Lingvay, Ildiko (12763009500)Ildiko (12763009500)LingvayDesouza, Cyrus V. (7005628017)Cyrus V. (7005628017)DesouzaLalic, Katarina S. (13702563300)Katarina S. (13702563300)LalicRose, Ludger (55836268600)Ludger (55836268600)RoseHansen, Thomas (6602275841)Thomas (6602275841)HansenZacho, Jeppe (57203441073)Jeppe (57203441073)ZachoPieber, Thomas R. (7005520071)Thomas R. (7005520071)Pieber2025-07-022025-07-022018https://doi.org/10.2337/dc17-2381https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052435161&doi=10.2337%2fdc17-2381&partnerID=40&md5=c6715c7f8ebb53671040b842a37936eehttps://remedy.med.bg.ac.rs/handle/123456789/12889OBJECTIVE: To investigate the efficacy and safety of once-daily semaglutide in comparison with once-daily liraglutide and placebo in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: This 26-week, multicenter, double-blind trial involved patients diagnosed with type 2 diabetes with HbA1c 7.0-10.0% (53-86 mmol/mol) and treated with diet and exercise with or without metformin. Patients were randomized 2:2:1 to once-daily semaglutide, liraglutide, or placebo in one of four volume-matched doses (semaglutide 0.05,0.1,0.2, or 0.3 mg and liraglutide 0.3,0.6, 1.2, or 1.8 mg, with both compared within each volume-matched dose group). Primary end point was change in HbA1c from baseline to week 26. RESULTS: In total, 705 randomized patients were exposed to trial products. At week 26, a dose-dependent change in HbA1c was observed with semaglutide from 21.1% (0.05 mg) to 21.9% (0.3 mg) and with liraglutide from 20.5% (0.3 mg) to 21.3% (1.8 mg) (all P < 0.001 in favor of volume-matched semaglutide dose). Change with pooled placebo was 20.02% (P < 0.0001 vs. semaglutide). Gastrointestinal (GI) disorders were the most common adverse events (AEs) with semaglutide and liraglutide, occurring in 32.8-54.0% and 21.9-41.5% of patients, respectively. CONCLUSIONS: Once-daily semaglutide at doses up to 0.3 mg/day resulted in greater reductions in HbA1c compared with liraglutide or placebo but with a higher frequency of GI AEs. © 2018 by the American Diabetes Association.