Svetel, Marina (6701477867)Marina (6701477867)SvetelPotrebić, Aleksandra (6507575592)Aleksandra (6507575592)PotrebićPekmezović, Tanja (7003989932)Tanja (7003989932)PekmezovićTomić, Aleksandra (26654535200)Aleksandra (26654535200)TomićKresojević, Nikola (26644117100)Nikola (26644117100)KresojevićJešić, Rada (6701488512)Rada (6701488512)JešićDragašević, Nataša (59157743200)Nataša (59157743200)DragaševićKostić, Vladimir S. (35239923400)Vladimir S. (35239923400)Kostić2025-07-022025-07-022009https://doi.org/10.1016/j.parkreldis.2009.01.010https://www.scopus.com/inward/record.uri?eid=2-s2.0-70450253340&doi=10.1016%2fj.parkreldis.2009.01.010&partnerID=40&md5=812880dd4a268822271933137b3dcfe8https://remedy.med.bg.ac.rs/handle/123456789/14190The objective of the current cross-sectional study was to use standardized psychiatric interviews (the Structured Clinical Interview for DSM-IV Axis I Disorders and the Neuropsychiatric Inventory; NPI) in order to better characterize psychiatric symptoms in 50 consecutive, treated and clinically stable patients with Wilson's disease (WD). Nine patients (18%) had one, 7 patients (14%) had two, and 20 (40%) had ≥ 3 neuropsychiatric symptoms present. The most often endosed symptoms were anxiety (62%), depression (36%), irritability (26%), as well as disinhibition and apathy (24% each). Twenty two patients (44%) had a score ≥ 4 on at least one of the NPI items: again, most frequently anxiety (17 patients; 34%), depression (13 patients; 26%) and apathy (9 patients; 18%). Therefore, even among stable, long-term treated patients with WD approximately 70% experienced psychiatric symptoms. © 2009 Elsevier Ltd. All rights reserved.Neuropsychiatric inventoryPsychiatric symptomsWilson's disease