Zivanic, A. (57215494207)A. (57215494207)ZivanicStankovic, I. (57197589922)I. (57197589922)StankovicIlic, I. (57210906813)I. (57210906813)IlicPutnikovic, B. (6602601858)B. (6602601858)PutnikovicNeskovic, A.N. (35597744900)A.N. (35597744900)Neskovic2025-06-122025-06-122020https://doi.org/10.1007/s00059-019-4817-4https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081003106&doi=10.1007%2fs00059-019-4817-4&partnerID=40&md5=0a0f86b10363c92ce2da5ceb68b033ebhttps://remedy.med.bg.ac.rs/handle/123456789/4564Background: There is a common assumption that patients with coronary slow flow (CSF) have an excellent prognosis in the absence of coronary artery stenoses. Little is known about whether a history of previous coronary events affects the long-term survival in this population. In this retrospective, observational study, we assessed the possible association of a previous coronary event and long-term prognosis in patients with CSF but without significant coronary artery stenoses. Methods: A total of 141 patients (70 male; median age: 59 years, range: 33–78 years) with CSF and normal coronary angiograms were included in the study. Patients were followed up for all-cause mortality during a period of 47 ± 22 months. Results: Previous myocardial infarction (MI) was reported by 16 (11%) patients who had similar left ventricular ejection fraction (LVEF) as those without previous MI (51 ± 16 vs. 53 ± 16%, p = 0.595). Patients with previous MI more often had an abnormal resting electrocardiogram (69 vs. 40%, p = 0.03), while there were no significant differences in other baseline clinical characteristics (p > 0.05 for age, gender, risk factors, pharmacological treatment). In univariate Cox analysis, only previous MI was associated with unfavorable long-term survival (log-rank p = 0.012), while an abnormal electrocardiogram, LVEF, and other clinical variables were not (log-rank p > 0.05, for all). Kaplan–Meier analysis revealed unfavorable long-term survival in patients with CSF and a history of previous MI. Conclusion: In patients with CSF and an otherwise normal coronary angiogram, a history of a previous MI is associated with unfavorable long-term outcomes. © 2019, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.AngiographyCoronary stenosisHeart attackPrognosisRisk factors