Tolassa (57205609717) ;Wallin, Mitchell T. (57201573668) ;Wang, Yuan-Pang (8576812100) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Weiss, Daniel J. (8609275600) ;Werdecker, Andrea (57208964895) ;Westerman, Ronny (57218361023) ;Whetter, Brian (57201998502) ;Whiteford, Harvey A. (55906494000) ;Wijeratne, Tissa (14051317700) ;Wiysonge, Charles Shey (6507441509) ;Woldeyes, Belete Getahun (57195329524) ;Wolfe, Charles D.A. (57202754705) ;Woodbrook, Rachel (57200298006) ;Workicho, Abdulhalik (56720337100) ;Xavier, Denis (55403963100) ;Xiao, Qingyang (59797114300) ;Xu, Gelin (57203583113) ;Yaghoubi, Mohsen (57212400558) ;Yakob, Bereket (57203811497) ;Yano, Yuichiro (57196965200) ;Yaseri, Mehdi (23029507000) ;Yimam, Hassen Hamid (57196325590) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922) ;Zegeye, Elias Asfaw (57209171278) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zerfu, Taddese Alemu (55358278900) ;Zhang, Anthony Lin (56391112900) ;Zhang, Xueying (56283378700) ;Zipkin, Ben (57200737130) ;Zodpey, Sanjay (7003415080) ;Lopez, Alan D. (7401455668)Murray, Christopher J.L. (55481130700)Background: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specifc mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. Methods: We estimated cause-specifc deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specifc causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specifc deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016. Findings: The quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72·3% (95% uncertainty interval [UI] 71·2-73·2) of deaths in 2016 with 19·3% (18·5-20·4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8·43% (8·00-8·67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006-16 - age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1·80 million deaths (95% UI 1·59 million to 1·89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176-181) increase in deaths in ages 90-94 years and a 210% (208-212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL signifcantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2·89%); the median annualised rate of change for all other causes was lower (a decrease of 1·59%) during the same interval. Globally, the fve leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a fner level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations. Other leading causes of YLLs for which YLLs were notably lower than expected included neonatal preterm birth complications in many locations in both south Asia and southeast Asia, and cerebrovascular disease in western Europe. Interpretation: The past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages suggests success in reducing many causes of early death. YLLs have increased globally for causes such as diabetes mellitus or some neoplasms, and in some locations for causes such as drug use disorders, and confict and terrorism. Increasing levels of YLLs might refect outcomes from conditions that required high levels of care but for which efective treatments remain elusive, potentially increasing costs to health systems. Copyright © 2017 The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016(2017) ;Gakidou, Emmanuela (57202567277) ;Afshin, Ashkan (57217465455) ;Abajobir, Amanuel Alemu (57203613441) ;Abate, Kalkidan Hassen (57207943858) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abd-Allah, Foad (36503428900) ;Abdulle, Abdishakur M. (6603592018) ;Abera, Semaw Ferede (57205180598) ;Aboyans, Victor (56214736500) ;Abu-Raddad, Laith J. (14032724700) ;Abu-Rmeileh, Niveen M.E. 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(6603260895) ;Brenner, Hermann (7201832825) ;Brugha, Traolach S. (35370057100) ;Bulto, Lemma Negesa Bulto (57196074547) ;Baumgarner, Blair R. (57208560663) ;Butt, Zahid A. (57202522739) ;Cahuana-Hurtado, Lucero (57207890731) ;Cárdenas, Rosario (57216482927) ;Carrero, Juan Jesus (16834646800) ;Castañeda-Orjuela, Carlos A. (35769124700) ;Catalá-López, Ferrán (57202553733) ;Cercy, Kelly (57208777587) ;Chang, Hsing-Yi (7407523087) ;Charlson, Fiona J. (57191632086) ;Chimed-Ochir, Odgerel (57217262222) ;Chisumpa, Vesper Hichilombwe (56761895800) ;Chitheer, Abdulaal A. (57209314488) ;Christensen, Hanne (57202099623) ;Christopher, Devasahayam Jesudas (57209863533) ;Cirillo, Massimo (35247478400) ;Cohen, Aaron J. (7404780942) ;Comfort, Haley (57218875721) ;Cooper, Cyrus (36041345700) ;Coresh, Josef (7005367498) ;Cornaby, Leslie (57191837051) ;Cortesi, Paolo Angelo (57200306512) ;Criqui, Michael H. (7005209601) ;Crump, John A. 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(57200298415) ;Hachinski, Vladimir (7101953309) ;Hafezi-Nejad, Nima (57216814261) ;Hailu, Gessessew Bugssa (57219637263) ;Hamadeh, Randah Ribhi (57202769526) ;Hamidi, Samer (24366336000) ;Hammami, Mouhanad (57216961083) ;Handal, Alexis J. (57208977398) ;Hankey, Graeme J. (7102816661) ;Harb, Hilda L. (57221443122) ;Hareri, Habtamu Abera (57195292447) ;Hassanvand, Mohammad Sadegh (35085056400) ;Havmoeller, Rasmus (57212075728) ;Hawley, Caitlin (57196078801) ;Hay, Simon I. (7101875313) ;Hedayati, Mohammad T. (23979915700) ;Hendrie, Delia (6602071966) ;Heredia-Pi, Ileana Beatriz (36941085200) ;Hoek, Hans W. (57202570421) ;Horita, Nobuyuki (57217110823) ;Hosgood, H. Dean (56353204400) ;Hostiuc, Sorin (24829099800) ;Hoy, Damian G. (57216593652) ;Hsairi, Mohamed (57209033943) ;Hu, Guoqing (57218106596) ;Huang, Hsiang (57202278530) ;Huang, John J. (56135699200) ;Iburg, Kim Moesgaard (57216814160) ;Ikeda, Chad (57202720108) ;Inoue, Manami (57202880842) ;Irvine, Caleb Mackay Salpeter (57203666733) ;Jackson, Maria Delores (55456026100) ;Jacobsen, Kathryn H. (26029163100) ;Jahanmehr, Nader (57203122718) ;Jakovljevic, Mihajlo B. (14318929700) ;Jauregui, Alejandra (57204716988) ;Javanbakht, Mehdi (57204619886) ;Jeemon, Panniyammakal (57216324831) ;Johansson, Lars R.K. (7401510247) ;Johnson, Catherine O. (57212301236) ;Jonas, Jost B. (7202492953) ;Jürisson, Mikk (55547524800) ;Kabir, Zubair (57207901718) ;Kadel, Rajendra (57196080325) ;Kahsay, Amaha (57216608121) ;Kamal, Ritul (57203177242) ;Karch, André (57223444197) ;Karema, Corine Kakizi (57202557522) ;Kasaeian, Amir (57195540738) ;Kassebaum, Nicholas J. 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(8549393000) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922) ;Zavala-Arciniega, Luis (57196083471) ;Zhang, Xueying (56283378700) ;Zimsen, Stephanie Raman M. (57196078433) ;Zipkin, Ben (57200737130) ;Zodpey, Sanjay (7003415080) ;Lim, Stephen S. (57201800433)Murray, Christopher J.L. (55481130700)Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. Methods: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2016. This study included 481 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk (RR) and exposure estimates from 22 717 randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources, according to the GBD 2016 source counting methods. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. Finally, we explored four drivers of trends in attributable burden: population growth, population ageing, trends in risk exposure, and all other factors combined. Findings: Since 1990, exposure increased significantly for 30 risks, did not change significantly for four risks, and decreased significantly for 31 risks. Among risks that are leading causes of burden of disease, child growth failure and household air pollution showed the most significant declines, while metabolic risks, such as body-mass index and high fasting plasma glucose, showed significant increases. In 2016, at Level 3 of the hierarchy, the three leading risk factors in terms of attributable DALYs at the global level for men were smoking (124.1 million DALYs [95% UI 111.2 million to 137.0 million]), high systolic blood pressure (122.2 million DALYs [110.3 million to 133.3 million], and low birthweight and short gestation (83.0 million DALYs [78.3 million to 87.7 million]), and for women, were high systolic blood pressure (89.9 million DALYs [80.9 million to 98.2 million]), high body-mass index (64.8 million DALYs [44.4 million to 87.6 million]), and high fasting plasma glucose (63.8 million DALYs [53.2 million to 76.3 million]). In 2016 in 113 countries, the leading risk factor in terms of attributable DALYs was a metabolic risk factor. Smoking remained among the leading five risk factors for DALYs for 109 countries, while low birthweight and short gestation was the leading risk factor for DALYs in 38 countries, particularly in sub-Saharan Africa and South Asia. In terms of important drivers of change in trends of burden attributable to risk factors, between 2006 and 2016 exposure to risks explains an 9.3% (6.9-11.6) decline in deaths and a 10.8% (8.3-13.1) decrease in DALYs at the global level, while population ageing accounts for 14.9% (12.7-17.5) of deaths and 6.2% (3.9-8.7) of DALYs, and population growth for 12.4% (10.1-14.9) of deaths and 12.4% (10.1-14.9) of DALYs. The largest contribution of trends in risk exposure to disease burden is seen between ages 1 year and 4 years, where a decline of 27.3% (24.9-29.7) of the change in DALYs between 2006 and 2016 can be attributed to declines in exposure to risks. Interpretation: Increasingly detailed understanding of the trends in risk exposure and the RRs for each risk-outcome pair provide insights into both the magnitude of health loss attributable to risks and how modification of risk exposure has contributed to health trends. Metabolic risks warrant particular policy attention, due to their large contribution to global disease burden, increasing trends, and variable patterns across countries at the same level of development. GBD 2016 findings show that, while it has huge potential to improve health, risk modification has played a relatively small part in the past decade. © The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016(2017) ;Hay, Simon I. (7101875313) ;Abajobir, Amanuel Alemu (57203613441) ;Abate, Kalkidan Hassen (57207943858) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abd-Allah, Foad (36503428900) ;Abdulle, Abdishakur M. (6603592018) ;Abebo, Teshome Abuka (57195738441) ;Abera, Semaw Ferede (57205180598) ;Aboyans, Victor (56214736500) ;Abu-Raddad, Laith J. (14032724700) ;Ackerman, Ilana N. (8925517400) ;Adedeji, Isaac A. 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(57207920084)Background: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). Methods: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE difered from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. Findings: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and 1·96 years (1·69-2·13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2·3% [-5·9 to 0·9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs ofset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the fve lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16·1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally. Interpretation: At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs ofset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention eforts, and development assistance for health, including fnancial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support. © The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016(2017) ;Vos, Theo (57223885848) ;Abajobir, Amanuel Alemu (57203613441) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abate, Kalkidan Hassen (57207943858) ;Abd-Allah, Foad (36503428900) ;Abdulle, Abdishakur M. (6603592018) ;Abebo, Teshome Abuka (57195738441) ;Abera, Semaw Ferede (57205180598) ;Aboyans, Victor (56214736500) ;Abu-Raddad, Laith J. (14032724700) ;Ackerman, Ilana N. 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(57193559189) ;Ghajar, Alireza (56226089600) ;Gibney, Katherine B. (57202564104) ;Gill, Paramjit Singh (7202766660) ;Gillum, Richard F. (7103181331) ;Ginawi, Ibrahim Abdelmageem Mohamed (57192378390) ;Giref, Ababi Zergay (57219994468) ;Gishu, Melkamu Dedefo (57202568734) ;Giussani, Giorgia (57200843076) ;Godwin, William W. (57191841675) ;Gold, Audra L. (57194129483) ;Goldberg, Ellen M. (57191842703) ;Gona, Philimon N. (57219703762) ;Goodridge, Amador (55801980200) ;Gopalani, Sameer Vali (57190277891) ;Goto, Atsushi (36339255500) ;Goulart, Alessandra Carvalho (57201181348) ;Griswold, Max (57191836595) ;Gugnani, Harish Chander (7005567008) ;Gupta, Rahul (57204120071) ;Gupta, Rajeev (55705295300) ;Gupta, Tanush (57219956402) ;Gupta, Vipin (57199940653) ;Hafezi-Nejad, Nima (57216814261) ;Hailu, Alemayehu Desalegne (57225733572) ;Hailu, Gessessew Bugssa (57219637263) ;Hamadeh, Randah Ribhi (57202769526) ;Hamidi, Samer (24366336000) ;Handal, Alexis J. (57208977398) ;Hankey, Graeme J. (7102816661) ;Hao, Yuantao (57202554333) ;Harb, Hilda L. (57221443122) ;Hareri, Habtamu Abera (57195292447) ;Haro, Josep Maria (57215877903) ;Harvey, James (57196074369) ;Hassanvand, Mohammad Sadegh (35085056400) ;Havmoeller, Rasmus (57212075728) ;Hawley, Caitlin (57196078801) ;Hay, Roderick J. (56785229200) ;Hay, Simon I. (7101875313) ;Henry, Nathaniel J. (57196076616) ;Heredia-Pi, Ileana Beatriz (36941085200) ;Heydarpour, Pouria (57189359029) ;Hoek, Hans W. (57202570421) ;Hoffman, Howard J. (7201677665) ;Horita, Nobuyuki (57217110823) ;Hosgood, H. Dean (56353204400) ;Hostiuc, Sorin (24829099800) ;Hotez, Peter J. (7004958298) ;Hoy, Damian G. (57216593652) ;Htet, Aung Soe (57202555179) ;Hu, Guoqing (57218106596) ;Huang, Hsiang (57202278530) ;Huynh, Chantal (57202556112) ;Iburg, Kim Moesgaard (57216814160) ;Igumbor, Ehimario Uche (26537691100) ;Ikeda, Chad (57202720108) ;Irvine, Caleb Mackay Salpeter (57203666733) ;Jacobsen, Kathryn H. (26029163100) ;Jahanmehr, Nader (57203122718) ;Jakovljevic, Mihajlo B. (14318929700) ;Jassal, Simerjot K. (57190118903) ;Javanbakht, Mehdi (57204619886) ;Jayaraman, Sudha P. (57204716526) ;Jeemon, Panniyammakal (57216324831) ;Jensen, Paul N. (57224209864) ;Jha, Vivekanand (7005119423) ;Jiang, Guohong (56984997300) ;John, Denny (57194230095) ;Johnson, Catherine O. (57212301236) ;Johnson, Sarah Charlotte (57207904886) ;Jonas, Jost B. (7202492953) ;Jürisson, Mikk (55547524800) ;Kabir, Zubair (57207901718) ;Kadel, Rajendra (57196080325) ;Kahsay, Amaha (57216608121) ;Kamal, Ritul (57203177242) ;Kan, Haidong (7101602991) ;Karam, Nadim E. (57221993192) ;Karch, André (57223444197) ;Karema, Corine Kakizi (57202557522) ;Kasaeian, Amir (57195540738) ;Kassa, Getachew Mullu (56229895500) ;Kassaw, Nigussie Assefa (57196473578) ;Kassebaum, Nicholas J. (57202562224) ;Kastor, Anshul (56652275600) ;Katikireddi, Srinivasa Vittal (6508254091) ;Kaul, Anil (16156995700) ;Kawakami, Norito (35377339000) ;Keiyoro, Peter Njenga (57203177260) ;Kengne, Andre Pascal (7801322838) ;Keren, Andre (7005620132) ;Khader, Yousef Saleh (55654192600) ;Khalil, Ibrahim A. (58255049500) ;Khan, Ejaz Ahmad (57218791274) ;Khang, Young-Ho (57198904674) ;Khosravi, Ardeshir (57201190837) ;Khubchandani, Jagdish (57211720011) ;Kieling, Christian (57218820714) ;Kim, Daniel (57223019104) ;Kim, Pauline (57191593761) ;Kim, Yun Jin (57211086375) ;Kimokoti, Ruth W. (8647554600) ;Kinfu, Yohannes (12770281900) ;Kisa, Adnan (6603346067) ;Kissimova-Skarbek, Katarzyna A. (6508376962) ;Kivimaki, Mika (7004391239) ;Knudsen, Ann Kristin (57192966362) ;Kokubo, Yoshihiro (56155004000) ;Kolte, Dhaval (26321613900) ;Kopec, Jacek A. (7006284395) ;Kosen, Soewarta (57211346192) ;Koul, Parvaiz A. (14022262900) ;Koyanagi, Ai (57197741912) ;Kravchenko, Michael (57202569007) ;Krishnaswami, Sanjay (7101616028) ;Krohn, Kristopher J. (57194138806) ;Kuate Defo, Barthelemy (6602271655) ;Kucuk Bicer, Burcu (57204528360) ;Kumar, G. Anil (57139550500) ;Kumar, Pushpendra (57208849920) ;Kumar, Sanjiv (57202477407) ;Kyu, Hmwe H. (57217040073) ;Lal, Dharmesh Kumar (57222488984) ;Lalloo, Ratilal (57189334553) ;Lambert, Nkurunziza (57196083761) ;Lan, Qing (23970641100) ;Larsson, Anders (56381985300) ;Lavados, Pablo M. (57188955599) ;Leasher, Janet L. (57197789738) ;Lee, Jong-Tae (57196083400) ;Lee, Paul H. (57200302692) ;Leigh, James (7202089604) ;Leshargie, Cheru Tesema (57195295462) ;Leung, Janni (57214397752) ;Leung, Ricky (56276497100) ;Levi, Miriam (54893035000) ;Li, Yichong (57218426673) ;Li, Yongmei (56147667800) ;Li Kappe, Darya (57215878218) ;Liang, Xiaofeng (26662590300) ;Liben, Misgan Legesse (57188568119) ;Lim, Stephen S. (57201800433) ;Linn, Shai (7102590173) ;Liu, Angela (57196080772) ;Liu, Patrick Y. (56170368200) ;Liu, Shiwei (57209574351) ;Liu, Yang (57202561981) ;Lodha, Rakesh (7007019609) ;Logroscino, Giancarlo (7004888005) ;London, Stephanie J. (56988756100) ;Looker, Katharine J. (57202553673) ;Lopez, Alan D. (7401455668) ;Lorkowski, Stefan (57203677656) ;Lotufo, Paulo A. (7003331101) ;Low, Nicola (7006432437) ;Lozano, Rafael (7102198442) ;Lucas, Timothy C.D. (57216683591) ;Macarayan, Erlyn Rachelle King (56330601800) ;Magdy Abd El Razek, Hassan (57195948985) ;Magdy Abd El Razek, Mohammed (57201191366) ;Mahdavi, Mahdi (57190276959) ;Majdan, Marek (36147855100) ;Majdzadeh, Reza (9246620000) ;Majeed, Azeem (7102027801) ;Malekzadeh, Reza (7005197760) ;Malhotra, Rajesh (7202423297) ;Malta, Deborah Carvalho (15835283500) ;Mamun, Abdullah A. (55666602500) ;Manguerra, Helena (57208121153) ;Manhertz, Treh (57195486490) ;Mantilla, Ana (57215877671) ;Mantovani, Lorenzo G. (7006357517) ;Mapoma, Chabila C. (57208956832) ;Marczak, Laurie B. (57200295553) ;Martinez-Raga, Jose (57202861191) ;Martins-Melo, Francisco Rogerlândio (57204796807) ;Martopullo, Ira (57193550189) ;März, Winfried (57220877383) ;Mathur, Manu Raj (55270329300) ;Mazidi, Mohsen (57200232563) ;McAlinden, Colm (35325278500) ;McGaughey, Madeline (57206867033) ;McGrath, John J. (57202560550) ;McKee, Martin (7202304775) ;McNellan, Claire (56771422500) ;Mehata, Suresh (57211773159) ;Mehndiratta, Man Mohan (57202557864) ;Mekonnen, Tefera Chane (57193872649) ;Memiah, Peter (57217207827) ;Memish, Ziad A. (7005059350) ;Mendoza, Walter (57216905642) ;Mengistie, Mubarek Abera (56045752700) ;Mengistu, Desalegn Tadese (57194776802) ;Mensah, George A. (57196028147) ;Meretoja, Atte (12775885500) ;Meretoja, Tuomo J. (57202554188) ;Mezgebe, Haftay Berhane (57222113213) ;Micha, Renata (25632461800) ;Millear, Anoushka (57204879537) ;Miller, Ted R. (7403948600) ;Mills, Edward J. (57205301363) ;Mirarefin, Mojde (57222113397) ;Mirrakhimov, Erkin M. (57216202888) ;Misganaw, Awoke (57202808713) ;Mishra, Shiva Raj (57208010960) ;Mitchell, Philip B. (35354747000) ;Mohammad, Karzan Abdulmuhsin (57205300378) ;Mohammadi, Alireza (56720095000) ;Mohammed, Kedir Endris (57216551957) ;Mohammed, Shafiu (57838689000) ;Mohanty, Sanjay K. (59796713300) ;Mokdad, Ali H. (7004813962) ;Mollenkopf, Sarah K. (57203646247) ;Monasta, Lorenzo (7801520497) ;Hernandez, Julio Montañez (57199371040) ;Montico, Marcella (57202563609) ;Moradi-Lakeh, Maziar (35617421300) ;Moraga, Paula (46761426800) ;Mori, Rintaro (57072757600) ;Morozoff, Chloe (57190373716) ;Morrison, Shane D. (45661573100) ;Moses, Mark (57117385200) ;Mountjoy-Venning, Cliff (57196081878) ;Mruts, Kalayu Birhane (57221822877) ;Mueller, Ulrich O. (8512347500) ;Muller, Kate (57196075658) ;Murdoch, Michele E. (57202097865) ;Murthy, Gudlavalleti Venkata Satyanarayana (7101778322) ;Musa, Kamarul Imran (57194536466) ;Nachega, Jean B. (6701544088) ;Nagel, Gabriele (7103201623) ;Naghavi, Mohsen (57207906323) ;Naheed, Aliya (57202560989) ;Naidoo, Kovin S. (35564549000) ;Naldi, Luigi (7004954781) ;Nangia, Vinay (57201490837) ;Natarajan, Gopalakrishnan (55804491100) ;Negasa, Dumessa Edessa (57196084386) ;Negoi, Ionut (57200640014) ;Negoi, Ruxandra Irina (55566106200) ;Newton, Charles R. (35465836500) ;Ngunjiri, Josephine Wanjiku (57195296110) ;Nguyen, Cuong Tat (56531347200) ;Nguyen, Grant (57191591002) ;Nguyen, Minh (58203329200) ;Nguyen, Quyen Le (57223642100) ;Nguyen, Trang Huyen (59142352200) ;Nichols, Emma (57205756163) ;Ningrum, Dina Nur Anggraini (57195329470) ;Nolte, Sandra (24073274400) ;Nong, Vuong Minh (55507077200) ;Norrving, Bo (12792377500) ;Noubiap, Jean Jacques N. (55490374000) ;O'Donnell, Martin J. (57210591242) ;Ogbo, Felix Akpojene (57200737136) ;Oh, In-Hwan (57204090669) ;Okoro, Anselm (54682112200) ;Oladimeji, Olanrewaju (57216495380) ;Olagunju, Andrew Toyin (26029995700) ;Olagunju, Tinuke Oluwasefunmi (57203076824) ;Olsen, Helen E. (57203080494) ;Olusanya, Bolajoko Olubukunola (57218504682) ;Olusanya, Jacob Olusegun (57222488860) ;Ong, Kanyin (57224697159) ;Opio, John Nelson (57200124403) ;Oren, Eyal (36815569400) ;Ortiz, Alberto (7201911399) ;Osgood-Zimmerman, Aaron (57195835977) ;Osman, Majdi (59804857900) ;Owolabi, Mayowa O. (57222581892) ;Pa, Mahesh (57212735186) ;Pacella, Rosana E. (57194839077) ;Pana, Adrian (57191837583) ;Panda, Basant Kumar (57196077672) ;Papachristou, Christina (7005498635) ;Park, Eun-Kee (57216814178) ;Parry, Charles D. (7102561312) ;Parsaeian, Mahboubeh (57196467994) ;Patten, Scott B. (57201492915) ;Patton, George C. (7102184358) ;Paulson, Katherine (57203437789) ;Pearce, Neil (56491440700) ;Pereira, David M. (57200690024) ;Perico, Norberto (56481931200) ;Pesudovs, Konrad (7004576721) ;Peterson, Carrie Beth (57202568667) ;Petzold, Max (7003628893) ;Phillips, Michael Robert (57202563610) ;Pigott, David M. (55320335600) ;Pillay, Julian David (57197803061) ;Pinho, Christine (57212482983) ;Plass, Dietrich (57217142114) ;Pletcher, Martin A. (57196075669) ;Popova, Svetlana (56848085800) ;Poulton, Richie G. (7006256743) ;Pourmalek, Farshad (8309390500) ;Prabhakaran, Dorairaj (7004283783) ;Prasad, Narayan (23028765700) ;Prasad, Noela M. (8899838800) ;Purcell, Carrie (56203575500) ;Qorbani, Mostafa (24831040300) ;Quansah, Reginald (14825606700) ;Rabiee, Rynaz H.S. (57205452058) ;Radfar, Amir (57194428768) ;Rafay, Anwar (57212263323) ;Rahimi, Kazem (58482212900) ;Rahimi-Movaghar, Afarin (8696686900) ;Rahimi-Movaghar, Vafa (6507646446) ;Rahman, Mahfuzar (35571661300) ;Rahman, Mohammad Hifz Ur (57208867497) ;Rai, Rajesh Kumar (51864423900) ;Rajsic, Sasa (57196448260) ;Ram, Usha (26653819000) ;Ranabhat, Chhabi Lal (56719695500) ;Rankin, Zane (57200251742) ;Rao, Paturi Vishnupriya (7404661983) ;Rao, Puja C. (57191835613) ;Rawaf, Salman (6602475959) ;Ray, Sarah E. (57196078769) ;Reiner, Robert C. (57203229088) ;Reinig, Nikolas (57208577401) ;Reitsma, Marissa B. (57208766315) ;Remuzzi, Giuseppe (56466188600) ;Renzaho, Andre M.N. (6505786588) ;Resnikoff, Serge (7006012071) ;Rezaei, Satar (55791003000) ;Ribeiro, Antonio L. (7201676223) ;Ronfani, Luca (6602565620) ;Roshandel, Gholamreza (14034446800) ;Roth, Gregory A. (55074747400) ;Roy, Ambuj (7402704658) ;Rubagotti, Enrico (57208389589) ;Ruhago, George Mugambage (50761517500) ;Saadat, Soheil (16310355800) ;Sadat, Nafis (57219687343) ;Safdarian, Mahdi (57203849024) ;Safi, Sare (57219477293) ;Safiri, Saeid (56009654100) ;Sagar, Rajesh (26643103100) ;Sahathevan, Ramesh (35332739200) ;Salama, Joseph (57202975625) ;Salomon, Joshua A. (56745638600) ;Salvi, Sundeep Santosh (7005258777) ;Samy, Abdallah M. (36973661300) ;Sanabria, Juan R. (7006262917) ;Santomauro, Damian (56912450700) ;Santos, Itamar S. (57198312911) ;Santos, João Vasco (57226214352) ;Santric Milicevic, Milena M. (57211144346) ;Sartorius, Benn (12788526800) ;Satpathy, Maheswar (57202563691) ;Sawhney, Monika (57217153893) ;Saxena, Sonia (57203151746) ;Schmidt, Maria Inês (7404398885) ;Schneider, Ione J.C. (57201292772) ;Schöttker, Ben (37665918200) ;Schwebel, David C. (6603681532) ;Schwendicke, Falk (55639536600) ;Seedat, Soraya (7003445887) ;Sepanlou, Sadaf G. (36248136000) ;Servan-Mori, Edson E. (57202594826) ;Setegn, Tesfaye (37075667700) ;Shackelford, Katya Anne (57202959163) ;Shaheen, Amira (57202560956) ;Shaikh, Masood Ali (57203122601) ;Shamsipour, Mansour (57197846052) ;Shariful Islam, Sheikh Mohammed (56400111100) ;Sharma, Jayendra (57195329457) ;Sharma, Rajesh (58228412600) ;She, Jun (57209122131) ;Shi, Peilin (57203064901) ;Shields, Chloe (57196083232) ;Shigematsu, Mika (23968093000) ;Shinohara, Yukito (57203303862) ;Shiri, Rahman (57200737050) ;Shirkoohi, Reza (12776374400) ;Shirude, Shreya (57216599051) ;Shishani, Kawkab (14025005500) ;Shrime, Mark G. (57204703404) ;Sibai, Abla Mehio (7005466998) ;Sigfusdottir, Inga Dora (57195363778) ;Silva, Diego Augusto Santos (36985158000) ;Silva, João Pedro (7403023631) ;Silveira, Dayane Gabriele Alves (57190284103) ;Singh, Jasvinder A. (7404421736) ;Singh, Narinder Pal (57211864736) ;Sinha, Dhirendra Narain (7201637609) ;Skiadaresi, Eirini (37100428500) ;Skirbekk, Vegard (57202564482) ;Slepak, Erica Leigh (57205356367) ;Sligar, Amber (57190284582) ;Smith, David L. (55574206203) ;Smith, Mari (57195484737) ;Sobaih, Badr H.A. (57202564080) ;Sobngwi, Eugene (6701427993) ;Sorensen, Reed J.D. (57196918748) ;Sousa, Tatiane Cristina Moraes (57195329460) ;Sposato, Luciano A. (25640261000) ;Sreeramareddy, Chandrashekhar T. (57212263335) ;Srinivasan, Vinay (57196077031) ;Stanaway, Jeffrey D. (57201210928) ;Stathopoulou, Vasiliki (57195644148) ;Steel, Nicholas (6603791873) ;Stein, Dan J. (55769747595) ;Stein, Murray B. (7402996817) ;Steiner, Caitlyn (57205358084) ;Steiner, Timothy J. (16837503200) ;Steinke, Sabine (57203777687) ;Stokes, Mark Andrew (7102859000) ;Stovner, Lars Jacob (57201788390) ;Strub, Bryan (57211781720) ;Subart, Michelle (57194140438) ;Sufiyan, Muawiyyah Babale (58294633600) ;Suliankatchi Abdulkader, Rizwan (57195295816) ;Sunguya, Bruno F. (57209060557) ;Sur, Patrick J. (57218360398) ;Swaminathan, Soumya (7102380757) ;Sykes, Bryan L. (57211183396) ;Sylte, Dillon O. (57211183601) ;Tabarés-Seisdedos, Rafael (6602981102) ;Taffere, Getachew Redae (59807215200) ;Takala, Jukka S. (35425471300) ;Tandon, Nikhil (7101833756) ;Tavakkoli, Mohammad (57202524239) ;Taveira, Nuno (6602731390) ;Taylor, Hugh R. (55550572900) ;Tehrani-Banihashemi, Arash (57204006020) ;Tekelab, Tesfalidet (56721378300) ;Temam Shifa, Girma (57217000284) ;Terkawi, Abdullah Sulieman (57211144258) ;Tesfaye, Dawit Jember (59264414500) ;Tesssema, Belay (57195294962) ;Thamsuwan, Ornwipa (55484605700) ;Thomas, Katie E. (56239717800) ;Thrift, Amanda G. (7004824524) ;Tiruye, Tenaw Yimer (57194055872) ;Tobe-Gai, Ruoyan (57209276611) ;Tollanes, Mette C. (16833860000) ;Tonelli, Marcello (7103102534) ;Topor-Madry, Roman (57211182892) ;Tortajada, Miguel (16242320900) ;Touvier, Mathilde (8877033300) ;Tran, Bach Xuan (57209107515) ;Tripathi, Suryakant (57225821627) ;Troeger, Christopher (57195223624) ;Truelsen, Thomas (57202824565) ;Tsoi, Derrick (57196074984) ;Tuem, Kald Beshir (57216106503) ;Tuzcu, Emin Murat (7005951350) ;Tyrovolas, Stefanos (57207793475) ;Ukwaja, Kingsley N. (57202824584) ;Undurraga, Eduardo A. (57204092789) ;Uneke, Chigozie Jesse (57202824589) ;Updike, Rachel (57204698680) ;Uthman, Olalekan A. (23026328100) ;Uzochukwu, Benjamin S. Chudi (57211633289) ;Van Boven, Job F.M. (53464198500) ;Varughese, Santosh (22942817500) ;Vasankari, Tommi (23096834700) ;Venkatesh, S. (57201538443) ;Venketasubramanian, Narayanaswamy (56804702100) ;Vidavalur, Ramesh (57201445172) ;Violante, Francesco S. (7003555890) ;Vladimirov, Sergey K. (57195959162) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Wadilo, Fiseha (57194049305) ;Wakayo, Tolassa (57205609717) ;Wang, Yuan-Pang (8576812100) ;Weaver, Marcia (7201548872) ;Weichenthal, Scott (57202555239) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Werdecker, Andrea (57208964895) ;Westerman, Ronny (57218361023) ;Whiteford, Harvey A. (55906494000) ;Wijeratne, Tissa (14051317700) ;Wiysonge, Charles Shey (6507441509) ;Wolfe, Charles D.A. (57202754705) ;Woodbrook, Rachel (57200298006) ;Woolf, Anthony D. (7102882171) ;Workicho, Abdulhalik (56720337100) ;Wulf Hanson, Sarah (57212263269) ;Xavier, Denis (55403963100) ;Xu, Gelin (57203583113) ;Yadgir, Simon (57192837280) ;Yaghoubi, Mohsen (56402926900) ;Yakob, Bereket (57203811497) ;Yan, Lijing L. (35933756700) ;Yano, Yuichiro (57196965200) ;Ye, Pengpeng (57202839295) ;Yimam, Hassen Hamid (57196325590) ;Yip, Paul (7102503720) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Zaidi, Zoubida (57197376721) ;Zaki, Maysaa El Sayed (57203666922) ;Zegeye, Elias Asfaw (57209171278) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zhang, Xueying (56283378700) ;Zhou, Maigeng (57054557200) ;Zipkin, Ben (57200737130) ;Zodpey, Sanjay (7003415080) ;Zuhlke, Liesl Joanna (57209027746)Murray, Christopher J.L. (55481130700)Background As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. Methods We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8-75·9 million [7·2%, 6·0-8·3]), 45·1 million (29·0-62·8 million [5·6%, 4·0-7·2]), 36·3 million (25·3-50·9 million [4·5%, 3·8-5·3]), 34·7 million (23·0-49·6 million [4·3%, 3·5-5·2]), and 34·1 million (23·5-46·0 million [4·2%, 3·2-5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3-3·1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10·4% (95% UI 9·0-11·8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout were the main conditions contributing to higher YLD rates in women. Men had higher age-standardised rates of substance use disorders, diabetes, cardiovascular diseases, cancers, and all injuries apart from sexual violence. Globally, we noted much less geographical variation in disability than has been documented for premature mortality. In 2016, there was a less than two times difference in age-standardised YLD rates for all causes between the location with the lowest rate (China, 9201 YLDs per 100 000, 95% UI 6862-11943) and highest rate (Yemen, 14 774 YLDs per 100 000, 11 018-19 228). Interpretation The decrease in death rates since 1990 for most causes has not been matched by a similar decline in age-standardised YLD rates. For many large causes, YLD rates have either been stagnant or have increased for some causes, such as diabetes. As populations are ageing, and the prevalence of disabling disease generally increases steeply with age, health systems will face increasing demand for services that are generally costlier than the interventions that have led to declines in mortality in childhood or for the major causes of mortality in adults. Up-todate information about the trends of disease and how this varies between countries is essential to plan for an adequate health-system response. © The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: A systematic analysis for the Global Burden of Disease Study 2016(2017) ;Wang, Haidong (16507828100) ;Abajobir, Amanuel Alemu (57203613441) ;Abate, Kalkidan Hassen (57207943858) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abd-Allah, Foad (36503428900) ;Abera, Semaw Ferede (57205180598) ;Abraha, Haftom Niguse (57195289877) ;Abu-Raddad, Laith J. (14032724700) ;Abu-Rmeileh, Niveen M.E. (57216675148) ;Adedeji, Isaac Akinkunmi (57208456508) ;Adedoyin, Rufus Adesoji (55947572800) ;Adetifa, Ifedayo Morayo O. 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(57195959162) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Vos, Theo (57223885848) ;Waid, Jillian L. (57191965831) ;Wakayo, Tolassa (57205609717) ;Wang, Yuan-Pang (8576812100) ;Weichenthal, Scott (57202555239) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Werdecker, Andrea (57208964895) ;Wesana, Joshua (56688521300) ;Wijeratne, Tissa (14051317700) ;Wilkinson, James D. (57207903571) ;Wiysonge, Charles Shey (6507441509) ;Woldeyes, Belete Getahun (57195329524) ;Wolfe, Charles D.A. (57202754705) ;Workicho, Abdulhalik (56720337100) ;Workie, Shimelash Bitew (57191837199) ;Xavier, Denis (55403963100) ;Xu, Gelin (57203583113) ;Yaghoubi, Mohsen (56402926900) ;Yakob, Bereket (57203811497) ;Yalew, Ayalnesh Zemene (57190286375) ;Yan, Lijing L. (57198311895) ;Yano, Yuichiro (57196965200) ;Yaseri, Mehdi (23029507000) ;Ye, Pengpeng (57202839295) ;Yimam, Hassen Hamid (57196325590) ;Yip, Paul (7102503720) ;Yirsaw, Biruck Desalegn (49664327400) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922) ;Zeeb, Hajo (57203073012) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zerfu, Taddese Alemu (55358278900) ;Zhang, Anthony Lin (56391112900) ;Zhang, Xueying (56283378700) ;Zodpey, Sanjay (7003415080) ;Zuhlke, Liesl Joanna (57209027746) ;Lopez, Alan D. (7401455668)Murray, Christopher J.L. (55481130700)Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods: We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0.5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Socio-demographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. Findings: Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates - a measure of relative inequality - increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86.9 years (95% UI 86.7-87.2), and for men in Singapore, at 81.3 years (78.8-83.7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, and the gap between male and female life expectancy increased with progression to higher levels of SDI. Some countries with exceptional health performance in 1990 in terms of the difference in observed to expected life expectancy at birth had slower progress on the same measure in 2016. Interpretation Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both level and rate of changes in age-specific mortality; increases in mortality for certain age groups occurred in some locations. We found evidence that the absolute gap between countries in age-specific death rates has declined, although the relative gap for some age-sex groups increased. Countries that now lead in terms of having higher observed life expectancy than that expected on the basis of development alone, or locations that have either increased this advantage or rapidly decreased the deficit from expected levels, could provide insight into the means to accelerate progress in nations where progress has stalled. Copyright © The Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: A novel analysis from the global burden of disease study 2015(2017) ;Barber, Ryan M. (57202560423) ;Fullman, Nancy (57211064970) ;Sorensen, Reed J.D. (57196918748) ;Bollyky, Thomas (36677045500) ;McKee, Martin (7202304775) ;Nolte, Ellen (7005556106) ;Abajobir, Amanuel Alemu (57203613441) ;Abate, Kalkidan Hassen (57207943858) ;Abbafati, Cristiana (54917122400) ;Abbas, Kaja M. (57190285707) ;Abd-Allah, Foad (36503428900) ;Abdulle, Abdishakur M. (6603592018) ;Abdurahman, Ahmed Abdulahi (56677630600) ;Abera, Semaw Ferede (57205180598) ;Abraham, Biju (57202568691) ;Abreha, Girmatsion Fisseha (6504124710) ;Adane, Kelemework (57202841698) ;Adelekan, Ademola Lukman (57216109261) ;Adetifa, Ifedayo Morayo O. 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(7404421736) ;Singh, Om Prakash (57207807888) ;Singh, Prashant Kumar (57208090732) ;Singh, Virendra (57191848598) ;Sinke, Abiy Hiruye (57195329519) ;Sinshaw, Aklilu Endalamaw (57202040629) ;Skirbekk, Vegard (57202564482) ;Sliwa, Karen (57207223988) ;Smith, Alison (57191843859) ;Sobngwi, Eugene (6701427993) ;Soneji, Samir (57204096389) ;Soriano, Joan B. (7101973935) ;Sousa, Tatiane Cristina Moraes (57195329460) ;Sposato, Luciano A. (25640261000) ;Sreeramareddy, Chandrashekhar T. (57212263335) ;Stathopoulou, Vasiliki (57195644148) ;Steel, Nicholas (6603791873) ;Steiner, Caitlyn (57205358084) ;Steinke, Sabine (57203777687) ;Stokes, Mark Andrew (7102859000) ;Stranges, Saverio (7003835008) ;Strong, Mark (12783473200) ;Stroumpoulis, Konstantinos (57211777127) ;Sturua, Lela (37662283900) ;Sufiyan, Muawiyyah Babale (58294633600) ;Suliankatchi, Rizwan Abdulkader (57195295816) ;Sun, Jiandong (55547135892) ;Sur, Patrick (57218360398) ;Swaminathan, Soumya (7102380757) ;Sykes, Bryan L. (57211183396) ;Tabarés-Seisdedos, Rafael (6602981102) ;Tabb, Karen M. (51162023700) ;Taffere, Getachew Redae (59807215200) ;Talongwa, Roberto Tchio (57195568335) ;Tarajia, Musharaf (56041372500) ;Tavakkoli, Mohammad (57202524239) ;Taveira, Nuno (6602731390) ;Teeple, Stephanie (57191850890) ;Tegegne, Teketo Kassaw (57216998561) ;Tehrani-Banihashemi, Arash (57204006020) ;Tekelab, Tesfalidet (56721378300) ;Tekle, Dejen Yemane (57191848698) ;Temam Shifa, Girma (57217000284) ;Terkawi, Abdullah Sulieman (57211144258) ;Tesema, Azeb Gebresilassie (57194530110) ;Thakur, J.S. (57204002123) ;Thomson, Alan J. (57969994200) ;Tillmann, Taavi (57190211142) ;Tiruye, Tenaw Yimer (57194055872) ;Tobe-Gai, Ruoyan (57209276611) ;Tonelli, Marcello (7103102534) ;Topor-Madry, Roman (57211182892) ;Tortajada, Miguel (16242320900) ;Troeger, Christopher (57195223624) ;Truelsen, Thomas (57202824565) ;Tura, Abera Kenay (57195623051) ;Uchendu, Uche S. (56328470200) ;Ukwaja, Kingsley N. (57202824584) ;Undurraga, Eduardo A. (57204092789) ;Uneke, Chigozie Jesse (57202824589) ;Uthman, Olalekan A. (23026328100) ;Van Boven, Job F.M. (53464198500) ;Van Dingenen, Rita (57203088526) ;Varughese, Santosh (22942817500) ;Vasankari, Tommi (57200592416) ;Venketasubramanian, Narayanaswamy (56804702100) ;Violante, Francesco S. (7003555890) ;Vladimirov, Sergey K. (57195959162) ;Vlassov, Vasiliy Victorovich (57211633239) ;Vollset, Stein Emil (57196315778) ;Vos, Theo (57223885848) ;Wagner, Joseph A. (56990441500) ;Wakayo, Tolassa (57205609717) ;Waller, Stephen G. (57201445180) ;Walson, Judd L. (57203254111) ;Wang, Haidong (16507828100) ;Wang, Yuan-Pang (8576812100) ;Watkins, David A. (35207242300) ;Weiderpass, Elisabete (57205018947) ;Weintraub, Robert G. (7006079405) ;Wen, Chi-Pang (58460870400) ;Werdecker, Andrea (57208964895) ;Wesana, Joshua (56688521300) ;Westerman, Ronny (57218361023) ;Whiteford, Harvey A. (55906494000) ;Wilkinson, James D. (57207903571) ;Wiysonge, Charles Shey (6507441509) ;Woldeyes, Belete Getahun (57195329524) ;Wolfe, Charles D.A. (57202754705) ;Won, Sungho (57207796874) ;Workicho, Abdulhalik (56720337100) ;Workie, Shimelash Bitew (57191837199) ;Wubshet, Mamo (54409732600) ;Xavier, Denis (55403963100) ;Xu, Gelin (57203583113) ;Yadav, Ajit Kumar (57197675591) ;Yaghoubi, Mohsen (56402926900) ;Yakob, Bereket (57203811497) ;Yan, Lijing L. (57198311895) ;Yano, Yuichiro (57196965200) ;Yaseri, Mehdi (23029507000) ;Yimam, Hassen Hamid (57196325590) ;Yip, Paul (7102503720) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Younis, Mustafa Z. (8549393000) ;Yu, Chuanhua (57201889726) ;Zaidi, Zoubida (57197376721) ;El Sayed Zaki, Maysaa (57203666922) ;Zambrana-Torrelio, Carlos (57193255530) ;Zapata, Tomas (57194968519) ;Zenebe, Zerihun Menlkalew (57200737185) ;Zodpey, Sanjay (7003415080) ;Zoeckler, Leo (57203905510) ;Zuhlke, Liesl Joanna (57209027746)Murray, Christopher J.L. (55481130700)Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015. Methods We mapped the most widely used list of causes amenable to personal health care developed by Nolte and McKee to 32 GBD causes. We accounted for variations in cause of death certification and misclassifications through the extensive data standardisation processes and redistribution algorithms developed for GBD. To isolate the effects of personal health-care access and quality, we risk-standardised cause-specific mortality rates for each geography-year by removing the joint effects of local environmental and behavioural risks, and adding back the global levels of risk exposure as estimated for GBD 2015. We employed principal component analysis to create a single, interpretable summary measure-the Healthcare Quality and Access (HAQ) Index-on a scale of 0 to 100. The HAQ Index showed strong convergence validity as compared with other health-system indicators, including health expenditure per capita (r=0·88), an index of 11 universal health coverage interventions (r=0·83), and human resources for health per 1000 (r=0·77). We used free disposal hull analysis with bootstrapping to produce a frontier based on the relationship between the HAQ Index and the Socio-demographic Index (SDI), a measure of overall development consisting of income per capita, average years of education, and total fertility rates. This frontier allowed us to better quantify the maximum levels of personal health-care access and quality achieved across the development spectrum, and pinpoint geographies where gaps between observed and potential levels have narrowed or widened over time. Findings Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. Of 195 geographies, 167 had statistically significant increases in HAQ Index levels since 1990, with South Korea, Turkey, Peru, China, and the Maldives recording among the largest gains by 2015. Performance on the HAQ Index and individual causes showed distinct patterns by region and level of development, yet substantial heterogeneities emerged for several causes, including cancers in highest-SDI countries; chronic kidney disease, diabetes, diarrhoeal diseases, and lower respiratory infections among middle-SDI countries; and measles and tetanus among lowest-SDI countries. While the global HAQ Index average rose from 40·7 (95% uncertainty interval, 39·0-42·8) in 1990 to 53·7 (52·2-55·4) in 2015, far less progress occurred in narrowing the gap between observed HAQ Index values and maximum levels achieved; at the global level, the difference between the observed and frontier HAQ Index only decreased from 21·2 in 1990 to 20·1 in 2015. If every country and territory had achieved the highest observed HAQ Index by their corresponding level of SDI, the global average would have been 73·8 in 2015. Several countries, particularly in eastern and western sub-Saharan Africa, reached HAQ Index values similar to or beyond their development levels, whereas others, namely in southern sub-Saharan Africa, the Middle East, and south Asia, lagged behind what geographies of similar development attained between 1990 and 2015. Interpretation This novel extension of the GBD Study shows the untapped potential for personal health-care access and quality improvement across the development spectrum. Amid substantive advances in personal health care at the national level, heterogeneous patterns for individual causes in given countries or territories suggest that few places have consistently achieved optimal health-care access and quality across health-system functions and therapeutic areas. This is especially evident in middle-SDI countries, many of which have recently undergone or are currently experiencing epidemiological transitions. The HAQ Index, if paired with other measures of health-system characteristics such as intervention coverage, could provide a robust avenue for tracking progress on universal health coverage and identifying local priorities for strengthening personal health-care quality and access throughout the world. Copyright © The Author(s). Published by Elsevier Ltd. - Some of the metrics are blocked by yourconsent settings
Publication Trends in HIV/AIDS morbidity and mortality in Eastern Mediterranean countries, 1990–2015: findings from the Global Burden of Disease 2015 study(2018) ;Mokdad, Ali H. (7004813962) ;El Bcheraoui, Charbel (25027689700) ;Wang, Haidong (16507828100) ;Khalil, Ibrahim (58255049500) ;Afshin, Ashkan (57217465455) ;Collison, Michael (57202309052) ;Daoud, Farah (57201079837) ;Chew, Adrienne (57209171085) ;Krohn, Kristopher J. (57194138806) ;Carter, Austin (57201756395) ;Foreman, Kyle J. (57209064414) ;He, Fei (59031207400) ;Kassebaum, Nicholas J. (57202562224) ;Kutz, Michael (57195617315) ;Mirarefin, Mojde (57222113397) ;Nguyen, Grant (57191591002) ;Silpakit, Naris (57202401404) ;Sligar, Amber (57190284582) ;Larson, Heidi J. (57202559142) ;Vollset, Stein Emil (57196315778) ;Vos, Theo (57223885848) ;Hay, Simon I. (7101875313) ;Naghavi, Mohsen (57207906323) ;Murray, Christopher J. L. (55481130700) ;Rawaf, David Laith (57209228052) ;Rawaf, Salman (6602475959) ;Charara, Raghid (56514085300) ;Moradi-Lakeh, Maziar (35617421300) ;Abajobir, Amanuel Alemu (57203613441) ;Abate, Kalkidan Hassen (57207943858) ;Gebrehiwot, Tsegaye Tewelde (57216482917) ;Gesesew, Hailay Abrha (56412148300) ;Wakayo, Tolassa (57205609717) ;Workicho, Abdulhalik (56720337100) ;Abbas, Kaja M. (57190285707) ;Abd-Allah, Foad (36503428900) ;Abera, Semaw Ferede (57205180598) ;Adane, Kelemework (57202841698) ;Agarwal, Arnav (57214768208) ;Kiadaliri, Aliasghar Ahmad (57199100665) ;Ahmadi, Alireza (56336080700) ;Ahmed, Muktar Beshir (57207802317) ;Al Lami, Faris Hasan (57200737005) ;Alam, Khurshid (57203681299) ;Mekonnen, Alemayehu B. (57200179648) ;Alasfoor, Deena (57211114684) ;Alizadeh-Navaei, Reza (57226214128) ;Al-Maskari, Fatma (25824744400) ;Al-Raddadi, Rajaa (57219673720) ;Altirkawi, Khalid A. (57202762923) ;Sobaih, Badr H. A. (57202564080) ;Temsah, Mohamad-Hani (56115852000) ;Alvis-Guzman, Nelson (57210741239) ;Ammar, Walid (57208159281) ;Harb, Hilda L. (57221443122) ;Anber, Nahla (57202351369) ;Antonio, Carl Abelardo T. (55247644500) ;Anwari, Palwasha (57217465526) ;Asayesh, Hamid (55334322800) ;Asghar, Rana Jawad (57209013760) ;Atey, Tesfay Mehari (57209784978) ;Hailu, Gessessew Bugssa (57219637263) ;Mezgebe, Haftay Berhane (57222113213) ;Yalew, Ayalnesh Zemene (57190286375) ;Arthur Avokpaho, Euripide Frinel G. (57202307726) ;Ayele, Tadesse Awoke (55431232600) ;Tesssema, Belay (57195294962) ;Azzopardi, Peter (56861081000) ;Bacha, Umar (57200173721) ;Barac, Aleksandra (55550748700) ;Bärnighausen, Till (23011726900) ;Bazargan-Hejazi, Shahrzad (57205912040) ;Bedi, Neeraj (57202557520) ;Bensenor, Isabela M. (7004830338) ;Berhane, Adugnaw (57200410735) ;Bessong, Pascal Obong (6506832973) ;Beyene, Addisu Shunu (57209036705) ;Bhutta, Zulfiqar A. (24342648300) ;Birungi, Charles (57195448297) ;Bidgoli, Hassan Haghparast (57201491554) ;Butt, Zahid A. (57202522739) ;Cahuana-Hurtado, Lucero (57207890731) ;Danawi, Hadi (57201079895) ;Neves, Josédas (57208073193) ;Deribe, Kebede (57193912587) ;Deribew, Amare (25625914400) ;Des Jarlais, Don C. (56990451200) ;Dharmaratne, Samath D. (57226838689) ;Djalalinia, Shirin (37113718000) ;Doyle, Kerrie E. (55693710800) ;Endries, Aman Yesuf (57216324852) ;Shifa, Girma Temam (57211793093) ;Hareri, Habtamu Abera (57195292447) ;Kassaw, Nigussie Assefa (57196473578) ;Woldu, Minyahil Alebachew (55648411900) ;Eshrati, Babak (16030619200) ;Faraon, Emerito Jose Aquino (57195414019) ;Farvid, Maryam S. (57216534761) ;Feyissa, Tesfaye Regassa (57222562476) ;Tekelab, Tesfalidet (56721378300) ;Fischer, Florian (55508208800) ;Garcia-Basteiro, Alberto L. (57200187168) ;Gishu, Melkamu Dedefo (57202568734) ;Glaser, Elizabeth (56133254300) ;Gona, Philimon N. (57219703762) ;Gugnani, Harish Chander (7005567008) ;Gupta, Rahul (57204120071) ;Hamadeh, Randah Ribhi (57202769526) ;Hambisa, Mitiku Teshome (57203666810) ;Mengesha, Melkamu Merid (57192953602) ;Roba, Hirbo Shore (7102027801) ;Hamidi, Samer (24366336000) ;Horita, Nobuyuki (57217110823) ;Husseini, Abdullatif (6603689690) ;Ibrahim, Ahmed (59644932100) ;James, Spencer Lewis (57202557998) ;Jonas, Jost B. (7202492953) ;Kasaeian, Amir (57195540738) ;Khader, Yousef Saleh (55654192600) ;Khan, Ejaz Ahmad (57218791274) ;Khan, Gulfaraz (6701635515) ;Khoja, Abdullah Tawfih Abdullah (57194229795) ;Khubchandani, Jagdish (57211720011) ;Kim, Yun Jin (57211086375) ;Koyanagi, Ai (59269920500) ;Defo, Barthelemy Kuate (6602271655) ;Latif, Asma Abdul (57201620992) ;Leshargie, Cheru Tesema (57195295462) ;Tegegne, Teketo Kassaw (57216998561) ;Lunevicius, Raimundas (57216165063) ;El Razek, Mohammed Magdy Abd (57216629996) ;Majdzadeh, Reza (9246620000) ;Majeed, Azeem (57217722657) ;Malekzadeh, Reza (7005197760) ;Roshandel, Gholamreza (14034446800) ;Sepanlou, Sadaf G. (36248136000) ;Manyazewal, Tsegahun (57204150906) ;Markos, Desalegn (57210741352) ;Farid, Habibolah Masoudi (57191592768) ;Mehari, Alem (57211114616) ;Memiah, Peter (57217207827) ;Memish, Ziad A. (7005059350) ;Mendoza, Walter (57216905642) ;Mengistu, Desalegn Tadese (57194776802) ;Mhimbira, Francis Apolinary (57207789910) ;Miller, Ted R. (7403948600) ;Moore, Ami R. (57216303682) ;Mumtaz, Ghina R. (57191452190) ;Natarajan, Gopalakrishnan (55804491100) ;Negin, Joel (25937447400) ;Obermeyer, Carla Makhlouf (57209300189) ;Ogbo, Felix Akpojene (57217186813) ;Oh, In-Hwan (57204090669) ;Ota, Erika (57202554474) ;Pereira, David M. (57200690024) ;Pourmalek, Farshad (8309390500) ;Qorbani, Mostafa (24831040300) ;Radfar, Amir (57194428768) ;Rafay, Anwar (57212263323) ;Rahimi-Movaghar, Vafa (6507646446) ;Salamati, Payman (14045860600) ;Rai, Rajesh Kumar (51864423900) ;Ram, Usha (26653819000) ;Renzaho, Andre M. N. (6505786588) ;Rezaei, Satar (55791003000) ;Rezai, Mohammad Sadegh (55273796300) ;Safdarian, Mahdi (57203849024) ;Safiri, Saeid (56009654100) ;Sahraian, Mohammad Ali (55886074600) ;Samy, Abdallah M. (36973661300) ;Sartorius, Benn (12788526800) ;Shaikh, Masood Ali (57203122601) ;Shamsizadeh, Morteza (57195940127) ;Sibamo, Ephrem Lejore Sibamo (57195508024) ;Wadilo, Fiseha (57194049305) ;Workie, Shimelash Bitew (57191837199) ;Singh, Jasvinder A. (7404421736) ;Soshnikov, Sergey (57195195606) ;Sufiyan, Muawiyyah Babale (58294633600) ;Sykes, Bryan L. (57218362022) ;Taveira, Nuno (6602731390) ;Tehrani-Banihashemi, Arash (57204006020) ;Topor-Madry, Roman (57211182892) ;Ukwaja, Kingsley Nnanna (57202824584) ;Uthman, Olalekan A. (23026328100) ;Yaghoubi, Mohsen (56402926900) ;Yimam, Hassen Hamid (57196325590) ;Yonemoto, Naohiro (57204947657) ;Yoon, Seok-Jun (24823148900) ;Yotebieng, Marcel (26325950800) ;Younis, Mustafa Z. (8549393000) ;Zaki, Maysaa El Sayed (57203666922)Jumaan, Aisha O. (6603612494)Objectives: We used the results of the Global Burden of Disease 2015 study to estimate trends of HIV/AIDS burden in Eastern Mediterranean Region (EMR) countries between 1990 and 2015. Methods: Tailored estimation methods were used to produce final estimates of mortality. Years of life lost (YLLs) were calculated by multiplying the mortality rate by population by age-specific life expectancy. Years lived with disability (YLDs) were computed as the prevalence of a sequela multiplied by its disability weight. Results: In 2015, the rate of HIV/AIDS deaths in the EMR was 1.8 (1.4–2.5) per 100,000 population, a 43% increase from 1990 (0.3; 0.2–0.8). Consequently, the rate of YLLs due to HIV/AIDS increased from 15.3 (7.6–36.2) per 100,000 in 1990 to 81.9 (65.3–114.4) in 2015. The rate of YLDs increased from 1.3 (0.6–3.1) in 1990 to 4.4 (2.7–6.6) in 2015. Conclusions: HIV/AIDS morbidity and mortality increased in the EMR since 1990. To reverse this trend and achieve epidemic control, EMR countries should strengthen HIV surveillance, and scale up HIV antiretroviral therapy and comprehensive prevention services. © 2017, The Author(s).
