Browsing by Author "Šipetić, S. (6701802171)"

Purpose: Dietary factors have been suggested as having a major role in the etiology of prostate cancer. The purpose of this study was to investigate whether there are differences in the dietary factors between younger and older men with prostate cancer. Materials and methods: A case-control study was conducted in two towns of Serbia without provinces. The case group consisted of 101 patients with histologically confirmed prostate cancer and the control group of 202 hospital patients with no neoplastic disorders (for each case two controls were chosen). Cases and controls were individualy matched by age (± 2 years), time of hospital admission and place of residence. Univariate and multivariate logistic regression methods were used for result anlayses. Results: After adjustment for a variety of confounding variables, a significant relationship between prostate cancer and vitamin B 12 (odds ratio - OR = 4.77; 95% confidence interval - 95% C.I. = 1.74-13.07) and potassium (OR = 0.18; 95% C.I. = 0.07-0.49) was found in men ≤ 70 years old. In men > 70 years old daily intake of retinol and atocopherol were independently significantly related to prostate cancer (OR = 3.20; 95% C.I. = 1.38-7.43 and OR = 0.42; 95% C.I. = 0.18-0.99, respectively). Conclusion: Differences between younger and older men in the dietary factors related to prostate cancer (retinol and a-tocopherol) are in line with the existing literature data. The relationship of prostate cancer with vitamin B12 and potassium should be corroborated by other authors.

Purpose: Dietary factors have been suggested as having a major role in the etiology of prostate cancer. The purpose of this study was to investigate whether there are differences in the dietary factors between younger and older men with prostate cancer. Materials and methods: A case-control study was conducted in two towns of Serbia without provinces. The case group consisted of 101 patients with histologically confirmed prostate cancer and the control group of 202 hospital patients with no neoplastic disorders (for each case two controls were chosen). Cases and controls were individualy matched by age (± 2 years), time of hospital admission and place of residence. Univariate and multivariate logistic regression methods were used for result anlayses. Results: After adjustment for a variety of confounding variables, a significant relationship between prostate cancer and vitamin B 12 (odds ratio - OR = 4.77; 95% confidence interval - 95% C.I. = 1.74-13.07) and potassium (OR = 0.18; 95% C.I. = 0.07-0.49) was found in men ≤ 70 years old. In men > 70 years old daily intake of retinol and atocopherol were independently significantly related to prostate cancer (OR = 3.20; 95% C.I. = 1.38-7.43 and OR = 0.42; 95% C.I. = 0.18-0.99, respectively). Conclusion: Differences between younger and older men in the dietary factors related to prostate cancer (retinol and a-tocopherol) are in line with the existing literature data. The relationship of prostate cancer with vitamin B12 and potassium should be corroborated by other authors.

Aims/hypothesis: We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes. Methods: Relevant studies published before February 2009 were identified from literature searches using MEDLINE, Web of Science and EMBASE. Authors of all studies containing relevant data were contacted and asked to provide individual patient data or conduct pre-specified analyses. Risk estimates of type 1 diabetes by category of birthweight were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were then used to derive combined ORs and investigate heterogeneity between studies. Results: Data were available for 29 predominantly European studies (five cohort, 24 case-control studies), including 12,807 cases of type 1 diabetes. Overall, studies consistently demonstrated that children with birthweight from 3.5 to 4 kg had an increased risk of diabetes of 6% (OR 1.06 [95% CI 1.01-1.11]; p=0.02) and children with birthweight over 4 kg had an increased risk of 10% (OR 1.10 [95% CI 1.04-1.19]; p=0.003), compared with children weighing 3.0 to 3.5 kg at birth. This corresponded to a linear increase in diabetes risk of 3% per 500 g increase in birthweight (OR 1.03 [95% CI 1.00-1.06]; p=0.03). Adjustments for potential confounders such as gestational age, maternal age, birth order, Caesarean section, breastfeeding and maternal diabetes had little effect on these findings. Conclusions/interpretation: Children who are heavier at birth have a significant and consistent, but relatively small increase in risk of type 1 diabetes. © 2010 Springer-Verlag.

The objective of the work was to study blood pressure and some anthropometric characteristics in children. The study design included the prevalence study at Belgrade, Serbia and Montenegro. The study comprised 1651 subjects (809 boys and 842 girls) aged 7-14 years, that is, 2.6% of all relevant population. The average levels of systolic and diastolic blood pressures (SBP and DBF) were 113.4/70.3 mmHg in boys and 114.6/71.1 mmHg in girls. High SBP was present in 4.7% of boys and in 5.3% of girls. High DBP was found in 5.6% of boys and in 4.8% of girls. According to multivariate regression analysis, in boys SBP and DBP were significantly associated with age, body mass index (BMI) and subscapular skinfold, SBP was also associated with body weight, and DBP with triceps skinfold. In girls, SBP was significantly related to BMI, suprailiac skinfold and body height, and DBP was significantly associated with BMI, suprailiac and subscapular skinfolds. The results of the present study support the opinion that BMI is a significant predictor of blood pressure in children and point out to suprailiac skinfold in girls as a possible predictor of blood pressure.

Aims/hypothesis: The aim of this study was to investigate the evidence of an increased risk of childhood-onset type 1 diabetes in children born by Caesarean section by systematically reviewing the published literature and performing a meta-analysis with adjustment for recognised confounders. Methods: After MEDLINE, Web of Science and EMBASE searches, crude ORs and 95% CIs for type 1 diabetes in children born by Caesarean section were calculated from the data reported in each study. Authors were contacted to facilitate adjustments for potential confounders, either by supplying raw data or calculating adjusted estimates. Meta-analysis techniques were then used to derive combined ORs and to investigate heterogeneity between studies. Results: Twenty studies were identified. Overall, there was a significant increase in the risk of type 1 diabetes in children born by Caesarean section (OR 1.23, 95% CI 1.15-1.32, p<0.001). There was little evidence of heterogeneity between studies (p=0.54). Seventeen authors provided raw data or adjusted estimates to facilitate adjustments for potential confounders. In these studies, there was evidence of an increase in diabetes risk with greater birthweight, shorter gestation and greater maternal age. The increased risk of type 1 diabetes after Caesarean section was little altered after adjustment for gestational age, birth weight, maternal age, birth order, breast-feeding and maternal diabetes (adjusted OR 1.19, 95% CI 1.04-1.36, p=0.01). Conclusions/interpretation: This analysis demonstrates a 20% increase in the risk of childhood-onset type 1 diabetes after Caesarean section delivery that cannot be explained by known confounders. © 2008 Springer-Verlag.

The aim of the study was to evaluate association of type 1 diabetes in children and adolescents with positive family history of type 1 diabetes, type 2 diabetes, and thyroid, adrenal, rheumatic, allergic, celiac and some other diseases. A case-control study was conducted in Belgrade. The case group comprised 105 subjects ≤16 years old who were for the first time hospitalized because of type 1 diabetes during the period 1994-1997. For each case, two controls were chosen among children and adolescents treated for skin diseases. Cases and controls were individually matched by age (± one year), sex and place of residence (all were from Belgrade). In the statistical analysis we used X2 test, Fisher's exact test and univariate and multivariate logistic regressions. According to multivariate logistic regression analysis, risk of type 1 diabetes was significantly associated with a positive family history for type 1 diabetes (OR=8.58; 95% CI, 3.28-22.46), type 2 diabetes (OR=4.04; 95% CI, 2.31-7.07), allergic diseases (OR=3.32; 95% CI, 1.63-6.76), celiac and Crohn's diseases (OR=11.02; 95% CI, 1.14-106.89) and other diseases (thrombocytopenia, alopecia areata, psoriasis, chronic uveitis and pernicious anemia; OR=3.63; 95% CI, 1.05-12.48).

The aim of the study was to evaluate association of type 1 diabetes in children and adolescents with positive family history of type 1 diabetes, type 2 diabetes, and thyroid, adrenal, rheumatic, allergic, celiac and some other diseases. A case-control study was conducted in Belgrade. The case group comprised 105 subjects ≤16 years old who were for the first time hospitalized because of type 1 diabetes during the period 1994-1997. For each case, two controls were chosen among children and adolescents treated for skin diseases. Cases and controls were individually matched by age (± one year), sex and place of residence (all were from Belgrade). In the statistical analysis we used X2 test, Fisher's exact test and univariate and multivariate logistic regressions. According to multivariate logistic regression analysis, risk of type 1 diabetes was significantly associated with a positive family history for type 1 diabetes (OR=8.58; 95% CI, 3.28-22.46), type 2 diabetes (OR=4.04; 95% CI, 2.31-7.07), allergic diseases (OR=3.32; 95% CI, 1.63-6.76), celiac and Crohn's diseases (OR=11.02; 95% CI, 1.14-106.89) and other diseases (thrombocytopenia, alopecia areata, psoriasis, chronic uveitis and pernicious anemia; OR=3.63; 95% CI, 1.05-12.48).

The incidence of gonorrhea in Belgrade decreased 55.5% from 1988 to 1994, but a decreasing trend of gonorrhea incidence actually started many years before. In all age groups gonorrhea incidence was higher in men than women, and the male/female ratio increased with age. The incidence was highest in men and women 20-29 years old. In both sexes the lowest incidence was below 15 years of age and in persons 50 or more years of age. In men, service and industrial workers were the most frequently affected by gonorrhea. In women the disease was commonest among unemployed persons and among workers of the service and industrial sectors. In both sexes gonorrhea infection was commonest in populations who had never married, and in the divorced population.

During the period of 1975-1989, in the Belgrade population increasing mortality trends were established for colon and rectal cancer, cancer of the pancreas and gallbladder and bile ducts cancer, for both sexes, and for esophageal cancer in males. Stomach and liver cancer mortality decreased in females. In males, stomach cancer mortality after a prolonged steady decrease suddenly rose in the years 1988 and 1989. Mortality rates series for esophageal cancer in females and for liver cancer in males did not fit any usual trend function. © 1994 Kluwer Academic Publishers.

[No abstract available]