Markovic, Maja Milosevic (57959449200)Maja Milosevic (57959449200)MarkovicPetrovic, Milan (57276493600)Milan (57276493600)PetrovicLatas, Milan (6507748007)Milan (6507748007)LatasDjordjevic, Igor (56524146500)Igor (56524146500)DjordjevicMilovanovic, Srdjan (25621995600)Srdjan (25621995600)MilovanovicJovanovic, Svetlana (9940008300)Svetlana (9940008300)Jovanovic2025-06-122025-06-122024https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183606943&partnerID=40&md5=ef296d37d02504004ad868a62d9ee820https://remedy.med.bg.ac.rs/handle/123456789/1450Background: Oral squamous cell carcinoma (OSCC) has numerous physical, psychosocial and financial implications, which significantly affect patients' quality of life. We aimed to determine the health-related quality of life (HRQoL) and identify quality of life (QoL) predictors in patients with OSCC. Methods: We included 64 consecutive patients aged 40 to 80 yr treated for OSCC from Jan to Dec 2021. Health-related QoL was evaluated using the 30-item Cancer Quality of Life Questionnaire (QLQ-C30) and the 35-item Head and Neck Cancer-Quality of Life Questionnaire (QLQ-H&N35). The demographic questionnaire and clinical parameters were also presented. Results: The functioning scale in the QLQ-C30 questionnaire with the lowest average score was Global health status. The mean QLQ-C30 summary score (80.92 ± 10.4) was higher than the Global health status score (50.5 ± 22.2). In the QLQ-H&N35 questionnaire, the symptoms with highest scores were weight loss, dry mouth, and social eating. Linear regression analysis demonstrated that Global health status score was associated with education level [β-coefficient = 19.33 (95% CI: 10.7-24.9, P=0.004], alcohol consumption [β-coefficient=10.04 (95% CI: 4.5-14.8), P=0.023] and invasive surgical procedure [β-coefficient=22.75 (95% CI: 15.0-30.5), P=0.002]. The QLQ-C30 summary score was associated with living alone [β-coefficient=-20.05 (95% CI: −29.91-(−10.21), P=0.018], smoking status [β-coefficient=4.35 (95% CI: 1.8-6.91), P=0.043] and alcohol consumption [β-coefficient =4.59 (95% CI: 1.99-7.19), P=0.037]. Conclusion: We found several significant predictors of worse perception of HRQoL among patients with OSCC, which may be useful for specific prevention and treatment in order to achieve better QoL. © 2024 Milosevic Markovic et al.Health-related quality of lifeMouth neoplasmsOral squamous cell carcinomaQuestionnaires and surveys