Nesic, V.S. (6701399959)V.S. (6701399959)NesicDjordjevic, V.Z. (57189371857)V.Z. (57189371857)DjordjevicTomic-Spiric, V. (6603500319)V. (6603500319)Tomic-SpiricDudvarski, Z.R. (6504165244)Z.R. (6504165244)DudvarskiSoldatovic, I.A. (35389846900)I.A. (35389846900)SoldatovicArsovic, N.A. (17033449500)N.A. (17033449500)Arsovic2025-06-122025-06-122016https://doi.org/10.1017/S0022215116009087https://www.scopus.com/inward/record.uri?eid=2-s2.0-84995451114&doi=10.1017%2fS0022215116009087&partnerID=40&md5=9ea606a6c73a53649c5c1f0808ed2356https://remedy.med.bg.ac.rs/handle/123456789/7419Objective: This study aimed to compare two sampling methods for nasal nitric oxide in healthy individuals and allergic rhinitis patients, and to examine the within-subject reliability of nasal nitric oxide measurement. Methods: The study included 23 allergic rhinitis patients without concomitant asthma and 10 healthy individuals. For all participants, nitric oxide levels were measured non-invasively from the lungs through the mouth (i.e. the oral fractional exhaled nitric oxide) and the nose. Nasal nitric oxide was measured by two different methods: (1) nasal aspiration via one nostril during breath holding and (2) single-breath quiet exhalation against resistance through a tight facemask (i.e. the nasal fractional exhaled nitric oxide). Results: Compared with healthy participants, allergic rhinitis patients had significantly higher average oral and nasal nitric oxide levels. All methods of nitric oxide measurement had excellent reliability. Conclusion: Nasal nitric oxide measurement is a useful and reliable clinical tool for diagnosing allergic rhinitis in patients without asthma in an out-patient setting. © JLO (1984) Limited 2016.AllergicNitric OxideNosePerennialReproducibility of ResultsRhinitis