Browsing by Author "Šantrić, Veljko (55598984100)"

Background/Aim. Benign prostatic hyperplasia (BPH) is a pathological process, which is one of the most common causes of so-called lower urinary tract symptoms (LUTS). LUTS affect many aspects of daily activities and almost all domains of health-related quality of life (HRQoL). The objective of this study was to evaluate the effects of operative treatment of BPH using standard clinical diagnostic procedures and effects on LUTS using the symptom-score validated to Serbian language as well as implications on HRQoL. Methods. Seventy-four patients underwent surgical treatment for BPH. The study protocol included objective and subjective parameters of the following sets of variables measured before and after the surgery: voiding and incontinence symptoms were measured using the International Continence Society male Short Form (ICS male SF) questionnaire, HRQoL was measured using the SF-36 questionnaire along with standard clinical measurement of residual urine and urine flow. Results. After the surgery, all patients had decrease of voiding scores (13.5 ± 3.3 before and 1.5 ± 1.4 after surgery) and incontinence symptoms (5.7 ± 3.9 before and 0.6 ± 0.8 after surgery) in comparison to period before operative treatment. Significant improvements in all dimensions of HRQoL were noticed, particularly in emotional health. Although mental and physical total scores were significantly better than prior to the surgery, the level of improvement of voiding and incontinence scores were significantly correlated only with the level of improvement of mental score. Conclusion. After BPH surgery, patients are likely to have normal voiding symptoms, barely some involuntary control over urination and overll better HRQoL, particularly in emotional domain. © 2019 Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved.

Objective: Mutation of p53 is detected in more than 50% of human cancers, expression of p53 has a potential prognostic value in patients with renal cell carcinoma (RCC). Survivin is a member of the inhibitor of apoptosis protein family, its overexpression is observed in many malignancies, including RCC. The aim of the study was to estimate a correlation between survivin and p53 expression in tumor samples and the histologic type of a tumor, tumor stage, tumor grade, and survival of patients. Materials and Methods: Tumor samples were collected from surgical specimens of 90 patients who underwent radical or partial nephrectomy for RCC between November 2017 and July 2020. Tumors were staged according to the UICC (The Union for International Cancer Control) TNM classification system and histopathologically graded according to Fuhrman nuclear grade system. Histopathological diagnosis was confirmed with standard light microscopic evaluation, using hematoxylin and eosin staining and standard p53 and survivin antibodies. Results: Positive p53 staining was observed in 36.7% of tumor specimens and 24.4% were survivin positive. There was a statistically significant correlation between p53 or survivin expression and histologic subtype of clear cell RCC as well as Type I and II of papillary RCC. There was a statistically significant correlation between p53 expression and tumor size, stage, and grade. The p53 or survivin expression was related to lower overall survival. Conclusion: The results of this study suggest that p53 overexpression and survivin positivity in RCC patients could be associated with poor prognosis. Thus, these proteins could be used as prognostic markers in RCC. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.

Intravesical BCG (Bacillus Calmette–Guerin) therapy represents the therapy of choice for intermediary-and high-risk non-muscle invasive bladder cancers after transurethral resection. However, up to 40% of these patients do not show adequate response to the therapy (BCG failure) and 15% of them experience the progression of the disease to muscle-invasive bladder cancer. In such cases, radical cystectomy is indicated. Studies suggest that early radical cystectomy in patients with BCG failure is followed by better survival compared to delayed radical cystectomy. The prediction of response to BCG therapy could en-able early identification of patients on which this therapy would have no effect and who should undergo early radical cystectomy. © 2022, Serbia Medical Society. All rights reserved.

Introduction/Objective The COVID-19 pandemic affected the functioning of health care systems, includ-ing emergency services worldwide. The aim of this study was to examine the impact of the pandemic and lockdown on the care of urgent urological patients in daily practice. Methods Data were retrospectively collected from patients urgently hospitalized at Emergency Department of Clinic of Urology, University Clinical Center of Serbia, during the first three months of lockdown between March 15 and June 15, 2020, and compared to the same period in 2019. The collected data included demographic and clinical characteristics, as well as treatment characteristics and treatment outcomes. Results This study included 80 patients who were hospitalized during the 2020 lockdown and 68 patients who were hospitalized in the same period in 2019. There was no difference in total number of hospitalized patients, age and sex when comparing these two periods. Among patients with urinary tract infection, the number of patients with urosepsis was significantly higher in 2020 (p = 0.028). The median time from symptoms’ onset to hospitalization was significantly longer in patients who were hospitalized in 2020 (p = 0.049). No difference was found in duration of hospitalization and characteristics of treatment between the two periods. The number of deaths was significantly higher in 2020 (p = 0.034). Conclusion During lockdown in Serbia, patients sought emergency urology service significantly later. Furthermore, a higher number of patients with urosepsis and a higher number of deaths among hospitalized patients were found during lockdown compared to the previous year. © 2023, Serbia Medical Society. All rights reserved.