Vlajinac, Hristina (7006581450)Hristina (7006581450)VlajinacSipetic, Sandra (6701802171)Sandra (6701802171)SipeticMarinkovic, Jelena (7004611210)Jelena (7004611210)MarinkovicRatkov, Isidora (55957120100)Isidora (55957120100)RatkovMaksimovic, Jadranka (23567176900)Jadranka (23567176900)MaksimovicDzoljic, Eleonora (6603126705)Eleonora (6603126705)DzoljicKostic, Vladimir (57189017751)Vladimir (57189017751)Kostic2025-07-022025-07-022013https://doi.org/10.1002/smi.2424https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873413871&doi=10.1002%2fsmi.2424&partnerID=40&md5=5f787dfa65ea236df9a6f102e6a7994bhttps://remedy.med.bg.ac.rs/handle/123456789/13884A case-control study was conducted in order to investigate the possible link between stressful life events and Parkinson's disease (PD). A group of 110 consecutive newly diagnosed PD cases treated at the Institute of Neurology, Faculty of Medicine, Belgrade University, was compared with a control group comprising 220 subjects with degenerative joint disease and some diseases of the digestive tract. The case and control subjects were matched by sex, age (±2 years) and place of residence (urban/rural). According to conditional multivariate logistic regression analysis, PD was found to be significantly related to retirement (odds ratio - OR 18.73, 95% confidence interval - 95%CI 1.9-175.4), birth of own child (OR 66.22, 95%CI 8.3-526.3) and air raids (OR 5.66, 95%CI 2.4-13.5). The risk of PD significantly increased with the number of stressful events. The results of the present study support the hypothesis that stress may play a role in the development of PD. Copyright © 2012 John Wiley & Sons, Ltd.case-control studyParkinson's diseasestress