Atanaskovic-Markovic, Marina (6506020842)Marina (6506020842)Atanaskovic-MarkovicCaubet, Jean-Christoph (36460677400)Jean-Christoph (36460677400)Caubet2025-06-122025-06-122016https://doi.org/10.1080/17512433.2016.1213131https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988524933&doi=10.1080%2f17512433.2016.1213131&partnerID=40&md5=cb63d43485bdb81b81eb5b975a9ebd6ehttps://remedy.med.bg.ac.rs/handle/123456789/7502Introduction: Several recent studies confirmed that drug allergy in children is over diagnosed, which is a major public health problem, and results in use of alternative drugs, increasing resistance and health costs. Areas covered: Articles in English with data on drug hypersensitivity in children were identified by searching the databases of MEDLINE (National Library of Medicine) from 1990 till 2016. Expert commentary: It is crucial to make a precise diagnosis with performing a complete allergy work-up based on carefully selected diagnostic tests depending on whether an immediate or a non-immediate reaction is suspected. The drug provocation test remains the gold standard in diagnostic drug hypersensitivity in children. © 2016 Informa UK Limited, trading as Taylor & Francis Group.Allergychildrendrug hypersensitivitydrug provocation testsimmediate reactionsnon-immediate reactionsnon-steroidal anti-inflammatory drugsnon-β-lactam antibioticsskin testsβ-lactam antibiotics