Terzic, M. (55519713300)M. (55519713300)TerzicStimec, B. (7003411337)B. (7003411337)StimecSulovic, V. (7006602555)V. (7006602555)SulovicPlecas, D. (18336978100)D. (18336978100)PlecasVojdovic, L.J. (6508267593)L.J. (6508267593)Vojdovic2025-06-122025-06-121994https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028183381&partnerID=40&md5=8b5829c94dcb181fdf4d04aa765e19bahttps://remedy.med.bg.ac.rs/handle/123456789/1693The possible influence of both beta-endorphin and insulin secretion on diabetes development in pregnant women was studied by means of radioimmunoassay technique (RIA-Nichols Institute). The study was carried out by determination of beta endorphins in peripheral blood samples of 28 pregnant women with gestational diabetes. They consisted of two subgroups: 14 women with insulin independence, and 14 with insulin-dependent disease. Beta endorphin increase was found in both groups, according to the progression of gestation, and the rise was significantly higher in the insulin-dependent group. At the same time, insulin application caused a marked growth of beta-endorphins in insulin-dependent group. Beta-endorphins, inhibiting insulin secretion, can influence gestional diabetes development.beta-endorphinsgestational diabetes