Plavsic, Ljiljana (6505599081)Ljiljana (6505599081)PlavsicKnezevic, Olivera M. (37063293000)Olivera M. (37063293000)KnezevicSovtic, Aleksandar (16234625700)Aleksandar (16234625700)SovticMinic, Predrag (6603400160)Predrag (6603400160)MinicVukovic, Rade (37027529000)Rade (37027529000)VukovicMazibrada, Ilijana (12239600600)Ilijana (12239600600)MazibradaStanojlovic, Olivera (6602159151)Olivera (6602159151)StanojlovicHrncic, Dragan (13907639700)Dragan (13907639700)HrncicRasic-Markovic, Aleksandra (23480382100)Aleksandra (23480382100)Rasic-MarkovicMacut, Djuro (35557111400)Djuro (35557111400)Macut2025-07-022025-07-022020https://doi.org/10.1139/apnm-2019-0137https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078720368&doi=10.1139%2fapnm-2019-0137&partnerID=40&md5=35e282893fe693cdf118b5fee51964b4https://remedy.med.bg.ac.rs/handle/123456789/12563The aim of the study was to compare the effects of high-intensity interval training (HIIT) and nutrition advice on cardiometabolic biomarkers, hormonal parameters, and cardiorespiratory fitness in adolescent girls with obesity. Adolescent girls with obesity (n = 44, aged 13–19 years) were randomized into a 12-week intervention as follows: (i) dietary advice and HIIT (n = 22), and (ii) dietary advice only (n = 22). The concentration of biomarkers of inflammation, biochemical and hormonal testing, oral glucose tolerance test, cardiorespiratory fitness, physical activity levels, and nutrition were assessed. After a 3-month intervention, the diet+HIIT group significantly increased insulin sensitivity index (–0.34 ± 1.52 vs. 1.05 ± 3.21; p = 0.001) and work load (0.6 ± 11.3 W vs. 14.6 ± 20.2 W; p = 0.024) and decreased glucose area under the curve (–0.29 ± 4.69 vs. −0.98 ± 4.06; p = 0.040), insulin area under the curve (−9.65 ± 117.9 vs. −98.7 ± 201.8; p = 0.003), and high-sensitivity C-reactive protein (hs-CRP) (0.12 ± 1.92 mg/L vs. −1.47 ± 3.67 mg/L; p = 0.039) in comparison with the diet group. Regarding within-group changes, both groups had significant improvements in body mass index (BMI), BMI-standard deviation score, body fat percentage, and systolic blood pressure. Positive impact on waist circumference, waist circumference/height ratio, diastolic blood pressure, hs-CRP, work load, maximal heart rate, and resting heart rate was observed only after the diet+HIIT intervention. No significant change was noted in peak oxygen uptake, lipid profile, and hormonal parameters between groups after intervention. Novelty • HIIT and nutrition advice increased insulin sensitivity and decreased BMI, bodyfat, systolicbloodpressure, and diastolicblood pressure. • Nutrition advice decreased BMI, body fat, and systolic blood pressure in adolescent girls with obesity. © 2020, Canadian Science Publishing. All rights reserved.AdolescentsCardiorespiratory fitnessCardiovascular riskHIITHypocaloric dietInsulin sensitivityObesity